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Locally Advanced Unresectable Cervical Adenocarcinoma

MedGen UID:
1651985
•Concept ID:
C4744726
•
Neoplastic Process

Definition

A cervical adenocarcinoma that has spread from its original site of growth to nearby tissues or lymph nodes and is not amenable to surgical resection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLocally Advanced Unresectable Cervical Adenocarcinoma

Professional guidelines

PubMed

Adenoid cystic carcinoma. An indolent but aggressive tumour. Part B: treatment and prognosis.
Cantù G
Acta Otorhinolaryngol Ital 2021 Aug;41(4):296-307. doi: 10.14639/0392-100X-N1729. PMID: 34533533Free PMC Article
Pembrolizumab for the treatment of esophageal cancer.
Yamamoto S, Kato K
Expert Opin Biol Ther 2020 Oct;20(10):1143-1150. Epub 2020 Jul 14 doi: 10.1080/14712598.2020.1792881. PMID: 32620063
Vandetanib for the treatment of medullary thyroid cancer.
Chau NG, Haddad RI
Clin Cancer Res 2013 Feb 1;19(3):524-9. Epub 2012 Dec 11 doi: 10.1158/1078-0432.CCR-12-2353. PMID: 23231950

Recent clinical studies

Etiology

Pancreaticoduodenectomy with celiac artery resection (PD-CAR) for unresctable locally advanced pancreatic ductal adenocarcinoma.
Kimura K, Amano R, Tauchi J, Nishio K, Ohira G, Shinkawa H, Tanaka S, Yamamoto A, Motomura H, Ishizawa T
Langenbecks Arch Surg 2023 May 4;408(1):174. doi: 10.1007/s00423-023-02860-1. PMID: 37140679
Adenoid cystic carcinoma. An indolent but aggressive tumour. Part B: treatment and prognosis.
Cantù G
Acta Otorhinolaryngol Ital 2021 Aug;41(4):296-307. doi: 10.14639/0392-100X-N1729. PMID: 34533533Free PMC Article
Role of concurrent chemoradiation on locally advanced unresectable adenoid cystic carcinoma.
Ha H, Keam B, Ock CY, Kim TM, Kim JH, Chung EJ, Kwon SK, Ahn SH, Wu HG, Sung MW, Heo DS
Korean J Intern Med 2021 Jan;36(1):175-181. Epub 2020 Mar 30 doi: 10.3904/kjim.2019.104. PMID: 32218101Free PMC Article
A prospective phase II study of combined androgen blockade in patients with androgen receptor-positive metastatic or locally advanced unresectable salivary gland carcinoma.
Fushimi C, Tada Y, Takahashi H, Nagao T, Ojiri H, Masubuchi T, Matsuki T, Miura K, Kawakita D, Hirai H, Hoshino E, Kamata S, Saotome T
Ann Oncol 2018 Apr 1;29(4):979-984. doi: 10.1093/annonc/mdx771. PMID: 29211833Free PMC Article
Surgery and postoperative radiotherapy in the management of extensive cancer of the cervical lymph nodes from an unknown primary.
Wax MK, Briant TD
J Otolaryngol 1993 Feb;22(1):34-8. PMID: 8383209

Diagnosis

Adenoid cystic carcinoma. An indolent but aggressive tumour. Part B: treatment and prognosis.
Cantù G
Acta Otorhinolaryngol Ital 2021 Aug;41(4):296-307. doi: 10.14639/0392-100X-N1729. PMID: 34533533Free PMC Article
KEYNOTE-975 study design: a Phase III study of definitive chemoradiotherapy plus pembrolizumab in patients with esophageal carcinoma.
Shah MA, Bennouna J, Doi T, Shen L, Kato K, Adenis A, Mamon HJ, Moehler M, Fu X, Cho BC, Bordia S, Bhagia P, Shih CS, Desai A, Enzinger P
Future Oncol 2021 Apr;17(10):1143-1153. Epub 2021 Feb 3 doi: 10.2217/fon-2020-0969. PMID: 33533655Free PMC Article
Role of concurrent chemoradiation on locally advanced unresectable adenoid cystic carcinoma.
Ha H, Keam B, Ock CY, Kim TM, Kim JH, Chung EJ, Kwon SK, Ahn SH, Wu HG, Sung MW, Heo DS
Korean J Intern Med 2021 Jan;36(1):175-181. Epub 2020 Mar 30 doi: 10.3904/kjim.2019.104. PMID: 32218101Free PMC Article
Pembrolizumab for the treatment of esophageal cancer.
Yamamoto S, Kato K
Expert Opin Biol Ther 2020 Oct;20(10):1143-1150. Epub 2020 Jul 14 doi: 10.1080/14712598.2020.1792881. PMID: 32620063
A prospective phase II study of combined androgen blockade in patients with androgen receptor-positive metastatic or locally advanced unresectable salivary gland carcinoma.
Fushimi C, Tada Y, Takahashi H, Nagao T, Ojiri H, Masubuchi T, Matsuki T, Miura K, Kawakita D, Hirai H, Hoshino E, Kamata S, Saotome T
Ann Oncol 2018 Apr 1;29(4):979-984. doi: 10.1093/annonc/mdx771. PMID: 29211833Free PMC Article

