GEO DataSets

(Submitter supplied) Background: Increased epigenetic age acceleration (EAA) in survivors of childhood cancer is associated with specific treatment exposures, unfavorable health behaviors, and presence of certain chronic health conditions. To better understand inter-individual variability, we investigated the genetic basis underlying EAA. Methods: Genome-wide association studies of EAA based on multiple epigenetic clocks (Hannum, Horvath, PhenoAge, and GrimAge) were performed. more...

Organism:

Homo sapiens

Type:

Methylation profiling by genome tiling array

Platform:

GPL21145

2138 Samples

Download data: IDAT, TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Methylation profiling by genome tiling array

Platform:

GPL21145

2922 Samples

Download data: IDAT

(Submitter supplied) Background: Increased epigenetic age acceleration (EAA) in survivors of childhood cancer is associated with specific treatment exposures, unfavorable health behaviors, and presence of certain chronic health conditions. To better understand inter-individual variability, we investigated the genetic basis underlying EAA. Methods: Genome-wide association studies of EAA based on multiple epigenetic clocks (Hannum, Horvath, PhenoAge, and GrimAge) were performed. more...

Organism:

Homo sapiens

Type:

Methylation profiling by genome tiling array

Platform:

GPL21145

282 Samples

Download data: IDAT, TXT

(Submitter supplied) Background: Increased epigenetic age acceleration (EAA) in survivors of childhood cancer is associated with specific treatment exposures, unfavorable health behaviors, and presence of certain chronic health conditions. To better understand inter-individual variability, we investigated the genetic basis underlying EAA. Methods: Genome-wide association studies of EAA based on multiple epigenetic clocks (Hannum, Horvath, PhenoAge, and GrimAge) were performed. more...

Organism:

Homo sapiens

Type:

Methylation profiling by genome tiling array

Platform:

GPL21145

502 Samples

Download data: IDAT, TXT

(Submitter supplied) Background: It is well-established that cancer treatment substantially increases risk of long-term adverse health outcomes among childhood cancer survivors. However, there is limited research on the underlying mechanisms. To elucidate the pathophysiology and a possible causal pathway from treatment exposures to cardiometabolic conditions, we conducted epigenome-wide association studies (EWAS) to identify DNA methylation (DNAm) sites associated with cancer treatment exposures and examined whether treatment-associated DNAm sites mediate associations between specific treatments and cardiometabolic conditions. more...

Organism:

Homo sapiens

Type:

Methylation profiling by genome tiling array

Platform:

GPL23976

2052 Samples

Download data: IDAT, TXT

(Submitter supplied) Genome wide DNA methylation profiling of normal colon samples. The Illumina Infinium HumanMethylation450 and EPIC Beadchip arrays were used to obtain DNA methylation profiles across approximately 450,000 and 850,000 CpGs. Samples were from nomal colons of 334 subjects with low, medium or high CRC risk according to their personal adenoma or cancer history.

Organism:

Homo sapiens

Type:

Methylation profiling by genome tiling array

Platforms:

GPL21145 GPL13534

334 Samples

Download data: IDAT

(Submitter supplied) We evaluated biological aging using five epigenetic clocks (Horvath, Hannum, PhenoAge, GrimAge and DunedinPoAm) calculated from DNA methylation measured in peripheral blood cells in a trans-diagnostic psychiatric sample including healthy controls. We found that burden of psychiatric disease, represented by a weighted score, was significantly associated with biological age acceleration as measured by GrimAge and DunedinPoAm. more...

