GEO DataSets

Analysis of pancreatic lymph nodes of Early Insulin AutoAntibodies (E-IAA) positive 5 wk-old Non Obese Diabetic (NOD) mice. E-IAA mark the first measurable phenotypic checkpoint in T1D pathogenesis. Results provide insight into molecular mechanisms underlying initiation of T1D.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 genotype/variation sets

Platform:

GPL81

Series:

GSE15582

9 Samples

Download data: CEL

(Submitter supplied) The aim of this study is to identify genes implicated in the early steps of the autoimmune process, prior to inflammation in type 1 diabetes. Early Insulin AutoAntibodies (E-IAA) have been used as subphenotypic marker to select individual animals as type 1 diabetes prone and to compare gene expression patterns with insulin autoantibody negative NOD. Variation of gene expression patterns in the pancreatic lymph nodes (PLN) issued from E-IAA positive and negative mice have been analyzed by DNA microarrays

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS4024

Platform:

GPL81

9 Samples

Download data: CEL

(Submitter supplied) Analysis of gene expression levels in ex-vivo and p79-stimulated splenic CD4+ T cells.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL14828

12 Samples

Download data: TXT

(Submitter supplied) Gene expression in the pancreas of NOD vs. NOD.B10 mice at 12 weeks of age

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL7202

8 Samples

Download data: TXT

(Submitter supplied) These experiments were performed to identify differentially expressed genes in the pancreas of healthy humans, auto-antibody positive and type 1 diabetic patients. All samples were obtained from the network of pancreatic organ donors with diabetes (nPOD). ID numbers are specified. Patient information can be obtained at http://www.jdrfnpod.org/

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL14550

23 Samples

Download data: TXT

(Submitter supplied) miR-193b-3p and miR-365-3p expression values are increased in pancreas infiltrating neutrophils and basophils of new-onset diabetic NOD mice. We performed CITE-sequencing technology to investigate their phenotype and frequency. Using differentially expressed gene (DEGs) analysis, we further compared the different transcriptome profiles of pancreas infiltrating versus blood circulating neutrophils and basophils in new-onset diabetic NOD mice.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24247

12 Samples

Download data: H5

(Submitter supplied) To search for new therapeutic targets for type 1 & 2 diabetes, we have applied genome wide transcriptional profiling and systems biology oriented bioinformatics analysis to examine the impact of the Power mix(PM) and Alpha-1 Anti-Trypsin( AAT) regimens upon pancreatic lymph node (PLN) and fat, a crucial tissue for insulin dependent glucose disposal, in new onset diabetic NOD mice.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

19 Samples

Download data: CEL, CHP

(Submitter supplied) Islet leukocytic infiltration (insulitis) is first obvious at around 4 weeks of age in the NOD mouse – a model for human type 1 diabetes (T1DM). The molecular events leading to insulitis are poorly understood. Since TIDM is caused by numerous genes, we hypothesized that multiple molecular pathways are altered and interact to initiate this disease. Analysis of the global gene expression profiles using microarrays followed by hierarchical clustering revealed that the majority (~90%) of the differentially expressed genes in NOD mice relative to control mice were repressed. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platforms:

GPL340 GPL339

60 Samples

Download data: CEL

(Submitter supplied) Gene expression in the islets of diseased NOD mice compared to congenic healthy NOD.B10 mice at various ages, during the progression of NOD disease.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL7202

24 Samples

Download data: TXT

(Submitter supplied) Expression profiling of cell cycle genes in human pancreatic islets with and without type 2 diabetes

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6244

10 Samples

Download data: CEL

(Submitter supplied) Close to 50 genetic loci have been associated with type 2 diabetes (T2D), but they explain only 15% of the heritability. In an attempt to identify additional T2D genes, we analyzed global gene expression in human islets from 63 donors.

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS4337

Platform:

GPL6244

63 Samples

Download data: CEL

Analysis of pancreatic islets from type 2 diabetes (T2D) and non-diabetic cadaver donors. Glycemic control (HbA1c) levels also measured from the same individuals (normoglycemic: HbA1c < 6%; hyperglycemic: HbA1c ≥ 6%). Results provided insight into molecular basis of islet dysfunction in T2D.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 disease state, 23 other sets

Platform:

GPL6244

Series:

GSE38642

63 Samples

Download data: CEL

(Submitter supplied) Our current understanding of the pathogenesis of T1D arose in large part from studies using the non-obese diabetic (NOD) mouse model of type 1 diabetes (T1D). Of concern, therapeutic interventions shown to significantly dampen or even reverse disease in mouse models have not successfully translated into interventions in human T1D. The present study addresses this disconnect in research translation by directly analyzing human donor islets from individuals with T1D, aiming to provide insight into disease mechanisms and identify potential target pathways for therapeutic intervention. more...

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL21290

5 Samples

Download data: GTF

(Submitter supplied) Type 1 diabetes is a multigenic disease caused by T-cell mediated destruction of the insulin producing β-cells. Although conventional (targeted) approaches of identifying causative genes have advanced our knowledge of this disease, many questions remain unanswered. Using a whole molecular systems study, we unraveled the genes/molecular pathways that are altered in CD4 T-cells from young NOD mice prior to insulitis (lymphocytic infiltration into the pancreas). more...

Organism:

Mus musculus

Type:

Expression profiling by array

Datasets:

GDS5018 GDS5019 GDS5020

Platform:

GPL1261

44 Samples

Download data: CEL

Analysis of CD4 T-cells from 4-week old NOD females in the preinsulitis stage of Type 1 diabetes. Control strains NOR (~88% similarity to NOD genome) and C57BL/6 (genetically distant) are both insulitis- and diabetes-free. Results provide insight into molecular basis of CD4 T-cell diabetogenesis.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 disease state, 3 strain sets

Platform:

GPL1261

Series:

GSE46600

15 Samples

Download data: CEL

Analysis of CD4 T-cells from 3-week old NOD females in the preinsulitis stage of Type 1 diabetes. Control strains NOR (~88% similarity to NOD genome) and C57BL/6 (genetically distant) are both insulitis- and diabetes-free. Results provide insight into molecular basis of CD4 T-cell diabetogenesis.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 disease state, 3 strain sets

Platform:

GPL1261

Series:

GSE46600

15 Samples

Download data: CEL

Analysis of CD4 T-cells from 2-week old NOD females in the preinsulitis stage of Type 1 diabetes. Control strains NOR (~88% similarity to NOD genome) and C57BL/6 (genetically distant) are both insulitis- and diabetes-free. Results provide insight into molecular basis of CD4 T-cell diabetogenesis.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 disease state, 3 strain sets

Platform:

GPL1261

Series:

GSE46600

14 Samples

Download data: CEL

(Submitter supplied) Gene expression in the total RNA and heavy polysome fractions of Eif4g3 siRNA treated lymph node stromal cells (LNSCs) compared to control-sIRNA treated samples The objective of this study was to identify genes whose translation are reduced after silencing Eif4g3 (the gene which encodes the translation initiation factor eIF4GII). Genes with reduced translation are expected to have lower expression in RNA samples isolated from heavy polysomes but not in RNA samples isolated from whole cell lysates.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL7202

8 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL7202

11 Samples

Download data: TXT

(Submitter supplied) Gene expression in the the pancreatic lymph node of 4, 12, and 30 week old Deaf1-knockout (KO) mice compared to BALB/c littermate controls.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL7202

8 Samples

Download data: TXT