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Series GSE242996 Query DataSets for GSE242996
Status Public on Sep 13, 2023
Title Real-time quantitative PCR analysis of rat's brain mRNAs
Organism Rattus norvegicus
Experiment type Expression profiling by RT-PCR
Summary We investigated the therapeutic effect of the extracellular vesicles secreted by glial progenitor cells (GPC-EV) derived from human induced pluripotent stem cell in a traumatic brain injury model. The injury was modeled using the dosed concussion to the open brain method. The male Wistar rats were performed traumatic brain injury (TBI), and after 24 hours animals were randomly divided into two groups: group 1 — rats with intranasal administration of PBS (control), and group 2 — rats with similar administration of extracellular visicles (EV) derived from glial progenitor cells. PCR analysis of brain tissues ( cortex, striatum, hippocampus) were performed on postoperative day 7 and 14 to investigate genes associated with apoptosis, and inflammation.
Overall design qPCR gene expression profiling. The brain tissue was collected at 7 and 14 days post-TBI, as indicated in the summary.
Web link
Contributor(s) Salikhova DI
Citation(s) 37989873
Submission date Sep 12, 2023
Last update date Dec 13, 2023
Contact name Diana Salikhova
Organization name RUDN University
Department Institute of molecular and cellular medecine
Lab Laboratory of cellular biotechnology
Street address Miklukho-Maklaya, 8
City Moscow
ZIP/Postal code 117198
Country Russia
Platforms (1)
GPL33755 Bio-Rad Rat Custom brain PCR assay
Samples (60)
GSM7776906 rat#5-control_cortex_7d
GSM7776907 rat#7-control_cortex_7d
GSM7776908 rat#2-control_cortex_7d
BioProject PRJNA1015693

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE242996_fold-change.txt.gz 916 b (ftp)(http) TXT
GSE242996_non-normalized_data.txt.gz 3.3 Kb (ftp)(http) TXT

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