Similar studies for GEO DataSets (Select 200098497) - GEO DataSets

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Items: 20

Select item 2000984971.

Comparing the Transcriptomes of Wild Type and Mtor-Gdf9-Cre mediated Oocyte-Conditional Knockout Mouse ovaries by RNA-Seq Analysis

(Submitter supplied) The goal of this study is to identify the differentially expressed genes in Gdf9-Cre mediated Mtor oocyte-specific knockout (CKO) ovaries by comparing the transcriptomes of Mtor Wild-Type (WT) and CKO Mouse ovaries via RNA-Seq Analysis.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21273
12 Samples

Download data: TXT

Series

Accession:: GSE98497

ID:: 200098497

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001141262.

Comparing the Transcriptomes of Wild Type (WT) and Gdf9-Cre or Zp3-Cre mediated Mtor Oocyte-Conditional Knockout (referred to as MG and MZ, respectively) Mouse GV-stage fully-grown oocytes (FGO) by RNA-Seq Analysis

(Submitter supplied) The goal of this study is to identify the differentially expressed genes in Gdf9-Cre and Zp3-Cre mediated Mtor oocyte-specific knockout (CKO) GV-stage fully-grown oocytes (FGO) by comparing their transcriptomes with that of the wild-type (WT) via RNA-Seq Analysis.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21273
9 Samples

Download data: TXT

Series

Accession:: GSE114126

ID:: 200114126

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Select item 2000802553.

Comparison of transcriptomes of mouse cumulus cells collected from mice before and after 6-h of hCG priming.

(Submitter supplied) We sought to identify genes that are regulated by the ovulatory signals in mouse cumulus cells. We compared the transcriptomes between cumulus cells colected from mice before (hCG-0h) and after 6 h (hCG-6h) of hCG injection.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
6 Samples

Download data: CEL

Series

Accession:: GSE80255

ID:: 200080255

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Select item 2000798624.

Comparison of transcriptomes between DMSO-5uM and Torin1-5uM treated mouse cumulus-oocyte complexes cultured in vitro for 14h

(Submitter supplied) We sought to identify the potential specific roles of the MTOR signalling in cumulus cells by comparing the transcriptomes of the Control (treated with the DMSO vehicle) and MTOR-specific inhibitor Torin 1(5uM)-treated cumulus-oocyte complexes that were cultured for 16 hours. We compared the transcriptomes between DMSO- and Torin 1- treated cumulus-oocyte complexes.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL17400
6 Samples

Download data: CEL

Series

Accession:: GSE79862

ID:: 200079862

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Select item 2000970265.

Next Generation Sequencing Analysis of Wild Type(WT) and Gdf9-Cre;Kat8 fl/fl(Kat8 Gdf9 cKO) Oocyte Transcriptome

(Submitter supplied) Purpose: The goal of this study is to compare oocyte transcriptome profiling in WT and Kat8 Gdf9 cKO mice Methods: Oocyte mRNA profiles of 2 weeks old WT and Kat8 Gdf9 cKO mice were generated by deep sequencing using Illumina HiSeq 2500. Results: Using an optimized data analysis workflow, we mapped about 54-63 million sequence reads per sample to the mouse genome (build mm10) and identified 18,468 transcripts in the oocytes of WT and Kat8 Gdf9 cKO mice. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
2 Samples

Download data: XLS

Series

Accession:: GSE97026

ID:: 200097026

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Select item 2000798866.

Bovine cumulus cells transcriptome in relation with oocyte chromatin configuration of the germinal vesicle

(Submitter supplied) Gene expression analysis in cc from COCs with different chromatin configuration (GV0-3)

Organism:: Bos taurus

Type:: Expression profiling by array

Platform:: GPL13226
12 Samples

Download data: TXT

Series

Accession:: GSE79886

ID:: 200079886

Select item 2001360057.

Single-cell RNA-seq of the goat oocytes samples from high fertility group (>three babys per birth) and low fertility group (< two babys per birth)

(Submitter supplied) The goal of this study was designed to search for the important genes contribution to fertility. Single-cell RNA-seq of the goat oocytes samples from high fertility group (>three babys per birth) and low fertility group (< two babys per birth). And each group was divided into three subgroup based in the size of follicles: large, medium, and small follicles.

