Similar studies for GEO DataSets (Select 4962) - GEO DataSets

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Items: 20

Select item 49621.

Transcription factor ETS fusion EWS/FLI1 knockdown in Ewing sarcoma cell line: time course

Analysis of A673 Ewing Sarcoma cell line for up to 96hrs after inducible EWSR1/FLI1 knockdown. Oncogenic ETS fusions are driver mutations in diverse cancers, including Ewing sarcoma. Results provide insight into the molecular mechanisms underlying ETS-driven tumorigenesis.

Organism:: Homo sapiens

Type:: Expression profiling by array, transformed count, 2 protocol, 6 time sets

Platform:: GPL571
Series:: GSE27524
16 Samples

Download data: CEL

DataSet

Accession:: GDS4962

ID:: 4962

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2000275242.

A functional liaison between E2F and the aberrant ETS oncogene EWS/FLI1 in Ewing's sarcoma

(Submitter supplied) Translocations of ETS transcription factors are driver mutations in diverse cancers. We investigated the genomic network of the ETS fusion EWS/FLI1 in Ewing's sarcoma (ESFT) as a model of ETS-driven tumorigenesis. ChIP-Seq and transcriptional analysis identified E2F3 as a principle co-factor of EWSFLI1 defining functionally distinct gene sets. While EWS/FLI1 binding independent of E2F3 predominantly associated with repressed differentiation genes, significant co-localization with E2F3 was discovered at proximal promoters of activated growth-related genes. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS4962
Platform:: GPL571
16 Samples

Download data: CEL

Series

Accession:: GSE27524

ID:: 200027524

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000730923.

High-throughput RNAi cell viability screen to identify selective targets for EWS-FLI1 positive Ewing sarcoma

(Submitter supplied) We have performed a high-throughput RNA interference screen to identify targets inhibiting EWS-FLI1 driven cell proliferation in Ewing sarcoma cells. EWS-FLI1 expressing A673 Ewing sarcoma cells were screened both in presence and absence of EWS-FLI1 shRNA induction with druggable siRNA library. Leucine rich repeats and WD repeat Domain containing 1 (LRWD1) targeting siRNA pool was the strongest anti-proliferative hit identified only in presence of EWS-FLI1. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
9 Samples

Download data: TXT

Series

Accession:: GSE73092

ID:: 200073092

Select item 2000810184.

Expression data for analysis of genes regulated by EWS/FLI1 protein levels in Ewing sarcoma cell line A673

(Submitter supplied) Comparison of gene expression profile of Ewing sarcoma cells which have an exchange of the endogenous EWS/FLI1 to either wild-type or a turnover-deficient mutant EWS/FLI1. Most target genes are saturated as only a few target genes are soly driven by increasing protein amount. The effect of a stable EWS/FLI1 mutant on global gene expression was evaluated in A673 Ewing sarcoma cells.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL16686
9 Samples

Download data: CEL

Series

Accession:: GSE81018

ID:: 200081018

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001086315.

Genome-wide maps of EWS-FLI1 binding sites and histone modification in murine Ewing sarcoma cells

(Submitter supplied) We identified global DNA binding properties of EWS-FLI1 in mouse Ewing sarcoma. GGAA microsatellites were found as binding sites of EWS-FLI1 but with less frequency than that in human Ewing sarcoma, and genomic distribution is not conserved between human and mouse.

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL9185
6 Samples

Download data: BED, TDF

Series

Accession:: GSE108631

ID:: 200108631

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000909786.

Gene expression profiles of mouse CIC-DUX4 sarcoma

(Submitter supplied) CIC-DUX4 sarcoma (CDS) or CIC-rearranged sarcoma is a subcategory of small round cell sarcoma resembling the morphological phenotypes of Ewing sarcoma (ES). Recent clinicopathologic and molecular genetic analyses indicate that CDS is an independent disease entity from ES. Although a few ancillary markers have been used in the differential diagnosis of CDS, additional CDS-specific biomarkers are needed in challenging diagnosis for a more definitive classification. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL11180
20 Samples

Download data: CEL

Series

Accession:: GSE90978

ID:: 200090978

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000865027.

Gene expression profiles of the mouse model for alveolar soft part sarcoma

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL11180
29 Samples

Download data: CEL

Series

Accession:: GSE86502

ID:: 200086502

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2002432798.

EWSR1::FLI1 fusion oncoproteins’ regulation of ETS1 (RNA-seq)

(Submitter supplied) Ewing sarcomas harbor few mutations beyond the chromosomal translocation that initiates disease and the mechanistic basis for the metastasis of these tumors remains poorly understood. The epigenome of Ewing sarcoma (EWS) cells reflects the regulatory state of genes associated with the DNA binding activity of the fusion oncoproteins EWSR1::FLI1 or EWSR1::ERG. In this study, we examined the repressive activities of the EWSR1::FLI1/ERG fusion oncoproteins. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL30173
9 Samples

Download data: TXT

Series

Accession:: GSE243279

ID:: 200243279

PubMed Full text in PMC Similar studies

Select item 2002432779.

EWSR1::FLI1 fusion oncoproteins’ regulation of ETS1 (CUT&RUN)

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL30173
14 Samples

Download data: BED, BIGWIG

Series

Accession:: GSE243277

ID:: 200243277

PubMed Full text in PMC Similar studies

Select item 20024318410.

