Similar studies for GEO DataSets (Select 200156890) - GEO DataSets

Select item 2001568901.

Identification of genes regulated by Fer2 in the fly brain using an overexpression approach

(Submitter supplied) The transcription factor Fer2 plays a neuroprotective role in the dopaminergic neurons of the fly brain, but the underlying molecular mechanisms are not understood. By performing RNA-seq on fly heads after Fer2 inducible overexpression, we identified hundreds of genes differentially regulated in response to Fer2 overexpression. Combining this dataset with Fer2 ChIP-seq on the fly head, we obtained a list of 26 direct target genes, bound and regulated by Fer2.

Organism:: Drosophila melanogaster

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17275
18 Samples

Download data: XLSX

Series

Accession:: GSE156890

ID:: 200156890

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Select item 2001575892.

Identification of genes regulated by Fer2 in PAM neurons using an overexpression approach

(Submitter supplied) The transcription factor Fer2 plays a neuroprotective role in the dopaminergic neurons of the fly brain, but the underlying molecular mechanisms are not understood. By performing RNA-seq on isolated dopaminergic PAM neurons after Fer2 constitutive overexpression, we identified over one hundred genes differentially regulated in response to PAM-specific Fer2 overexpression.

Organism:: Drosophila melanogaster

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17275
6 Samples

Download data: XLSX

Series

Accession:: GSE157589

ID:: 200157589

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Select item 2001568933.

Fer2 in the fly brain

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Drosophila melanogaster

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL17275
22 Samples

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Series

Accession:: GSE156893

ID:: 200156893

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Select item 2001568924.

Genome-wide map of the binding sites of the transcription factor Fer2 in the fly brain

(Submitter supplied) The transcription factor Fer2 plays a neuroprotective role in the dopaminergic neurons of the fly brain, but the underlying molecular mechanisms are not understood. By using chromatin immunoprecipitation coupled to sequecing (ChIP-seq), we identified over 250 genomic binding sites bound by Fer2 in the fly brain. Combining this dataset with RNA-seq of fly heads upon inducible Fer2 overexpression, we obtained a list of 26 direct target genes, bound and regulated by Fer2.

Organism:: Drosophila melanogaster

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL17275
4 Samples

Download data: TXT

Series

Accession:: GSE156892

ID:: 200156892

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Select item 2000932755.

Specificity of Pitx3-Dependent Gene Regulatory Networks in Subsets of Midbrain Dopamine Neurons

(Submitter supplied) Global binding patterns of Pitx3 on genomic DNA of human dopaminergic cells revealed that Pitx3 is often co-recruited to regions that foster the formation of GATA-bHLH-BRN complexes, which usually involve Lmo co-regulatory proteins

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL11154
2 Samples

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Series

Accession:: GSE93275

ID:: 200093275

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Select item 2001625666.

Infection with herpesviridae in pregnant dams alters midbrain dopaminergic signatures in adult offspring

(Submitter supplied) The adult offspring of MHV68 infected dams had a significantly decreased expression of genes linked to dopamine neurons (Th, lmx1b, and foxa1). Deconvolution analysis revealed that the proportion of dopamine neurons in the midbrain was reduced. Pathway analyses indicated mitochondrial dysfunction, with reductions in genes associated with ATP synthesis, mitochondrial respiratory chain, and mitochondrial translation in the offspring of dams infected with MHV68. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
48 Samples

Download data: TSV

Series

Accession:: GSE162566

ID:: 200162566

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Select item 2000821007.

ChIP-Seq and RNA-Seq of mouse E12.5

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL11002 GPL13112
18 Samples

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Series

Accession:: GSE82100

ID:: 200082100

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Select item 2000820998.

RNA-Seq of mouse E12.5 brain regions

(Submitter supplied) Investigations into the roles for Pbx1 and its transcriptional network in dopaminergic neuron development and Parkinson's Disease

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
15 Samples

Download data: TXT

Series

Accession:: GSE82099

ID:: 200082099

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Select item 2000820989.

ChIP-Seq for Pbx1 in the mouse E12.5 ventral midbrain

(Submitter supplied) Investigations into the roles for Pbx1 and its transcriptional network in dopaminergic neuron development and Parkinson's Disease

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL11002
3 Samples

Download data: XLSX

Series

Accession:: GSE82098

ID:: 200082098

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Select item 20010802010.

Single-cell RNA-seq of mouse dopaminergic neurons informs candidate gene selection for sporadic Parkinson's disease

(Submitter supplied) Genetic variation modulating risk of sporadic Parkinson’s disease (PD) has been primarily explored through genome wide association studies (GWAS). However, like many other common genetic diseases, the impacted genes remain largely unknown. Here, we used single-cell RNA-seq to characterize dopaminergic (DA) neuron populations in the mouse brain at embryonic and early postnatal timepoints. These data facilitated unbiased identification of DA neuron subpopulations through their unique transcriptional profiles, including a novel postnatal neuroblast population and substantia nigra (SN) DA neurons. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
473 Samples

Download data: TXT

Series

Accession:: GSE108020

ID:: 200108020

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Select item 20022508411.

Evaluating the mouse neural precursor line, SN4741, as a suitable proxy for midbrain dopaminergic neurons

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Other; Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL24247
28 Samples

Download data: MTX, TSV, XLS

Series

Accession:: GSE225084

ID:: 200225084

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Select item 20022508212.

Evaluating the mouse neural precursor line, SN4741, as a suitable proxy for midbrain dopaminergic neurons [Hi-C]

(Submitter supplied) To overcome the ethical and technical limitations of in vivo human disease models, the broader scientific community frequently employs model organism-derived cell lines to investigate of disease mechanisms, pathways, and therapeutic strategies. Despite the widespread use of certain in vitro models, many still lack contemporary genomic analysis supporting their use as a proxy for the affected human cells and tissues. more...