U.S. flag

An official website of the United States government

Format
Items per page
Sort by

Send to:

Choose Destination

Links from GEO DataSets

Items: 20

1.
Full record GDS4433

MyD88 and TRIF deficient spleen response to septic peritonitis

Analysis of spleens of MyD88 and TRIF double null mutants following surgical induction of septic peritonitis. MyD88 and TRIF are involved in innate immune responses that combat bacterial infections. Results provide insight into the role of MyD88 and TRIF in the pathogenesis of septic peritonitis.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 disease state, 2 genotype/variation sets
Platform:
GPL6246
Series:
GSE24327
12 Samples
Download data: CEL
DataSet
Accession:
GDS4433
ID:
4433
2.

Lack of Toll-like Receptor Signaling Improves Host Defense in Severe Septic Peritonitis in Severe Septic Peritonitis

(Submitter supplied) TLRs are considered important for innate immune responses that combat bacterial infections. Here, the role of TLRs in severe septic peritonitis using the colon ascendens stent peritonitis (CASP) model was examined. We demonstrate that mice deficient for MyD88 and TRIF had markedly reduced bacterial numbers both in peritoneal cavity and peripheral blood, indicating that bacterial clearance in this model is inhibited by TLR signals. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS4433
Platform:
GPL6246
12 Samples
Download data: CEL
Series
Accession:
GSE24327
ID:
200024327
3.

ANA-1 macrophages infected with Chlamydia pneumoniae

(Submitter supplied) This experiment is an additional experiment to GSE6688. Mouse macrophages (ANA-1 cells) were infected in vitro with C. pneumoniae with a M.O.I. of 10. Twenty two genes were significantly upregulated. Examples of the most upregulated genes in mouse macrophages after C. pneumoniae infection are serum amyloid A3 (saa3), a protein that is mainly produced by activated macrophages during tissue injury or inflammation, MIP-2 (cxcl2) and irg1. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS2651
Platform:
GPL81
4 Samples
Download data: CEL
Series
Accession:
GSE6690
ID:
200006690
4.

MyD88-dependent changes in the pulmonary transcriptome after infection with Chlamydia pneumoniae

(Submitter supplied) Chlamydia pneumoniae, an obligate intracellular bacterium, causes pneumonia in humans and mice. Toll-like receptors and the key adaptor molecule MyD88 play a critical role in inducing immunity against this microorganism and are crucial to survive the infection. To explore the influence of MyD88 on induction of immune responses in vivo on a genome wide level, WT or MyD88-/- mice were infected with C. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS2650
Platform:
GPL339
12 Samples
Download data: CEL
Series
Accession:
GSE6688
ID:
200006688
5.
Full record GDS2651

Macrophage cell line response to Chlamydia pneumoniae infection

Analysis of ANA-1 macrophage cells infected with Chlamydia pneumoniae, an intracellular bacterium that causes pneumonia. Results provide insight into the contribution of the macrophage cell type in host defense against C. pneumoniae.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 infection sets
Platform:
GPL81
Series:
GSE6690
4 Samples
Download data: CEL
DataSet
Accession:
GDS2651
ID:
2651
6.
Full record GDS2650

Signal transduction adaptor MyD88 deficient lung response to Chlamydia pneumoniae infection

Analysis of lungs from MyD88 null mutants following Chlamydia pneumoniae infection. Toll-like receptors and key adaptor protein MyD88 play a critical role in inducing immunity against this microorganism. Results provide insight into the molecular mechanisms underlying this MyD88-mediated induction.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 genotype/variation, 2 infection sets
Platform:
GPL339
Series:
GSE6688
12 Samples
Download data: CEL
DataSet
Accession:
GDS2650
ID:
2650
7.

