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| Status |
Public on Sep 27, 2006 |
| Title |
Molecular characterization of very early relapsed childhood ALL |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Purpose: In childhood acute lymphoblastic leukemia (ALL), approximately 25% of patients suffer from relapse. In recurrent disease, despite intensified therapy, overall cure rates of 40% remain unsatisfactory and survival rates are particularly poor in certain subgroups. The probability of long-term survival after relapse is predicted from well-established prognostic factors, i. e. time and site of relapse, immunophenotype and minimal residual disease. However, the underlying biological determinants of these prognostic factors remain poorly understood.
Results: We show here that patients with very early relapse of ALL are characterized by a distinctive gene expression pattern. We identified a set of 83 genes differentially expressed in very early relapsed ALL compared to late relapsed disease. The vast majority of genes was up-regulated and many were late cell cycle genes with a function in mitosis. In addition, samples from patients with very early relapse showed a significant increase in the percentage of S and G/2M phase cells and this correlated well with the expression level of cell cycle genes.
Conclusions: Very early relapse of ALL is characterized by an increased proliferative capacity of leukemic blasts and up-regulated mitotic genes. The latter suggests that novel drugs, targeting late cell cycle proteins, might be beneficial for these patients that typically face a dismal prognosis.
Keywords: disease state analysis
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| Overall design |
We performed gene expression profiling on 60 prospectively collected samples of children with first relapse of acute lymphoblastic leukemia enrolled on the relapse trial ALL-REZ BFM 2002 of the Berlin-Frankfurt-Muenster study group.
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| Contributor(s) |
Kirschner-Schwabe R, Lottaz C, Toedling J, Thein P, Karawajew L, Eckert C, von Stackelberg A, Ungethuem U, Kostka D, Kulozik AE, Ludwig W, Henze G, Spang R, Hagemeier C, Seeger K |
| Citation(s) |
16899601 |
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| Submission date |
Apr 21, 2006 |
| Last update date |
Nov 14, 2018 |
| Contact name |
Renate Kirschner-Schwabe |
| E-mail(s) |
R.Kirschner@charite.de
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| Phone |
+4930450566088
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| Fax |
+4930450566946
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| URL |
http://www.charite.de/paedonko
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| Organization name |
Charité - Universitätsmedizin Berlin
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| Department |
Pediatric Oncology/Hematology
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| Lab |
Molecular Genetics
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| Street address |
Augustenburger Platz 1
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| City |
Berlin |
| ZIP/Postal code |
12167 |
| Country |
Germany |
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| Platforms (1) |
| GPL96 |
[HG-U133A] Affymetrix Human Genome U133A Array |
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| Samples (60)
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| Relations |
| BioProject |
PRJNA96749 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE4698_RAW.tar |
202.6 Mb |
(http)(custom) |
TAR (of CEL, EXP) |
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