Organism:: Capra hircus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL15473
29 Samples

Download data: TXT

Series

Accession:: GSE136005

ID:: 200136005

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Select item 2001358978.

Single-cell RNA-seq of the goat ovarian granulosa cells samples from high and low fertility groups

(Submitter supplied) The goal of this study was designe to search for the granulosa cells contribution on fertility. Single-cell RNA-seq of the goat ovarian granulosa cells samples from high fertility group (>three babys per birth) and low fertility group (< two babys per birth). And each group was divided into three subgroup based in the size of follicles: large, medium, and small follicles.

Organism:: Capra hircus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL15473
30 Samples

Download data: TXT

Series

Accession:: GSE135897

ID:: 200135897

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Select item 2001629279.

Transcriptomic profiling of neonatal mouse granulosa cells reveals new insights into primordial follicle activation

(Submitter supplied) The dormant population of ovarian primordial follicles is determined at birth and serves as the reservoir for future female fertility. Of equal importance to fertility is the rate that primordial follicles activate and enter folliculogenesis, yet our understanding of the molecular, biochemical, and cellular processes underpinning primordial follicle activation remains limited. The survival of primordial follicles relies on the correct complement and morphology of granulosa cells, which provide signalling factors essential for oocyte and follicular survival. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
8 Samples

Download data: TXT

Series

Accession:: GSE162927

ID:: 200162927

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Select item 20002565210.

Development of Laser Capture Microdissection to study the gene expression of the sheep early ovarian folliculogenesis

(Submitter supplied) Background Correct achievement of early ovarian folliculogenesis is a crucial phase for further ovarian function. This process is closely regulated by cell-cell interactions and coordinated expression of genes from oocyte and granulosa cells. But, despite of the large number of studies, little is known about the precise gene expression patterns driving early folliculogenesis. The experimental limitations concerned the very small size of these follicles and the mixture of the different developmental stages within an ovary that make the study of isolated follicular components much more difficult. more...

Organism:: Bos taurus; Ovis aries

Type:: Expression profiling by array

Platform:: GPL2112
10 Samples

Download data: CEL

Series

Accession:: GSE25652

ID:: 200025652

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Select item 20004091611.

Granulosa cell differentiation in vivo and developmental competence of oocytes in the bovine model

(Submitter supplied) Transcriptional profiling of in vivo granulosa cells collected at 20h, 44h, 68h, and 92h of coasting in lactating cow (breed Holstein)

Organism:: Bos taurus

Type:: Expression profiling by array

Platform:: GPL13226
36 Samples

Download data: TXT

Series

Accession:: GSE40916

ID:: 200040916

Select item 20010774612.

Transcriptome Landscape of Human Folliculogenesis Reveals Oocytes and Granulosa Cells Interactions

(Submitter supplied) The dynamic transcriptional regulation and interactions of human germlines and surrounding somatic cells during folliculogenesis remains unknown. Using RNA-Seq analysis of human oocytes and corresponding granulosa cells (GCs) spanning five follicular stages, we revealed unique features in transcriptional machinery, transcription factor networks and reciprocal interactions in human oocytes and GCs that displayed developmental-stage-specific expression patterns. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20795
148 Samples

Download data: TXT

Series

Accession:: GSE107746

ID:: 200107746

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Select item 20009738813.

In vitro differentiation of human embryonic stem cells into ovarian follicle-like cells

(Submitter supplied) Understanding the unique mechanisms of human oogenesis necessitates the development of an in vitro system of stem cell differentiation into oocytes. Specialized cell types and organoids have been derived from human pluripotent stem cells in vitro, but generating a human ovarian follicle remains a challenge. Here we report that human embryonic stem cells (hESCs) can be induced to differentiate into ovarian follicle-like cells in vitro. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
6 Samples

Download data: TXT

Series

Accession:: GSE97388

ID:: 200097388

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Select item 20024943414.

Single-cell profiling reveals transcriptome dynamics during bovine oocyte growth

(Submitter supplied) Mammalian follicle development is characterised by extensive changes in morphology, endocrine responsiveness, and function, providing the optimum environment for oocyte growth, development, and resumption of meiosis. In cattle, the first signs of transcription activation in the oocyte are observed in the secondary follicle, later than during mouse and human oogenesis. While many studies have generated extensive datasets characterising gene expression in bovine oocytes, they are mostly limited to the analysis of fully grown and matured oocytes. more...

