Similar studies for GEO DataSets (Select 200093254) - GEO DataSets

Select item 2000932541.

Hypoxic microenvironment activates GLI2 through synergistic action of TGF-β2 and HIF-1α to confer chemoresistance and poor clinical outcome in colorectal cancer [IlluminaExpr_2_CAF_SF_SD208]

(Submitter supplied) Microenvironment has been suggested as an important factor contributing to how the colorectal cancer cells escape therapy, but the exact mechanism leading to chemoresistance remains elusive. Here, through modeling in vitro by cocultivation of patient-derived cancer associated fibroblasts (CAFs) with cancer stem cells (CSCs), we show that CAFs-secreted TGF-β2 is a key stromal factor that coordinates with hypoxia to promote CSC stemness and resistance to chemotherapy. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10558
4 Samples

Download data: XLSX

Series

Accession:: GSE93254

ID:: 200093254

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000932552.

Hypoxic microenvironment activates GLI2 through synergistic action of TGF-β2 and HIF-1α to confer chemoresistance and poor clinical outcome in colorectal cancer

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10558
11 Samples

Download data

Series

Accession:: GSE93255

ID:: 200093255

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000932533.

Hypoxic microenvironment activates GLI2 through synergistic action of TGF-β2 and HIF-1α to confer chemoresistance and poor clinical outcome in colorectal cancer [IlluminaExpr_1_CAF_NF]

(Submitter supplied) Analysis of gene expression profiles of three cancer-associated fibroblasts (CAFs) and four normal fibroblasts (NFs), which are derived from tumor tissues and adjacent normal mucosa of colorectal cancer patients, respectively.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10558
7 Samples

Download data: XLSX

Series

Accession:: GSE93253

ID:: 200093253

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2002105994.

Essential role of PLD2 in hypoxia-induced stemness and therapy resistance in ovarian tumors

(Submitter supplied) Ovarian cancer (OC) is the most lethal gynecological cancer due to its late diagnosis and, importantly, its high rate of chemoresistance. Hypoxia in solid tumors is an important source of chemoresistance that can determine poor patient prognosis. Such chemoresistance relies on the presence of cancer stem cells (CSCs), and hypoxia promotes their generation through transcriptional activation by HIF transcription factors. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL28038
8 Samples

Download data: NARROWPEAK

Series

Accession:: GSE210599

ID:: 200210599

PubMed Full text in PMC Similar studies

Select item 2001004335.

Identification of gene signature in human colorectal CD44+ cancer stem cells

(Submitter supplied) We prospectively isolated human colorectal CD44+ cancer stem cells (CSCs) from organoids and primary colorectal cancer. The gene expression of CD44+ CSCs are relevant to each other between organoids and primary tissues. The common gene signature in two different modality identifies CSCs' properties with the biological significance shown in original article.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL17077
16 Samples

Download data: TXT

Series

Accession:: GSE100433

ID:: 200100433

Select item 2001085656.

Identification of the molecular signature of distinctive breast cancer associated fibroblasts (CAFs)

(Submitter supplied) Cancer associated fibroblasts (CAFs) are highly heterogeneous and different subsets of CAFs may exhibit distinct functions, To identify the molecular signature of distinctive CAFs , we compared mRNA expression profiles of CAFs isolated from tumors in sensitive patients and resistant ones before neo-adjuvant chemotherapy. Compared the CAFs from sensitive samples, those from refractory samples exhibited a distinctive signature.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL16025
14 Samples

Download data: PAIR

Series

Accession:: GSE108565

ID:: 200108565

Select item 2002430147.

Expression data from colorectal cancer cell lines with USP51 overexpression

(Submitter supplied) USP51 enhances colorectal cancer stemness and chemoresistance, and elevated USP51 expression predicts poorer survival in colorectal cancer patients. To probe the role of USP51, we conducted RNA-seq data analysis, comparing control and USP51-overexpressing SW480 and HCT116 cells.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL23227
12 Samples

Download data: TXT

Series

Accession:: GSE243014

ID:: 200243014

Select item 2001810268.

Response to TGF-Beta in CCD-18Co

(Submitter supplied) We obtained the gene expression signature from TGF-beta-treated fibroblasts and quantified the association of TGF-beta-activated fibroblasts with disease progression in colorectal cancer.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL13158
4 Samples

Download data: CEL, CHP

Series

Accession:: GSE181026

ID:: 200181026

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001810209.

Response to oxaliplatin in CCD-18Co

(Submitter supplied) We obtained the gene expression signature from oxaliplatin-treated fibroblasts and quantified the association of oxaliplatin-activated fibroblasts with disease progression in colorectal cancer.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL15207
6 Samples

Download data: CEL, CHP

Series

Accession:: GSE181020

ID:: 200181020

PubMed Full text in PMC Similar studies Analyze with GEO2R

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