Similar studies for GEO DataSets (Select 4071) - GEO DataSets

Select item 40711.

TGFβ1 effect on HMEC-TR mammary epithelial cell line deficient in Smad4 or TIF1γ

Analysis of HMEC-TR cells silenced for TIF1γ or Smad4 and treated with TGFβ. A strong EMT increase was observed in TIF1γ-silenced cells after TGFβ1 treatment; Smad4 inactivation completely blocked this process. Results show the relationship between TIF1γ and Smad4 in TGF-β signaling and EMT.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 2 agent, 3 genotype/variation sets

Platform:: GPL570
Series:: GSE28448
11 Samples

Download data: CEL, CHP

DataSet

Accession:: GDS4071

ID:: 4071

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2000284482.

Antagonistic regulation of EMT by TIF1γ and Smad4 in mammary epithelial cells

(Submitter supplied) TGFβ is known to be a potent inducer of EMT, a process involved in tumor invasion. TIF1γ has been reported to participate to TGFβ signaling. In order to understand the role of TIF1γ in TGFβ signaling and its requirement for EMT, we analyzed the TGFβ1 response of human mammary epithelial cell lines. A strong EMT increase was observed in TIF1γ-silenced cells after TGFβ1 treatment, whereas Smad4 inactivation completely blocked this process. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS4071
Platform:: GPL570
11 Samples

Download data: CEL, CHP

Series

Accession:: GSE28448

ID:: 200028448

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001585463.

Mnt Represses Epithelial Identity To Promote Epithelial to Mesenchymal Transition

(Submitter supplied) The multi-step process of epithelial to mesenchymal transition (EMT), whereby static epithelial cells become migratory mesenchymal cells, is heavily involved in development, wound healing, and disease states. Despite the major involvement of basic helix-loop-helix (bHLH) transcription factors (TFs) in cell-fate determination, few have examined them for their involvement in fundamental processes that require EMT. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
6 Samples

Download data: TXT

Series

Accession:: GSE158546

ID:: 200158546

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000547174.

Basonuclin-1 modulates epithelial plasticity and TGF-β1-induced loss of epithelial cell integrity

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by array

Platforms:: GPL18223 GPL18243
21 Samples

Download data: CEL

Series

Accession:: GSE54717

ID:: 200054717

Select item 2000547165.

Basonuclin-1 modulates epithelial plasticity and TGF-β1-induced loss of epithelial cell integrity [NIAC-NTR]

(Submitter supplied) TGF-b1-stimulation induces an epithelial dedifferentiation-process, throughout which epithelial cell sheets disintegrate and gradually switch into fibroblastic-appearing cells (EMT-like transition). The purpose of these profiles was to identify differentially expressed genes that are regulated transcriptionally. Standard microarry-based gene expression profiles measure steady-state RNA but do not provide insight into underlying regulatory principles. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL18223
12 Samples

Download data: CEL

Series

Accession:: GSE54716

ID:: 200054716

Select item 2000547156.

Basonuclin-1 modulates epithelial plasticity and TGF-β1-induced loss of epithelial cell integrity [BNC1]

(Submitter supplied) TGF-b1-stimulation induces an epithelial dedifferentiation-process, throughout which epithelial cell sheets disintegrate and gradually switch into fibroblastic-appearing cells (EMT-like transition). Several transcription factors, some of them being TGF-b1-responsive, are functionally involved in such a switch and affect epithelial differentiation and plasticity. We used microarray-based gene expression profiling of mammary epithelial cells that actively undergo TGF-b1-induced epithelial dedifferentiation. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL18243
9 Samples

Download data: CEL

Series

Accession:: GSE54715

ID:: 200054715

Select item 2000329057.

EMT inducers catalyze malignant transformation of mammary epithelial cells and drive tumorigenesis towards claudin-low tumors

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens; Mus musculus

Type:: Expression profiling by array

Platforms:: GPL570 GPL1261
17 Samples

Download data: CEL, CHP

Series

Accession:: GSE32905

ID:: 200032905

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000329048.

EMT inducers catalyze malignant transformation of mammary epithelial cells and drive tumorigenesis towards claudin-low tumors [mouse]

(Submitter supplied) The newly identified claudin-low subtype of cancer is believed to represent the most primitive breast malignancies, having arisen from transformation of an early epithelial precursor with inherent stemness properties and metaplastic features. Challenging this hypothesis, we show both in vitro and in vivo that transcription factors inducing epithelial-mesenchymal transition can drive the development of claudin-low tumors from differentiated mammary epithelial cells, by playing a dual role in cell transformation and dedifferentiation.