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Links from GEO DataSets

Items: 20

1.

The role of Erg in B cell development (RNA-Seq)

(Submitter supplied) RNA-seq of pre-proB, proB and preB populations from Ergfl/fl bone marrow, pre-proB cell population from Rag1CreT/+;ErgΔ/Δ bone marrow
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL19057
8 Samples
Download data: TXT
Series
Accession:
GSE132854
ID:
200132854
2.

Hi-C profiling of B-cell progenitors from Erg KO and WT mice

(Submitter supplied) Hi-C was used to examine long range chromatin interactions in B cell progenitors in the presence and absence of the Erg transcription factor. Specifically, OP9 cultured B220+ B-cell progenitors derived from the bone marrow of Rag1CreT/+;ErgΔ/Δ mice and from Rag1CreT/+ and Rag1Cre+/+;Erg fl/fl control mice were isolated and DNA interactions were profiled by in situ Hi-C.
Organism:
Mus musculus
Type:
Other
Platform:
GPL19057
6 Samples
Download data: BED, MTX
Series
Accession:
GSE133246
ID:
200133246
3.

The role of Erg in B cell development (ChIP-Seq)

(Submitter supplied) ChIP-seq of B-cell progenitors and Rag1CreT/+;ErgΔ/Δ thymocytes for Erg transcription factor
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL19057
2 Samples
Download data: NARROWPEAK
Series
Accession:
GSE132853
ID:
200132853
4.

The role of Erg in B cell development (ATAC-Seq)

(Submitter supplied) ATAC-seq of pre-proB, proB and preB populations from Ergfl/fl bone marrow, pre-proB cell population from Rag1CreT/+;ErgΔ/Δ bone marrow, and pre-proB, proB and preB populations from from Rag1CreT/+;ErgΔ/Δ;IgHVH10tar bone marrow.
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL19057
7 Samples
Download data: BED
Series
Accession:
GSE132852
ID:
200132852
5.

Microarray expression analysis of wild type and Erg knockdown bone marrow hematopoietic stem and progenitor cells

(Submitter supplied) Erg is an ETS family transcription factor frequently overexpressed in human leukemias and has been implicated as a key regulator of hematopoietic stem cells (HSCs). However how Erg controls normal hematopoiesis, particularly at the stem cell level, remains poorly understood. Using homologous recombination, we generated an Erg knockdown allele (Ergkd) in which Erg expression can be restored upon Cre-mediated excision of a Stopper cassette. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
6 Samples
Download data: CEL
Series
Accession:
GSE48600
ID:
200048600
6.

ERG controls B-cell development by promoting Igh V-to-DJ recombination

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by array; Expression profiling by high throughput sequencing
Platforms:
GPL6246 GPL18480 GPL19057
38 Samples
Download data: BIGWIG, CEL
Series
Accession:
GSE128978
ID:
200128978
7.

ERG controls B-cell development by promoting Igh V-to-DJ recombination [RNA-seq]

(Submitter supplied) B-cell development is dependent on the coordinated expression and cooperation of several transcription factors. Here, we show that the transcription factor ETS Related Gene (ERG) is crucial for normal B-cell development, and that its deletion results in a substantial loss of bone marrow B-cell progenitors and peripheral B-cells as well as a skewing of splenic B-cell populations. We found that ERG-deficient B-lineage cells exhibited an early developmental block, at the pre-B cell stage, and proliferated less. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL19057
24 Samples
Download data: XLS
Series
Accession:
GSE128977
ID:
200128977
8.

ERG controls B-cell development by promoting Igh V-to-DJ recombination [microarray]

(Submitter supplied) B-cell development is dependent on the coordinated expression and cooperation of several transcription factors. Here, we show that the transcription factor ETS Related Gene (ERG) is crucial for normal B-cell development, and that its deletion results in a substantial loss of bone marrow B-cell progenitors and peripheral B-cells as well as a skewing of splenic B-cell populations. We found that ERG-deficient B-lineage cells exhibited an early developmental block, at the pre-B cell stage, and proliferated less. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
6 Samples
Download data: CEL
Series
Accession:
GSE128976
ID:
200128976
9.

ERG controls B-cell development by promoting Igh V-to-DJ recombination [ATAC-seq]

(Submitter supplied) B-cell development is dependent on the coordinated expression and cooperation of several transcription factors. Here, we show that the transcription factor ETS Related Gene (ERG) is crucial for normal B-cell development, and that its deletion results in a substantial loss of bone marrow B-cell progenitors and peripheral B-cells as well as a skewing of splenic B-cell populations. We found that ERG-deficient B-lineage cells exhibited an early developmental block, at the pre-B cell stage, and proliferated less. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL18480
8 Samples
Download data: BED, BIGWIG, TXT
Series
Accession:
GSE128975
ID:
200128975
10.

Expression data from long-term Ebf1-deficient, CD19+, Bcl2tg cells

(Submitter supplied) An assessment of a role of Ebf1 in committed B lineage cells. In this study, we adopted the strategy of deleting Ebf1 after reconstitution of Rag2-/-Il2rg-/- mice and found that committed pre-B cells could be converted into T cells and ILCs upon deletion of Ebf1.
Organism:
Mus musculus
Type:
Expression profiling by array; Third-party reanalysis
Platform:
GPL6246
3 Samples
Download data: CEL, TXT
Series
Accession:
GSE46349
ID:
200046349
11.