Therapy

Tislelizumab plus chemotherapy versus placebo plus chemotherapy as first line treatment for advanced gastric or gastro-oesophageal junction adenocarcinoma: RATIONALE-305 randomised, double blind, phase 3 trial.
Qiu MZ, Oh DY, Kato K, Arkenau T, Tabernero J, Correa MC, Zimina AV, Bai Y, Shi J, Lee KW, Wang J, Poddubskaya E, Pan H, Rha SY, Zhang R, Hirano H, Spigel D, Yamaguchi K, Chao Y, Wyrwicz L, Disel U, Cid RP, Fornaro L, Evesque L, Wang H, Xu Y, Li J, Sheng T, Yang S, Li L, Moehler M, Xu RH; RATIONALE-305 Investigators
BMJ 2024 May 28;385:e078876. doi: 10.1136/bmj-2023-078876. PMID: 38806195
Medullary thyroid carcinoma in children: current state of the art and future perspectives.
Kiriakopoulos A, Dimopoulou A, Nastos C, Dimopoulou D, Dimopoulou K, Menenakos E, Zavras N
J Pediatr Endocrinol Metab 2022 Jan 27;35(1):1-10. Epub 2021 Oct 1 doi: 10.1515/jpem-2021-0502. PMID: 34592078
KEYNOTE-975 study design: a Phase III study of definitive chemoradiotherapy plus pembrolizumab in patients with esophageal carcinoma.
Shah MA, Bennouna J, Doi T, Shen L, Kato K, Adenis A, Mamon HJ, Moehler M, Fu X, Cho BC, Bordia S, Bhagia P, Shih CS, Desai A, Enzinger P
Future Oncol 2021 Apr;17(10):1143-1153. Epub 2021 Feb 3 doi: 10.2217/fon-2020-0969. PMID: 33533655Free PMC Article
Pembrolizumab for the treatment of esophageal cancer.
Yamamoto S, Kato K
Expert Opin Biol Ther 2020 Oct;20(10):1143-1150. Epub 2020 Jul 14 doi: 10.1080/14712598.2020.1792881. PMID: 32620063
A prospective phase II study of combined androgen blockade in patients with androgen receptor-positive metastatic or locally advanced unresectable salivary gland carcinoma.
Fushimi C, Tada Y, Takahashi H, Nagao T, Ojiri H, Masubuchi T, Matsuki T, Miura K, Kawakita D, Hirai H, Hoshino E, Kamata S, Saotome T
Ann Oncol 2018 Apr 1;29(4):979-984. doi: 10.1093/annonc/mdx771. PMID: 29211833Free PMC Article

