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Parotid gland cancer

MedGen UID:
152885
•Concept ID:
C0747273
•
Neoplastic Process
Synonyms: Cancer of Parotid; Cancer of the Parotid; Cancer, Parotid; Cancers, Parotid; Parotid Cancer; Parotid Cancers
SNOMED CT: Cancer of parotid gland (363379000); CA - Cancer of parotid gland (363379000); Malignant tumor of parotid gland (363379000)
 
Monarch Initiative: MONDO:0004700

Definition

A primary or metastatic malignant neoplasm involving the parotid gland. Representative examples include carcinoma, malignant mixed tumor, and non-Hodgkin lymphoma. [from NCI]

Professional guidelines

PubMed

Clinical outcomes of bulky parotid gland cancers: need for self-examination and screening program for early diagnosis of parotid tumors.
Choi SY, Lee E, Kim E, Chung MK, Son YI, Baek CH, Jeong HS
BMC Cancer 2021 Feb 18;21(1):178. doi: 10.1186/s12885-021-07902-9. PMID: 33602169Free PMC Article
Clinical-pathological prognostic factors and treatment failure patterns in T1-2 high-grade parotid gland cancer.
Park YM, Yoon SO, Koh YW, Kim SH, Lim JY, Choi EC
Oral Oncol 2020 Nov;110:104884. Epub 2020 Jul 3 doi: 10.1016/j.oraloncology.2020.104884. PMID: 32629407
An evidence-based analysis of the management of N0 neck in patients with cancer of the parotid gland.
Vartanian JG, Gonçalves Filho J, Kowalski LP, Shah JP, Suárez C, Rinaldo A, De Bree R, Rodrigo JP, Hamoir M, Takes RP, Mäkitie AA, Zbären P, Andreasen S, Poorten VV, Sanabria A, Hellquist H, Robbins KT, Bödeker CC, Silver C, Ferlito A
Expert Rev Anticancer Ther 2019 Oct;19(10):899-908. Epub 2019 Oct 8 doi: 10.1080/14737140.2019.1674143. PMID: 31591950

Recent clinical studies

Etiology

Dosimetric and NTCP analyses for selecting parotid gland cancer patients for proton therapy.
Camarda AM, Vincini MG, Russo S, Comi S, Emiro F, Bazani A, Ingargiola R, Vischioni B, Vecchi C, Volpe S, Orecchia R, Jereczek-Fossa BA, Orlandi E, Alterio D
Tumori 2024 Aug;110(4):273-283. Epub 2024 May 21 doi: 10.1177/03008916241252544. PMID: 38769916Free PMC Article
Current Issues in Treatment of Parotid Gland Cancer and Advanced Surgical Technique of Robotic Parotidectomy.
Park YM, Koh YW
Curr Oncol Rep 2022 Feb;24(2):203-208. Epub 2022 Jan 21 doi: 10.1007/s11912-021-01167-y. PMID: 35061197
Predicting cancer-specific mortality in patients with parotid gland carcinoma by competing risk nomogram.
Luo X, Liu S, Chen Y, Qiu X, Huang D, Zhang D, Liang Q, Yang Y, Zeng X
Head Neck 2021 Dec;43(12):3888-3898. Epub 2021 Oct 11 doi: 10.1002/hed.26890. PMID: 34632674
Pre-treatment MRI predictor of high-grade malignant parotid gland cancer.
Baba A, Kessoku H, Akutsu T, Shimura E, Matsushima S, Kurokawa R, Ota Y, Suzuki T, Kawasumi Y, Yamauchi H, Ikeda K, Ojiri H
Oral Radiol 2021 Oct;37(4):611-616. Epub 2021 Jan 2 doi: 10.1007/s11282-020-00498-z. PMID: 33389599
Prognostic Factors and Treatment Outcomes of Parotid Gland Cancer: A 10-Year Single-Center Experience.
Chang JW, Hong HJ, Ban MJ, Shin YS, Kim WS, Koh YW, Choi EC
Otolaryngol Head Neck Surg 2015 Dec;153(6):981-9. Epub 2015 Jul 22 doi: 10.1177/0194599815594789. PMID: 26203086