Gene Expression data from LPS (2 hour) - treated PPP2CA alpha conditional knockout Bone Marrow Derived Macrophages (PP2ACαfl/fl;lyM-Cre, cre-loxp mediated exon1 deletion in myeloid cells)

(Submitter supplied) PP2A regulates inflammatory cytokine/chemokine gene expression by dephosphorylating protein kinases at multiple signaling pathways from stimulated cells. In this dataset, Affymetrix mouse Gene ST 2.1 Array was used to assay total RNA extracted from LPS-treated PP2ACα knockout BMDM (PP2ACαfl/fl;lyM-Cre) and the control BMDM (PP2ACαfl/fl) In this dataset, we include the expression data obtained from LPS-stimulated PP2ACα conditional knockout BMDM (PP2ACαfl/fl;lyM-Cre) and control BMDM (PP2ACαfl/fl). more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL17400
4 Samples
Download data: CEL
Series
Accession:
GSE83517
ID:
200083517
8.

Homeostatic intestinal epithelial gene expression

(Submitter supplied) Intestinal epithelial cells of 28-day-old female mice were isolated according to a recently published protocol (Lotz et al., J Exp. Med. 2006).
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL4134
20 Samples
Download data: TXT
Series
Accession:
GSE51269
ID:
200051269
9.

Gene expression profile of the Myd88 gene depletion on mouse salivary glands

(Submitter supplied) MyD88 is an important adaptor protein for signal transduction downstream of Toll-like receptors and TACI, receptors for regulation of innate immunity and B cell responses, respectively. The surfaces of oral mucosa are protected from infections by antimicrobial proteins and natural immunoglobulins that are constantly secreted in saliva, serving as principal innate immune defense in the oral cavity. Although MyD88-mediated signaling has a regulatory role in the intestinal mucosal immunity, its specific role in the oral cavity has been remained elusive. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL10787
4 Samples
Download data: TXT
Series
Accession:
GSE61339
ID:
200061339
10.

Dendritic cell response to hypoxia and poly I:C

(Submitter supplied) Investigation whether hypoxic stabilization of HIF-1alpha quantitatively or qualitatively modifies the gene expression pattern induced by poly I:C, a TLR ligand that does not induce normoxic HIF-1alpha stabilization on its own (non-HIF-1alpha-stabilizing TLR ligand). Keywords: Comparison of single and combined treatment
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
4 Samples
Download data: CEL, TXT
Series
Accession:
GSE24995
ID:
200024995
11.

Expression data from mock treated/oxidized HF after 24h incubation with/without monocytes

(Submitter supplied) Cells are constantly exposed to stress. Most of those stresses do not necessarily cause cell death or visible damage. The present study explores the way the immune system responds to such sub lethal stressed cells.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10739
6 Samples
Download data: CEL
Series
Accession:
GSE33631
ID:
200033631
12.

Effect of Batf2 deficiency on gene epxression in murine alveolar macrophages treated ex vivo with IFNg and K. pneumoniae supernatant

(Submitter supplied) Basic leucine zipper transcription factor ATF-like 2 (BATF2) is a transcription factor that is emerging as an important regulator of the innate immune system. We previously identified BATF2 among the top upregulated genes in human alveolar macrophages treated with LPS, but the signaling pathways that induce BATF2 expression in response to Gram-negative stimuli are incompletely understood. In addition, the role of BATF2 in the host response to pulmonary infection with a Gram-negative pathogen like Klebsiella pneumoniae (Kp) is not known. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL30172
8 Samples
Download data: XLSX
Series
Accession:
GSE235114
ID:
200235114
13.

The in vivo cellular response to adenovirus and its regulation through MyD88

(Submitter supplied) While recent studies of immunity have uncovered many aspects of the innate immune system, there has been precious little investigation of the cellular response to viruses in vivo. To this end, we exploited high titer adenoviral (Ad) vectors to investigate the cellular response to non-enveloped viral infection in vivo. Our results indicate a potent cellular transcriptome response early after infection, with global assessments revealing significant dysregulation in ~15% of measured transcripts derived from Ad infected tissue. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL3222
36 Samples
Download data
Series
Accession:
GSE4339
ID:
200004339
14.

