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Nutritional Rickets

MedGen UID:
1385792
•Concept ID:
C4330845
•
Disease or Syndrome

Definition

Rickets due to dietary deficiency of calcium, phosphate, or vitamin D. [from NCI]

Professional guidelines

PubMed

Rickets guidance: part II-management.
Haffner D, Leifheit-Nestler M, Grund A, Schnabel D
Pediatr Nephrol 2022 Oct;37(10):2289-2302. Epub 2022 Mar 29 doi: 10.1007/s00467-022-05505-5. PMID: 35352187Free PMC Article
Nutritional rickets & osteomalacia: A practical approach to management.
Uday S, Högler W
Indian J Med Res 2020 Oct;152(4):356-367. doi: 10.4103/ijmr.IJMR_1961_19. PMID: 33380700Free PMC Article
Global Consensus Recommendations on Prevention and Management of Nutritional Rickets.
Munns CF, Shaw N, Kiely M, Specker BL, Thacher TD, Ozono K, Michigami T, Tiosano D, Mughal MZ, Mäkitie O, Ramos-Abad L, Ward L, DiMeglio LA, Atapattu N, Cassinelli H, Braegger C, Pettifor JM, Seth A, Idris HW, Bhatia V, Fu J, Goldberg G, Sävendahl L, Khadgawat R, Pludowski P, Maddock J, Hyppönen E, Oduwole A, Frew E, Aguiar M, Tulchinsky T, Butler G, Högler W
J Clin Endocrinol Metab 2016 Feb;101(2):394-415. Epub 2016 Jan 8 doi: 10.1210/jc.2015-2175. PMID: 26745253Free PMC Article

Recent clinical studies

Etiology

Vitamin D: Before, during and after Pregnancy: Effect on Neonates and Children.
Mansur JL, Oliveri B, Giacoia E, Fusaro D, Costanzo PR
Nutrients 2022 May 1;14(9) doi: 10.3390/nu14091900. PMID: 35565867Free PMC Article
The health effects of vitamin D supplementation: evidence from human studies.
Bouillon R, Manousaki D, Rosen C, Trajanoska K, Rivadeneira F, Richards JB
Nat Rev Endocrinol 2022 Feb;18(2):96-110. Epub 2021 Nov 23 doi: 10.1038/s41574-021-00593-z. PMID: 34815552Free PMC Article
Nutritional rickets & osteomalacia: A practical approach to management.
Uday S, Högler W
Indian J Med Res 2020 Oct;152(4):356-367. doi: 10.4103/ijmr.IJMR_1961_19. PMID: 33380700Free PMC Article
Rickets.
Carpenter TO, Shaw NJ, Portale AA, Ward LM, Abrams SA, Pettifor JM
Nat Rev Dis Primers 2017 Dec 21;3:17101. doi: 10.1038/nrdp.2017.101. PMID: 29265106
Global Consensus Recommendations on Prevention and Management of Nutritional Rickets.
Munns CF, Shaw N, Kiely M, Specker BL, Thacher TD, Ozono K, Michigami T, Tiosano D, Mughal MZ, Mäkitie O, Ramos-Abad L, Ward L, DiMeglio LA, Atapattu N, Cassinelli H, Braegger C, Pettifor JM, Seth A, Idris HW, Bhatia V, Fu J, Goldberg G, Sävendahl L, Khadgawat R, Pludowski P, Maddock J, Hyppönen E, Oduwole A, Frew E, Aguiar M, Tulchinsky T, Butler G, Högler W
J Clin Endocrinol Metab 2016 Feb;101(2):394-415. Epub 2016 Jan 8 doi: 10.1210/jc.2015-2175. PMID: 26745253Free PMC Article