Diagnosis

Dosimetric and NTCP analyses for selecting parotid gland cancer patients for proton therapy.
Camarda AM, Vincini MG, Russo S, Comi S, Emiro F, Bazani A, Ingargiola R, Vischioni B, Vecchi C, Volpe S, Orecchia R, Jereczek-Fossa BA, Orlandi E, Alterio D
Tumori 2024 Aug;110(4):273-283. Epub 2024 May 21 doi: 10.1177/03008916241252544. PMID: 38769916Free PMC Article
Irreversible facial nerve palsy as a revelator ofparotid gland cancer.
Marszał J, Bartochowska A, Klimza H, Nogal P, Wierzbicka M
Otolaryngol Pol 2023 Sep 29;77(5):8-13. doi: 10.5604/01.3001.0053.4090. PMID: 38032327
Clinical-pathological prognostic factors and treatment failure patterns in T1-2 high-grade parotid gland cancer.
Park YM, Yoon SO, Koh YW, Kim SH, Lim JY, Choi EC
Oral Oncol 2020 Nov;110:104884. Epub 2020 Jul 3 doi: 10.1016/j.oraloncology.2020.104884. PMID: 32629407
Prognostic Factors and Treatment Outcomes of Parotid Gland Cancer: A 10-Year Single-Center Experience.
Chang JW, Hong HJ, Ban MJ, Shin YS, Kim WS, Koh YW, Choi EC
Otolaryngol Head Neck Surg 2015 Dec;153(6):981-9. Epub 2015 Jul 22 doi: 10.1177/0194599815594789. PMID: 26203086
Targeted next generation sequencing of parotid gland cancer uncovers genetic heterogeneity.
Grünewald I, Vollbrecht C, Meinrath J, Meyer MF, Heukamp LC, Drebber U, Quaas A, Beutner D, Hüttenbrink KB, Wardelmann E, Hartmann W, Büttner R, Odenthal M, Stenner M
Oncotarget 2015 Jul 20;6(20):18224-37. doi: 10.18632/oncotarget.4015. PMID: 26053092Free PMC Article

Therapy

Dosimetric and NTCP analyses for selecting parotid gland cancer patients for proton therapy.
Camarda AM, Vincini MG, Russo S, Comi S, Emiro F, Bazani A, Ingargiola R, Vischioni B, Vecchi C, Volpe S, Orecchia R, Jereczek-Fossa BA, Orlandi E, Alterio D
Tumori 2024 Aug;110(4):273-283. Epub 2024 May 21 doi: 10.1177/03008916241252544. PMID: 38769916Free PMC Article
Predicting cancer-specific mortality in patients with parotid gland carcinoma by competing risk nomogram.
Luo X, Liu S, Chen Y, Qiu X, Huang D, Zhang D, Liang Q, Yang Y, Zeng X
Head Neck 2021 Dec;43(12):3888-3898. Epub 2021 Oct 11 doi: 10.1002/hed.26890. PMID: 34632674
Clinical-pathological prognostic factors and treatment failure patterns in T1-2 high-grade parotid gland cancer.
Park YM, Yoon SO, Koh YW, Kim SH, Lim JY, Choi EC
Oral Oncol 2020 Nov;110:104884. Epub 2020 Jul 3 doi: 10.1016/j.oraloncology.2020.104884. PMID: 32629407
Subcutaneous Injection of Hyaluronic Acid to Decrease Acute Skin Toxicity After Adjuvant Interstitial Brachytherapy in Parotid Gland Cancer Patients: A Nonrandomized Controlled Trial.
Wu WJ, Gao Y, Liu SM, Xu K, Zhang J, Huang MW
J Oral Maxillofac Surg 2020 Jan;78(1):167-172. Epub 2019 Sep 14 doi: 10.1016/j.joms.2019.09.005. PMID: 31604061
An overview of the rare parotid gland cancer.
Ho K, Lin H, Ann DK, Chu PG, Yen Y
Head Neck Oncol 2011 Sep 14;3:40. doi: 10.1186/1758-3284-3-40. PMID: 21917153Free PMC Article

