Similar studies for GEO DataSets (Select 200133927) - GEO DataSets

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Items: 20

Select item 2001339271.

RNA-Sequencing analysis of Meox1 siRNA knockdown in p53 and PTEN deficient triple negative breast cancer in vitro cell lines of BT-549 and MDA-MB-468

(Submitter supplied) The goal for this experiment was to analyze how knockdown of homeobox transcription factor Meox1 altered functional and mechanist biology of p53 and PTEN deficient triple negative breast cancer in vitro cell lines of claudin-low BT-549 and basal-like MDA-MB-468.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20301
16 Samples

Download data: CSV

Series

Accession:: GSE133927

ID:: 200133927

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Select item 2000759892.

Targeted Pten deletion plus p53-R270H mutation in mouse mammary epithelium induces aggressive claudin-low and basal-like breast cancer

(Submitter supplied) WAP-Cre:Ptenf/f:p53lox.stop.lox_R270H composite mice were generated by genetic crossing. In these mice, Pten is deleted and a R270H p53 mutation in the DNA binding domain is induced upon expression of Cre recombinase in pregnancy-identified alveolar progenitors. Tumors were characterized by histology, marker analysis, various bioinformatics methods, high-throughput (HTP) FDA-drug screen as well as orthotopic injection to quantify tumor initiating cells (TICs) and tail-vein injection to identify lung-metastasis. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6246
31 Samples

Download data: CEL

Series

Accession:: GSE75989

ID:: 200075989

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Select item 2000399553.

Expression data comparing Pten-, p53-, and combined deficient mouse mammary tumors

(Submitter supplied) To model the effect of Pten loss on breast cancer, we deleted Pten using a floxed allele and the deleter lines MMTV-Cre(NLST), which targets stem/bi-potent progenitor cells, and WAP-Cre, which targets CD24-positive, pregnancy-identified stem cells/alveolar progenitors. Mammary tumors were detected in WAP-Cre:Ptenf/f females with a latency of 15.2 months. By 18 months, nearly all mice had succumbed to cancer. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6246
42 Samples

Download data: CEL

Series

Accession:: GSE39955

ID:: 200039955

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Select item 2000764334.

p53 deficiency linked to BTG2 loss enhances metastatic potential by promoting tumor growth in primary and metastatic sites in PDX models of triple negative breast cancer

(Submitter supplied) We performed differential expression analyses from RNA-seq data derived from isogenic p53 wild-type and p53-knockdown triple negative breast tumors

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL15433
7 Samples

Download data: TXT

Series

Accession:: GSE76433

ID:: 200076433

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Select item 2000254885.

Expression data from C3(1)Tag mammary tumors, tumor derived cell line (M6) and normal mammary tissue (FVB)

(Submitter supplied) M6 cells expression a similar genetic signature as the parent tumor, C3(1)Tag tumor. The mammary tumors, and tumor cell line, are distinct from normal mammary epithelial tissue (FVB) BRCA/p53, cmyc, h2n, p53ERneg, p53ERpos, pymt and ras samples were not reported in this paper.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL8321
47 Samples

Download data: CEL

Series

Accession:: GSE25488

ID:: 200025488

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Select item 2000254876.

Expression of SV40 TAg signature in MDAMB231 cells, tumors, and normal human mammary epithelial cells (M98040 and M99005)

(Submitter supplied) MDAMB231 cells express the SV40TAg signature. The normal mammary epithelial tissue does not express the signature. CK0082, Empty1 and Gata3 samples are not reported in this manuscript

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
21 Samples

Download data: CEL

Series

Accession:: GSE25487

ID:: 200025487

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Select item 2000405457.

RB pathway deregulation promotes invasion and disease progression in a mouse model of MYC-overexpressing mammary tumorigenesis

(Submitter supplied) Breast cancer is a highly heterogeneous disease that is categorized into distinct tumor subtypes based on specific molecular attributes, which ultimately influence therapeutic options. Unlike ER+ and/or HER2+ cancers that are subject to specific targeted therapies, triple negative breast cancers (TNBCs) do not express these receptors, which leaves patients with limited treatment options. Thus, significant focus has been placed on identifying molecular attributes of basal-like disease that could be used to develop and/or direct novel treatment regimens. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6246
15 Samples

Download data: CEL

Series

Accession:: GSE40545

ID:: 200040545

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Select item 2000185398.

Molecular characterization of Georgia cohort of primary breast cancer FFPE tissues on custom breast cancer DASL panel

(Submitter supplied) Analysis of 143 formalin-fixed, paraffin-embedded (FFPE) primary breast tumors using a Custom Breast Cancer Panel and Human Cancer Panel for the DASL platform. Molecular markers between the pathology defined subtypes of breast cancer were assessed to hypothesize potential therapeutic targets specific to the subtypes

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL9006
143 Samples

Download data: TXT

Series

Accession:: GSE18539

ID:: 200018539

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Select item 2000176509.

Molecular characterization of Quebec Cohort of Primary Breast Cancer FFPE Tissues on the Human Cancer Panel

(Submitter supplied) Analysis of 97 formalin-fixed, paraffin-embedded (FFPE) primary breast tumors using Illumina DASL microarray technology on a Custom Breast Cancer Panel and the Illumina Human Cancer Panel. Molecular markers between the pathology defined subtypes of breast cancer were assessed to hypothesize potential therapeutic targets specific to the subtypes

Organism:: Homo sapiens

Type:: Expression profiling by array

Platforms:: GPL9006 GPL5858
177 Samples

Download data: TXT

Series

Accession:: GSE17650

ID:: 200017650

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Select item 20006210110.

aCGH data of Rb/p53 deficient mammary tumors

(Submitter supplied) To investigate the impact of combined Rb and p53 loss in mammary tumorigenesis, we used transgenic and viral approaches to delete Rb and p53 floxed alleles specifically in the mouse mammary epithelium. Although MMTV-Cre (NLST) targets stem/bi-potent progenitors in the mammary gland, a subset of MMTV-Cre:Rbf/f;p53f/f mice developed non-mammary tumors. Thus, freshly isolated primary mammary epithelial cells from these animals were transplanted into the mammary fat pads of immunodeficient mice and monitored for tumor formation. more...

