GEO DataSets

Analysis of the response of luminal epithelium derived breast cancer line MCF-7 to either doxorubicin or 5-fluorouracil. Cells examined 12, 24, and 36 hours following treatment. Results provide insight into the response of breast cancers derived from different cell types to chemotherapeutics.

Organism:

Homo sapiens

Type:

Expression profiling by array, log ratio, 3 agent, 3 time sets

Platform:

GPL550

Series:

GSE763

19 Samples

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(Submitter supplied) Recent studies have identified clinical subtypes of breast tumors that arise from different cell types and have different outcomes in response to chemotherapy. Tumors derived from basal epithelium have a poorer prognosis than tumors derived from luminal epithelium. To gain insight into differences underlying this disparity, we treated cell lines derived from basal epithelium (immortalized human mammary epithelial cells) and those derived from luminal epithelium (MCF-7 and ZR-75-1) with two chemotherapeutics commonly used in the treatment of breast cancer. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Datasets:

GDS845 GDS846 GDS847 GDS848

Platform:

GPL550

75 Samples

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Analysis of the response of luminal epithelium derived breast cancer line ZR-75-1 to either doxorubicin or 5-fluorouracil. Cells examined 12, 24, and 36 hours following treatment. Results provide insight into the response of breast cancers derived from different cell types to chemotherapeutics.

Organism:

Homo sapiens

Type:

Expression profiling by array, log ratio, 3 agent, 3 time sets

Platform:

GPL550

Series:

GSE763

19 Samples

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Analysis of the response of basal epithelium derived breast cancer line HME-CC to either doxorubicin or 5-fluorouracil. Cells examined 12, 24, and 36 hours following treatment. Results provide insight into the response of breast cancers derived from different cell types to chemotherapeutics.

Organism:

Homo sapiens

Type:

Expression profiling by array, log ratio, 3 agent, 3 time sets

Platform:

GPL550

Series:

GSE763

19 Samples

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Analysis of the response of the basal epithelium derived breast cancer line ME16C to either doxorubicin or 5-fluorouracil. Cells examined 12, 24, and 36 hours following treatment. Results provide insight into the response of breast cancers derived from different cell types to chemotherapeutics.

Organism:

Homo sapiens

Type:

Expression profiling by array, log ratio, 3 agent, 3 time sets

Platform:

GPL550

Series:

GSE763

18 Samples

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(Submitter supplied) Tumor cell lines and drug-resistant counterparts. These data support the publication Gyorffy et al, Oncogene 2005 (July), Prediction of doxorubicin sensitivity in breast tumors based on gene expression profiles of drug-resistant cell lines correlates with patient survival. We contrasted the expression profiles of 13 different human tumor cell lines of gastric (EPG85-257), pancreatic (EPP85-181), colon (HT29) and breast (MCF7 and MDA-MB-231) origin and their counterparts resistant to the topoisomerase inhibitors daunorubicin, doxorubicin or mitoxantrone. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL2705 GPL2706

13 Samples

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(Submitter supplied) Spotted cDNA Orestes clones. This set includes 4608 orestes in build 175 of the human UniGene database. Keywords = spotted, cDNA

Organism:

Homo sapiens

13 Series

1103 Samples

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(Submitter supplied) Spotted cDNA Orestes clones and PCR amplified fragments on glass. This set includes 664 orestes and 197 PCR amplified fragments based upon representative sequences in build 175 of the human UniGene database. Keywords = spotted Keywords = cDNA

Organism:

Homo sapiens

1 Series

118 Samples

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(Submitter supplied) Global gene expression profiling has demonstrated that the predominant cellular response to a range of toxicants is a general stress response. This stereotyped environmental stress response commonly includes repression of protein synthesis and cell cycle regulated genes and induction of DNA damage and oxidative stress responsive genes. Our laboratory has recently characterized the general stress response of breast cell lines derived from basal-like and luminal epithelium following treatment with doxorubicin (DOX) or 5-fluorouracil (5FU) and showed that each cell type has a distinct response. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS1627

Platform:

GPL550

83 Samples

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Analysis of 4 breast cell lines treated for up to 36 hrs with the chemotherapeutic agents 5-fluorouracil (5FU), doxorubicin (DOX), or etoposide (ETOP), a drug mechanistically similar to DOX. Expression profiles for DOX- and 5FU-treated cells were used to successfully predict the response to ETOP.

