Similar studies for GEO DataSets (Select 200171626) - GEO DataSets

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Items: 13

Select item 2001716261.

ΔNp63/p73 drive metastatic colonization by controlling a regenerative epithelial stem cell program in quasi-mesenchymal cancer stem cells

(Submitter supplied) p63/p73 are master transcriptional regulators of ITGB4-hi cancer stem cells and are required to maintain CSCs in a quasi-mesenchymal state and for metastatic colonization

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
12 Samples

Download data: TXT

Series

Accession:: GSE171626

ID:: 200171626

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 2001716292.

ΔNp63/p73 drive metastatic colonization by controlling a regenerative epithelial stem cell program in quasi-mesenchymal cancer stem cells

(Submitter supplied) p63/p73 are master transcriptional regulators of ITGB4-hi cancer stem cells and are required to maintain CSCs in a quasi-mesenchymal state and for metastatic colonization

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
12 Samples

Download data: TXT

Series

Accession:: GSE171629

ID:: 200171629

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 2001716283.

ΔNp63/p73 drive metastatic colonization by controlling a regenerative epithelial stem cell program in quasi-mesenchymal cancer stem cells

(Submitter supplied) p63/p73 are master transcriptional regulators of ITGB4-hi cancer stem cells and are required to maintain CSCs in a quasi-mesenchymal state and for metastatic colonization

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL11154
2 Samples

Download data: MTX, TSV

Series

Accession:: GSE171628

ID:: 200171628

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000955404.

Integrin-b4 identifies cancer stem cell-enriched populations of partially mesenchymal carcinoma cells

(Submitter supplied) We report the gene expression profiles of normal epithelial and carcinoma cell populations that differ in their relative levels of integrin-beta 4 expression. ITGB4 high, mesenchymal subtype, triple-negative breast cancer cells were found to be more epithelial than related ITGB4 low cells.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
36 Samples

Download data: TXT

Series

Accession:: GSE95540

ID:: 200095540

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 2000443355.

HMLER cells expressing either FOXC2 or a vector control

(Submitter supplied) We used microarrays to investigate the transcription profile of FOXC2 expression in a human mammary epithelial cell line.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
6 Samples

Download data: CEL

Series

Accession:: GSE44335

ID:: 200044335

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001191496.

Acquisition of a hybrid E/M state is essential for tumorigenicity of basal breast cancer cells

(Submitter supplied) Using the recently described CD104+/CD44hi antigen combination we demonstrate that tumorigenicity depends on individual cells residing in a hybrid E/M state. Acquisition of this E/M hybrid state is facilitated by the differential expression of EMT- TFs, like Snail accompanied by the expression of adult stem-cell programs. Transition from the highly tumorigenic E/M state to a fully mesenchymal phenotype, achieved by constitutive ectopic expression of Zeb1, is sufficient to drive cells out of the E/M hybrid state into an extreme mesenchymal (xM) state, which is accompanied by a substantial loss of tumorigenicity and a switch from canonical to non-canonical Wnt signaling.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
12 Samples

Download data: TXT

Series

Accession:: GSE119149

ID:: 200119149

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 2000523277.

Expression data of ALDH+ breast cancer cells

(Submitter supplied) It has been suggested that breast cancers are driven and maintained by a cellular subpopulation with stem cell properties. These breast cancer stem cells (BCSCs) mediate metastasis and by virtue of their resistance to radiation and chemotherapy, contribute to relapse. Although several BCSC markers have been described, it is unclear whether these markers identify the same or independent BCSC populations. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
16 Samples

Download data: CEL

Series

Accession:: GSE52327

ID:: 200052327

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000522628.

Expression data of CD24-CD44+ and ALDH+ cells

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
27 Samples

Download data: CEL

Series

Accession:: GSE52262

ID:: 200052262

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000622309.

Expression of miR-200c in claudin-low breast cancer alters stem cell functionality, enhances chemosensitivity and reduces metastatic potential

(Submitter supplied) Claudin-low tumors are a highly aggressive breast cancer subtype with no targeted treatments and a clinically documented resistance to chemotherapy. They are significantly enriched in cancer stem cells (CSCs), which makes claudin-low tumor models particularly attractive for studying CSC behavior and developing novel approaches to minimize CSC therapy resistance. One proposed mechanism by which CSCs arise is via an epithelial-mesenchymal transition (EMT), and reversal of this process may provide a potential therapeutic approach for increasing tumor chemosensitivity. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL11383
7 Samples

Download data

Series

Accession:: GSE62230

ID:: 200062230

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20010475510.

The role of LSD1 in Epithelial to Mesenchymal Transition: gene expression profiling and ChIP-seq

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL16686 GPL18573
7 Samples

Download data: BED, BEDGRAPH, CEL

Series

Accession:: GSE104755

ID:: 200104755

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20010475411.

LSD1 activation promotes inducible EMT programs and modulates the tumour microenvironment in breast cancer

(Submitter supplied) Complex regulatory networks control epithelial-to-mesenchymal transition (EMT) but the underlying epigenetic control is poorly understood. Lysine-specific demethylase 1 (LSD1) is a key histone demethylase that alters the epigenetic landscape. Here we explored the role of LSD1 in global epigenetic regulation of EMT, cancer stem cells (CSCs), the tumour microenvironment, and therapeutic resistance in breast cancer. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL18573
3 Samples

Download data: BED, BEDGRAPH

Series

Accession:: GSE104754

ID:: 200104754

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20010475312.

The role of LSD1 in Epithelial to Mesenchymal Transition

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL16686
4 Samples

Download data: CEL

Series

Accession:: GSE104753

ID:: 200104753

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20007710713.

Plasticity between Epithelial and Mesenchymal States Unlinks EMT from Metastasis-Enhancing Stem Cell Capacity

(Submitter supplied) In this study we studied the presence of tumor cells that underwent epithelial-to-mesenchymal transition within polyoma middle T antigen (PyMT) breast tumors. For this we dissociated tumors and isolated Ecad positive tumor cells by FACS sorting. We confirmed that PyMT tumors contain a small set of tumor cells that have undergone EMT in the primary tumor and that E-cadherin can be used as a marker on single cell level for mesenchymal status in this model.