Diagnosis

Refractory Rickets.
Chinoy A, Padidela R
Indian J Pediatr 2023 Jun;90(6):574-581. Epub 2023 Apr 19 doi: 10.1007/s12098-023-04538-4. PMID: 37074534Free PMC Article
Rickets guidance: part I-diagnostic workup.
Haffner D, Leifheit-Nestler M, Grund A, Schnabel D
Pediatr Nephrol 2022 Sep;37(9):2013-2036. Epub 2021 Dec 15 doi: 10.1007/s00467-021-05328-w. PMID: 34910242Free PMC Article
Nutritional rickets & osteomalacia: A practical approach to management.
Uday S, Högler W
Indian J Med Res 2020 Oct;152(4):356-367. doi: 10.4103/ijmr.IJMR_1961_19. PMID: 33380700Free PMC Article
Rickets.
Carpenter TO, Shaw NJ, Portale AA, Ward LM, Abrams SA, Pettifor JM
Nat Rev Dis Primers 2017 Dec 21;3:17101. doi: 10.1038/nrdp.2017.101. PMID: 29265106
Global Consensus Recommendations on Prevention and Management of Nutritional Rickets.
Munns CF, Shaw N, Kiely M, Specker BL, Thacher TD, Ozono K, Michigami T, Tiosano D, Mughal MZ, Mäkitie O, Ramos-Abad L, Ward L, DiMeglio LA, Atapattu N, Cassinelli H, Braegger C, Pettifor JM, Seth A, Idris HW, Bhatia V, Fu J, Goldberg G, Sävendahl L, Khadgawat R, Pludowski P, Maddock J, Hyppönen E, Oduwole A, Frew E, Aguiar M, Tulchinsky T, Butler G, Högler W
J Clin Endocrinol Metab 2016 Feb;101(2):394-415. Epub 2016 Jan 8 doi: 10.1210/jc.2015-2175. PMID: 26745253Free PMC Article

Therapy

Refractory Rickets.
Chinoy A, Padidela R
Indian J Pediatr 2023 Jun;90(6):574-581. Epub 2023 Apr 19 doi: 10.1007/s12098-023-04538-4. PMID: 37074534Free PMC Article
Rickets guidance: part II-management.
Haffner D, Leifheit-Nestler M, Grund A, Schnabel D
Pediatr Nephrol 2022 Oct;37(10):2289-2302. Epub 2022 Mar 29 doi: 10.1007/s00467-022-05505-5. PMID: 35352187Free PMC Article
Calcifediol (25OH Vitamin D(3)) Deficiency: A Risk Factor from Early to Old Age.
Bouillon R, Antonio L, Olarte OR
Nutrients 2022 Mar 10;14(6) doi: 10.3390/nu14061168. PMID: 35334824Free PMC Article
The health effects of vitamin D supplementation: evidence from human studies.
Bouillon R, Manousaki D, Rosen C, Trajanoska K, Rivadeneira F, Richards JB
Nat Rev Endocrinol 2022 Feb;18(2):96-110. Epub 2021 Nov 23 doi: 10.1038/s41574-021-00593-z. PMID: 34815552Free PMC Article
Global Consensus Recommendations on Prevention and Management of Nutritional Rickets.
Munns CF, Shaw N, Kiely M, Specker BL, Thacher TD, Ozono K, Michigami T, Tiosano D, Mughal MZ, Mäkitie O, Ramos-Abad L, Ward L, DiMeglio LA, Atapattu N, Cassinelli H, Braegger C, Pettifor JM, Seth A, Idris HW, Bhatia V, Fu J, Goldberg G, Sävendahl L, Khadgawat R, Pludowski P, Maddock J, Hyppönen E, Oduwole A, Frew E, Aguiar M, Tulchinsky T, Butler G, Högler W
J Clin Endocrinol Metab 2016 Feb;101(2):394-415. Epub 2016 Jan 8 doi: 10.1210/jc.2015-2175. PMID: 26745253Free PMC Article

