Similar studies for GEO DataSets (Select 200139927) - GEO DataSets

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Items: 20

Select item 2001399271.

LSD1 mediates AKT activity in PIK3CA mutant colorectal cancer

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL18573
30 Samples

Download data: BIGWIG

Series

Accession:: GSE139927

ID:: 200139927

PubMed Full text in PMC Similar studies

Select item 2001399252.

LSD1 mediates AKT activity in PIK3CA mutant colorectal cancer [ChIP-Seq]

(Submitter supplied) Activation of the epithelial-mesenchymal transition (EMT) program is a critical mechanism for initiating cancer progression and migration. Colorectal cancers (CRCs) contain many genetic and epigenetic alterations that can contribute to EMT. Mutations activating the PI3K/AKT signaling pathway are observed in >40% of patients with CRC contributing to increased invasion and metastasis. Little is known about how oncogenic signaling pathways such as PI3K/AKT synergize with chromatin modifiers to activate the EMT program. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL18573
12 Samples

Download data: BED, BIGWIG

Series

Accession:: GSE139925

ID:: 200139925

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001399243.

LSD1 mediates AKT activity in PIK3CA mutant colorectal cancer [RNA-Seq]

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18573
18 Samples

Download data: TXT

Series

Accession:: GSE139924

ID:: 200139924

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 2001047554.

The role of LSD1 in Epithelial to Mesenchymal Transition: gene expression profiling and ChIP-seq

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL16686 GPL18573
7 Samples

Download data: BED, BEDGRAPH, CEL

Series

Accession:: GSE104755

ID:: 200104755

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001047545.

LSD1 activation promotes inducible EMT programs and modulates the tumour microenvironment in breast cancer

(Submitter supplied) Complex regulatory networks control epithelial-to-mesenchymal transition (EMT) but the underlying epigenetic control is poorly understood. Lysine-specific demethylase 1 (LSD1) is a key histone demethylase that alters the epigenetic landscape. Here we explored the role of LSD1 in global epigenetic regulation of EMT, cancer stem cells (CSCs), the tumour microenvironment, and therapeutic resistance in breast cancer. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL18573
3 Samples

Download data: BED, BEDGRAPH

Series

Accession:: GSE104754

ID:: 200104754

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001047536.

The role of LSD1 in Epithelial to Mesenchymal Transition

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL16686
4 Samples

Download data: CEL

Series

Accession:: GSE104753

ID:: 200104753

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001629377.

Profiling of Lsd1 and chromatin marks in epithelial cells overexpressing HOTAIR variants

(Submitter supplied) Epithelial-to-mesenchymal transitions (EMT) underlie a loss of epithelial traits by normal cells during development and neoplastic cells during cancer metastasis. The long noncoding RNA HOTAIR triggers EMT, in part by serving as a scaffold for Polycomb Repressive Complex 2 (PRC2) and thus promoting repressive histone H3 Lys27 methylation. In addition to PRC2, HOTAIR interacts with the Lsd1 lysine demethylase, an epigenetic regulator of cell fate during development and differentiation. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL24676
40 Samples

Download data: GFF

Series

Accession:: GSE162937

ID:: 200162937

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001065178.

HOTAIR lncRNA role in epithelial-mesenchymal transition

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platforms:: GPL16791 GPL24676
68 Samples

Download data: TXT

Series

Accession:: GSE106517

ID:: 200106517

PubMed Full text in PMC Similar studies

Select item 2001065169.

Identification and functional characterization of long non-coding RNAs associated with epithelial-to-mesenchymal transition

(Submitter supplied) In the last decade, new high-throughput sequencing techniques have revealed the complexity of the human transcriptome, allowing the characterization of long non-coding (lnc)RNAs. Since their expression has been reported as very specific to tissue, developmental stage and pathological variations, some lncRNAs have been proposed as biomarkers for diagnosis as well as prognosis of tumors. In this project, we aime in identification of lncRNAs associated with the epithelial-to-mesenchymal transition (EMT), a biological process that promotes metastasis. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
12 Samples

Download data: TXT

Series

Accession:: GSE106516

ID:: 200106516

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 20018215410.

A novel therapeutic strategy targeting the mesenchymal phenotype of malignant pleural mesothelioma by suppressing LSD1

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL23159 GPL18573
13 Samples

Download data: BW, CEL, CHP

Series

Accession:: GSE182154

ID:: 200182154

Select item 20018215311.

A novel therapeutic strategy targeting the mesenchymal phenotype of malignant pleural mesothelioma by suppressing LSD1 [ATAC-seq]

(Submitter supplied) ATAC-seq analysis of following knock down of LSD1 in ACC-MESO-1 cells.

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL18573
4 Samples

Download data: BW

Series

Accession:: GSE182153

ID:: 200182153

PubMed Similar studies SRA Run Selector

Select item 20018173512.

