Similar studies for GEO DataSets (Select 4150) - GEO DataSets

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Items: 20

Select item 41501.

Identical twins discordant for Multiple sclerosis: CD4+ and CD8+ T cells

Analysis of CD4+ and CD8+ T lymphocytes sorted from PBMCs from 4 monozygotic twin pairs discordant for relapsing remitting Multiple sclerosis (RRMS). The affected twin was free of disease-modifying therapies. Results provide insight into molecular mechanisms underlying the etiopathogenesis of RRMS.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 2 cell type, 2 disease state, 4 individual sets

Platform:: GPL570
Series:: GSE16461
16 Samples

Download data: CEL

DataSet

Accession:: GDS4150

ID:: 4150

Select item 2000164612.

Gene expression profile in CD4+ and CD8+ T cells from identical twins discordant for Multiple sclerosis

(Submitter supplied) To gain insight into the etiopathogenesis of Multiple sclerosis (MS) we investigated gene expression changes in CD4+ and CD8+ T lymphocytes from monozygotic twins (MZ) discordant for relapsing remitting MS. We studied 4 monozygotic twin pairs discordant for disease, with the affected co-twin free of disease modifying therapies (F/M = 3/1, mean age 36.25±3.9). Following leukapheresis, CD4+ and CD8+ T cells were separated and studied by Affymetrix GeneChip®

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS4150
Platform:: GPL570
16 Samples

Download data: CEL

Series

Accession:: GSE16461

ID:: 200016461

Select item 2000420513.

Gene expression profiling: human CD8+CD45RO+ memory T cells in IL23 responsive and nonresponsive individuals

(Submitter supplied) The interleukin-23 (IL-23) pathway plays a critical role in the pathogenesis of multiple chronic inflammatory disorders, however, inter-individual variability in IL-23-induced signal transduction in circulating human lymphocytes has not been well-defined. In this study, we observed marked, reproducible inter-individual differences in IL-23 responsiveness (measured by STAT3 phosphorylation) in peripheral blood CD8+CD45RO+ memory T and CD3+CD56+ NKT cells. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL5175
8 Samples

Download data: CEL, CHP

Series

Accession:: GSE42051

ID:: 200042051

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000620994.

CD161 defines a transcriptional and functional phenotype shared across distinct human T cell lineages

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platforms:: GPL13607 GPL6884
26 Samples

Download data: TXT

Series

Accession:: GSE62099

ID:: 200062099

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Select item 2000620975.

CD161 defines a transcriptional and functional phenotype shared across distinct human T cell lineages (TCRgd)

(Submitter supplied) T lymphocytes are conventionally divided into subsets based upon expression of co-receptors, cytokines and surface molecules. By mRNA microarray analysis, T lymphocytes that express the C-type lectin CD161 were identified to share a transcriptional profile, which led to the identification of an innate function across these previously defined subsets, including CD8, CD4 and TCRgd T cells.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL13607
8 Samples

Download data: TXT

Series

Accession:: GSE62097

ID:: 200062097

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Select item 2000620966.

CD161 defines a transcriptional and functional phenotype shared across distinct human T cell lineages (CD 8)

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6884
12 Samples

Download data: TXT

Series

Accession:: GSE62096

ID:: 200062096

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Select item 2000620957.

CD161 defines a transcriptional and functional phenotype shared across distinct human T cell lineages (CD4)

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6884
6 Samples

Download data: TXT

Series

Accession:: GSE62095

ID:: 200062095

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Select item 2000434028.

Gene expression profile of TCR Vdelta1 positive gammadelta T cells expressed CD161

(Submitter supplied) To elucidate the difference between CD161-negative TCR Vdelta1 and CD161-positive TCR Vdelta1 cells, we performed GeneChip analysis of these two types of cells in peripheral blood mononuclear cells from healthy donors. Such analysis identified 192 genes that were expressed at two-fold or higher levels on CD161-positive TCR Vdelta1 cells than on CD161-negative TCR Vdelta1 cells. Expression of three genes (CCL3, CCL4 and CD161) from this signature was quantified in the same RNA samples by real-time PCR.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL14550
6 Samples

Download data: TXT

Series

Accession:: GSE43402

ID:: 200043402

Select item 2002086379.

Next Generation Sequencing facilitates to identify the differential expression genes of liver tissue from with liver injury(AST>40) or without liver injury(AST<40) from HBV-infected patients.

(Submitter supplied) We obtained HBV-infected liver tissues from liver surgery(AST<40) and liver transplantation(AST>40) to perform next-generation sequencing (NGS). Illumina mRNA-seq sample preparation kit was used to perform paired-end library sequencing with Illumina HiSeq 2000 and sequence analysis was determined using the Illumina data analysis pipeline. Based on the comparison results, we performed the GO and KEGG pathway enrichment analysis. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
10 Samples

Download data: TXT

Series

Accession:: GSE208637

ID:: 200208637

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Select item 20020853510.

Next Generation Sequencing facilitates identification of differentially expressed genes in circulating and hepatic CD161+CD8+T cells (CD161P), CD161-CD8+T cells (CD161N) and MAIT cells from healthy donors(HD) and HBV-infected patients

(Submitter supplied) We enriched circulating and hepatic CD161N, CD161P and MAIT cells through flow sorting from heathy donors and HBV-infected patients to perform next-generation sequencing (NGS). Illumina mRNA-seq sample preparation kit was used to perform paired-end library sequencing with Illumina novaseq 6000 and sequence analysis was determined using the Illumina data analysis pipeline. Based on the comparison results, we performed the GO and KEGG pathway enrichment analysis. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
16 Samples

Download data: TXT

Series

Accession:: GSE208535

ID:: 200208535

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Select item 20001017811.