Organism:

Homo sapiens

Type:

Expression profiling by array, log2 ratio, 4 agent, 4 cell line, 3 time sets

Platform:

GPL550

Series:

GSE1647

83 Samples

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(Submitter supplied) Anti-estrogens and aromatase inhibitors are important drugs in the treatment of estrogen-dependent breast cancer. In order to investigate the effects of these drugs on gene expression in breast cancer cells, we treated estrogen receptor-positive MCF-7 cells, stably transfected with the aromatase gene (known as MCF-7aro cells), with testosterone, 17β-estradiol, two aromatase inhibitors (letrozole and anastrozole), and an anti-estrogen (tamoxifen). more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS1873

Platform:

GPL96

18 Samples

Download data: CEL, EXP

Analysis of estrogen receptor positive, aromatase transfected MCF-7 cells after treatment with an antiestrogen (AE) or an aromatase inhibitor (AI). AEs and AIs are used to treat estrogen-dependent breast cancer. Cells also treated with androgen which is converted to estrogen by aromatase.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 6 agent, 4 other sets

Platform:

GPL96

Series:

GSE2225

18 Samples

Download data: CEL, EXP

(Submitter supplied) Breast cancer subtypes identified in genomic studies have different underlying genetic defects. Mutations in the tumor suppressor p53 occur more frequently in estrogen receptor (ER) negative, basal-like and HER2-amplified tumors than in luminal, ER positive tumors. Thus, because p53 mutation status is tightly linked to other characteristics of prognostic importance, it is difficult to identify p53's independent prognostic effects. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL887 GPL885

48 Samples

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(Submitter supplied) Genome wide DNA methylation profiling of locally advanced breast tumors before and after treatment with doxorubicin and 5-fluorouracil Mitomycin C

Organism:

Homo sapiens

Type:

Methylation profiling by array

Platform:

GPL8490

61 Samples

Download data: IDAT

(Submitter supplied) Treatment-related morbidities have been linked to the large post-operative treatment volumes required for external beam partial breast irradiation (PBI). Alternative PBI techniques require equipment that is not readily available. To address these issues, we designed a phase I trial utilizing widely available technology to 1) evaluate the safety of a single radiation treatment delivered preoperatively to the small-volume, intact breast tumor and 2) identify imaging and genomic markers of radiation response.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL17586

62 Samples

Download data: CEL

(Submitter supplied) Introduction: Breast radiotherapy is currently “one size fits all” regardless of breast cancer subtype (eg. luminal, basal). However, recent clinical data suggests that radiation response may vary significantly among subtypes. Therefore, current practice leads to over- or under-treatment of women whose tumors are more or less radiation responsive. We hypothesized that this clinical variability may be due, in part, to differences in cellular radiation response. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL571

96 Samples

Download data: CEL

(Submitter supplied) The 60 cell lines of the NCI Anti-Cancer Drug Screen (NCI60) constitute the most extensively characterized in vitro cancer cell model, and have been tested for sensitivity to over 100,000 potential chemotherapy agents. We have used the NCI60 cell lines and three additional lymphoblast lines to develop a database of responses of cancer cells to ionizing radiation. We compared clonogenic survival, apoptosis induction, and gene expression response by microarray analysis. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL5080

63 Samples

Download data: TXT

(Submitter supplied) We have utilized a version 2.0 of our Fusion gene microarray (version 1.0 described by PMID: 19152679 and GEO, GPL8078) to screen cancer cell lines for known fusion genes We assembled a comprehensive database of published fusion genes, including those which have been reported only in individual studies and samples, and fusion genes resulting from deep sequencing of cancer genomes and transcriptomes. more...

Organism:

Homo sapiens

Type:

Expression profiling by array; Genome variation profiling by array

Platform:

GPL11054

67 Samples

Download data: PAIR

(Submitter supplied) Doxorubicin is considered one of the most potent established chemotherapeutics in the treatment of liposarcoma; however, the response rates usually below 30%, are still disappointing. This study was performed to identify gene expression changes in liposarcoma after doxorubicin treatment. Cells of 19 primary human liposarcoma were harvested intraoperatively and brought into cell culture. Cells were incubated with doxorubicin for 24 h, RNA was isolated and differential gene expression was analysed by the microarray technique. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3514

Platform:

GPL96

38 Samples

Download data: CEL, CHP

Analysis of various types of liposarcomas treated with doxorubicin in vitro. While doxorubicin is an established chemotherapeutic for treating liposarcomas, the response to this drug is low. Results provide insight into the molecular basis of the resistance of liposarcomas to doxorubicin.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 agent, 3 development stage, 6 disease state, 19 specimen sets

Platform:

GPL96

Series:

GSE12972

38 Samples

Download data: CEL, CHP