Organism:: Mus musculus

Type:: Genome variation profiling by genome tiling array

Platform:: GPL10448
9 Samples

Download data: TXT

Series

Accession:: GSE62101

ID:: 200062101

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Select item 20006201611.

Expression data comparing Rb/p53 and p53 deficient mammary tumors and normal mammary tissue

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6246
18 Samples

Download data: CEL

Series

Accession:: GSE62016

ID:: 200062016

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Select item 20003511812.

Primary TNBC tumor in the presence or absence of SHP2

(Submitter supplied) The first bona fide PTP proto-oncogene was the Src-homology 2 domain-containing phosphatase SHP2 (encoded by PTPN11), an ubiquitously expressed PTP that transduces mitogenic, pro-survival, cell fate and/or pro-migratory signals from numerous growth factor-, cytokine- and extracellular matrix receptors. In malignancies, SHP2 is hyperactivated either downstream of oncoproteins or by mutations.We provide analysis of a primary triple-negative breast tumor grown as xenografts in the presence or absence of SHP2 for 30 days.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6244
14 Samples

Download data: CEL

Series

Accession:: GSE35118

ID:: 200035118

Select item 20003452513.

BT474 tumors, primary TN tumors and MCF10A-HER2/3 cells in the presence or absence of SHP2

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6244
36 Samples

Download data: CEL

Series

Accession:: GSE34525

ID:: 200034525

Select item 20003452414.

MCF10A-HER2/3 cells grown in 3D cultures in the presence or absence of SHP2

(Submitter supplied) The first bona fide PTP proto-oncogene was the Src-homology 2 domain-containing phosphatase SHP2 (encoded by PTPN11), an ubiquitously expressed PTP that transduces mitogenic, pro-survival, cell fate and/or pro-migratory signals from numerous growth factor-, cytokine- and extracellular matrix receptors. In malignancies, SHP2 is hyperactivated either downstream of oncoproteins or by mutations.We provide analysis of the mammary epithelial cells MCF10A overexpressing human HER2 and HER3 and grown in 3D cultures for 15 days in the presence or absence of SHP2.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6244
6 Samples

Download data: CEL

Series

Accession:: GSE34524

ID:: 200034524

Select item 20003452315.

BT474 tumors in the presence or absence of SHP2

(Submitter supplied) The first bona fide PTP proto-oncogene was the Src-homology 2 domain-containing phosphatase SHP2 (encoded by PTPN11), an ubiquitously expressed PTP that transduces mitogenic, pro-survival, cell fate and/or pro-migratory signals from numerous growth factor-, cytokine- and extracellular matrix receptors. In malignancies, SHP2 is hyperactivated either downstream of oncoproteins or by mutations.We provide analysis of the breast cancer cells BT474 grown as xenografts in the presence or absence of SHP2 for 30 days.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6244
16 Samples

Download data: CEL

Series

Accession:: GSE34523

ID:: 200034523

Select item 20005330016.

Gene expression profiling of breast cancer cells with knockdown of PTEN

(Submitter supplied) Activation of the PI3K pathway in estrogen receptor α (ER)-positive (+) breast cancer is associated with reduced ER expression and activity, luminal B subtype, and poor outcome. PTEN is a negative regulator of the PI3K pathway typically lost in ER-negative (-) breast cancer. To clarify the effect of PTEN down-regulation on the response of ER+/HER2- breast cancer to endocrine therapy, we established reduced PTEN cell models using inducible knockdown. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL9052
2 Samples

Download data: FPKM_TRACKING

Series

Accession:: GSE53300

ID:: 200053300

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 20008557917.

Genomic Regulation of Invasion by STAT3 in Triple Negative Breast Cancer

(Submitter supplied) Breast cancer is a heterogeneous disease comprised of four molecular subtypes defined by whether the tumor-originating cells are luminal or basal epithelial cells. Breast cancers arising from the luminal mammary duct often express estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth receptor 2 (HER2). Tumors expressing ER and/or PR are treated with anti-hormonal therapies, while tumors overexpressing HER2 are targeted with monoclonal antibodies. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platform:: GPL11154
54 Samples

Download data: BEDGRAPH, TXT

Series

Accession:: GSE85579

ID:: 200085579

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Select item 20012121718.

Global gene expression analysis in PTEN versus GFP expressing H1650 lung adenocarcinoma cells

(Submitter supplied) PTEN or GFP were stably expressed in PTEN-deficient lung adenocarcinoma cells by viral transfection followed by puromycin selection. Microarray analysis of total RNA isolated from H1650 cells stably expressing PTEN or GFP was performed to identify potential PTEN responsive genes.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
6 Samples

Download data: CEL

Series

Accession:: GSE121217

ID:: 200121217

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Select item 20023208619.

Epigenetic heterogeneity and transcriptional drivers of triple-negative breast cancer [ChIP-Seq]

(Submitter supplied) Triple-negative breast cancer (TNBC) is a heterogeneous disease with limited treatment options. To characterize TNBC heterogeneity and treatment response, we combined functional and molecular profiling with computational analysis tools. Using these approaches, we defined transcriptional, epigenetic, and metabolic subtypes, and identified subtype-driving super-enhancers. Single cell RNA sequencing analyses revealed relative homogeneity of the three major transcriptional subtypes (luminal, basal and mesenchymal) within tumors. more...