GEO DataSets

Analysis of mock and deltaNp73alpha-expressing C2C12 myoblasts 6 and 24 hours after shifting the cells to a differentiation medium. DeltaNp73alpha, a p73alpha isoform, functions as a transdominant inhibitor of other p53 family members, interfering with multiple developmental programs.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 cell line, 3 time sets

Platform:

GPL1261

Series:

GSE5447

6 Samples

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(Submitter supplied) The p53 family comprises the tumor suppressor p53 and the structural homologs p63 and p73. How the three family members cooperate in tumor suppression remains unclear. Here, we report different but complementary functions of the individual members for regulating retinoblastoma protein (RB) function during myogenic differentiation. Whereas p53 transactivates the retinoblastoma gene, p63 and p73 induce the cyclin-dependent kinase inhibitor p57 to maintain RB in an active, hypophosphorylated state. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS2420

Platform:

GPL1261

6 Samples

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(Submitter supplied) The squamous cell carcinomas represent the aggressive type of non melanoma skin cancer, the most frequent malignancy among human population. We have studied here the possible relationship between these two pathways in skin using epidermal-specific mutant mice. Loss of p53, but not pRb, produces spontaneous tumor development, indicating that, contrary to pRb, p53 is the predominant tumor suppressor acting in mouse epidermis. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL339

8 Samples

Download data: CEL

(Submitter supplied) SW480 were stably transfected with an episomal plasmid expressing GFP and miRNA34 from a bidirectional doxycyclin regulatable promoter (Bornkamm et al Nucleic Acids Res. 2005 Sep 7;33(16)). Polyclonal cell lines were obtained by selection with Hygromycin at 350ug/ml for 10 days. The cell llnes identified as GFP only express GFP, whereas the cell lines identified as miRNA34a express both GFP and miRNA34 under doxycyclin control. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

8 Samples

Download data: CEL, TXT, XLS

(Submitter supplied) RNA expression data was generated as part of a colon cancer study. Samples were obtained from patients, including primary colon cancer, polyps, metastases, and matched normal mucosa (obtained from the margins of the resection). The RNA was extracted from tissue samples obtained from resections and hybridized to Affymetrix HG-U133 arrays. RNA expression data was also obtained for a few cell lines.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL96

390 Samples

Download data: CEL, CHP

(Submitter supplied) Interferons have been ascribed to mediate antitumor effects. IRF-1 is a major target gene of interferons. It inhibits cell proliferation and oncogenic transformation. Here we show that 60% of all mRNAs deregulated by oncogenic transformation mediated by c-myc and H-ras are reverted to the expression levels of non-transformed cells by IRF-1. These include cell cycle regulating genes. Activation of IRF-1 decreases cyclin D1 expression and CDK4 kinase activity concomitant with dephosphorylation of pRb. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS2752

Platform:

GPL81

6 Samples

Download data: CEL

Analysis of myc/ras transformed cells expressing interferon regulatory factor-1 (IRF-1). IRF-1 mediates proliferation inhibition and reversion of the transformed phenotype of oncogenic cells. Results provide insight into the molecular alterations initiated by the action of IRF-1.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 cell type, 2 protocol sets

Platform:

GPL81

Series:

GSE6505

6 Samples

Download data: CEL

(Submitter supplied) Rhabdomyosarcoma is a childhood tumor with features of aberrant muscle differentiation. We studied samples from 101 rhabdomyosarcoma patients to determine core gene expression signatures relevant in the disease.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL5175

101 Samples

Download data: CEL

(Submitter supplied) Rhabdomyosarcomas (RSCs) are skeletal muscle neoplasms found in humans and domestic mammals. The A/J inbred strain developed a high frequency of RSC by 20 months of age while BALB/cJ and BALB/cByJ also develop RSC but less frequently. These neoplasms affected skeletal muscle surrounding either the axial or proximal appendicular skeleton and were characterized by pleomorphic cells with abundant eosinophilic cytoplasm, multiple nuclei, and cross striations that invaded locally. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS5527

Platform:

GPL6481

12 Samples

Download data: TXT

Analysis of rhabdomyosarcoma samples from A/J animals that are about 450 days old. A/J animals develop adult pleomorphic type rhabdomyosarcomas at a high frequency over 20 months of age. Results provide insight into the molecular pathogenesis of rhabdomyosarcoma.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 strain, 2 tissue sets

Platform:

GPL6481

Series:

GSE29775

12 Samples

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