U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Female Reproductive System Adenofibroma

MedGen UID:
1626416
•Concept ID:
C4520837
•
Neoplastic Process

Definition

A benign or borderline neoplasm characterized by the presence of connective tissue stroma and epithelial structures. It occurs in the ovary, fallopian tube, uterine corpus, and cervix. [from NCI]

Professional guidelines

PubMed

Uterine adenosarcoma: a clinicopathologic study of 11 cases with a reevaluation of histologic criteria.
Czernobilsky B, Hohlweg-Majert P, Dallenbach-Hellweg G
Arch Gynecol 1983;233(4):281-94. doi: 10.1007/BF02133803. PMID: 6318673

Recent clinical studies

Etiology

Cystadenofibromas: Can transvaginal ultrasound appearance reduce some surgical interventions?
Goldstein SR, Timor-Tritsch IE, Monteagudo A, Monda S, Popiolek D
J Clin Ultrasound 2015 Jul-Aug;43(6):393-6. Epub 2014 Oct 1 doi: 10.1002/jcu.22241. PMID: 25271400
Pregnancy after laparoscopic bilateral partial ovarian decortication for stage IC borderline ovarian tumour.
Hamed AH, Emerson R, Bonaventura L, Saso S, Del Priore G
J Obstet Gynaecol Can 2014 Sep;36(9):826-829. doi: 10.1016/S1701-2163(15)30486-2. PMID: 25222363
Aspiration cytology of 147 adnexal cysts with histologic correlation.
Martínez-Onsurbe P, Ruiz Villaespesa A, Sanz Anquela JM, Valenzuela Ruiz PL
Acta Cytol 2001 Nov-Dec;45(6):941-7. doi: 10.1159/000328368. PMID: 11726122
Magnetic resonance imaging of benign ovarian masses.
Mawhinney RR, Powell MC, Worthington BS, Symonds EM
Br J Radiol 1988 Mar;61(723):179-86. doi: 10.1259/0007-1285-61-723-179. PMID: 3349259
Benign and borderline clear cell adenofibromas of the ovary.
Bell DA, Scully RE
Cancer 1985 Dec 15;56(12):2922-31. doi: 10.1002/1097-0142(19851215)56:12<2922::aid-cncr2820561233>3.0.co;2-l. PMID: 4052962

Diagnosis

A Rare Case of Bilateral Serous Cystadenofibroma in a Malignant Disguise.
Ansari SA, AlSindi K, Aldoseri F
Gulf J Oncolog 2022 Sep;1(40):67-70. PMID: 36448072
Three-dimensional ultrasound and HDlive in tubal serous cystadenofibroma: a case report and literature review.
Grigore M, Popovici R, Furnica C, Pristavu A, Hamod A, Gafitanu D
Med Ultrason 2017 Nov 29;19(4):444-446. doi: 10.11152/mu-986. PMID: 29197922
Fibrous tumours of the ovary: aetiologies and MRI features.
Montoriol PF, Mons A, Da Ines D, Bourdel N, Tixier L, Garcier JM
Clin Radiol 2013 Dec;68(12):1276-83. Epub 2013 Aug 9 doi: 10.1016/j.crad.2013.07.005. PMID: 23937826
A pathologist's road map to benign, precancerous, and malignant intraepithelial proliferations in the fallopian tube.
Mehrad M, Ning G, Chen EY, Mehra KK, Crum CP
Adv Anat Pathol 2010 Sep;17(5):293-302. doi: 10.1097/PAP.0b013e3181ecdee1. PMID: 20733351
My approach to the interpretation of endometrial biopsies and curettings.
McCluggage WG
J Clin Pathol 2006 Aug;59(8):801-12. doi: 10.1136/jcp.2005.029702. PMID: 16873562Free PMC Article

Therapy

Benign, borderline, and malignant endometrioid neoplasia arising in endometriosis in association with tamoxifen therapy.
McCluggage WG, Bryson C, Lamki H, Boyle DD
Int J Gynecol Pathol 2000 Jul;19(3):276-9. doi: 10.1097/00004347-200007000-00013. PMID: 10907178
Tamoxifen and the endometrium: review of 102 cases and comparison with HRT-related and non-HRT-related endometrial pathology.
Kennedy MM, Baigrie CF, Manek S
Int J Gynecol Pathol 1999 Apr;18(2):130-7. PMID: 10202670
Myometrial and stromal lesions of the uterus.
Smoot JS, Zaloudek C
Clin Lab Med 1995 Sep;15(3):545-73. PMID: 8542723
Epidemiology and endocrinology of benign breast disease.
Wang DY, Fentiman IS
Breast Cancer Res Treat 1985;6(1):5-36. doi: 10.1007/BF01806008. PMID: 3902125
The surgical pathology of the reproductive system and breast during oral contraceptive therapy.
Fechner RE
Pathol Annu 1971;6:299-319. PMID: 4949369

Prognosis

Ovarian Clear Cell Tumors Associated With Seromucinous Borderline Tumor: A Case Series.
Vroobel KM, McCluggage WG
Int J Gynecol Pathol 2022 Jan 1;41(1):76-81. doi: 10.1097/PGP.0000000000000768. PMID: 33741765
Focal calcifications in otherwise ultrasonographically normal ovaries.
Brandt KR, Thurmond AS, McCarthy JL
Radiology 1996 Feb;198(2):415-7. doi: 10.1148/radiology.198.2.8596842. PMID: 8596842
Magnetic resonance imaging of benign ovarian masses.
Mawhinney RR, Powell MC, Worthington BS, Symonds EM
Br J Radiol 1988 Mar;61(723):179-86. doi: 10.1259/0007-1285-61-723-179. PMID: 3349259
Benign and borderline clear cell adenofibromas of the ovary.
Bell DA, Scully RE
Cancer 1985 Dec 15;56(12):2922-31. doi: 10.1002/1097-0142(19851215)56:12<2922::aid-cncr2820561233>3.0.co;2-l. PMID: 4052962
Adenosarcoma of the ovary. A light- and electron-microscopic study with review of the literature.
Czernobilsky B, Gillespie JJ, Roth LM
Diagn Gynecol Obstet 1982 Spring;4(1):25-36. PMID: 6280945

Clinical prediction guides

A case of ovarian serous cystadenofibroma with scattered lesions in pelvic cavity, like malignant disseminations.
Fujita K, Ogawa C, Sako T, Utsumi F, Inada KI, Shibata K
J Obstet Gynaecol Res 2021 Dec;47(12):4496-4501. Epub 2021 Sep 6 doi: 10.1111/jog.15018. PMID: 34490687Free PMC Article
Aspiration cytology of 147 adnexal cysts with histologic correlation.
Martínez-Onsurbe P, Ruiz Villaespesa A, Sanz Anquela JM, Valenzuela Ruiz PL
Acta Cytol 2001 Nov-Dec;45(6):941-7. doi: 10.1159/000328368. PMID: 11726122
Accumulation of collagen in ovarian benign tumours.
Wolańska M, Sobolewski K, Bańkowski E, Drozdzewicz M
Acta Biochim Pol 1999;46(4):941-7. PMID: 10824863
Myometrial and stromal lesions of the uterus.
Smoot JS, Zaloudek C
Clin Lab Med 1995 Sep;15(3):545-73. PMID: 8542723
Magnetic resonance imaging of benign ovarian masses.
Mawhinney RR, Powell MC, Worthington BS, Symonds EM
Br J Radiol 1988 Mar;61(723):179-86. doi: 10.1259/0007-1285-61-723-179. PMID: 3349259

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...