GEO DataSets

Analysis of lungs from embryonic day 12 to adulthood. Results provide insight into the molecular mechanisms governing normal lung development.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 11 age sets

Platform:

GPL75

Series:

GSE10889

11 Samples

Download data: CEL, EXP

(Submitter supplied) Mammalian lung development is a complex morphogenetic process, which initiates near mid-gestation and continues through early postnatal life. The lung arises as two lateral buds that emerge from the ventral foregut endoderm at ~ 9 days after fertilization (in mouse) and undergo numerous rounds of dichotomous branching to form the bronchial tree. This stage of development is referred to as the pseudoglandular phase, histologically characterized by loose mesenchyme surrounding undifferentiated epithelial tubes. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Datasets:

GDS3447 GDS3448

Platforms:

GPL76 GPL75

22 Samples

Download data: CEL, EXP

Analysis of lungs from embryonic day 12 to adulthood. Results provide insight into the molecular mechanisms governing normal lung development.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 11 age sets

Platform:

GPL76

Series:

GSE10889

11 Samples

Download data: CEL, EXP

(Submitter supplied) Lung alveolarization is a complex process that involves interactions between several cell types and leads to considerable increase in gas-exchange surface area. The step designated secondary septation includes elastogenesis from interstitial fibroblasts. We used microarrays to detail the global programme of fibroblast gene expression that underly secondary septation, and identified numerous genes that undergo signficant changes in expression Keywords: Time course

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL1355

9 Samples

Download data: CEL

(Submitter supplied) Mechanical forces are essential for normal fetal lung development. However, the cellular and molecular mechanisms regulating this process remain largely unknown. In the present study, we used oligonucleotide microarray technology to investigate gene expression profile in cultured E19 rat fetal lung type II epithelial cells exposed to a level of mechanical strain similar to that observed in utero. Significance Analysis of Microarrays (SAM) identified 92 genes differentially expressed by strain. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS2225

Platform:

GPL341

6 Samples

Download data: CEL, EXP

Analysis of embryonic day 19 fetal lung type II epithelial cells exposed to mechanical strain for 16 hours. Mechanical forces are essential for normal fetal lung development. Results provide insight into the mechanisms regulating lung development in response to mechanical forces.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 stress sets

Platform:

GPL341

Series:

GSE3541

6 Samples

Download data: CEL, EXP

(Submitter supplied) Purpose: The morphology of the RPE shows minimal change as the neural retina and choriocapillaris differentiate. Nonetheless, initial studies of barrier-related proteins suggest extensive remodeling of the RPE in response to this changing environment. A genomic approach was used to investigate the extent of this remodeling. Methods: RPE was isolated from E7, E10, E14 and E18 chick embryos and total RNA extracted for probing the entire genome on Affymetrix microarray chips. more...

Organism:

Gallus gallus

Type:

Expression profiling by array

Dataset:

GDS2964

Platform:

GPL3213

14 Samples

Download data: CEL, EXP

Analysis of retinal pigment epithelia (RPE) of E7 to E18 embryos. The RPE regulates transport between the neural retina and fenestrated capillaries of the choroid, a vascular layer between the retina and sclera. Results provide insight into the extent of remodeling of the RPE during development.

Organism:

Gallus gallus

Type:

Expression profiling by array, count, 4 development stage sets

Platform:

GPL3213

Series:

GSE7176

14 Samples

Download data: CEL, EXP

(Submitter supplied) Gene expression profiling of the rat lung following intratracheal instillation with C60 fullerene particles was employed to gain insights into these molecular events.

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL7294

22 Samples

Download data: TXT

(Submitter supplied) The biological mechanisms by which cerebral aneurysms emerge, enlarge and rupture are not totally understood. In the present study, we analyzed the genome-wide gene expression profile in human intracranial aneurysms using cDNA microarrays.

