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Locally Advanced Unresectable Cervical Adenocarcinoma

MedGen UID:
1651985
•Concept ID:
C4744726
•
Neoplastic Process

Definition

A cervical adenocarcinoma that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLocally Advanced Unresectable Cervical Adenocarcinoma

Professional guidelines

PubMed

Adenoid cystic carcinoma. An indolent but aggressive tumour. Part B: treatment and prognosis.
Cantù G
Acta Otorhinolaryngol Ital 2021 Aug;41(4):296-307. doi: 10.14639/0392-100X-N1729. PMID: 34533533Free PMC Article
Pembrolizumab for the treatment of esophageal cancer.
Yamamoto S, Kato K
Expert Opin Biol Ther 2020 Oct;20(10):1143-1150. Epub 2020 Jul 14 doi: 10.1080/14712598.2020.1792881. PMID: 32620063
Vandetanib for the treatment of medullary thyroid cancer.
Chau NG, Haddad RI
Clin Cancer Res 2013 Feb 1;19(3):524-9. Epub 2012 Dec 11 doi: 10.1158/1078-0432.CCR-12-2353. PMID: 23231950

Recent clinical studies

Etiology

Adenoid cystic carcinoma. An indolent but aggressive tumour. Part B: treatment and prognosis.
Cantù G
Acta Otorhinolaryngol Ital 2021 Aug;41(4):296-307. doi: 10.14639/0392-100X-N1729. PMID: 34533533Free PMC Article
Role of concurrent chemoradiation on locally advanced unresectable adenoid cystic carcinoma.
Ha H, Keam B, Ock CY, Kim TM, Kim JH, Chung EJ, Kwon SK, Ahn SH, Wu HG, Sung MW, Heo DS
Korean J Intern Med 2021 Jan;36(1):175-181. Epub 2020 Mar 30 doi: 10.3904/kjim.2019.104. PMID: 32218101Free PMC Article
Cabozantinib and vandetanib for unresectable locally advanced or metastatic medullary thyroid cancer: a systematic review and economic model.
Tappenden P, Carroll C, Hamilton J, Kaltenthaler E, Wong R, Wadsley J, Moss L, Balasubramanian S
Health Technol Assess 2019 Feb;23(8):1-144. doi: 10.3310/hta23080. PMID: 30821231Free PMC Article
Adjuvant and Neoadjuvant Therapy, Treatment for Advanced Disease, and Genetic Considerations for Adrenocortical Carcinoma: An Update from the SSO Endocrine and Head and Neck Disease Site Working Group.
Dickson PV, Kim L, Yen TWF, Yang A, Grubbs EG, Patel D, Solórzano CC
Ann Surg Oncol 2018 Nov;25(12):3453-3459. Epub 2018 Sep 14 doi: 10.1245/s10434-018-6750-9. PMID: 30218246
A prospective phase II study of combined androgen blockade in patients with androgen receptor-positive metastatic or locally advanced unresectable salivary gland carcinoma.
Fushimi C, Tada Y, Takahashi H, Nagao T, Ojiri H, Masubuchi T, Matsuki T, Miura K, Kawakita D, Hirai H, Hoshino E, Kamata S, Saotome T
Ann Oncol 2018 Apr 1;29(4):979-984. doi: 10.1093/annonc/mdx771. PMID: 29211833Free PMC Article