Organism:

Homo sapiens

Type:

Methylation profiling by genome tiling array

Platform:

GPL21145

420 Samples

Download data: TXT

(Submitter supplied) DNA-methylation profiling of Whole blood genomic DNAs collected at EDIC baseline and monocytes at EDIC years 16/17 years from participants of Diabetes Control and Complications Trial/ Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) study This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Methylation profiling by genome tiling array

Platform:

GPL16304

124 Samples

Download data: IDAT

(Submitter supplied) Study the association of DNA-methylation and metabolic memory by examing DNA-methylation alternation between cases (received conventional therapy in DCCT and showing retinopathy or albuminuria progression at EDIC year-10) and Controls(in DCCT intensive treatment group and did not have retinopathy or nephropathy progression during EDIC]

Organism:

Homo sapiens

Type:

Methylation profiling by genome tiling array

Platform:

GPL16304

61 Samples

Download data: IDAT, TXT

(Submitter supplied) Study the association of DNA-methylation and metabolic memory by examing DNA-methylation alternation between cases (received conventional therapy in DCCT and showing retinopathy or albuminuria progression at EDIC year-10) and Controls (in DCCT intensive treatment group and did not have retinopathy or nephropathy progression during EDIC).

Organism:

Homo sapiens

Type:

Methylation profiling by genome tiling array

Platform:

GPL16304

63 Samples

Download data: IDAT, TXT

(Submitter supplied) The gene expression approach has provided promising insights into the pathophysiology of PTSD. However, few studies used hypothesis-free transcriptome-wide expression approach. Transcriptome-wide expression study using RNA sequencing (RNA-Seq) of whole blood was conducted in 324 World Trade Center responders (201 with never, 81 current and 42 past PTSD). The current and never PTSD samples were randomly split to form both discovery (N=195) and replication (N=87) cohorts. more...

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL11154

324 Samples

Download data: CSV

(Submitter supplied) An Infinium microarray platform (GPL28271, HorvathMammalMethylChip40) was used to generate DNA methylation data from human postmortem tissue samples. n=661 tissues. Adipose, Lung, Blood, Bone marrow, Heart, Kidney, Liver, Spleen, Lymph node, Skeletal muscle, Pituitary gland,

Organism:

Mus musculus; Rattus norvegicus; Homo sapiens

Type:

Methylation profiling by array

Platform:

GPL28271

661 Samples

Download data: CSV, DOCX, IDAT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Methylation profiling by array

Platform:

GPL23976

96 Samples

Download data: IDAT

(Submitter supplied) Genome wide DNA methylation profiling of samples from adult survivors of childhood and young adult cancer, using the Illumina Infinium Human MethylationEPIC Beadchip arrays. Samples included 32 samples, all sampled at least 10 years after diagnosis . Specific therapies and duration between sampling and diagnosis varied.

Organism:

Homo sapiens

Type:

Methylation profiling by array

Platform:

GPL23976

32 Samples

Download data: IDAT, RDATA

(Submitter supplied) Genome wide DNA methylation profiling of paired samples from childhood cancer patients undergoing chemotherapy treatment, using the Illumina Infinium Human MethylationEPIC Beadchip arrays. Samples included 32 paired samples (i.e. total 64 samples), with the second sample taken after treatment . Specific therapies and duration between samples varied.

Organism:

Homo sapiens

Type:

Methylation profiling by array

Platform:

GPL23976

64 Samples

Download data: IDAT, RDATA

(Submitter supplied) DNA methylation measured in mice belonging to the BXD Family using the HorvathMammalMethylChip40

Organism:

Homo sapiens; Mus musculus; Rattus norvegicus

Type:

Methylation profiling by array

Platform:

GPL28271

339 Samples

Download data: IDAT

(Submitter supplied) This study included whole-genome DNA methylation data from 64 whole-blood samples from patients recruited from the Hospital Psiquiatrico Infantil Juan N. Navarro in Mexico City. The project explored epigenetic changes associated with eating disorders in children and adolescents from a Mexican population.

Organism:

Homo sapiens

Type:

Methylation profiling by array

Platform:

GPL21145

64 Samples

Download data: CSV

(Submitter supplied) Genome-wide DNA methylation profile of peripheral blood leukocyte samples taken from patients under clozapine treatment. The Infinium MethylationEPIC BeadChip was analyzed to obtain DNA methylation profiles in samples from 31 patients with psychotic disorders under treatment with clozapine and 56 patients with psychiatric disorders naïve to psychopharmacological treatment

Organism:

Homo sapiens

Type:

Methylation profiling by genome tiling array

Platform:

GPL23976

32 Samples

Download data: TXT