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Locally Advanced Adenocarcinoma

MedGen UID:
1718547
•Concept ID:
C5239285
•
Neoplastic Process

Definition

Adenocarcinoma that has spread to nearby tissues or lymph nodes. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLocally Advanced Adenocarcinoma

Professional guidelines

PubMed

Primary Surgery Not Inferior to Neoadjuvant Chemoradiotherapy for Esophageal Adenocarcinoma.
Bouckaert A, Moons J, Lerut T, Coosemans W, Depypere L, Van Veer H, Nafteux P
Ann Thorac Surg 2023 Sep;116(3):571-578. Epub 2023 Mar 30 doi: 10.1016/j.athoracsur.2023.02.060. PMID: 37003580
Management of Locally Advanced Adenocarcinoma of the Esophagus and Gastroesophageal Junction: Finally a Consensus.
Kleinberg L, Brock M, Gibson M
Curr Treat Options Oncol 2015 Jul;16(7):35. doi: 10.1007/s11864-015-0352-6. PMID: 26112428Free PMC Article
The role of neoadjuvant and adjuvant treatment for adenocarcinoma of the upper gastrointestinal tract.
Matuschek C, Bölke E, Peiper M, Knoefel WT, Budach W, Erhardt A, Scherer A, Gerber PA, Buhren BA, Gattermann N, Baldus SE, Rusnak E, Shukla V, Orth K
Eur J Med Res 2011 Jun 21;16(6):265-74. doi: 10.1186/2047-783x-16-6-265. PMID: 21810561Free PMC Article

Recent clinical studies

Etiology

Trimodality therapy versus perioperative chemotherapy in the management of locally advanced adenocarcinoma of the oesophagus and oesophagogastric junction (Neo-AEGIS): an open-label, randomised, phase 3 trial.
Reynolds JV, Preston SR, O'Neill B, Lowery MA, Baeksgaard L, Crosby T, Cunningham M, Cuffe S, Griffiths GO, Parker I, Risumlund SL, Roy R, Falk S, Hanna GB, Bartlett FR, Alvarez-Iglesias A, Achiam MP, Nilsson M, Piessen G, Ravi N, O'Toole D, Johnston C, McDermott RS, Turkington RC, Wahed S, Sothi S, Ford H, Wadley MS, Power D; Neo-AEGIS Investigators and Trial Group
Lancet Gastroenterol Hepatol 2023 Nov;8(11):1015-1027. Epub 2023 Sep 18 doi: 10.1016/S2468-1253(23)00243-1. PMID: 37734399Free PMC Article
The immune microenvironment landscape shows treatment-specific differences in rectal cancer patients.
Graham Martínez C, Barella Y, Kus Öztürk S, Ansems M, Gorris MAJ, van Vliet S, Marijnen CAM, Nagtegaal ID
Front Immunol 2022;13:1011498. Epub 2022 Sep 27 doi: 10.3389/fimmu.2022.1011498. PMID: 36238289Free PMC Article
Rethinking the significance of surgery for uterine cervical cancer.
Shimada M, Tsuji K, Shigeta S, Nagai T, Watanabe Z, Tokunaga H, Kigawa J, Yaegashi N
J Obstet Gynaecol Res 2022 Mar;48(3):576-586. Epub 2021 Dec 14 doi: 10.1111/jog.15112. PMID: 34908207
Preoperative chemotherapy versus chemoradiotherapy in locally advanced adenocarcinomas of the oesophagogastric junction (POET): Long-term results of a controlled randomised trial.
Stahl M, Walz MK, Riera-Knorrenschild J, Stuschke M, Sandermann A, Bitzer M, Wilke H, Budach W
Eur J Cancer 2017 Aug;81:183-190. doi: 10.1016/j.ejca.2017.04.027. PMID: 28628843
Hypertensive late hemothorax following left pneumonectomy.
Rus O, Motas C, Motas N, Achim D, Horvat T
Chirurgia (Bucur) 2014 Nov-Dec;109(6):827-31. PMID: 25560508

Diagnosis

Hypertensive late hemothorax following left pneumonectomy.
Rus O, Motas C, Motas N, Achim D, Horvat T
Chirurgia (Bucur) 2014 Nov-Dec;109(6):827-31. PMID: 25560508
Advanced-stage pancreatic cancer: therapy options.
Werner J, Combs SE, Springfeld C, Hartwig W, Hackert T, Büchler MW
Nat Rev Clin Oncol 2013 Jun;10(6):323-33. Epub 2013 Apr 30 doi: 10.1038/nrclinonc.2013.66. PMID: 23629472
Pancreatic adenocarcinoma in paraduodenal pancreatitis: a note of caution for conservative treatments.
Patriti A, Castellani D, Partenzi A, Carlani M, Casciola L
Updates Surg 2012 Dec;64(4):307-9. Epub 2011 Aug 25 doi: 10.1007/s13304-011-0106-3. PMID: 21866417
Radical prostatectomy for the patient with locally advanced prostate cancer.
Ward JF, Zincke H
Curr Urol Rep 2003 Jun;4(3):196-204. doi: 10.1007/s11934-003-0069-0. PMID: 12756082
Optimising treatment for resectable rectal cancer: is preoperative therapy beneficial?
Ngan SY
Drugs Aging 2001;18(2):79-85. doi: 10.2165/00002512-200118020-00001. PMID: 11346129