Diagnosis

Adenoid cystic carcinoma. An indolent but aggressive tumour. Part B: treatment and prognosis.
Cantù G
Acta Otorhinolaryngol Ital 2021 Aug;41(4):296-307. doi: 10.14639/0392-100X-N1729. PMID: 34533533Free PMC Article
KEYNOTE-975 study design: a Phase III study of definitive chemoradiotherapy plus pembrolizumab in patients with esophageal carcinoma.
Shah MA, Bennouna J, Doi T, Shen L, Kato K, Adenis A, Mamon HJ, Moehler M, Fu X, Cho BC, Bordia S, Bhagia P, Shih CS, Desai A, Enzinger P
Future Oncol 2021 Apr;17(10):1143-1153. Epub 2021 Feb 3 doi: 10.2217/fon-2020-0969. PMID: 33533655Free PMC Article
Role of concurrent chemoradiation on locally advanced unresectable adenoid cystic carcinoma.
Ha H, Keam B, Ock CY, Kim TM, Kim JH, Chung EJ, Kwon SK, Ahn SH, Wu HG, Sung MW, Heo DS
Korean J Intern Med 2021 Jan;36(1):175-181. Epub 2020 Mar 30 doi: 10.3904/kjim.2019.104. PMID: 32218101Free PMC Article
Pembrolizumab for the treatment of esophageal cancer.
Yamamoto S, Kato K
Expert Opin Biol Ther 2020 Oct;20(10):1143-1150. Epub 2020 Jul 14 doi: 10.1080/14712598.2020.1792881. PMID: 32620063
A prospective phase II study of combined androgen blockade in patients with androgen receptor-positive metastatic or locally advanced unresectable salivary gland carcinoma.
Fushimi C, Tada Y, Takahashi H, Nagao T, Ojiri H, Masubuchi T, Matsuki T, Miura K, Kawakita D, Hirai H, Hoshino E, Kamata S, Saotome T
Ann Oncol 2018 Apr 1;29(4):979-984. doi: 10.1093/annonc/mdx771. PMID: 29211833Free PMC Article

Therapy

KEYNOTE-975 study design: a Phase III study of definitive chemoradiotherapy plus pembrolizumab in patients with esophageal carcinoma.
Shah MA, Bennouna J, Doi T, Shen L, Kato K, Adenis A, Mamon HJ, Moehler M, Fu X, Cho BC, Bordia S, Bhagia P, Shih CS, Desai A, Enzinger P
Future Oncol 2021 Apr;17(10):1143-1153. Epub 2021 Feb 3 doi: 10.2217/fon-2020-0969. PMID: 33533655Free PMC Article
Role of concurrent chemoradiation on locally advanced unresectable adenoid cystic carcinoma.
Ha H, Keam B, Ock CY, Kim TM, Kim JH, Chung EJ, Kwon SK, Ahn SH, Wu HG, Sung MW, Heo DS
Korean J Intern Med 2021 Jan;36(1):175-181. Epub 2020 Mar 30 doi: 10.3904/kjim.2019.104. PMID: 32218101Free PMC Article
Pembrolizumab for the treatment of esophageal cancer.
Yamamoto S, Kato K
Expert Opin Biol Ther 2020 Oct;20(10):1143-1150. Epub 2020 Jul 14 doi: 10.1080/14712598.2020.1792881. PMID: 32620063
A prospective phase II study of combined androgen blockade in patients with androgen receptor-positive metastatic or locally advanced unresectable salivary gland carcinoma.
Fushimi C, Tada Y, Takahashi H, Nagao T, Ojiri H, Masubuchi T, Matsuki T, Miura K, Kawakita D, Hirai H, Hoshino E, Kamata S, Saotome T
Ann Oncol 2018 Apr 1;29(4):979-984. doi: 10.1093/annonc/mdx771. PMID: 29211833Free PMC Article
Vandetanib for the treatment of medullary thyroid cancer.
Chau NG, Haddad RI
Clin Cancer Res 2013 Feb 1;19(3):524-9. Epub 2012 Dec 11 doi: 10.1158/1078-0432.CCR-12-2353. PMID: 23231950