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3903

Platform:

GPL570

6 Samples

Download data: CEL

Analysis of unruptured intracranial arterial aneurysm (IAA). IAA is a cerebrovascular disorder in which weakness in a cerebral artery wall causes localized dilation and possible rupture. Results provide insight into the molecular mechanisms underlying cerebral aneurysms.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 disease state sets

Platform:

GPL570

Series:

GSE26969

6 Samples

Download data: CEL

(Submitter supplied) 10.5dpc Metanephric Mesenchyme V Intermediate Mesoderm Keywords: repeat sample

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1873

4 Samples

Download data

(Submitter supplied) Direct comparison of dissected 10.5dpc metanephric mesenchyme Vs 13.5dpc fetal kidneys Keywords: repeat sample

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1873

3 Samples

Download data

(Submitter supplied) Direct comparison of dissected pools of 11.5dpc metanephroi V 13.5dpc fetal kidneys. Keywords: repeat sample

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1873

3 Samples

Download data

(Submitter supplied) Direct comparison of dissected 10.5dpc metanephric mesenchyme Vs 11.5dpc metanephroi Keywords: repeat sample

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1873

3 Samples

Download data

(Submitter supplied) Array Design; Mouse Compugen 22K Spotted Oligo Author; Sean Grimmond Common Reference (Yes/No, ID); Yes Mouse universal Reference (Stratagene) Concentration; 100 Data processing/normalization; Lowess Normalisation GeneSpring) Developmental Stage; embryonic Diseased/Normal; normal Dye Swap; red/green Experiment Type; time course Genetic Characteristic; Wild type Image Analysis Software; Imagene5.5 (Biodiscovery) Labeling Protocol; Amino Allyl Message Amp- Ambion Organ/Organism part; kidney Organism; Mus Musculus RNA type; aRNA Message Amp-ambion Tissue Type; Pool of whole organs Organization; IMB, Uni of QLD, Brisbane Australia Sample Source; primary tissue Sampling Method; Dissection of whole organ Sex; Pool of both sexes Strain/Cell-line; CD1 Series_overall_design: To account for dye swap, the signal channel and control channel measurements for each sample were reversed. more...

Organism:

Homo sapiens; Mus musculus

Type:

Expression profiling by array

Platforms:

GPL1873 GPL80

38 Samples

Download data

(Submitter supplied) Triplicate pairwise comparsion of FACS sorted GFP+ve Vs GFP-ve cells from the kidneys of the HoxB7-GFP transgenic mice on compugen 22K mouse arrays. HoxB7-GFP mice express GFP in the ureteric tree and its derivatives while the metanephric mesenchyme, interstitium, developing vasculature etc do not. Keywords: repeat sample

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1873

3 Samples

Download data

(Submitter supplied) Knowledge of differential gene expression between pulp and odontoblasts might give insight to the regulation of these spatially related but functionally diverse cells. Our aim was large-scale analysis of expression profiles of native human pulp tissue and odontoblasts, and search for genes expressed only in odontoblasts. Keywords: comparative expression analysis

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL96 GPL570

2 Samples

Download data: CEL, CHP

(Submitter supplied) 2 normal lung parenchyma SAGE libraries, generated from 2 pools of 4 individuals each Discussed in the study: IDENTIFICATION OF NOVEL LUNG GENES IN BRONCHIAL EPITHELIUM BY SERIAL ANALYSIS OF GENE EXPRESSION Kim M. Lonergan1, Raj Chari1, Ronald J. deLeeuw1, Ashleen Shadeo1, Bryan Chi1, Ming-Sound Tsao2, Steven Jones3, Marco Marra3, Victor Ling1, Raymond Ng1,4, Calum MacAulay5, Stephen Lam5 and Wan L. more...

Organism:

Homo sapiens

Type:

Expression profiling by SAGE

Platform:

GPL4

2 Samples

Download data

(Submitter supplied) Using a multiorgan metastasis model of human NSCLC cells (ACC-LC319/bone2) in NK cell-depleted SCID mice, we attempted to identify genes involved in the organ-selective nature of lung cancer-metastasis process, especially bone metastasis. Genome-wide gene expression profile of 15 metastatic lesions from three organs (bone, lung and liver) in this mouse model revealed lot of genes that seemed to reflect the organ specificity of metastatic cells. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6480

19 Samples

Download data: TXT