Similar studies for GEO DataSets (Select 200229473) - GEO DataSets

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Items: 10

Select item 2002294731.

5P-Seq analysis of wt and new1-knockout yeast strain as well as New1:80S pull-down samples

(Submitter supplied) We present two sets of 5P-Seq experiments: i) comparison of wt and new1-KO S. cerevisiae ii) analysis of New1:80S pulldown samples. Collectively our results unravel codon-dependent nature of ribosomal stalling in S. cerevisiae lacking New1.

Organism:: Saccharomyces cerevisiae

Type:: Other

Platform:: GPL26302
20 Samples

Download data: WIG

Series

Accession:: GSE229473

ID:: 200229473

PubMed Full text in PMC Similar studies

Select item 2001627802.

Transcriptome-wide investigation of stop codon readthrough in Saccharomyces cerevisiae

(Submitter supplied) Translation of mRNA into a polypeptide is terminated when the release factor eRF1 recognizes a UAA, UAG, or UGA stop codon in the ribosomal A site and stimulates nascent peptide release. However, stop codon readthrough can occur when a near-cognate tRNA outcompetes eRF1 in decoding the stop codon, resulting in the continuation of the elongation phase of protein synthesis. At the end of a conventional mRNA coding region readthrough allows translation into the mRNA 3’-UTR. more...

Organism:: Saccharomyces cerevisiae W303

Type:: Expression profiling by high throughput sequencing; Other

Platform:: GPL27477
16 Samples

Download data: TXT

Series

Accession:: GSE162780

ID:: 200162780

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001386433.

Stop Codon Context Influences Genome-Wide Stimulation of Termination Codon Readthrough by Aminoglycosides

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
41 Samples

Download data: CSV

Series

Accession:: GSE138643

ID:: 200138643

PubMed Full text in PMC Similar studies

Select item 2001386424.

Stop Codon Context Influences Genome-Wide Stimulation of Termination Codon Readthrough by Aminoglycosides [Dataset 5]

(Submitter supplied) Stop codon readthrough (SCR) occurs when the ribosome miscodes at a stop codon. Such readthrough events can be therapeutically desirable when a premature termination codon (PTC) is found in a critical gene. To study SCR in vivo in a genome-wide manner, we treated mammalian cells with aminoglycosides and performed ribosome profiling. We find that in addition to stimulating readthrough of PTCs, aminoglycosides stimulate readthrough of normal termination codons (NTCs) genome-wide. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
6 Samples

Download data: CSV

Series

Accession:: GSE138642

ID:: 200138642

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 2001386415.

Stop Codon Context Influences Genome-Wide Stimulation of Termination Codon Readthrough by Aminoglycosides [Dataset 4]

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
2 Samples

Download data: CSV

Series

Accession:: GSE138641

ID:: 200138641

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001386406.

Stop Codon Context Influences Genome-Wide Stimulation of Termination Codon Readthrough by Aminoglycosides [Dataset 3]

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
3 Samples

Download data: CSV

Series

Accession:: GSE138640

ID:: 200138640

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001386397.

Stop Codon Context Influences Genome-Wide Stimulation of Termination Codon Readthrough by Aminoglycosides [Dataset 2]

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
4 Samples

Download data: CSV

Series

Accession:: GSE138639

ID:: 200138639

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001386388.

Stop Codon Context Influences Genome-Wide Stimulation of Termination Codon Readthrough by Aminoglycosides [Dataset 1]

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
26 Samples

Download data: CSV

Series

Accession:: GSE138638

ID:: 200138638

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 2000887259.

Global analysis of translation termination in E. coli using release factor manipulations

(Submitter supplied) Terminating protein translation accurately and efficiently is critical for both protein fidelity and ribosome recycling for continued translation. The three bacterial release factors (RFs) play key roles: RF1 and 2 recognize stop codons and terminate translation; and RF3 promotes disassociation of bound release factors. Probing release factors mutations with reporter constructs containing programmed frameshifting sequences or premature stop codons had revealed a propensity for readthrough or frameshifting at these specific sites, but their effects on translation genome-wide have not been examined. more...

Organism:: Escherichia coli

Type:: Expression profiling by high throughput sequencing; Other

Platform:: GPL14548
30 Samples

Download data: BEDGRAPH

Series

Accession:: GSE88725

ID:: 200088725

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20009106410.

Study of ribosome dynamics after eIF5A depletion in budding yeast

(Submitter supplied) eIF5A is an essential translation elongation factor present in all eukaryotes, and the only known protein to follow a post-translational modification called hypusination. Here, we performed a wide analysis of ribosome dynamics in S. cerevisiae eIF5A depleted cells using 5Pseq (Pelechano et al. 2015 PMID 26046441). This method allows the study of ribosome dynamics, by sequencing 5’ phosphorylated mRNA co-translational degradation intermediates. more...