GEO DataSets

Analysis of age-synchronized L3 nematodes exposed to LC10 of gold nanoparticles (Au-NPs). The Au-NPs are used as a model for studying particle-specific effects of manufactured nanomaterials (MNMs). Results provide insight into in vivo particle-specific toxicity of Au-NPs to C. elegans.

Organism:

Caenorhabditis elegans

Type:

Expression profiling by array, transformed count, 2 agent sets

Platform:

GPL200

Series:

GSE32521

6 Samples

Download data: CEL

(Submitter supplied) We used Au nanoparticles (Au-NPs) as a model for studying particle specific effects of manufactured nanomaterials (MNMs) by examining the toxicogenomic responses in a model soil organism, free living nematode Caenorhabditis elegans. Global genome expression for nematodes exposed to 4-nm citrate-coated Au-NPs at the LC10 (5.9 mg L-1) revealed significant differential expression of 797 genes. The levels of expression for five genes (apl-1, dyn-1, act-5, abu-11, and hsp-4) were confirmed independently with qRT-PCR. more...

Organism:

Caenorhabditis elegans

Type:

Expression profiling by array

Dataset:

GDS4571

Platform:

GPL200

6 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Caenorhabditis elegans

Type:

Expression profiling by array

Platform:

GPL19230

12 Samples

Download data: CEL

(Submitter supplied) Superparamagnetic Iron Oxide Nanoparticles (SPIONs) are currently being investigated for a range of biomedical applications. Their use have been related with different cytotoxic mechanisms including the generation of oxidative stress and the induction of metal detoxification pathways, among others. We have investigated the molecular mechanisms responsive to in-house fabricated citrate coated SPIONs (C-SPIONs) in the nematode C. more...

Organism:

Caenorhabditis elegans

Type:

Expression profiling by array

Platform:

GPL19230

6 Samples

Download data: CEL

(Submitter supplied) Superparamagnetic Iron Oxide Nanoparticles (SPIONs) are currently being investigated for a range of biomedical applications. Their use have been related with different cytotoxic mechanisms including the generation of oxidative stress and the induction of metal detoxification pathways, among others. Different NP coatings are being explored, among them albumin which has been applied in some drugs delivery systems. more...

Organism:

Caenorhabditis elegans

Type:

Expression profiling by array

Platform:

GPL19230

6 Samples

Download data: CEL

(Submitter supplied) RRF-3 and ERI-1 are first identified proteins required for accumulation of at least some endogenous secondary siRNAs in C.elegans. Genome wide gene expression analysis was performed on L4 stage rrf-3 and eri-1 mutant C. elegans to study effects caused by loss of these proteins. Mutant rrf-3 and eri-1 strains exhibited similar expression patterns when compared to N2 wild type, while 72 transcripts were found to be co-overexpressed and 4 transcripts co-underexpressed (> 2-fold, p< 0.05). more...

Organism:

Caenorhabditis elegans

Type:

Expression profiling by array

Dataset:

GDS3038

Platform:

GPL200

9 Samples

Download data: CEL, CHP

Analysis of L4 larvae mutant for RRF-3 or ERI-1. RRF-3 and ERI-1 encode proteins required for the accumulation of endogenous secondary siRNAs. Results provide insight into the transcriptional effects caused by the loss of the RRF-3 and ERI-1 proteins and provide further insight into their functions.

Organism:

Caenorhabditis elegans

Type:

Expression profiling by array, count, 3 genotype/variation sets

Platform:

GPL200

Series:

GSE8659

9 Samples

Download data: CEL, CHP

(Submitter supplied) To provide insights into the mechanism underlying the enhanced immunity of tag-24/octr-1 animals, we used genome microarrays to find clusters of genes commonly misregulated in tag-24 relative to wild-type animals grown on live P. aeruginosa.

Organism:

Caenorhabditis elegans

Type:

Expression profiling by array

Platform:

GPL200

6 Samples

Download data: CEL

(Submitter supplied) Humans are exposed to both inorganic and organic mercury. While the toxicity of mercury is well established, much remains to be resolved about how different mercurials act at the molecular level. To address this issue, we employed a toxicogenomics approach using the nematode C. elegans. Using sub-, low- or high-toxic exposures of either HgCl2 or CH3HgCl the effects of these mercurials on steady-state mRNA levels for the entire genome were determined. more...

Organism:

Caenorhabditis elegans

Type:

Expression profiling by array

Platform:

GPL7727

24 Samples

Download data: TXT

(Submitter supplied) Despite the increased utilization of nanoparticles, the behavior and effect in the environment is largely unknown and few resources are available for health and environmental effect studies. Enchytraeids are extensively used in studies of soil ecotoxicology and recently, a cDNA microarray for Enchytraeus albidus was developed, allowing also toxicogenomic studies in this species. These organisms are ecologically relevant small worms that indirectly contribute to the regulation and degradation of organic matter. more...

Organism:

Enchytraeus albidus

Type:

Expression profiling by array

Platform:

GPL11360

24 Samples

Download data: TXT

(Submitter supplied) Gold nanoparticles (Au NPs) are uniquely suited for various biomedical applications due to the combination of their optical properties with their easily functionalized surfaces. The Au NP surface can be tailored to improve biocompatibility while also attaching targeting ligands or drugs. However, information on how these tailored surface chemistries may affect cell gene expression is scarce. Using two model human cells line, human dermal fibroblasts and prostate cancer cells, microarray experiments measured gene expression over 27,000 human genes. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10332

30 Samples

Download data: GPR

(Submitter supplied) Acute phase reactants serum amyloid A-1, 3 and micro RNA-135b, -449a, and -1 are induced in lungs of mice exposed to subtoxic doses of nano-titanium dioxide particles by inhalation In the present study we investigate pulmonary mRNA and miRNA profiles of mice exposed to subtoxic dose of nano-titanium dioxide particles by inhalation. We show dramatic induction of acute phase reactants, chemoattractants, immune and host defence related genes. more...

Organism:

Mus musculus

Type:

Expression profiling by array; Non-coding RNA profiling by array

Platforms:

GPL8824 GPL4134

41 Samples

Download data: TXT