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Links from GEO DataSets

Items: 8

1.

Transcriptomic profiles of Pseudomonas aeruginosa PA14 grown in the presence or absence of mucins or mucin-glycans

(Submitter supplied) We use high-throughput sequencing to profile the response of the opportunistic mucosal pathogen Pseudomonas aeruginosa to mucins and mucin-glycans from the mucosal niche. We find that P. aeruginosa undergoes a genome-wide phenotypic shift in response to mucins and their attached glycans. Specifically, nearly all virulence pathways are downregulated in response to these host-produced factors. This study provides a framework for understanding how the host environment regulates bacterial function.
Organism:
Pseudomonas aeruginosa
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18644
14 Samples
Download data: CSV
Series
Accession:
GSE156995
ID:
200156995

PubMed Full text in PMC Similar studies SRA Run Selector

2.

Transcriptomic profiles of Pseudomonas aeruginosa PAO1 grown in the presence or absence of mucins or mucin-glycans

(Submitter supplied) We use high-throughput sequencing to profile the response of the opportunistic mucosal pathogen Pseudomonas aeruginosa to mucins and mucin-glycans from the mucosal niche. We find that P. aeruginosa undergoes a genome-wide phenotypic shift in response to mucins and their attached glycans. Specifically, nearly all virulence pathways are downregulated in response to these host-produced factors. This study provides a framework for understanding how the host environment regulates bacterial function.
Organism:
Pseudomonas aeruginosa
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18644
15 Samples
Download data: CSV
Series
Accession:
GSE136097
ID:
200136097

PubMed Full text in PMC Similar studies SRA Run Selector

3.

RNA-seq for AnvM

(Submitter supplied) Pseudomonas aeruginosa is one of the most common pathogens in hospital-acquired infection, which is tightly controlled by a multi-layered regulatory network including quorum sensing system (QS), type VI secretion system (T6SS) and resistance to host immunity. In the present study, we found that a PA3880 gene, which encodes an unknown protein, acted as a regulator of anaerobic metabolism, response to oxidative stress and virulence in P. more...
Organism:
Pseudomonas aeruginosa PAO1
Type:
Expression profiling by high throughput sequencing
Platform:
GPL19430
8 Samples
Download data: XLSX
Series
Accession:
GSE129571
ID:
200129571

PubMed Full text in PMC Similar studies SRA Run Selector

4.

ChIP-seq and RNA-seq analyses of genomic regulators in Pseudomonas aeruginosa

(Submitter supplied) Regulatory networks including virulence-related transcriptional factors (TFs) determine bacterial pathogenicity in response to different environmental cues. Pseudomonas aeruginosa, a Gram-negative opportunistic pathogen of humans, recruits numerous TFs in quorum sensing (QS) system, type III secretion system (T3SS) and Type VI secretion system (T6SS) to mediate the pathogenicity. Although many virulence-related TFs have been illustrated individually, very little is known about their crosstalks and regulatory network. more...
Organism:
Pseudomonas aeruginosa PAO1
Type:
Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing
Platform:
GPL19430
52 Samples
Download data: TXT, XLSX
Series
Accession:
GSE128430
ID:
200128430

PubMed Full text in PMC Similar studies SRA Run Selector

5.

RNA-seq for MvfR, RhlR and QscR

(Submitter supplied) Pseudomonas aeruginosa is a Gram-negative opportunistic pathogen of humans, most notably those with cystic fibrosis or whose immune systems are compromised. As a global regulator, MvfR,RhlR and QscR have been characterized to control a group of virulence-related factors and quorum sensing (QS) genes in P. aeruginosa, but its detailed molecular regulatory mechanism is largely elusive. To further gain insights into the direct targets of MvfR,RhlR and QscR in viv, this study focused on identifying the potential targets of MvfR,RhlR and QscR directly regulating QS system and other vireulence pathways. more...
Organism:
Pseudomonas aeruginosa PAO1
Type:
Expression profiling by high throughput sequencing
Platform:
GPL19430
10 Samples
Download data: XLSX
Series
Accession:
GSE121243
ID:
200121243

PubMed Full text in PMC Similar studies SRA Run Selector

6.

CRISPRi knockdown of essential genes in Pseudomonas aeruginosa

(Submitter supplied) To understand molecular pathways responding to loss of essential proteins in the inner- or outer-membrane, we knocked down essential genes in the inner- and outer membrane using a CRISPRi approach in Pseudomonas aeruginosa. CRISPRi is an inducible system with which even essential genes can be targeted by a specifig sg-RNA. In this study, we investigated the transcriptomic changes upon loss of BamA, LptD and FtsH. more...
Organism:
Pseudomonas aeruginosa
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21297
12 Samples
Download data: XLSX
Series
Accession:
GSE159327
ID:
200159327

PubMed Full text in PMC Similar studies SRA Run Selector

7.

Molecular Mechanisms of Master Regulator VqsM mediating Quorum-sensing and Antibiotic Resistance in Pseudomonas aeruginosa

(Submitter supplied) The Pseudomonas aeruginosa quorum-sensing (QS) systems contribute to bacterial homeostasis and pathogenicity. Although the AraC family transcription factor VqsM has been characterized to control the production of virulence factors and QS signaling molecules, its detailed regulatory mechanisms still remain elusive. Here, we report that VqsM directly binds to the lasI promoter region, and thus regulates its expression. more...
Organism:
Pseudomonas aeruginosa
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL18644
4 Samples
Download data: TXT
Series
Accession:
GSE57284
ID:
200057284

PubMed Full text in PMC Similar studies SRA Run Selector

8.

Determination of the regulons of 55 response regulators from P. aeruginosa by DAP-seq

(Submitter supplied) Determination of the binding sites of 55 transcription factors (all response regulators) in Pseudomonas aeruginosa strains PAO1, PA14 and IHMA87.
Organism:
Pseudomonas aeruginosa
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL21297
342 Samples
Download data: XLSX
Series
Accession:
GSE179001
ID:
200179001

PubMed Full text in PMC Similar studies SRA Run Selector

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