Prognosis

Nutritional rickets under 16 years: UK surveillance results.
Julies P, Lynn RM, Pall K, Leoni M, Calder A, Mughal Z, Shaw N, McDonnell C, McDevitt H, Blair M
Arch Dis Child 2020 Jun;105(6):587-592. Epub 2020 Jan 16 doi: 10.1136/archdischild-2019-317934. PMID: 31949032
Nutritional rickets: vitamin D, calcium, and the genetic make-up.
El Kholy M, Elsedfy H, Fernández-Cancio M, Hamza RT, Amr NH, Ahmed AY, Toaima NN, Audí L
Pediatr Res 2017 Feb;81(2):356-363. Epub 2016 Nov 3 doi: 10.1038/pr.2016.222. PMID: 27973470
Prevention and treatment of nutritional rickets.
Shaw NJ
J Steroid Biochem Mol Biol 2016 Nov;164:145-147. Epub 2015 Oct 19 doi: 10.1016/j.jsbmb.2015.10.014. PMID: 26493853
Rickets in Denmark.
Beck-Nielsen SS
Dan Med J 2012 Feb;59(2):B4384. PMID: 22293055
Incidence and prevalence of nutritional and hereditary rickets in southern Denmark.
Beck-Nielsen SS, Brock-Jacobsen B, Gram J, Brixen K, Jensen TK
Eur J Endocrinol 2009 Mar;160(3):491-7. Epub 2008 Dec 18 doi: 10.1530/EJE-08-0818. PMID: 19095780

Clinical prediction guides

Calcifediol (25OH Vitamin D(3)) Deficiency: A Risk Factor from Early to Old Age.
Bouillon R, Antonio L, Olarte OR
Nutrients 2022 Mar 10;14(6) doi: 10.3390/nu14061168. PMID: 35334824Free PMC Article
The health effects of vitamin D supplementation: evidence from human studies.
Bouillon R, Manousaki D, Rosen C, Trajanoska K, Rivadeneira F, Richards JB
Nat Rev Endocrinol 2022 Feb;18(2):96-110. Epub 2021 Nov 23 doi: 10.1038/s41574-021-00593-z. PMID: 34815552Free PMC Article
Screening for nutritional rickets in a community.
Pettifor JM
J Steroid Biochem Mol Biol 2016 Nov;164:139-144. Epub 2015 Sep 10 doi: 10.1016/j.jsbmb.2015.09.008. PMID: 26365554
Nutritional rickets around the world: causes and future directions.
Thacher TD, Fischer PR, Strand MA, Pettifor JM
Ann Trop Paediatr 2006 Mar;26(1):1-16. doi: 10.1179/146532806X90556. PMID: 16494699
Nutritional and metabolic rickets.
Teotia M, Teotia SP
Indian J Pediatr 1997 Mar-Apr;64(2):153-7. doi: 10.1007/BF02752435. PMID: 10771831

Recent systematic reviews

Vitamin D supplementation for term breastfed infants to prevent vitamin D deficiency and improve bone health.
Tan ML, Abrams SA, Osborn DA
Cochrane Database Syst Rev 2020 Dec 11;12(12):CD013046. doi: 10.1002/14651858.CD013046.pub2. PMID: 33305822Free PMC Article
Nutritional rickets around the world: an update.
Creo AL, Thacher TD, Pettifor JM, Strand MA, Fischer PR
Paediatr Int Child Health 2017 May;37(2):84-98. Epub 2016 Dec 6 doi: 10.1080/20469047.2016.1248170. PMID: 27922335
Interventions for the prevention of nutritional rickets in term born children.
Lerch C, Meissner T
Cochrane Database Syst Rev 2007 Oct 17;2007(4):CD006164. doi: 10.1002/14651858.CD006164.pub2. PMID: 17943890Free PMC Article
Nutritional rickets around the world: causes and future directions.
Thacher TD, Fischer PR, Strand MA, Pettifor JM
Ann Trop Paediatr 2006 Mar;26(1):1-16. doi: 10.1179/146532806X90556. PMID: 16494699
A systematic review of nutritional rickets in Ethiopia: status and prospects.
Wondale Y, Shiferaw F, Lulseged S
Ethiop Med J 2005 Jul;43(3):203-10. PMID: 16370553

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