A novel therapeutic strategy targeting the mesenchymal phenotype of malignant pleural mesothelioma by suppressing LSD1 [array]

(Submitter supplied) Transcriptome analysis following knock down of LSD1 in ACC-MESO-1 cells. Malignant pleural mesothelioma (MPM) is a highly aggressive tumor that has a low overall survival; however, no significant treatment advances have been made in the past 15 years. In this study we investigated whether targeting lysine-specific demethylase 1 (LSD1/KDM1), a histone-modifying enzyme responsible for demethylating histone H3 lysine 4 and lysine 9, could represent a novel therapeutic strategy for patients with MPM. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL23159
9 Samples

Download data: CEL, CHP

Series

Accession:: GSE181735

ID:: 200181735

Select item 20013299013.

ChIP-sequencing of mouse HPC7 cells

(Submitter supplied) We have expressed mouse Snai1, mutant Snai1 or empty vector in the HPC7 cell line and performed ChIP sequencing analysis of Snai1, H3K4me1 and H3K4me2

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL19057
44 Samples

Download data: NARROWPEAK, TXT

Series

Accession:: GSE132990

ID:: 200132990

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20013272414.

Expression profiling of mouse HPC7 cells

(Submitter supplied) We have expressed mouse Snai1, mutant Snai1 or empty vector in the HPC7 cell line and performed RNA sequencing analysis to identify targets of Snai1 in mouse hematopoietic progenitor cells.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
9 Samples

Download data: TXT

Series

Accession:: GSE132724

ID:: 200132724

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20016870615.

Cancer-associated E239K mutation of LSD1 promotes the migration and invasion of luminal breast cancer cells by reducing the expression of ERα

(Submitter supplied) Background: Epithelial to mesenchymal transition (EMT) plays an essential role in the metastasis of breast cancer by regulating the migration and invasion of cancer cells. Lysine specific demethylase 1 (LSD1) is an important histone demethylase that mediates EMT. However, the functional effects of the mutation on LSD1 in breast cancer remain unclear. Results: An E239K mutation of LSD1 was identified from TCGA Breast Invasive Carcinoma cohort. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
12 Samples

Download data: TXT

Series

Accession:: GSE168706

ID:: 200168706

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 20008075316.

LSD1 mediates MYCN control of epithelial-mesenchymal transition through silencing of metastatic suppressor NDRG1 gene

(Submitter supplied) Neuroblastoma (NB) with MYCN amplification is a highly metastatic tumor in children, and unraveling the key players involved in MYCN-induced invasion may identify new targets for therapy. Epithelial-mesenchymal transition (EMT) plays a critical role in promoting metastasis and we have recently determined that MYCN interacts with LSD1, a histone de-methylase flavin oxidase, which has been found to promote EMT. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18573
6 Samples

Download data: TXT

Series

Accession:: GSE80753

ID:: 200080753

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 20016726217.

LSD1 promotes secretory cell specification to drive BRAFmutant colorectal cancer

(Submitter supplied) Despite the connection to distinct mucus-containing colorectal cancer (CRC) histological subtypes, the role of secretory cells, including goblet and enteroendocrine (EEC) cells, in CRC progression has been underexplored. Analysis of TCGA and single cell RNA sequencing data demonstrates that multiple secretory progenitor populations are enriched in BRAF-mutant CRC patient tumors and cell lines. Enrichment of EEC progenitors in BRAF-mutant CRC is maintained by DNA methylation and silencing of NEUROD1, a key gene required for differentiation of EECs. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
4 Samples

Download data: CSV

Series

Accession:: GSE167262

ID:: 200167262

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20011571618.

SNAIL1 employs β-Catenin-LEF1 complexes to control colorectal cancer cell invasion and proliferation

(Submitter supplied) The transcription factor SNAIL1 is a master regulator of epithelial-to-mesenchymal transition, a process entailing massive gene expression changes. To better understand SNAIL1-induced transcriptional reprogramming we performed time-resolved transcriptome analysis upon conditional SNAIL1 expression in colorectal cancer cells. Bioinformatic analyses indicated that SNAIL1 strongly affected Wnt/β-Catenin pathway activity. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10558
27 Samples

Download data: TXT

Series

Accession:: GSE115716

ID:: 200115716

Select item 20016973519.

SMAD4 is dispensable for execution of epithelial-mesenchymal transition downstream of SNAIL1 in colorectal cancer cells

(Submitter supplied) Transforming growth factor beta (TGFβ) superfamily signaling is a prime inducer of epithelial-mesenchymal transitions (EMT) that foster cancer cell invasion and metastasis, a major cause of cancer-related deaths. Yet, TGFβ signaling is frequently inactivated in human tumor entities including colorectal cancer (CRC) and pancreatic adenocarcinoma (PAAD) with a high proportion of mutations incapacitating SMAD4, which codes for a transcription factor (TF) central to canonical TGFβ and bone morphogenetic protein (BMP) signaling. more...