Similar studies for GEO DataSets (Select 2728) - GEO DataSets

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Items: 20

Select item 27281.

CD133+ and CD133- glioblastoma-derived cancer stem cell lines

Comparison of CD133+ and CD133- glioblastoma-derived cancer stem cells (CSC). Both CSC subpopulations were derived from primary glioblastomas. Results provide insight into the role of CD133+ and CD133- CSCs in the pathogenesis of glioblastoma.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 2 cell line sets

Platform:: GPL570
Series:: GSE7181
6 Samples

Download data: CEL, CHP

DataSet

Accession:: GDS2728

ID:: 2728

Select item 2000071812.

CD133+ and CD133- CSC lines in primary human GBM

(Submitter supplied) We cultured tumor cells from 22 GBM under medium conditions favoring the growth of neural stem cells. 11 out of 15 primary GBM contained a significant CD133+ subpopulation that comprised cells showing all hallmarks of neural stem cells. Cell lines derived from these CD133+ GBM showed a neurosphere-like, non-adherent growth pattern. In contrast, 4 out of 15 cell lines derived from primary GBM grew adherent in vitro and were driven by CD133- tumor cells that fulfilled stem cell criteria. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS2728
Platform:: GPL570
6 Samples

Download data: CEL, CHP

Series

Accession:: GSE7181

ID:: 200007181

Select item 2000238063.

Expression data of glioblastoma stem-like (GS) cell lines, conventional glioma cell lines and primary tumors

(Submitter supplied) We compared a large panel of human glioblastoma stem-like (GS) cell lines, corresponding primary tumors and conventional glioma cell lines to identify cell lines that preserve the transcriptome of human glioblastomas most closely, thereby allowing identification of shared therapeutic targets. We used Affymetrix HG-U133 Plus 2.0 microarrays to compare human glioblastoma stem-like (GS) cell lines, corresponding primary tumors and conventional glioma cell lines.

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS3885
Platform:: GPL570
92 Samples

Download data: CEL, EXP

Series

Accession:: GSE23806

ID:: 200023806

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000080494.

Expression analyses of glioblastoma derived neurosphere cultures

(Submitter supplied) Recent studies demonstrated that tumor cells with stem cell-like properties can be cultured from human glioblastomas by using conditions that select for the expansion of neural stem cells. We established glioblastoma stem-like (GS-) cell cultures from 9 different glioblastomas, 8 of which generated stably expandable cell lines. Analyzing GS-cell cultures, we discovered two clearly discernable phenotypes. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
17 Samples

Download data: CEL, EXP

Series

Accession:: GSE8049

ID:: 200008049

Select item 38855.

Glioblastoma stem-like cell lines, glioblastomas, and glioma cell lines

Analysis of glioblastoma stem-like (GS) cell lines, corresponding glioblastoma primary tumors, conventional glioma cell lines, and GS neurospheres. Results provide insight into cell lines recapitulating transcriptional aspects of glioblastomas, thereby allowing identification of therapeutic targets.

Organism:: Homo sapiens

Type:: Expression profiling by array, transformed count, 7 specimen sets

Platform:: GPL570
Series:: GSE23806
92 Samples

Download data: CEL, EXP

DataSet

Accession:: GDS3885

ID:: 3885

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2000180156.

Molecular analysis of ex-vivo CD133+ GBM cells revealed a common invasive and angiogenic profile but different proliferative signatures among high grade gliomas.

(Submitter supplied) Background: Gliomas are the most common type of primary brain tumours, and in this group glioblastomas (GBMs) are the higher-grade gliomas with fast progression and unfortunate prognosis. Two major aspects of glioma biology that contributes to its awful prognosis are the formation of new blood vessels through the process of angiogenesis and the invasion of glioma cells. Despite of advances, two-year survival for GBM patients with optimal therapy is less than 30%. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
16 Samples

Download data: CEL, CHP, TXT

Series

Accession:: GSE18015

ID:: 200018015

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000196127.

A Hierarchy of Self-Renewing Tumor-Initiating Cell Types in Glioblastoma

(Submitter supplied) The neural stem cell marker CD133 is reported to identify cells within glioblastoma (GBM) that can initiate neurosphere growth and tumor formation, however, instances of CD133- cells exhibiting similar properties have also been reported. Here, we show that some PTEN-deficient GBM tumors produce a series of CD133+ and CD133- self-renewing tumor-initiating cell types and provide evidence that these cell types constitute a lineage hierarchy. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by SNP array; SNP genotyping by SNP array; Genome variation profiling by genome tiling array; Expression profiling by array

5 related Platforms
171 Samples

Download data: CEL, TXT

Series

Accession:: GSE19612

ID:: 200019612

Select item 2000213368.

GBM_SC_retinoic acid_gene_expression

(Submitter supplied) This study compared the gene expression change of glioblastoma stem-like cells before and after retinoic acid treatment

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL5175
12 Samples

Download data: CEL, TXT

Series

Accession:: GSE21336

ID:: 200021336

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000341529.

Expression data from GBM and normal neural CD133+ and CD133- cells

(Submitter supplied) We use gene expression data to provide a three-faceted analysis on the links between molecular subclasses of glioblastima, epithelial-to mesenchymal transition (EMT) and CD133 cell surface protein. The contribution of this paper is three-folded: First, we used a newly identified signature for epithelial-to-mesenchymal transition in human mammary epithelial cells, and demonstrated that genes in this signature have significant overlap with genes differentially expressed in all known GBM subtypes. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
8 Samples

Download data: CEL

Series

Accession:: GSE34152

ID:: 200034152

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20002542810.

