We evaluated biological aging using five epigenetic clocks (Horvath, Hannum, PhenoAge, GrimAge and DunedinPoAm) calculated from DNA methylation measured in peripheral blood cells in a trans-diagnostic psychiatric sample including healthy controls. We found that burden of psychiatric disease, represented by a weighted score, was significantly associated with biological age acceleration as measured by GrimAge and DunedinPoAm. The faster pace of aging was even further accelerated in individuals exposed to physical abuse in childhood
Overall design
The study sample included subjects with psychiatric disorders and self-reported healthy controls of two studies conducted at the Max Planck Institute of Psychiatry in Munich, Germany: the Biological Classification of Mental Disorders study (BeCOME, registered on ClinicalTrials.gov, TRN: NCT03984084) and a subset of patients recruited for major depression from a clinical psychotherapy study (OPTIMA, registered on ClinicalTrials.gov, TRN: NCT03287362) who agreed to participate in an additional biobanking project. Epigenetic age was calcualted with Horvaths’ New Methylation Age Calculator (https://dnamage.genetics.ucla.edu/new). DunedinPoAm was calculated with the DunedinPoAm38 R package (https://github.com/danbelsky/DunedinPoAm38). Final DNA methylation data comprised of 420 subjects.
***Please note that the algorithms to calculate epigenetic age need only small part of the CpGs on the array and due to privacy concerns, a partial dataset (i.e. only the necessary CpGs (N = 1922) for the calculation of the epigentic age by the 5 tools) was included in the records.
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