GEO DataSets

(Submitter supplied) Hemachromatosis (iron-overload) increases host susceptibility to siderophilic bacterial infections that cause serious complications, but the underlying mechanisms remain elusive. The present study demonstrates that oral infection with hyper-yersiniabactin (Ybt) producing Yersinia pseudotuberculosis Δfur mutant (termed Δfur) results in severe systemic infection and acute mortality to hemochromatotic mice due to rapid disruption of the intestinal barrier. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL19057

9 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Yersinia pseudotuberculosis

Type:

Expression profiling by array

Platform:

GPL15095

9 Samples

Download data: TXT

(Submitter supplied) Whole transcriptome assessment of the Yersinia pseudotuberculosis strain YPIII. The Y. pseudotuberculosis rovA regulon was determined in Yersinia minimal minimum developed for the study. RovA is a key regulator for Yersinia virulence.

Organism:

Yersinia pseudotuberculosis

Type:

Expression profiling by array

Platform:

GPL15095

3 Samples

Download data: TXT

(Submitter supplied) Whole transcriptome assessment of the Yersinia pseudotuberculosis strain YPIII. The Y. pseudotuberculosis csrA regulon was determined in Yersinia minimal minimum developed for the study. CsrA is a key regulator coordinating virulence and metabolism.

Organism:

Yersinia pseudotuberculosis

Type:

Expression profiling by array

Platform:

GPL15095

3 Samples

Download data: TXT

(Submitter supplied) Whole transcriptome assessment of the Yersinia pseudotuberculosis strain YPIII. The Y. pseudotuberculosis crp regulon was determined in Yersinia minimal minimum developed for the study. Crp is a key regulator coordinating virulence and metabolism.

Organism:

Yersinia pseudotuberculosis

Type:

Expression profiling by array

Platform:

GPL15095

3 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Yersinia pseudotuberculosis IP 32953; Yersinia pseudotuberculosis

Type:

Expression profiling by array

Platform:

GPL15095

16 Samples

Download data: TAB, TXT

(Submitter supplied) The Twin-arginine translocation (Tat) system promotes secretion of folded proteins that in bacteria are identified via an N-terminal signal peptide. Tat systems are associated with virulence in many bacterial pathogens and our previous studies revealed that Tat deficient Yersinia pseudotuberculosis was severely attenuated for virulence. However, in silico predictions did not reveal any obvious virulence factors among the potential Tat substrates encoded by Y. more...

Organism:

Yersinia pseudotuberculosis IP 32953; Yersinia pseudotuberculosis

Type:

Expression profiling by array

Platform:

GPL15095

4 Samples

Download data: TAB, TXT

(Submitter supplied) The Twin-arginine translocation (Tat) system promotes secretion of folded proteins that in bacteria are identified via an N-terminal signal peptide. Tat systems are associated with virulence in many bacterial pathogens and our previous studies revealed that Tat deficient Yersinia pseudotuberculosis was severely attenuated for virulence. However, in silico predictions did not reveal any obvious virulence factors among the potential Tat substrates encoded by Y. more...

Organism:

Yersinia pseudotuberculosis IP 32953; Yersinia pseudotuberculosis

Type:

Expression profiling by array

Platform:

GPL15095

4 Samples

Download data: TAB, TXT

(Submitter supplied) The Twin-arginine translocation (Tat) system promotes secretion of folded proteins that in bacteria are identified via an N-terminal signal peptide. Tat systems are associated with virulence in many bacterial pathogens and our previous studies revealed that Tat deficient Yersinia pseudotuberculosis was severely attenuated for virulence. However, in silico predictions did not reveal any obvious virulence factors among the potential Tat substrates encoded by Y. more...

Organism:

Yersinia pseudotuberculosis IP 32953; Yersinia pseudotuberculosis

Type:

Expression profiling by array

Platform:

GPL15095

4 Samples

Download data: TAB, TXT

(Submitter supplied) The Twin-arginine translocation (Tat) system promotes secretion of folded proteins that in bacteria are identified via an N-terminal signal peptide. Tat systems are associated with virulence in many bacterial pathogens and our previous studies revealed that Tat deficient Yersinia pseudotuberculosis was severely attenuated for virulence. However, in silico predictions did not reveal any obvious virulence factors among the potential Tat substrates encoded by Y. more...

Organism:

Yersinia pseudotuberculosis; Yersinia pseudotuberculosis IP 32953

Type:

Expression profiling by array

Platform:

GPL15095

4 Samples

Download data: TAB, TXT

(Submitter supplied) Yersinia pseudotuberculosis is a Gram-negative bacterium capable of causing gastrointestinal infection and is closely related to the highly virulent plague bacillus Yersinia pestis. Infection by both species are currently treatable with antibiotics such as ciprofloxacin, a quinolone-class drug of major clinical importance in the treatment of many other infections. Our current understanding of the mechanism of action of ciprofloxacin is that it inhibits DNA replication by targeting DNA gyrase, and that resistance is primarily due to mutation at this target site, along with generic efflux and detoxification strategies. more...

Organism:

Yersinia pseudotuberculosis IP 32953

Type:

Other

Platform:

GPL27002

3 Samples

Download data: TXT