GEO DataSets

Analysis of intestinal tissues from 4- or 7-day-old animals infected with Shigella flexineri strains for 2 or 4 hr. Animals >1 wk old are no longer susceptible to infection by Shigella. Results provide insight into the molecular basis of the switch from disease susceptibility to resistance.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 age, 3 infection, 3 time sets

Platform:

GPL339

Series:

GSE9785

36 Samples

Download data: CEL, CHP

(Submitter supplied) In order to identify the developmental changes controlling the switch from disease susceptibility to resistance, we performed global gene expression analysis on non-infected and infected intestinal tissues taken from 4-day- and 7-day-old animals. Keywords: time course of infection

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS3392

Platform:

GPL339

36 Samples

Download data: CEL, CHP

(Submitter supplied) Question Addressed: What is the host response (specifically apoptosis pathways) to Shigella infection and what is the contribution of MxiE to the host response? The arrays are apoptosis Exon hit arrays, thus splice variation can be determined. Array data from HeLa cells that remained Uninfected or were infected with wildtype S. flexneri serotype 2a strain 2457T or an isogenic mixE mutant. These groupings are further divided such that Uninfected or Infected cells remained untreated or were treated with the apopotosis inducer staurosporine (STS). more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10525

20 Samples

Download data

(Submitter supplied) Array data from HeLa cells that remained Uninfected or were infected with wildtype S. flexneri serotype 2a strain 2457T. These groupings are further divided such that Uninfected or Infected cells remained untreated or were treated with the apopotosis inducer staurosporine (STS). The design of the experiment was a time course and samples were harvested at the indicated time points (hr). All hybridizations were conducted against a common reference sample.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10525

14 Samples

Download data

(Submitter supplied) Paneth cells are a highly specialized population of intestinal epithelial cells located in the crypt adjacent to Lgr5+ stem cells, from which they differentiate through a process that requires downregulation of the Notch pathway. Their ability to store and release antimicrobial peptides protects the host from intestinal pathogens and controls intestinal inflammation. Here we show that PKCλ/ι is required for Paneth cell differentiation at the level of Atoh1 and Gfi1, through the control of EZH2 stability by direct phosphorylation. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6887

6 Samples

Download data: IDAT, TXT

(Submitter supplied) BACKGROUND & AIMS: Stems cells within the intestinal epithelium generate daughter cells which undergo lineage commitment and maturation through the concerted action of the Wnt and Notch signalling cascades. Both pathways, in turn, regulate transcription factor networks which further define differentiation towards either enterocytes or one of three secretory cell lineages (Paneth, goblet or enteroendocrine cells). more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL4134

20 Samples

Download data: TXT