Organism:: Bos taurus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL23055
179 Samples

Download data: TXT

Series

Accession:: GSE249434

ID:: 200249434

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Select item 20018650415.

Interactions between different maturation states of oocytes and granulosa cells in human antral follicles identified by single-cell transcriptomics

(Submitter supplied) Human ovarian folliculogenesis is an highly regulated and complex process. Characterization of follicular cell signatures during this dynamic process is important to understand follicle fate (to grow, become dominant or undergo atresia). The transcriptional signature of human oocytes and granulosa cells (GC) in early-growing and ovulatory follicles have been previously described, however that of oocytes with surrounding GCs in small antral follicles have not been studied yet. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL24676 GPL20301
141 Samples

Download data: TSV

Series

Accession:: GSE186504

ID:: 200186504

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Select item 20019820516.

SRSF1 regulates primordial follicle formation and number determination during meiotic prophase I

(Submitter supplied) Serine/arginine-rich splicing factor 1 (SRSF1; previously SF2/ASF) is a pivotal posttranscriptional regulator of gene expression in various biological processes. However, the physiological roles and mechanism of SRSF1 in mouse early-stage oocytes remain elusive. Here we show that SRSF1 is essential for primordial follicle formation and number determination during meiotic prophase I. The conditional knockout of Srsf1 in mouse oocytes impairs primordial follicle formation and leads to primary ovarian insufficiency (POI). more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
6 Samples

Download data: TXT

Series

Accession:: GSE198205

ID:: 200198205

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Select item 20017583617.

Granulosa cell mevalonate pathway abnormalities contribute to oocyte meiotic defects and aneuploidy

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus; Homo sapiens

Type:: Expression profiling by high throughput sequencing; Other

Platforms:: GPL24676 GPL24247
97 Samples

Download data: COOL, TXT

Series

Accession:: GSE175836

ID:: 200175836

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Select item 20012569918.

Oocyte-specific deletion of Mitofusin1 causes female infertility and accelerated follicular depletion

(Submitter supplied) We performed RNAseq analysis to determine the effect of MFN1 deletion on oocyte global gene expression profile. RNAseq revealed a total of 982 genes were significantly differentially expressed (p<0.05) in Mfn1-/- oocytes compared to WT (654 up-regulated and 337 down-regulated). Pathway analysis indicated significant over-representation of elements involved in regulation of ceramide biosynthesis, death receptor signaling and adherens junction signaling. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
7 Samples

Download data: TSV

Series

Accession:: GSE125699

ID:: 200125699

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Select item 20009663819.

Single-cell RNA sequencing of Zfp36l2 knock-out and floxed GV mouse oocytes.

(Submitter supplied) Global transcriptional silencing is a highly conserved evolutionary event central to the transition from the fully differentiated oocyte to the totipotent embryo. Despite its importance in the development of all animals, this pivotal genome-wide event remains poorly understood. Here, we report the unexpected finding that oocyte global transcriptional silencing depends on an mRNA decay activator. Oocyte-specific loss of ZFP36L2—an RNA-binding protein critical for AU-rich element-mediated mRNA decay—prevents oocytes from undergoing global transcriptional silencing. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
50 Samples

Download data: TXT

Series

Accession:: GSE96638

ID:: 200096638

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Select item 20004664020.

Comparison of the translational program in oocytes from wild type and Areg KO mice

(Submitter supplied) The study tests the hypothesis that maternal mRNA translation in oocytes is sensitive to the environment in which the oocytes mature. Amphiregulin (AREG) is a critical signal for oocyte maturation but also for oocyte developmental competence. Here we have used a genome-wide approach to determine whether the oocyte translational program is affected when oocytes mature in vivo in the absence of AREG. To this aim, polysome arrays were used to define patterns of transcript recruitment to the polysomes in oocytes derived from wild type mice and mice homozygous null for the Areg gene.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL17114
12 Samples

Download data: CEL

Series

Accession:: GSE46640

ID:: 200046640

PubMed Full text in PMC Similar studies Analyze with GEO2R

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