Prognosis

Is elective neck dissection necessary for patients with cT3-4N0 parotid gland cancer?
Adachi M, Tomioka T, Fujii S, Morishita Y, Okano W, Shinozaki T, Matsuura K, Hayashi R
Auris Nasus Larynx 2022 Oct;49(5):856-861. Epub 2022 Mar 26 doi: 10.1016/j.anl.2022.03.010. PMID: 35351350
Predicting cancer-specific mortality in patients with parotid gland carcinoma by competing risk nomogram.
Luo X, Liu S, Chen Y, Qiu X, Huang D, Zhang D, Liang Q, Yang Y, Zeng X
Head Neck 2021 Dec;43(12):3888-3898. Epub 2021 Oct 11 doi: 10.1002/hed.26890. PMID: 34632674
Pre-treatment MRI predictor of high-grade malignant parotid gland cancer.
Baba A, Kessoku H, Akutsu T, Shimura E, Matsushima S, Kurokawa R, Ota Y, Suzuki T, Kawasumi Y, Yamauchi H, Ikeda K, Ojiri H
Oral Radiol 2021 Oct;37(4):611-616. Epub 2021 Jan 2 doi: 10.1007/s11282-020-00498-z. PMID: 33389599
Prognostic Factors and Treatment Outcomes of Parotid Gland Cancer: A 10-Year Single-Center Experience.
Chang JW, Hong HJ, Ban MJ, Shin YS, Kim WS, Koh YW, Choi EC
Otolaryngol Head Neck Surg 2015 Dec;153(6):981-9. Epub 2015 Jul 22 doi: 10.1177/0194599815594789. PMID: 26203086
An overview of the rare parotid gland cancer.
Ho K, Lin H, Ann DK, Chu PG, Yen Y
Head Neck Oncol 2011 Sep 14;3:40. doi: 10.1186/1758-3284-3-40. PMID: 21917153Free PMC Article

Clinical prediction guides

Topology-based radiomic features for prediction of parotid gland cancer malignancy grade in magnetic resonance images.
Ikushima K, Arimura H, Yasumatsu R, Kamezawa H, Ninomiya K
MAGMA 2023 Oct;36(5):767-777. Epub 2023 Apr 20 doi: 10.1007/s10334-023-01084-0. PMID: 37079154
Predicting cancer-specific mortality in patients with parotid gland carcinoma by competing risk nomogram.
Luo X, Liu S, Chen Y, Qiu X, Huang D, Zhang D, Liang Q, Yang Y, Zeng X
Head Neck 2021 Dec;43(12):3888-3898. Epub 2021 Oct 11 doi: 10.1002/hed.26890. PMID: 34632674
Pre-treatment MRI predictor of high-grade malignant parotid gland cancer.
Baba A, Kessoku H, Akutsu T, Shimura E, Matsushima S, Kurokawa R, Ota Y, Suzuki T, Kawasumi Y, Yamauchi H, Ikeda K, Ojiri H
Oral Radiol 2021 Oct;37(4):611-616. Epub 2021 Jan 2 doi: 10.1007/s11282-020-00498-z. PMID: 33389599
An evidence-based analysis of the management of N0 neck in patients with cancer of the parotid gland.
Vartanian JG, Gonçalves Filho J, Kowalski LP, Shah JP, Suárez C, Rinaldo A, De Bree R, Rodrigo JP, Hamoir M, Takes RP, Mäkitie AA, Zbären P, Andreasen S, Poorten VV, Sanabria A, Hellquist H, Robbins KT, Bödeker CC, Silver C, Ferlito A
Expert Rev Anticancer Ther 2019 Oct;19(10):899-908. Epub 2019 Oct 8 doi: 10.1080/14737140.2019.1674143. PMID: 31591950
Targeted next generation sequencing of parotid gland cancer uncovers genetic heterogeneity.
Grünewald I, Vollbrecht C, Meinrath J, Meyer MF, Heukamp LC, Drebber U, Quaas A, Beutner D, Hüttenbrink KB, Wardelmann E, Hartmann W, Büttner R, Odenthal M, Stenner M
Oncotarget 2015 Jul 20;6(20):18224-37. doi: 10.18632/oncotarget.4015. PMID: 26053092Free PMC Article

Recent systematic reviews

Prognostic role of intraparotid lymph node metastasis in primary parotid cancer: Systematic review.
Guntinas-Lichius O, Thielker J, Robbins KT, Olsen KD, Shaha AR, Mäkitie AA, de Bree R, Vander Poorten V, Quer M, Rinaldo A, Kowalski LP, Rodrigo JP, Hamoir M, Ferlito A
Head Neck 2021 Mar;43(3):997-1008. Epub 2020 Nov 9 doi: 10.1002/hed.26541. PMID: 33169420

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