Similar studies for GEO DataSets (Select 200089827) - GEO DataSets

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Items: 15

Select item 2000898271.

(Submitter supplied) Background: The study of human lacrimal gland biology and development is limited. Lacrimal gland tissue is damaged or poorly functional in a number of disease states including dry eye disease. Development of cell based therapies for lacrimal gland diseases requires a better understanding of the gene expression and signaling pathways in lacrimal gland. Differential gene expression analysis between lacrimal gland and other embryologically similar tissues may be helpful in furthering our understanding of lacrimal gland development. more...

Organism:: Homo sapiens

Type:: Expression profiling by array; Third-party reanalysis

Platforms:: GPL6244 GPL17586
8 Samples

Download data: CEL, TXT, XLS

Series

Accession:: GSE89827

ID:: 200089827

PubMed Full text in PMC Similar studies

Select item 2002394642.

Characterization of immortalized human lacrimal gland epithelial cells in 2D and 3D cell culture models

(Submitter supplied) In humans, the lacrimal gland produces the aqueous component of the tear film, which e.g. moistens and nourishes the ocular surface to maintain ophthalmic health. Decreased production of the aqueous component leads to the development of dry eye disease, which affects over 250 million people worldwide. Despite the impact on patients, the availability of primary human material to study underlying disease mechanisms is severely constrained. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
16 Samples

Download data: TSV

Series

Accession:: GSE239464

ID:: 200239464

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001051493.

Gene Expression in the Human Lacrimal Gland

(Submitter supplied) Diagnosis of inflamed human lacrimal gland with standard clinical and histopathology evaluation data is imprecise. A large number of these patients are diagnosed with the catch-all classification of nonspecific orbital inflammation (NSOI). We utilized gene expression analysis of lacrimal gland biospy/surgical waste tissues to assist in the classification of sarcoidosis, granulomatosis with polyangiitis (GPA), thyroid eye disease (TED), and subdivisions of NSOI. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
49 Samples

Download data: CEL

Series

Accession:: GSE105149

ID:: 200105149

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Select item 2000013934.

A time course microarray study of gene expression in the mouse lacrimal gland after acute corneal trauma.

(Submitter supplied) Examine the effect of stimulation stress produced by chemical burn to the mice cornea in the lacrimal gland over a time course (0.5 - 360 hours) in comparison with the non-stimulated control animals. Using silver nitrate applicator (silver nitrate 37.5 mg and potassium nitrate 12.5 mg, Graham-Field,Inc.,) do two burns per eye, each with a separate applicator. For animals observed for more than 24 hours, eyes were then treated with gentamicin ointment to minimize infection. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Datasets:: GDS947 GDS948 GDS949
Platforms:: GPL1231 GPL1230 GPL1232
93 Samples

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Series

Accession:: GSE1393

ID:: 200001393

Select item 9495.

Lacrimal gland and cornea burn: time course (SMCmou6600Av2)

Examination of the effect of stimulation stress produced by chemical burn to the cornea in the lacrimal gland over a 1 to 360 hour time course in comparison with the non-stimulated controls.

Organism:: Mus musculus

Type:: Expression profiling by array, log ratio, 7 time sets

Platform:: GPL1232
Series:: GSE1393
29 Samples

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DataSet

Accession:: GDS949

ID:: 949

Select item 9486.

Lacrimal gland and cornea burn: time course (SMCmou6600Av1)

Examination of the effect of stimulation stress produced by chemical burn to the cornea in the lacrimal gland over a 0.5 to 24 hour time course in comparison with the non-stimulated controls.

Organism:: Mus musculus

Type:: Expression profiling by array, log ratio, 4 time sets

Platform:: GPL1231
Series:: GSE1393
18 Samples

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DataSet

Accession:: GDS948

ID:: 948

Select item 9477.

Lacrimal gland and cornea burn: time course (SMCmou8400A)

Examination of the effect of stimulation stress produced by chemical burn to the cornea in the lacrimal gland over a 0.5 to 360 hour time course in comparison with the non-stimulated controls.

Organism:: Mus musculus

Type:: Expression profiling by array, log ratio, 8 time sets

Platform:: GPL1230
Series:: GSE1393
46 Samples

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DataSet

Accession:: GDS947

ID:: 947

Select item 2000583318.

