GEO DataSets

Identification of CLOCK and CRY-regulated genes expressed in circadian manner in liver. Wild-type, Clock mutant and Cry-deficient C57BL/6 8-10 week old male mice examined at circadian times (CT) 14 and 2.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 3 strain, 2 time sets

Platform:

GPL81

Series:

GSE454

6 Samples

Download data

(Submitter supplied) Molecular analysis of circadian rhythm in mice. Liver tissue of wildtype, Clock mutant and Cry deficient C57BL/6 8- to 10-week-old male mice examined. Keywords = circadian rhythm Keywords: other

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS413

Platform:

GPL81

6 Samples

Download data

(Submitter supplied) Genome-wide expression analysis of two circadian oscillatory mechanisms in the mouse liver To identify the genes of which the circadian expression is regulated by endogenous glucocorticoids, we performed DNA microarray analysis using hepatic RNA from adrenalectomized (ADX) and sham-operated mice. Mice were housed in a 12:12 h light-dark cycle (LD12:12; lights on at zeitgeber time (ZT) 0) for at least two weeks before the day of the experiment. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS1870

Platform:

GPL81

4 Samples

Download data: CEL, EXP, RPT, TXT

Expression profiling of livers of adrenalectomized C57BL/6 males 2 hours into the light or dark periods of a 12:12 hour light cycle. Results identify genes regulated by endogenous glucocorticoids in a circadian manner.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 agent, 2 protocol, 2 time sets

Platform:

GPL81

Series:

GSE2162

4 Samples

Download data: CEL, EXP, RPT, TXT

(Submitter supplied) Using chromatin immuno-precipitation (ChIP) combined with deep sequencing (ChIP-seq) we obtained a time resolved and genome-wide map of BMAL1 binding in mouse liver, which allowed to identify over two thousand binding sites with peak binding narrowly centered around Zeitgeber time (ZT) 6. Annotation of BMAL1 targets confirms carbohydrate and lipid metabolism as the major output of the circadian clock in mouse liver. more...

Organism:

Mus musculus

Type:

Genome binding/occupancy profiling by high throughput sequencing

Platform:

GPL9185

13 Samples

Download data: BEDGRAPH

(Submitter supplied) One hundred ninety wildtype male C57BL/6J mice age 7-10 weeks were purchased from Jackson Laboratory and entrained to a 12:12 light:dark cycle for 2 weeks. Mice were placed in light-tight boxes on a 12:12 LD cycle for 4 weeks, then released into constant darkness. Starting 30 hours after entry into DD (CT18), tissues from 5 (skeletal muscle) or 10 (liver or SCN) wildtype mice were collected every 4 hours for 48 hours, for a total of 12 timepoints. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1073

76 Samples

Download data: CEL

(Submitter supplied) One hundred ninety wildtype male C57BL/6J mice age 7-10 weeks were purchased from Jackson Laboratory and entrained to a 12:12 light:dark cycle for 2 weeks. Mice were placed in light-tight boxes on a 12:12 LD cycle for 4 weeks, then released into constant darkness. Starting 30 hours after entry into DD (CT18), tissues from 5 (skeletal muscle) or 10 (liver or SCN) wildtype mice were collected every 4 hours for 48 hours, for a total of 12 timepoints. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1073

38 Samples

Download data: CEL

(Submitter supplied) One hundred ninety wildtype male C57BL/6J mice age 7-10 weeks were purchased from Jackson Laboratory and entrained to a 12:12 light:dark cycle for 2 weeks. Mice were placed in light-tight boxes on a 12:12 LD cycle for 4 weeks, then released into constant darkness. Starting 30 hours after entry into DD (CT18), the left leg muscle from 5 wildtype mice, and the right leg muscle from the same wildtype mice were collected every 4 hours for 48 hours, for a total of 12 timepoints. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1073

38 Samples

Download data: CEL

(Submitter supplied) Renal excretion of water and major electrolytes exhibits a significant circadian rhythm. This functional periodicity is believed to result, at least in part, from circadian changes in secretion/reabsorption capacities of the distal nephron and collecting ducts. Here, we studied the molecular mechanisms underlying circadian rhythms in the distal nephron segments, i.e. distal convoluted tubule (DCT) and connecting tubule (CNT) and, the cortical collecting duct (CCD). more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS4023

Platform:

GPL1261

24 Samples

Download data: CEL

Temporal analysis of microdissected distal nephron convoluted/connecting tubules (DCT/CNT) or cortical collecting ducts (CCD). Renal excretion of water and major electrolytes exhibits a significant circadian rhythm. Results provide insight into the role of molecular clock in renal function.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 6 time, 2 tissue sets

Platform:

GPL1261

Series:

GSE17739

24 Samples

Download data: CEL

(Submitter supplied) We established a cell line lacking endougous CRY, PER, and NR1D proteins (CPN_KO). By comparing the transcriptome of CPN_KO cells and the cells expressing CRY proteins (PN_KO), genes affected by CRY were analyzed. Parental cells expressing NR1D proteins (CP_KO) were also analyzed to identify genes regulated by NR1D proteins.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL13112

6 Samples

Download data: CSV, TXT

(Submitter supplied) The peripheral circadian oscillator plays an essential role in synchronizing local physiology to operate in a circadian manner via regulation of the expression of clock-controlled genes. In the murine uterus, the endometrial stromal cells undergo proliferation and differentiation into decidual cells in response to ovarian steroids and blastocyst implantation at the early stage of pregnancy. The circadian clock genes are attenuated in the decidualizing cells only 2 days after implantation. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL14746

12 Samples

Download data: TXT

(Submitter supplied) The timing of food intake and nutrient utilization is critical to health and regulated in part by the circadian clock. Recently, increased amplitude of circadian oscillations and metabolic output was found to improve health in diabetic and obesity mouse models. Here, we report a novel function for the circadian deadenylase Nocturnin as a regulator of metabolic amplitude across the day/night cycle and in response to nutrient challenge. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL17021

50 Samples

Download data: BW

(Submitter supplied) Genes encoding the circadian pacemaker in the hypothalamic suprachiasmatic nuclei (SCN) of mammals have recently been identified, but the molecubasis of circadian timing in peripheral tissue is not well understood. We used a bead-based microarray to identify mouse liver transcripts that show circadian cycles of abundance under constant conditions. Keywords: Time course

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6880

36 Samples

Download data: TXT

(Submitter supplied) The goal of this study is to identify, in the head of adult flies, mRNA species whose expresson level are altered by overexpression of the Drosophila RNA-binding protein LARK in CNS neurons. Keywords: genetic modification, gene experssion profile

Organism:

Drosophila melanogaster

Type:

Expression profiling by array

Dataset:

GDS2553

Platform:

GPL72

6 Samples

Download data: CEL, EXP

(Submitter supplied) Circadian behaviors are regulated by intrinsic biological clocks consisting of central molecular oscillators and output pathways. Despite significant progress in elucidating the central timekeeping mechanisms, the molecular pathways coupling the circadian pacemaker to overt rhythmic behavior and physiology remain elusive. The Drosophila LARK RNA-binding protein is a candidate for such a coupling factor. more...

Organism:

Drosophila melanogaster

Type:

Expression profiling by array

Platform:

GPL72

4 Samples

Download data: CEL, EXP

Analysis of heads of animals overexpressing the RNA-binding protein LARK. Results provide insight into the identity of transcripts regulated by LARK in the neurons of the central nervous system.

Organism:

Drosophila melanogaster

Type:

Expression profiling by array, count, 2 protocol sets

Platform:

GPL72

Series:

GSE6420

6 Samples

Download data: CEL, EXP

(Submitter supplied) Transcriptional crosstalk between mammary gland, liver and adipose tissue Keywords: Gene Expression experiment

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL1355

72 Samples

Download data: CEL

(Submitter supplied) Background: The prefrontal cortex is important in regulating sleep and mood. Diurnally regulated genes in the prefrontal cortex may be controlled by the circadian system, by the sleep-wake states, or by cellular metabolism or environmental responses. Bioinformatics analysis of these genes will provide insights into a wide-range of pathways that are involved in the pathophysiology of sleep disorders and psychiatric disorders with sleep disturbances. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS3080

Platform:

GPL1261

12 Samples

Download data: CEL

Analysis of prefrontal cortices from C57BL/6J animals at 4 Zeitgeber time (ZT) points, 3 and 9 hrs after lights on (ZT3 and ZT9) and 3 and 9 hs after lights off (ZT15 and ZT21). The prefrontal cortex is important in regulating sleep and mood. Results provide insight into genes with diurnal rhythms.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 4 time sets

Platform:

GPL1261

Series:

GSE9471

12 Samples

Download data: CEL