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Female Reproductive System Adenofibroma

MedGen UID:
1626416
•Concept ID:
C4520837
•
Neoplastic Process

Definition

A benign or borderline neoplasm characterized by the presence of connective tissue stroma and epithelial structures. It occurs in the ovary, fallopian tube, uterine corpus, and cervix. [from NCI]

Professional guidelines

PubMed

Uterine adenosarcoma: a clinicopathologic study of 11 cases with a reevaluation of histologic criteria.
Czernobilsky B, Hohlweg-Majert P, Dallenbach-Hellweg G
Arch Gynecol 1983;233(4):281-94. doi: 10.1007/BF02133803. PMID: 6318673

Recent clinical studies

Etiology

Imaging in gynecological disease (16): clinical and ultrasound characteristics of serous cystadenofibromas in adnexa.
Virgilio BA, De Blasis I, Sladkevicius P, Moro F, Zannoni GF, Arciuolo D, Mascilini F, Ciccarone F, Timmerman D, Kaijser J, Fruscio R, Van Holsbeke C, Franchi D, Epstein E, Leone FPG, Guerriero S, Czekierdowski A, Scambia G, Testa AC, Valentin L
Ultrasound Obstet Gynecol 2019 Dec;54(6):823-830. doi: 10.1002/uog.20277. PMID: 30937992
Ultrasound and Histopathologic Correlation of Ovarian Cystadenofibromas: Diagnostic Value of the "Shadow Sign".
Timor-Tritsch IE, Yoon E, Monteagudo A, Ciaffarano J, Brandon C, Mittal KR, Wallach RC, Boyd LR
J Ultrasound Med 2019 Nov;38(11):2973-2978. Epub 2019 Mar 29 doi: 10.1002/jum.15003. PMID: 30927305
Pathologic findings in prophylactic oophorectomy specimens in high-risk women.
Leeper K, Garcia R, Swisher E, Goff B, Greer B, Paley P
Gynecol Oncol 2002 Oct;87(1):52-6. doi: 10.1006/gyno.2002.6779. PMID: 12468342
Tamoxifen and the endometrium: review of 102 cases and comparison with HRT-related and non-HRT-related endometrial pathology.
Kennedy MM, Baigrie CF, Manek S
Int J Gynecol Pathol 1999 Apr;18(2):130-7. PMID: 10202670
Epidemiology and endocrinology of benign breast disease.
Wang DY, Fentiman IS
Breast Cancer Res Treat 1985;6(1):5-36. doi: 10.1007/BF01806008. PMID: 3902125

Diagnosis

A pathologist's road map to benign, precancerous, and malignant intraepithelial proliferations in the fallopian tube.
Mehrad M, Ning G, Chen EY, Mehra KK, Crum CP
Adv Anat Pathol 2010 Sep;17(5):293-302. doi: 10.1097/PAP.0b013e3181ecdee1. PMID: 20733351
Ovarian low-grade and high-grade serous carcinoma: pathogenesis, clinicopathologic and molecular biologic features, and diagnostic problems.
Vang R, Shih IeM, Kurman RJ
Adv Anat Pathol 2009 Sep;16(5):267-82. doi: 10.1097/PAP.0b013e3181b4fffa. PMID: 19700937Free PMC Article
My approach to the interpretation of endometrial biopsies and curettings.
McCluggage WG
J Clin Pathol 2006 Aug;59(8):801-12. doi: 10.1136/jcp.2005.029702. PMID: 16873562Free PMC Article
Uterine adenofibroma and adenosarcoma: CT and MR findings.
Lee HK, Kim SH, Cho JY, Yeon KM
J Comput Assist Tomogr 1998 Mar-Apr;22(2):314-6. doi: 10.1097/00004728-199803000-00030. PMID: 9530402
The surgical pathology of the reproductive system and breast during oral contraceptive therapy.
Fechner RE
Pathol Annu 1971;6:299-319. PMID: 4949369

