GEO DataSets

(Submitter supplied) Regulated in DNA Damage and Development 1 (REDD1) is a stress induced protein whose expression is highly induced in skeletal muscle following a single bout of aerobic exercise. However, the role of this induction is unknown We used microarrays to detail the change in gene signature within skeletal muscle following a single bout of aerobic exercise in wild type and REDD1 null mice

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL16570

12 Samples

Download data: CEL

(Submitter supplied) Glucocorticoids are a well recognized and common cause of muscle atrophy. Glucocorticoid-induced atrophy can be prevented by testosterone, but the molecular mechanisms underlying such protection have not been described. Thus, the global effects of testosterone on dexamethasone-induced changes in gene expression were evaluated in rat gastrocnemius muscle using Affymetrix 230_2 DNA microarrays. Gene expression was analyzed after 7 days administration of dexamethasone, dexamethasone plus testosterone, or vehicle. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL1355

9 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Sus scrofa

Type:

Expression profiling by array

Platform:

GPL5972

76 Samples

Download data: GPR

(Submitter supplied) Acute physical exercise elicits changes in gene expression in skeletal muscles to promote metabolic changes and to repair exercise-induced muscle injuries. Here, we investigated the impact of a single bout of running exercise until exhaustion on global transcriptional profiles in porcine skeletal muscles. Using a combined microarray and candidate gene approach, we identified a suite of genes that are differentially expressed in muscles during post-exercise recovery. more...

Organism:

Sus scrofa

Type:

Expression profiling by array

Platform:

GPL5972

39 Samples

Download data: GPR

(Submitter supplied) Acute physical exercise elicits changes in gene expression in skeletal muscles to promote metabolic changes and to repair exercise-induced muscle injuries. Here, we investigated the impact of a single bout of running exercise until exhaustion on global transcriptional profiles in porcine skeletal muscles. Using a combined microarray and candidate gene approach, we identified a suite of genes that are differentially expressed in muscles during post-exercise recovery. more...

Organism:

Sus scrofa

Type:

Expression profiling by array

Platform:

GPL5972

37 Samples

Download data: GPR

(Submitter supplied) Even though cutaneous atrophy is the major adverse effect of topical glucocorticoids, its molecular mechanisms are poorly understood. We found that glucocorticoids strongly increased the expression of REDD1 (regulated in development and DNA damage response 1), a stress-inducible inhibitor of mTOR, in mouse and human epidermis. We found that REDD1 knockout animals are partially resistant to glucocorticoid-induced epidermal and subcutaneous adipose atrophy which correlated with the protection of CD34+ follicular epithelial stem cells as well as p63+ keratinocyte progenitors in REDD1 knockout epidermis during chronic steroid treatment. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6885

8 Samples

Download data: TXT

(Submitter supplied) Unconditioned thoroughbred geldings were exercised to maximal heart rate or fatigue on an equine high-speed treadmill. Skeletal muscle biopsies were taken from the middle gluteal muscle before, immediately after and four hours after exercise. 

Organism:

Equus caballus

Type:

Expression profiling by array

Platform:

GPL8582

32 Samples

Download data: GPR

(Submitter supplied) The objective of this study was to understand the mechanisms behind the contribution of the alpha7BX2 integrin to improvements and growth in skeletal muscle post exercise. We utilized global gene profiling to identify novel signaling pathways and patterns of gene expression involved in this adaptation process, and found the alpha7BX2 integrin initiates transcription of genes that allow for protection from stress and modulation of protein synthesis.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6887

24 Samples

Download data: TXT

(Submitter supplied) To improve our understanding of the genetic reprogramming during the early phase of skeletal adaptation in response to endurance training, we employed cDNA microarray analysis to examine changes in mRNA expression in mouse plantaris muscle after a single bout voluntary running. Control untrained mice were compared with with R3h, R12h, P3h, P6h, P12h, P24h and R4w mice. We conclude that a single bout of voluntary running is sufficient to induce active remodeling processes, including cell proliferation, by a coordinated regulation of the genome in response to signals elicited from increased neuromuscular activity. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS1019

Platform:

GPL254

7 Samples

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(Submitter supplied) The 16K mouse cDNAs probes used in this microarray were designed using sequence information gathered from RIKEN FANTOM cDNA library. Probes can be 0.5 to 3 kb in length where about 60% of the probes represent full length transcripts. The PCR products were inkjet-printed on the array by Agilent Technologies (Palo Alto, CA).

Organism:

Mus musculus

35 DataSets

48 Series

641 Samples

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Analysis of plantaris muscle following a bout of voluntary running for 12 hours. Gene expression examined at various time points up to 24 hours following cessation of running. Results provide insight into molecular events occuring during the early phase of adaptation to endurance training.

Organism:

Mus musculus

Type:

Expression profiling by array, log ratio, 3 protocol, 5 time sets

Platform:

GPL254

Series:

GSE2001

7 Samples

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