Similar studies for GEO DataSets (Select 200165708) - GEO DataSets

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Items: 20

Select item 2001657081.

Epigenetic impairment and blunted transcriptional response to Mycobacterium tuberculosis of alveolar macrophages from persons living with HIV (RNA-Seq)

(Submitter supplied) Persons living with HIV (PLWH) are at increased risk of tuberculosis (TB). HIV-associated TB is mainly the result of recent infection with Mycobacterium tuberculosis (Mtb) followed by rapid progression to disease. Alveolar macrophages (AM) are the first cells of the innate immune system that engage Mtb, but how HIV and antiretroviral therapy (ART) impact on the anti-mycobacterial response of AM is not known. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20301
100 Samples

Download data: TXT

Series

Accession:: GSE165708

ID:: 200165708

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 2001657092.

Epigenetic impairment and blunted transcriptional response to Mycobacterium tuberculosis of alveolar macrophages from persons living with HIV

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL20301 GPL24676
212 Samples

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Series

Accession:: GSE165709

ID:: 200165709

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Select item 2001657053.

Epigenetic impairment and blunted transcriptional response to Mycobacterium tuberculosis of alveolar macrophages from persons living with HIV (ChIP-Seq)

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL24676
30 Samples

Download data: TXT

Series

Accession:: GSE165705

ID:: 200165705

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Select item 2001657034.

Epigenetic impairment and blunted transcriptional response to Mycobacterium tuberculosis of alveolar macrophages from persons living with HIV (ATAC-Seq)

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL20301
82 Samples

Download data: TXT

Series

Accession:: GSE165703

ID:: 200165703

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Select item 2000987505.

Alveolar macrophages from tuberculosis patients display an altered inflammatory gene expression profile

(Submitter supplied) Alveolar macrophages (AMs) are major targets of Mycobacterium tuberculosis (Mtb) infection, critical during the progression of active tuberculosis (TB). The complex immunopathology of TB generates diverse microenvironments in the lung, which shape immune responses by AMs. In the current study, we perform whole genome microarray transcriptional profiling on RNA isolated from AMs from TB patients (AMsTB) compared to AMs from control subjects (AMsCT) using bronchoalveolar lavage (BAL). more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10558
7 Samples

Download data: TXT

Series

Accession:: GSE98750

ID:: 200098750

Select item 2001398256.

Human alveolar and splenic macrophage populations display a disctinct transcriptomic response to infection with Mycobacterium tuberculosis

(Submitter supplied) Mycobacterium tuberculosis (Mtb) infects alveolar macrophages (AMs) causing pulmonary tuberculosis (PTB), the more frequent form of the disease. Less frequently, Mtb disseminates to many other organs and tissues resulting in different extrapulmonary forms of TB. Nevertheless, very few studies have addressed the global mRNA response of human AMs, in particular from humans with the active form of the disease. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10558
43 Samples

Download data: TXT

Series

Accession:: GSE139825

ID:: 200139825

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Select item 2001321857.

Gene expression analysis of Mtb-infected mouse alveolar macrophages from mice lacking Nrf2 in LysM- or CD11c-expressing cells

(Submitter supplied) The aim of this study was to measure the immune response of alveolar macrophages (AMs) from mice lacking Nrf2 in LysM- or CD11c-expressing cells to intracellular Mtb infection in vivo. We characterized the transcriptional profile of murine Mtb-infected AMs after aerosol infection by sorting cells from bronchoalveolar lavage fluid and performing low-input RNA-sequencing.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
12 Samples

Download data: TSV

Series

Accession:: GSE132185

ID:: 200132185

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Select item 2001252878.

Gene expression analysis of mouse alveolar macrophages infected with Mycobacterium tuberculosis

(Submitter supplied) The aim of this study was to measure the immune response of alveolar macrophages (AMs) to intracellular Mtb infection in vivo. We characterized the transcriptional profile of murine Mtb-infected AMs after aerosol infection by sorting cells from bronchoalveolar lavage fluid and performing low-input RNA-sequencing. To determine the effect of the transcription factor Nrf2 on this response we also measured the transcriptional profiles of AMs from mice lacking Nrf2.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
54 Samples

Download data: TSV

Series

Accession:: GSE125287

ID:: 200125287

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Select item 2002122059.

Gene expression analysis of BCG-vaccinated and CoMtb mice

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL24247 GPL19057
48 Samples

Download data: RDS

Series

Accession:: GSE212205

ID:: 200212205

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Select item 20021220410.

Single-cell gene expression analysis of pulmonary immune cells from BCG-vaccinated and CoMtb mice [scRNAseq]

(Submitter supplied) The aim of this study was to measure effect of BCG vaccination or contained Mtb infection (CoMTB) on the expression profile of pulmonary immune cells.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
6 Samples

Download data: RDS

Series

Accession:: GSE212204

ID:: 200212204

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Select item 20021220311.

Gene expression analysis of alveolar macrophages from BCG-vaccinated and CoMtb mice stimulated ex vivo [exvivoRNAseq]

(Submitter supplied) The aim of this study was to measure the response of alveolar macrophages (AMs) from BCG-vaccinated mice and mice with CoMtb to LPS, PAM3CSK4, and Mtb stimulation ex vivo.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
36 Samples

Download data: TSV

Series

Accession:: GSE212203

ID:: 200212203

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Select item 20021220212.