Prognosis

The SINTART 2 Study. A phase II non-randomised controlled trial of induction chemotherapy, photon-, proton- and carbon-ion-based radiotherapy integration in patients with locally advanced unresectable sinonasal tumours.
Bossi P, Orlandi E, Resteghini C, Vischioni B, Nicolai P, Castelnuovo P, Gambazza S, Locati LD, Turri-Zanoni M, Ferrari M, Facchinetti N, Iacovelli NA, Calareso G, Quattrone P, Cavallo A, Tuzi A, Licitra L
Eur J Cancer 2023 Jul;187:134-143. Epub 2023 Apr 7 doi: 10.1016/j.ejca.2023.03.034. PMID: 37163806
Proton therapy and/or helical tomotherapy for locally advanced sinonasal skull base adenoid cystic carcinoma: Focus on experience of the Institut Curie and review of literature.
Mavrikios A, Goudjil F, Beddok A, Zefkili S, Bolle S, Feuvret L, Le Tourneau C, Choussy O, Sauvaget E, Herman P, Dendale R, Calugaru V
Head Neck 2023 Jul;45(7):1619-1631. Epub 2023 Apr 25 doi: 10.1002/hed.27371. PMID: 37097003
Adenoid cystic carcinoma. An indolent but aggressive tumour. Part B: treatment and prognosis.
Cantù G
Acta Otorhinolaryngol Ital 2021 Aug;41(4):296-307. doi: 10.14639/0392-100X-N1729. PMID: 34533533Free PMC Article
Pembrolizumab for the treatment of esophageal cancer.
Yamamoto S, Kato K
Expert Opin Biol Ther 2020 Oct;20(10):1143-1150. Epub 2020 Jul 14 doi: 10.1080/14712598.2020.1792881. PMID: 32620063
Surgery and postoperative radiotherapy in the management of extensive cancer of the cervical lymph nodes from an unknown primary.
Wax MK, Briant TD
J Otolaryngol 1993 Feb;22(1):34-8. PMID: 8383209

Clinical prediction guides

Tislelizumab plus chemotherapy versus placebo plus chemotherapy as first line treatment for advanced gastric or gastro-oesophageal junction adenocarcinoma: RATIONALE-305 randomised, double blind, phase 3 trial.
Qiu MZ, Oh DY, Kato K, Arkenau T, Tabernero J, Correa MC, Zimina AV, Bai Y, Shi J, Lee KW, Wang J, Poddubskaya E, Pan H, Rha SY, Zhang R, Hirano H, Spigel D, Yamaguchi K, Chao Y, Wyrwicz L, Disel U, Cid RP, Fornaro L, Evesque L, Wang H, Xu Y, Li J, Sheng T, Yang S, Li L, Moehler M, Xu RH; RATIONALE-305 Investigators
BMJ 2024 May 28;385:e078876. doi: 10.1136/bmj-2023-078876. PMID: 38806195
The SINTART 2 Study. A phase II non-randomised controlled trial of induction chemotherapy, photon-, proton- and carbon-ion-based radiotherapy integration in patients with locally advanced unresectable sinonasal tumours.
Bossi P, Orlandi E, Resteghini C, Vischioni B, Nicolai P, Castelnuovo P, Gambazza S, Locati LD, Turri-Zanoni M, Ferrari M, Facchinetti N, Iacovelli NA, Calareso G, Quattrone P, Cavallo A, Tuzi A, Licitra L
Eur J Cancer 2023 Jul;187:134-143. Epub 2023 Apr 7 doi: 10.1016/j.ejca.2023.03.034. PMID: 37163806
Concurrent chemoradiotherapy for locally advanced unresectable adenoid cystic carcinoma of head and neck: experience from a single institute.
Swain M, Ghosh-Laskar S, Budrukkar A, Patil R, Murthy V, Gupta T, Mummudi N, Prabhash K, Joshi A, Patil VM, Naronha V, Agarwal JP
Eur Arch Otorhinolaryngol 2021 Nov;278(11):4423-4431. Epub 2021 Feb 9 doi: 10.1007/s00405-021-06654-3. PMID: 33564909
Pembrolizumab for the treatment of esophageal cancer.
Yamamoto S, Kato K
Expert Opin Biol Ther 2020 Oct;20(10):1143-1150. Epub 2020 Jul 14 doi: 10.1080/14712598.2020.1792881. PMID: 32620063
Imatinib mesylate as treatment for adenoid cystic carcinoma of the salivary glands: report of two successfully treated cases.
Alcedo JC, Fábrega JM, Arosemena JR, Urrutia A
Head Neck 2004 Sep;26(9):829-31. doi: 10.1002/hed.20094. PMID: 15350030

Recent systematic reviews

Cabozantinib and vandetanib for unresectable locally advanced or metastatic medullary thyroid cancer: a systematic review and economic model.
Tappenden P, Carroll C, Hamilton J, Kaltenthaler E, Wong R, Wadsley J, Moss L, Balasubramanian S
Health Technol Assess 2019 Feb;23(8):1-144. doi: 10.3310/hta23080. PMID: 30821231Free PMC Article

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