Similar studies for GEO DataSets (Select 200224037) - GEO DataSets

(Submitter supplied) Neuroblastoma cell lines (Kelly, BE2C) were subject to chromatin profiling by ATAC-seq ATAC-seq analysis of Neuroblastoma cell lines +/- shAhR knockdown

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL24676
18 Samples

Download data: BW, NARROWPEAK

Series

Accession:: GSE224390

ID:: 200224390

PubMed Full text in PMC Similar studies

Select item 2000533714.

Neuroblastoma: MYCN normal vs. MYCN amplified

(Submitter supplied) To evaluate the expression of genes associated with MYCN in NB, 10 tumors with MYCN amplification and 10 with normal MYCN copy number were subjected to oligonucleotide microarray using Agilent oligo microarray chips.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL887
20 Samples

Download data: TXT

Series

Accession:: GSE53371

ID:: 200053371

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000854325.

Targeting EZH2 in MYCN-amplified Neuroblastoma

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL11154
24 Samples

Download data: BW

Series

Accession:: GSE85432

ID:: 200085432

PubMed Full text in PMC Similar studies

Select item 2000854316.

Targeting EZH2 in MYCN-amplified Neuroblastoma [RNA-seq]

(Submitter supplied) Purpose: Identify new targets in MYCN-amplified Neuroblastoma Methods: Kelly and LAN-1 neuroblastoma cells were treated in duplicate with 2 uM GSK126 (Excess Biosciences M60071-2) or DMSO for 2 or 5 days. RNA was extracted from cells with the RNeasy Kit (Qiagen). RNA libraries were prepared for sequencing using standard Illumina protocols. The pool of sixteen samples was sequenced on two lanes of an Illumina HiSeq, generating single end reads of 32-76 bp length. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL11154
16 Samples

Download data: TXT

Series

Accession:: GSE85431

ID:: 200085431

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 2000854307.

Targeting EZH2 in MYCN-amplified Neuroblastoma [ChIP-seq]

(Submitter supplied) Purpose: Identify new targets in MYCN-amplified Neuroblastoma Methods: ChIP-Seq experiments were performed on Kelly and LAN-1 neuroblastoma cells by using the following antibodies: anti-EZH2 (Cell Signaling 5246S); anti-H3K27me3 (Millipore 07-449); anti-H3K4me3 (Abcam ab8580). We evaluated the global EZH2 PRC2-dependence by identifiying direct genome-wide target genes for EZH2, H3K27me3 and H3K4me3. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL11154
8 Samples

Download data: BW

Series

Accession:: GSE85430

ID:: 200085430

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000392188.

Functional MYCN signature predicts outcome of neuroblastoma irrespective of MYCN amplification.

(Submitter supplied) Neuroblastoma is a pediatric tumor of the sympathetic nervous system. MYCN (V-myc myelocytomatosis viral-related oncogene, neuroblastoma derived [avian]) is amplified in 20% of neuroblastomas, and these tumors carry a poor prognosis. However, tumors without MYCN amplification also may have a poor outcome. Here, we identified downstream targets of MYCN by shRNA-mediated silencing MYCN in neuroblastoma cells. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
11 Samples

Download data: CEL

Series

Accession:: GSE39218

ID:: 200039218

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Select item 2001560929.

FOXR2 stabilizes MYCN protein and identifies non-MYCN-amplified neuroblastoma patients with unfavorable outcome

(Submitter supplied) The stabilization of MYCN by FOXR2 represents an alternative mechanism to MYCN amplification to increase MYCN protein levels. As such, FOXR2 expression identifies another subset of neuroblastoma patients with unfavorable clinical outcome. Background: Clinical outcomes of neuroblastoma patients range from spontaneous tumor regression to fatality. Hence, understanding the mechanisms that cause tumor progression are crucial for the treatment of patients. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
12 Samples

Download data: CEL

Series

Accession:: GSE156092

ID:: 200156092

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Select item 20007462610.

Differential gene expression in neuroblastoma cells after transfection with control siRNA, MYCN siRNA or TFAP4 siRNA.