Therapy

Massive Ovarian Growth in a Woman With Severe Insulin-Resistant Polycystic Ovary Syndrome Receiving GnRH Analogue.
Singh P, Agress A, Madrigal VK, Magyar C, Ostrzega N, Chazenbalk GD, Dumesic DA
J Clin Endocrinol Metab 2019 Jul 1;104(7):2796-2800. doi: 10.1210/jc.2018-02464. PMID: 30759233Free PMC Article
Tamoxifen and the endometrium: review of 102 cases and comparison with HRT-related and non-HRT-related endometrial pathology.
Kennedy MM, Baigrie CF, Manek S
Int J Gynecol Pathol 1999 Apr;18(2):130-7. PMID: 10202670
Myometrial and stromal lesions of the uterus.
Smoot JS, Zaloudek C
Clin Lab Med 1995 Sep;15(3):545-73. PMID: 8542723
Epidemiology and endocrinology of benign breast disease.
Wang DY, Fentiman IS
Breast Cancer Res Treat 1985;6(1):5-36. doi: 10.1007/BF01806008. PMID: 3902125
The surgical pathology of the reproductive system and breast during oral contraceptive therapy.
Fechner RE
Pathol Annu 1971;6:299-319. PMID: 4949369

Prognosis

Ovarian Clear Cell Tumors Associated With Seromucinous Borderline Tumor: A Case Series.
Vroobel KM, McCluggage WG
Int J Gynecol Pathol 2022 Jan 1;41(1):76-81. doi: 10.1097/PGP.0000000000000768. PMID: 33741765
Endosalpingiosis in conjunction with ovarian serous cystadenoma mimicking metastatic ovarian malignancy.
Singhania N, Janakiraman N, Coslett D, Ahmad N
Am J Case Rep 2014 Aug 29;15:361-3. doi: 10.12659/AJCR.890921. PMID: 25180540Free PMC Article
Müllerian adenosarcoma presenting as cervical polyps: a report of seven cases and review of the literature.
Kerner H, Lichtig C
Obstet Gynecol 1993 May;81(5 ( Pt 1)):655-9. PMID: 8385764
Benign and borderline clear cell adenofibromas of the ovary.
Bell DA, Scully RE
Cancer 1985 Dec 15;56(12):2922-31. doi: 10.1002/1097-0142(19851215)56:12<2922::aid-cncr2820561233>3.0.co;2-l. PMID: 4052962
Adenosarcoma of the ovary. A light- and electron-microscopic study with review of the literature.
Czernobilsky B, Gillespie JJ, Roth LM
Diagn Gynecol Obstet 1982 Spring;4(1):25-36. PMID: 6280945

Clinical prediction guides

Synchronous ovarian and uterine mesonephric-like carcinoma that potentially arose from endometrioid adenofibroma: A case report.
Ishida K, Ashihara T, So M, Minamiguchi S, Matsumura N, Nonogaki T
J Obstet Gynaecol Res 2023 Mar;49(3):1052-1056. Epub 2023 Jan 3 doi: 10.1111/jog.15539. PMID: 36597276
Imaging in gynecological disease (16): clinical and ultrasound characteristics of serous cystadenofibromas in adnexa.
Virgilio BA, De Blasis I, Sladkevicius P, Moro F, Zannoni GF, Arciuolo D, Mascilini F, Ciccarone F, Timmerman D, Kaijser J, Fruscio R, Van Holsbeke C, Franchi D, Epstein E, Leone FPG, Guerriero S, Czekierdowski A, Scambia G, Testa AC, Valentin L
Ultrasound Obstet Gynecol 2019 Dec;54(6):823-830. doi: 10.1002/uog.20277. PMID: 30937992
Three-dimensional sonographic morphologic assessment in complex adnexal masses: preliminary experience.
Alcázar JL, Galán MJ, García-Manero M, Guerriero S
J Ultrasound Med 2003 Mar;22(3):249-54. doi: 10.7863/jum.2003.22.3.249. PMID: 12636324
Myometrial and stromal lesions of the uterus.
Smoot JS, Zaloudek C
Clin Lab Med 1995 Sep;15(3):545-73. PMID: 8542723
Uterine adenosarcoma: a clinicopathologic study of 11 cases with a reevaluation of histologic criteria.
Czernobilsky B, Hohlweg-Majert P, Dallenbach-Hellweg G
Arch Gynecol 1983;233(4):281-94. doi: 10.1007/BF02133803. PMID: 6318673

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