CHD4 is essential for transcriptional repression and lineage progression in B lymphopoiesis

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing
Platform:
GPL17021
10 Samples
Download data
Series
Accession:
GSE123504
ID:
200123504
12.

CHD4 is essential for transcriptional repression and lineage progression in B lymphopoiesis [ATAC-seq]

(Submitter supplied) Cell-lineage specification is a tightly regulated process that is dependent on appropriate expression of lineage- and developmental stage-specific transcriptional programs. Accessibility and inaccessibility of gene loci are controlled dynamically during cellular development. Here, we show that Chromodomain Helicase DNA-binding protein 4 (CHD4), a major ATPase/helicase subunit of Nucleosome Remodeling and Deacetylase Complexes (NuRD) in lymphocytes, is essential for specification of the early B cell lineage transcriptional program. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL17021
4 Samples
Download data: TXT
Series
Accession:
GSE123503
ID:
200123503
13.

CHD4 is essential for transcriptional repression and lineage progression in B lymphopoiesis [RNA-seq]

(Submitter supplied) Cell-lineage specification is a tightly regulated process that is dependent on appropriate expression of lineage- and developmental stage-specific transcriptional programs. Accessibility and inaccessibility of gene loci are controlled dynamically during cellular development. Here, we show that Chromodomain Helicase DNA-binding protein 4 (CHD4), a major ATPase/helicase subunit of Nucleosome Remodeling and Deacetylase Complexes (NuRD) in lymphocytes, is essential for specification of the early B cell lineage transcriptional program. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
6 Samples
Download data: TXT
Series
Accession:
GSE123502
ID:
200123502
14.

ERG promotes the maintenance of hematopoietic stem cells by restricting their differentiation

(Submitter supplied) To investigate the role of the transcription factor ERG in hematopoiesis we generated Erg heterozygous knockout and conditional Erg knockout mice. We found that several hematopoietic cell types were decreased in these mice. To define Erg downstream target genes in hematopoietic stem cells, we sorted Lineage-, Sca-1+, c-kit+, CD150+, CD48- cells from Erg +/- mice for gene expression analysis. To define Erg downstream target genes in hematopoietic progenitors, we sorted multipotent progenitors (Lineage-, Sca-1+, c-kit+, CD150-) from Erg -/- mice for gene expression analysis.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
12 Samples
Download data: CEL
Series
Accession:
GSE69873
ID:
200069873
15.

Expression data from Bmi1-null c-Kit+Sca-1+Lineage marker- (KSL) hematopoietic stem/progenitor cells

(Submitter supplied) Bmi1 is a component of polycomb repressive complex 1 and its role in the inheritance of the stemness of adult somatic stem cells has been well characterized. Bmi1 maintains the self-renewal capacity of adult stem cells, at least partially, by repressing the Ink4a/Arf locus that encodes a cyclin-dependent kinase inhibitor, p16Ink4a, and a tumor suppressor, p19Arf 14. Deletion of both Ink4a and Arf in Bmi1-deficient mice substantially restored the defective self-renewal capacity of HSCs and neural stem cells.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
7 Samples
Download data: CEL, CHP
Series
Accession:
GSE19796
ID:
200019796
16.

Single cell transcriptome datasets of murine B cell commitment

(Submitter supplied) To identify the “time-lapse” TF networks during B lineage commitment, we established multipotent progenitors harboring a tamoxifen-inducible form of Id3, an in vitro system where virtually all cells became B cells within 6 days by simply withdrawing 4-OHT. In this study, single cell transcriptomic analysis at pre- and post-commitment was performed using the culture system. In addition, we also performed single cell RNA-seq analysis of B cell precursor populations (LMPP, CLP and pro-B cells) in murine bone marrow.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
5 Samples
Download data: MTX, TSV
Series
Accession:
GSE107527
ID:
200107527
17.

Temporal transcriptomic and epigenomic profiles of transition from hematopoietic multipotent progenitors to B committed cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL18480
68 Samples
Download data: WIG
Series
Accession:
GSE106795
ID:
200106795
18.

Temporal epigenomic profiles of transition from hematopoietic multipotent progenitors to B committed cells [ChIP-seq]

(Submitter supplied) To identify the “time-lapse” TF networks during B lineage commitment, we established multipotent progenitors harboring a tamoxifen-inducible form of Id3, an in vitro system where virtually all cells became B cells within 6 days by simply withdrawing 4-OHT. In this study, epigenomic analysis at multiple time points was performed using the culture system.
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL18480
24 Samples
Download data: WIG
Series
Accession:
GSE106794
ID:
200106794
19.

Temporal transcriptomic profiles of transition from hematopoietic multipotent progenitors to B committed cells [RNA-seq]

(Submitter supplied) To identify the “time-lapse” TF networks during B lineage commitment, we established multipotent progenitors harboring a tamoxifen-inducible form of Id3, an in vitro system where virtually all cells became B cells within 6 days by simply withdrawing 4-OHT. In this study, transcriptome analysis at multiple time points was performed using the culture system.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18480
44 Samples
Download data: TXT
Series
Accession:
GSE106793
ID:
200106793
20.

Expression data comparing EBF1 versus Pax5 induced genes

(Submitter supplied) We used microarrays to establish whether EBF1 and Pax5 repress similar or unique genes. We found that EBF1 uniquely represses the expression of the T-lineage transcription factor Gata3.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
6 Samples
Download data: CEL, TXT
Series
Accession:
GSE46004
ID:
200046004
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