Gene expression in human orbit

(Submitter supplied) Diagnosis of inflamed human orbit tissue with standard clinical and histopathology evaluation data is imprecise. A large number of these patients are diagnosed with the catch-all classification of nonspecific orbital inflammation (NSOI). We utilized gene expression analysis of orbit biopsies to assist in the classification of sarcoidosis, granulomatosis with polyangiitis (GPA), thyroid eye disease (TED), IgG4-associated disease, and subdivisions of NSOI. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
175 Samples

Download data: CEL

Series

Accession:: GSE58331

ID:: 200058331

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000057839.

Estrogen's and progesterone's impact on gene expression in the mouse lacrimal and meibomoan gland.

(Submitter supplied) PURPOSE: The hypothesis tested in the study was that the effect of estrogen and progesterone on the lacrimal gland is mediated through specific receptors and that hormonal effects involve the regulation of gene expression and protein synthesis. METHODS: Lacrimal glands were collected from young adult, ovariectomized mice, that were treated with 17beta-estradiol, progesterone, 17beta-estradiol plus progesterone or vehicle for 2 weeks. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL4277
24 Samples

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Series

Accession:: GSE5783

ID:: 200005783

Select item 20000158210.

Male BALB/c Mouse Testosterone-Treated Submandibular/Lacrimal/Meibomian Glands

(Submitter supplied) Series includes pooled (n = 5 mice per biological replicate) samples from lacrimal, meibomian, and submandibular glands of male palcebo- and testosterone-treated BALB/c mice. All experiments were run in triplicate (pooled biological replicates) on CodeLink Mouse Uniset I Microarrays. Keywords: repeat sample

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS1361
Platform:: GPL1310
18 Samples

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Series

Accession:: GSE1582

ID:: 200001582

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Select item 136111.

Testosterone effect on meibomian gland

Analysis of meibomian glands from orchiectomized BALB/c adults treated with testosterone for 14 days. Androgen deficiency associated with glandular dysfunction and evaporative dry eye. Lacrimal and submandibular glands included. Results suggest pathways regulated by androgens in meibomian glands.

Organism:: Mus musculus

Type:: Expression profiling by array, transformed count, 2 agent, 3 tissue sets

Platform:: GPL1310
Series:: GSE1582
18 Samples

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DataSet

Accession:: GDS1361

ID:: 1361

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 20000587612.

Female and Male Mice from the MRL/lpr and Non-Obese Diabetic (NOD) Strains.

(Submitter supplied) The Effect of Sex on Lacrimal Gland Gene Expression in the MRL/lpr and Non-obese Diabetic Mouse Models of SjšgrenÕs Syndrome Keywords: Female vs Male Lacrimal Gland Gene Expression.

Organism:: Mus musculus

Type:: Expression profiling by array

Platforms:: GPL2894 GPL8321
24 Samples

Download data: CEL, TXT

Series

Accession:: GSE5876

ID:: 200005876

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Select item 20000084413.

Control LG vs Px LG

(Submitter supplied) Control rat lacrimal gland samples representing a normal unoperated, a sham, and paired contralateral controls. Experimental LG samples representing paired and unpaired contralateral controls. Paired contralateral control LGs represent LG from the same animal, one side was operated and the other side unoperated. Keywords: repeat sample

Organism:: Rattus norvegicus

Type:: Expression profiling by array

Dataset:: GDS508
Platform:: GPL85
10 Samples

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Series

Accession:: GSE844

ID:: 200000844

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 50814.

Denervation effect on lacrimal gland

Analysis of lacrimal gland (LG) 7 days after greater superficial petrosal nerve sectioning. LG ipsilateral to the experimental side, sham operated and unoperated controls included. LG denervation results in severe dry eye like symptoms.

Organism:: Rattus norvegicus

Type:: Expression profiling by array, count, 4 protocol sets

Platform:: GPL85
Series:: GSE844
10 Samples

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DataSet

Accession:: GDS508

ID:: 508

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 20007186715.

Gene expression in lacrimal gland

(Submitter supplied) To analyze the gene expression of mouse embryonic lacrimal gland and its developmental related organs such as harderian gland and eye lid. We performed microarray using them.