Gene expression profiles of ovarian cancer cell lines in the presence and absence of a DNA methyltransferase inhibitor

(Submitter supplied) Epithelial ovarian cancer is the leading cause of death among gynecologic malignancies. Diagnosis usually occurs after metastatic spread, largely reflecting vague symptoms of early disease combined with lack of an effective screening strategy. Epigenetic mechanisms of gene regulation, including DNA methylation, are fundamental to normal cellular function and also play a major role in carcinogenesis. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL3921
95 Samples

Download data: CEL

Series

Accession:: GSE25428

ID:: 200025428

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20001314411.

Knockdown of CD133 in melanoma cells

(Submitter supplied) CD133 (Prominin-1) is considered the most important cancer stem cell (CSC)-associated marker identified so far, with increased expression in the CSC fraction of a large variety of human malignancies, including melanoma. Here we investigated the effects of CD133 down-regulation in vitro and in vivo in human metastatic melanoma. The average number of CD133 molecules on the cell surface of FEMX-I melanoma cells was decreased by 8.7-fold and 1.8-fold using two different short hairpin RNAs. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS3489
Platform:: GPL7430
4 Samples

Download data: GPR

Series

Accession:: GSE13144

ID:: 200013144

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 348912.

CD133 depletion effect on metastatic melanoma cell line

Analysis of metastatic melanoma FEMX-I cells depleted for CD133. CD133 is a cancer stem cell-associated antigen expressed in many malignancies such as melanoma. Results provide insight into the role of CD133 in cancer progression.

Organism:: Homo sapiens

Type:: Expression profiling by array, transformed count, 2 protocol sets

Platform:: GPL7430
Series:: GSE13144
4 Samples

Download data: GPR

DataSet

Accession:: GDS3489

ID:: 3489

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 20004947013.

Three human glioma stem cell lines sorted for CD133 and one human neural precursor line sorted for CD133 to identify tumor-specific miRNA dysregulation.

(Submitter supplied) Several novel potential oncogenic and tumor suppressor miRNAs were identified by using the appropriate controls for stem cells. Expression profiles for human miRNAs in six samples were generated.

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by array

Platform:: GPL8227
6 Samples

Download data: TXT

Series

Accession:: GSE49470

ID:: 200049470

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20004393114.

Prominin 1/CD133 Endothelium Sustains Growth of Proneural Glioma

(Submitter supplied) As many other tumors, a subset of gliobastoma is thought to be maintained by a restricted population of cancer cells, stem-like cells that express CD133 transmembrane protein. Expression levels of CD133 gene has been linked to a poor prognostic molecular subgroup and is not overexpressed by the PDGF-driven proneural group. Thus, the significance of CD133+ cells for gliomagenesis of the proneural group is undetermined. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
2 Samples

Download data: CEL, CHP

Series

Accession:: GSE43931

ID:: 200043931

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20005245615.

Identification of a CD271-associated signaling network in human malignant melanoma cells

(Submitter supplied) Background: Large-scale genomic analyses of patient cohorts have revealed extensive heterogeneity between individual tumors, contributing to treatment failure and drug resistance. In malignant melanoma, heterogeneity is thought to arise as a consequence of the differentiation of melanoma-initiating cells that are defined by cell-surface markers like CD271 or CD133. Results: Here we identified the nerve growth factor receptor (CD271) as a crucial determinant of melanoma cell tumorigenicity, stem-like properties, heterogeneity and plasticity. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10558
9 Samples

Download data: TXT

Series

Accession:: GSE52456

ID:: 200052456

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20003694716.

Elevating Sox2 levels deleteriously affects the growth of glioblastoma and medulloblastoma cells.

(Submitter supplied) Induction of the transcription factor Sox2 from a doxycycline-inducible promoter in iSox2-DAOY medulloblastoma cells. Affymetrix microarrays were used to characterize the gene expression profile of iSox2-DAOY cells in the absence and presence of doxycycline.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6244
2 Samples

Download data: CEL, CHP

Series

Accession:: GSE36947

ID:: 200036947

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20002455817.

GBM brain tumors

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Genome variation profiling by array; Genome variation profiling by genome tiling array

Platforms:: GPL5175 GPL8736 GPL5477
41 Samples

Download data: CEL, CHP, TXT

Series

Accession:: GSE24558

ID:: 200024558

Select item 20002455718.

Exon-level expression profiles of GBM brain tumors

(Submitter supplied) Transcriptome analysis of RNAs from brain tumor Investigate potential of true exon level expression profiling .

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL5175
16 Samples

Download data: CEL, CHP

Series

Accession:: GSE24557

ID:: 200024557

Select item 20002445219.

Genetic abnormalities in various cell subpopulations of GBM brain tumors

(Submitter supplied) GBM is a heterogenous tumor. Based on membrane protein expression, the GBM single cell dissociates were seperated into different subfractions by FACS assay. The genomic aberration among each populations were compared by analysis of CGH data.

Organism:: Homo sapiens

Type:: Genome variation profiling by array

Platform:: GPL5477
14 Samples

Download data: TXT

Series

Accession:: GSE24452

ID:: 200024452

Select item 20002444620.

Genetic abnormalities in GBM brain tumors

(Submitter supplied) Examine the genetic abnormality in brain tumors

Organism:: Homo sapiens

Type:: Genome variation profiling by genome tiling array

Platform:: GPL8736
11 Samples

Download data: TXT

Series

Accession:: GSE24446

ID:: 200024446

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