Transcriptome comparison of NKp80+ and NKp80- CD8+ CCR7- TCR alpha beta + T cells

(Submitter supplied) We have performed whole genome expression arrays covering over 47000 transcripts comparing the transcriptional profile of NKp80+ to NKp80- CD8+ CCR7- alpha beta T cells. A highly similar global gene expression profile was observed between both memory phenotype T cell subsets. Interestingly, the majority of differentially expressed genes are immune-associated. NKp80+ cells contained markedly increased levels of transcripts encoding for MHC class I and II molecules and for numerous members of the KIR family. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
2 Samples

Download data: CEL, CHP

Series

Accession:: GSE10178

ID:: 200010178

Select item 20002366312.

Gene expression profiling of human CD8+ CD161hi and CD161lo memory and naïve T cell subsets

(Submitter supplied) Gene expression profiling of human CD8+ CD161hi and CD161lo central and effector memory and naïve T cell subsets. The mechanisms by which IL-17 secreting cells are regulated have not been completely elucidated. We previously identified a population of rhodamine-effluxing memory CD8+ T cells with high expression of CD161 that contributes to immune reconstitution after lymphopenia-inducing chemotherapy. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6884
30 Samples

Download data: TXT

Series

Accession:: GSE23663

ID:: 200023663

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Select item 20001155313.

Analysis of gene expression in different T cell clones

(Submitter supplied) The aim was to analyze the expression of genes in T cell clones having different functional profiles (Th1, Th0, Th17, Th2) obtained from the same individual. Keywords: Gene expression, T cell clones, Th17 characterisation

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL3307
8 Samples

Download data

Series

Accession:: GSE11553

ID:: 200011553

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Select item 20016727914.

Exon Level Expression Profiling: a Novel Unbiased Transcriptome (Human)

(Submitter supplied) Transcriptome analysis of RNA samples from magnetically sorted peripheral blood cells

Organism:: Homo sapiens

Type:: Expression profiling by array

Platforms:: GPL24539 GPL23126
24 Samples

Download data: CEL, CHP

Series

Accession:: GSE167279

ID:: 200167279

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Select item 20016727615.

Exon Level Expression Profiling: a Novel Unbiased Transcriptome (Mouse)

(Submitter supplied) Transcriptome analysis of RNA samples from flow cytometry sorted cells

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL20775
7 Samples

Download data: CEL, CHP

Series

Accession:: GSE167276

ID:: 200167276

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Select item 20020017316.

Gene expression profile at single cell level of mononuclear cells from the liver sinusoid

(Submitter supplied) This study identified a distinct liver sinusoidal NK-like CD56hiCD161-CD8+ T-cell population that expands in the liver with hepatitis B virus-associated chronic liver disease. CD56hiCD161-CD8+ T cells exert NKG2C-mediated NK-like effector functions even without TCR stimulation.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Other

Platform:: GPL21697
18 Samples

Download data: CSV, H5

Series

Accession:: GSE200173

ID:: 200200173

PubMed Similar studies

Select item 20022020017.

Targeting of the CD161 Inhibitory Receptor Enhances T cell-mediated Immunity Against Hematological Malignancies

(Submitter supplied) The CD161 inhibitory receptor is highly upregulated by tumor-infiltrating T cells in a number of human solid tumor types, and its ligand CLEC2D is expressed by both tumor cells and infiltrating myeloid cells. Here we assessed the role of the CD161 receptor in hematological malignancies. Systematic analysis of CLEC2D expression using the Cancer Cell Line Encyclopedia (CCLE) revealed that CLEC2D mRNA was most abundant in hematological malignancies, including B cell and T cell lymphomas as well as lymphocytic and myelogenous leukemias. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
4 Samples

Download data: CSV, MTX, TSV

Series

Accession:: GSE220200

ID:: 200220200

PubMed Similar studies

Select item 20001390618.

NK-cell associated receptors expression in EBV-positive gamma-delta T cell lines.

(Submitter supplied) The contribution of chronic antigen stimulation to the occurrence of lymphoproliferative disorder (LPD) with the gamma-delta T-cell lineage is unclear, despite the fact that Epstein-Barr virus (EBV) positive T-cell LPD is derived from antigen-stimulated cytotoxic T-cells. Given the possible association of antigen stimulation with the development of cytotoxic T-cell LPD, we compared gene expression patterns in Epstein-Barr virus (EBV)-positive gamma-delta T-cell lines derived from patients with nasal T-cell lymphoma and chronic active EBV infection and those in gamma-delta T-cells from healthy volunteers. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
10 Samples

Download data: CEL

Series

Accession:: GSE13906

ID:: 200013906

Select item 20016310819.

Inhibitory CD161 Receptor Identified in Glioma-infiltrating T cells by Single Cell Analysis

(Submitter supplied) T cells are critical effectors of cancer immunotherapies, but little is known about their gene expression programs in diffuse gliomas. Here, we leverage single-cell RNA-seq to chart the gene expression and clonal landscape of tumor-infiltrating T cells across 31 patients with IDH-wildtype glioblastoma and IDH-mutant glioma. We identify potential effectors of anti-tumor immunity in subsets of T cells that co-express cytotoxic programs and several NK cell genes. more...