Prognosis

Adenoid cystic carcinoma. An indolent but aggressive tumour. Part B: treatment and prognosis.
Cantù G
Acta Otorhinolaryngol Ital 2021 Aug;41(4):296-307. doi: 10.14639/0392-100X-N1729. PMID: 34533533Free PMC Article
Anlotinib in Locally Advanced or Metastatic Medullary Thyroid Carcinoma: A Randomized, Double-Blind Phase IIB Trial.
Li D, Chi Y, Chen X, Ge M, Zhang Y, Guo Z, Wang J, Chen J, Zhang J, Cheng Y, Li Z, Liu H, Qin J, Zhu J, Cheng R, Xu Z, Zheng X, Tang P, Gao M
Clin Cancer Res 2021 Jul 1;27(13):3567-3575. Epub 2021 Apr 8 doi: 10.1158/1078-0432.CCR-20-2950. PMID: 33832949
Pembrolizumab for the treatment of esophageal cancer.
Yamamoto S, Kato K
Expert Opin Biol Ther 2020 Oct;20(10):1143-1150. Epub 2020 Jul 14 doi: 10.1080/14712598.2020.1792881. PMID: 32620063
Surufatinib in Chinese Patients with Locally Advanced or Metastatic Differentiated Thyroid Cancer and Medullary Thyroid Cancer: A Multicenter, Open-Label, Phase II Trial.
Chen J, Ji Q, Bai C, Zheng X, Zhang Y, Shi F, Li X, Tang P, Xu Z, Huang R, Huang T, Pan Y, Fan S, Zhou J, Su W
Thyroid 2020 Sep;30(9):1245-1253. Epub 2020 Apr 6 doi: 10.1089/thy.2019.0453. PMID: 32075524
Outcomes of nonsurgical management of locally advanced carcinomas of the sinonasal cavity.
Chopra S, Kamdar DP, Cohen DS, Heilbrun LK, Smith D, Kim H, Lin HS, Jacobs JR, Yoo G
Laryngoscope 2017 Apr;127(4):855-861. Epub 2016 Nov 15 doi: 10.1002/lary.26228. PMID: 27859278Free PMC Article

Clinical prediction guides

Concurrent chemoradiotherapy for locally advanced unresectable adenoid cystic carcinoma of head and neck: experience from a single institute.
Swain M, Ghosh-Laskar S, Budrukkar A, Patil R, Murthy V, Gupta T, Mummudi N, Prabhash K, Joshi A, Patil VM, Naronha V, Agarwal JP
Eur Arch Otorhinolaryngol 2021 Nov;278(11):4423-4431. Epub 2021 Feb 9 doi: 10.1007/s00405-021-06654-3. PMID: 33564909
Pembrolizumab for the treatment of esophageal cancer.
Yamamoto S, Kato K
Expert Opin Biol Ther 2020 Oct;20(10):1143-1150. Epub 2020 Jul 14 doi: 10.1080/14712598.2020.1792881. PMID: 32620063
Outcomes of nonsurgical management of locally advanced carcinomas of the sinonasal cavity.
Chopra S, Kamdar DP, Cohen DS, Heilbrun LK, Smith D, Kim H, Lin HS, Jacobs JR, Yoo G
Laryngoscope 2017 Apr;127(4):855-861. Epub 2016 Nov 15 doi: 10.1002/lary.26228. PMID: 27859278Free PMC Article
Particle radiotherapy using protons or carbon ions for unresectable locally advanced head and neck cancers with skull base invasion.
Morimoto K, Demizu Y, Hashimoto N, Mima M, Terashima K, Fujii O, Otsuki N, Murakami M, Fuwa N, Nibu K
Jpn J Clin Oncol 2014 May;44(5):428-34. Epub 2014 Mar 11 doi: 10.1093/jjco/hyu010. PMID: 24620027
Treatment of locally advanced adenoid cystic carcinoma of the head and neck with neutron radiotherapy.
Douglas JG, Laramore GE, Austin-Seymour M, Koh W, Stelzer K, Griffin TW
Int J Radiat Oncol Biol Phys 2000 Feb 1;46(3):551-7. doi: 10.1016/s0360-3016(99)00445-9. PMID: 10701733

Recent systematic reviews

Cabozantinib and vandetanib for unresectable locally advanced or metastatic medullary thyroid cancer: a systematic review and economic model.
Tappenden P, Carroll C, Hamilton J, Kaltenthaler E, Wong R, Wadsley J, Moss L, Balasubramanian S
Health Technol Assess 2019 Feb;23(8):1-144. doi: 10.3310/hta23080. PMID: 30821231Free PMC Article

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