(Submitter supplied) We analyed the gene expression profiles after knocking down MYCN or TFAP4. Results showed that transcription factor MYCN and TFAP4 commonly regulats a subset of genes that may contribute to neuroblastoma cells proliferation and migration.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
6 Samples

Download data: CEL

Series

Accession:: GSE74626

ID:: 200074626

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Select item 20004740711.

GRHL1 acts as a tumor suppressor in neuroblastoma and is negatively regulated by MYCN and HDAC3

(Submitter supplied) Neuroblastoma is an embryonic solid tumor of neural crest origin and accounts for 11% of all cancer-related deaths in children. Novel therapeutic strategies are therefore urgently required. MYCN oncogene amplification, which occurs in 20% of neuroblastomas, is a hallmark of high risk. Here we aimed to exploit molecular mechanisms that can be pharmacologically addressed with epigenetically modifying drugs, such as histone deacetylase (HDAC) inhibitors. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS5263
Platform:: GPL10558
12 Samples

Download data: TXT

Series

Accession:: GSE47407

ID:: 200047407

Select item 526312.

Enforced Grainyhead-like 1 expression effect on BE(2)-C neuroblastoma cell line: time course

Analysis of BE(2)-C cells up to 72 hrs after transient transfection with construct pTRex-GRHL1. The three mammalian GRHL genes (GRHL1, -2, and -3) represent a highly conserved family of β-scaffold transcription factors. Results provide insight into the role of GRHL1 in neuroblastoma biology.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 2 protocol, 3 time sets

Platform:: GPL10558
Series:: GSE47407
12 Samples

Download data

DataSet

Accession:: GDS5263

ID:: 5263

Select item 20012633213.

The transcriptional repressor SNAI2 impairs neuroblastoma differentiation and inhibits response to retinoic acid therapy

(Submitter supplied) Analyses of the effect of CRISPR/CAS9 mediated knock out of the EMT-transcription factor SNAI2 on the mRNA expression profile of human neuroblastoma SH-SY5Y cells to identify genes that are differentially expressed upon loss of SNAI2. Results provide insight into genes that are repressed by SNAI2 in neuroblastoma cells under normal culture conditions, where loss of SNAI2 enhances the expression of genes involved in biological processes such as neuron development and neuron differentiation.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20301
9 Samples

Download data: TXT

Series

Accession:: GSE126332

ID:: 200126332

Select item 20004341914.

Expression data from MYCN transgenic mice

(Submitter supplied) TH-MYCN transgenic (Tg) mice are the model for neuroblastoma. One of the sympathetic ganglia is the origin of neuroblastoma in those mice. The tumor incidences of homozygotes and hemizygotes are 100% and 70-80%, respectively. The involvement of midkine (Mdk), a tumor-related growth factor, was also examined by knockout mice.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
20 Samples

Download data: CEL, CHP

Series

Accession:: GSE43419

ID:: 200043419

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Select item 20012980715.

Gene expression profiling of human neuroblastoma cell line LA1-55n expressing shGFP or shRNA to glycine decarboxylase (GLDC)

(Submitter supplied) Microarray gene expression profiling reveals that silencing GLDC expression downregulates genes required for DNA replication and cell cyle progression

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL16686
6 Samples

Download data: CEL

Series

Accession:: GSE129807

ID:: 200129807

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Select item 20020224116.

Super-enhancer-associated core regulatory circuits mediate susceptibility to retinoic acid in neuroblastoma cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL24676
63 Samples

Download data: BIGWIG, NARROWPEAK, TXT

Series

Accession:: GSE202241

ID:: 200202241

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Select item 20020223917.

Super-enhancer-associated core regulatory circuits mediate susceptibility to retinoic acid in neuroblastoma cells [ChIP-Seq]

(Submitter supplied) Neuroblastoma is a pediatric tumor that accounts for more than 15% of cancer-related deaths in children. Survival chances for high-risk patients are less than 50%. Retinoic acid treatment is part of the maintenance therapy given to neuroblastoma patients; however, not all tumors respond to retinoic acid-mediated differentiation. Among neuroblastoma tumors, two phenotypically distinct cell types-adrenergic (ADRN) and mesenchymal (MES), have been identified based on their super-enhancer landscape and transcriptional core regulatory circuitries. more...