ETS1, a target gene of the EWSR1::FLI1 fusion oncoprotein, regulates the expression of the focal adhesion protein TENSIN3

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platform:: GPL30173
63 Samples

Download data: BED, BIGWIG, NARROWPEAK

Series

Accession:: GSE243184

ID:: 200243184

PubMed Full text in PMC Similar studies

Select item 20024318311.

EWSR1::FLI1 fusion oncoproteins’ regulation of ETS1 (RNA-seq)

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL30173
18 Samples

Download data: TXT

Series

Accession:: GSE243183

ID:: 200243183

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20024317112.

EWSR1::FLI1 fusion oncoproteins’ regulation of ETS1 (ChIP-seq)

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL30173
22 Samples

Download data: NARROWPEAK

Series

Accession:: GSE243171

ID:: 200243171

PubMed Full text in PMC Similar studies

Select item 20003740913.

Re-activation of EWS-FLI1 suppressed FOXO1 expression as a novel therapeutic strategy for Ewing´s sarcoma

(Submitter supplied) Transient transfection of a Ewing's Sarcoma cell line expressing type I EWS-FLI1 fusion and doxycycline-inducible short hairpin RNA against EWS-FLI1 (A673sh)

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS4963
Platform:: GPL570
11 Samples

Download data: CEL

Series

Accession:: GSE37409

ID:: 200037409

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 496314.

Transcription factor FOXO1 silencing effect on Ewing Sarcoma cell line

Analysis of Ewing sarcoma cell line A673sh (a doxycycline-inducible, EWS-FLI1-shRNA expressing derivative of A673) transfected with pRS-sh-FOXO1 plasmid targeting FOXO1wt, in the presence or absence of Dox. Results provide insight into FOXO1's contribution to the EWS-FLI1 transcriptional signature.

Organism:: Homo sapiens

Type:: Expression profiling by array, transformed count, 4 protocol sets

Platform:: GPL570
Series:: GSE37409
8 Samples

Download data: CEL

DataSet

Accession:: GDS4963

ID:: 4963

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 20007267315.

Targeting the EWS/ETS transcriptional program by BET bromodomain inhibition in Ewing sarcoma

(Submitter supplied) Ewing sarcomas (ES) are highly malignant, osteolytic bone or soft tissue tumors, which are characterized by early metastasis into lung and bone. Genetically, ES are defined by balanced chromosomal EWS/ETS translocations, which give rise to chimeric proteins (EWS-ETS) that generate an oncogenic transcriptional program associated with altered epigenetic marks throughout the genome. By use of an inhibitor (JQ1) blocking BET bromodomain binding proteins (BRDs) we strikingly observed a strong down-regulation of the predominant EWS-ETS protein EWS/FLI1 in a dose dependent manner. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6244
4 Samples

Download data: CEL

Series

Accession:: GSE72673

ID:: 200072673

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20010383716.

Inhibition of the oncogenic fusion protein EWS-FLI1 causes G2/M cell cycle arrest and enhanced vincristine sensitivity in Ewing sarcoma

(Submitter supplied) A chimeric fusion between the RNA binding protein EWS and the ETS family transcription factor FLI1 (EWS-FLI1), created from a chromosomal translocation, is implicated in driving the majority of Ewing sarcomas (ES) by modulation of transcription and alternative splicing. The small molecule YK-4-279 inhibits EWS-FLI1 function and induces apoptosis. We tested 69 anti-cancer drugs in combination with YK-4-279 and found that vinca alkaloids exhibited synergy with YK-4-279 in five ES cell lines. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
3 Samples

Download data: TXT

Series

Accession:: GSE103837

ID:: 200103837

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 20010384317.

Genome-wide profiling of siRNA targeting EWS-FLI1 in TC32 Ewing sarcoma cell line

(Submitter supplied) Identification of genes and pathways that were influenced by knock-down EWS-FLI1 in TC32 Ewing sarcoma cell line.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL11154
6 Samples

Download data: TXT

Series

Accession:: GSE103843

ID:: 200103843

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 20022078018.

Effect of RREB1 knockdown using siRNA in A673 Ewing sarcoma cells (RNA-seq)

(Submitter supplied) Ewing sarcoma (EwS) is a rare bone and soft tissue malignancy driven by chromosomal translocations encoding chimeric transcription factors, such as EWSR1-FLI1, that bind GGAA motifs forming novel enhancers that alter nearby expression. We propose germline microsatellite variation at the 6p25.1 EwS susceptibility locus could impact downstream gene expression and EwS biology. We performed targeted long-read sequencing of EwS blood DNA to characterize variation and genomic features important for EWSR1-FLI1 binding. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
6 Samples

Download data: CSV

Series

Accession:: GSE220780

ID:: 200220780

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20006773619.

Expression profiling of the TC32 Ewing sarcoma cell line following silencing of SUPT6H, SF3B1 or HNRNPH1

(Submitter supplied) The investigation of the function of SUPT6H, SF3B1 and HNRNPH1 in Ewing sarcoma

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10558
36 Samples

Download data: IDAT, TXT

Series

Accession:: GSE67736

ID:: 200067736

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20006754820.

Expression profiling of Ewing sarcoma cell lines exposed to 5nM Pladienolide B (PlaB) for 24 hours

(Submitter supplied) Identification of genes and pathways altered by PlaB, a bacterial natural product that acts as a spliceosome modulator by targeting the SF3b subunit of the spliceosome

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10558
24 Samples

Download data: IDAT, TXT

Series

Accession:: GSE67548

ID:: 200067548

PubMed Full text in PMC Similar studies Analyze with GEO2R

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