The cellular response to 1st and 2nd generation Ad vector infection at different time points in vivo

(Submitter supplied) Mice were injected intravenously with 1st generation or 2nd generation Ad vectors (each bearing a LacZ transgene) or mock infected (controls) to completely transduce the liver. At different time points post-injection (6 hours, 3 days, and 3 weeks (21 days)), the liver was harvested and the overall transcriptome response to viral infection was assayed to measure the cellular immune response. Keywords: Immune Response
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL3223
20 Samples
Download data
Series
Accession:
GSE3739
ID:
200003739
15.

Plasma microRNA array analysis following cardiac ischemia-reperfusion (I/R) injury

(Submitter supplied) In this study, total 68 cardiac diseases-related miRNAs were detected
Organism:
Mus musculus
Type:
Other
Platform:
GPL21136
15 Samples
Download data: TXT
Series
Accession:
GSE74951
ID:
200074951
16.

Macrophage Response to LPS, poly(I:C) and CpG DNA Stimulation

(Submitter supplied) Molecular Pathways and Transcriptional Networks Involved in the Macrophage Response to LPS, poly(I:C) and CpG DNA Stimulation Background: Toll-like family of receptors recognizes pathogen-associated molecular patterns (PAMPs) from different organisms. TLR4 is the receptor for bacterial lipopolysaccharide (LPS), dsRNA viral mimic poly(I:C) binds to TLR3, and bacterial CpG DNA signals through TLR9. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6466
54 Samples
Download data: TXT
Series
Accession:
GSE15066
ID:
200015066
17.

Postnatal monocyte maturation requires age-dependent initiation of regulatory gene programs when losing birth-associated stress tolerance

(Submitter supplied) We disprove that the impaired Myd88-dependent proinflammatory response of neonatal monocytes is a correlate for immaturity and confirm it as display of transient alarmin-mediated stress tolerization. We find a strong inducibility of TRIF-dependent genes in neonatal monocytes by LPS but a barely detectable expression at baseline.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platforms:
GPL96 GPL570
12 Samples
Download data: CEL
Series
Accession:
GSE78697
ID:
200078697
18.

Expression profiling of Irgm1-/- (Lrg-47) HSCs

(Submitter supplied) To assess gene expression changes in Irgm1 (Lrg-47) deficient HSCs Keywords: genetic modification, knockout
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
6 Samples
Download data: CEL
Series
Accession:
GSE11591
ID:
200011591
19.

Genome-wide analysis of LPS or PBS challenged DUSP3-KO and WT female mice peritoneal macrophages gene expression

(Submitter supplied) Analysis of gene expression profile in peritoneal macrophage extracted from LPS or PBS challenged DUSP3-/- and WT mice. DUSP3 deletion protects mice from sepsis and endotoxemia. We performed a microarray analysis to get insights into the differentially regulated pathways between WT and KO under inflammatory conditions.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6887
12 Samples
Download data: TXT
Series
Accession:
GSE66782
ID:
200066782
20.

Gene expression profiles of LPS-stimulated RAW264.7 macrophages overexpressing Tbc1d23 novel innate immune gene

(Submitter supplied) We previously identified Tbc1d23 as a candidate novel regulator of innate immunity using comparative genomics RNAi screens in C. elegans and mouse macrophages. Using mice with an engineered knockout mutation in Tbc1d23 and macrophages engineered to overexpress Tbc1d23, we now show that Tbc1d23 is a general but not universal inhibitor of the innate immune response, inhibiting multiple Toll-like receptor (TLR) and Dectin signaling pathways but not NOD signaling pathways. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL4134
24 Samples
Download data: TXT
Series
Accession:
GSE30840
ID:
200030840
Format
Items per page
Sort by

Send to:

Choose Destination

Supplemental Content

db=gds|term=|query=2|qty=3|blobid=MCID_6723a98a6cd4725ffc76472b|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
   Taxonomic Groups  [List]
Tree placeholder
    Top Organisms  [Tree]

Find related data

Recent activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...
Support Center