Gene expression analysis of mouse alveolar macrophages infected with Mycobacterium tuberculosis isolated from BCG-vaccinated mice [balRNAseq]

(Submitter supplied) The aim of this study was to measure the immune response of alveolar macrophages (AMs) from BCG-vaccinated mice to intracellular Mtb infection in vivo. We characterized the transcriptional profile of murine Mtb-infected AMs after aerosol infection by sorting cells from bronchoalveolar lavage fluid and performing low-input RNA-sequencing.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
6 Samples

Download data: TSV

Series

Accession:: GSE212202

ID:: 200212202

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Select item 20015820813.

Antiretroviral treatment induced decrease in immune activation contributes to reduced susceptibility to tuberculosis in HIV-TB co-infected persons

(Submitter supplied) Antiretroviral treatment (ART) reduces the risk of developing active tuberculosis (TB) in HIV co-infected persons. We aimed to investigate the mechanisms of ART-mediated prevention of TB in HIV and TB co-infected patients on antiretroviral therapy (ART), recruited in Khayelitsha, South Africa. RNA was extracted from whole blood collected in TempusTM Blood RNA tubes at day 0 and at 1, 3 and 6 months of ART. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20301
12 Samples

Download data: TSV

Series

Accession:: GSE158208

ID:: 200158208

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Select item 20016723214.

Integration of M. tuberculosis phenotype with single cell RNA-seq to interrogate host macrophage heterogeneity in vivo.

(Submitter supplied) Over the last several years, scRNA-seq has proven an invaluable tool for dissecting the role of the immune environment in many diseases. However, for infectious disease studies, the absence of information regarding the transcriptional status of the infecting agent reduces our functional appreciation of the roles of different immune effector cells in determining control versus progression of disease. more...

Organism:: Homo sapiens; Mus musculus

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

4 related Platforms
24 Samples

Download data: CSV, RDS, TSV

Series

Accession:: GSE167232

ID:: 200167232

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Select item 20011437115.

AmpliSeq Transcriptome Analysis of Human Alveolar and Monocyte-Derived Macrophages Over Time in Response to Mycobacterium tuberculosis infection

(Submitter supplied) Human alveolar macrophages (HAM) are primary bacterial niche and immune response cells during Mycobacterium tuberculosis (M.tb) infection, and human blood monocyte-derived macrophages (MDM) are a model for investigating M.tb-macrophage interactions. Here, we use a targeted RNA-Seq method to measure transcriptome-wide changes in RNA expression patterns of freshly obtained HAM (used within 6 h) and 6 day cultured MDM upon M.tb infection over time (2, 24 and 72 h), in both uninfected and infected cells from three donors each. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing

Platform:: GPL17303
36 Samples

Download data: TXT

Series

Accession:: GSE114371

ID:: 200114371

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Select item 20024595016.

CD38+ Alveolar Macrophages mediate early control of M.tuberculosis proliferation in the lung [CITE-seq]

(Submitter supplied) Tuberculosis, caused by M.tuberculosis (Mtb), remains an enduring global health challenge, especially given the limited efficacy of current therapeutic interventions. Much of existing research has focused on immune failure as a driver of tuberculosis. However, the crucial role of host macrophage biology in controlling the disease remains underexplored. While we have gained deeper insights into how alveolar macrophages (AMs) interact with Mtb, the precise AM subsets that mediate protection and potentially prevent tuberculosis progression have yet to be identified. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Other

Platforms:: GPL19057 GPL30172
17 Samples

Download data: MTX, TSV, TXT

Series

Accession:: GSE245950

ID:: 200245950

PubMed Full text in PMC Similar studies

Select item 20024583617.

CD38+ Alveolar Macrophages mediate early control of M.tuberculosis proliferation in the lung [scATAC-seq]

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL19057
1 Sample

Download data: TBI, TSV

Series

Accession:: GSE245836

ID:: 200245836

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Select item 20022386318.

Human alveolar macrophage response to Mycobacterium tuberculosis: immune characteristics underlying large inter-individual variability.

(Submitter supplied) This is a replication study on human alveolar macrophages (HAMs) from a smaller cohort from South Africa in order to support the RNA data of a relatively larger cohort from the US (Ohio & Texas). In this replication cohort, using full RNA-seq, a substantial portion of significant differentially expressed RNAs overlap with those identified with Ampliseq from the larger cohort over time, yielding similar enriched functional terms, e.g., interferon, interleukin, and IDO1 signaling.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21290
30 Samples

Download data: XLSX

Series

Accession:: GSE223863

ID:: 200223863

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20018999619.

Alveolar macrophage immunobiology and functional genomics: Unlocking human to human variation in host response to M. tuberculosis

(Submitter supplied) An innovative, high-throughput approach was proposed to identify key gene expression profiles and regulatory polymorphisms affecting innate immunity to TB by studying interactions between M.tb and human alveolar macrophages (AMs). We systematically analyzed interactions of a virulent M.tb strain with freshly isolated human AMs from 28 healthy adult donors, measuring host RNA expression and secreted candidate proteins associated with TB pathogenesis over 72h. more...