Therapy

Trimodality therapy versus perioperative chemotherapy in the management of locally advanced adenocarcinoma of the oesophagus and oesophagogastric junction (Neo-AEGIS): an open-label, randomised, phase 3 trial.
Reynolds JV, Preston SR, O'Neill B, Lowery MA, Baeksgaard L, Crosby T, Cunningham M, Cuffe S, Griffiths GO, Parker I, Risumlund SL, Roy R, Falk S, Hanna GB, Bartlett FR, Alvarez-Iglesias A, Achiam MP, Nilsson M, Piessen G, Ravi N, O'Toole D, Johnston C, McDermott RS, Turkington RC, Wahed S, Sothi S, Ford H, Wadley MS, Power D; Neo-AEGIS Investigators and Trial Group
Lancet Gastroenterol Hepatol 2023 Nov;8(11):1015-1027. Epub 2023 Sep 18 doi: 10.1016/S2468-1253(23)00243-1. PMID: 37734399Free PMC Article
Preoperative chemotherapy versus chemoradiotherapy in locally advanced adenocarcinomas of the oesophagogastric junction (POET): Long-term results of a controlled randomised trial.
Stahl M, Walz MK, Riera-Knorrenschild J, Stuschke M, Sandermann A, Bitzer M, Wilke H, Budach W
Eur J Cancer 2017 Aug;81:183-190. doi: 10.1016/j.ejca.2017.04.027. PMID: 28628843
Hypertensive late hemothorax following left pneumonectomy.
Rus O, Motas C, Motas N, Achim D, Horvat T
Chirurgia (Bucur) 2014 Nov-Dec;109(6):827-31. PMID: 25560508
Capecitabine induced cardiotoxicity: a case report and review of literature.
Tunio MA, Hashmi A, Shoaib M
Pak J Pharm Sci 2012 Jan;25(1):277-81. PMID: 22186341
CPT-11 and concomitant hyperfractionated accelerated radiotherapy induce efficient local control in rectal cancer patients: results from a phase II.
Voelter V, Zouhair A, Vuilleumier H, Matter M, Bouzourene H, Leyvraz S, Bauer J, Coucke P, Stupp R
Br J Cancer 2006 Sep 18;95(6):710-6. Epub 2006 Aug 29 doi: 10.1038/sj.bjc.6603322. PMID: 16940980Free PMC Article

Prognosis

Prognosis after neoadjuvant chemoradiation or chemotherapy for locally advanced gastro-oesophageal junctional adenocarcinoma.
Vos EL, Carr RA, Hsu M, Nakauchi M, Nobel T, Russo A, Barbetta A, Tan KS, Tang L, Ilson D, Ku GY, Wu AJ, Janjigian YY, Yoon SS, Bains MS, Jones DR, Coit D, Molena D, Strong VE
Br J Surg 2021 Nov 11;108(11):1332-1340. doi: 10.1093/bjs/znab228. PMID: 34476473Free PMC Article
Hypertensive late hemothorax following left pneumonectomy.
Rus O, Motas C, Motas N, Achim D, Horvat T
Chirurgia (Bucur) 2014 Nov-Dec;109(6):827-31. PMID: 25560508
Advanced-stage pancreatic cancer: therapy options.
Werner J, Combs SE, Springfeld C, Hartwig W, Hackert T, Büchler MW
Nat Rev Clin Oncol 2013 Jun;10(6):323-33. Epub 2013 Apr 30 doi: 10.1038/nrclinonc.2013.66. PMID: 23629472
CPT-11 and concomitant hyperfractionated accelerated radiotherapy induce efficient local control in rectal cancer patients: results from a phase II.
Voelter V, Zouhair A, Vuilleumier H, Matter M, Bouzourene H, Leyvraz S, Bauer J, Coucke P, Stupp R
Br J Cancer 2006 Sep 18;95(6):710-6. Epub 2006 Aug 29 doi: 10.1038/sj.bjc.6603322. PMID: 16940980Free PMC Article
Radical prostatectomy for the patient with locally advanced prostate cancer.
Ward JF, Zincke H
Curr Urol Rep 2003 Jun;4(3):196-204. doi: 10.1007/s11934-003-0069-0. PMID: 12756082

Clinical prediction guides

Locally Advanced Adenocarcinoma of the Esophagus: Is Esophagectomy Associated with Improved Overall Survival?
Kramer SP, Swanson J, Fernando M, Park S, Verm R, Abdelsattar Z, Cohn T, Luchette FA, Baker MS
J Am Coll Surg 2024 Jul 1;239(1):68-75. Epub 2024 Mar 14 doi: 10.1097/XCS.0000000000001073. PMID: 38483131
Primary Surgery Not Inferior to Neoadjuvant Chemoradiotherapy for Esophageal Adenocarcinoma.
Bouckaert A, Moons J, Lerut T, Coosemans W, Depypere L, Van Veer H, Nafteux P
Ann Thorac Surg 2023 Sep;116(3):571-578. Epub 2023 Mar 30 doi: 10.1016/j.athoracsur.2023.02.060. PMID: 37003580
Hypertensive late hemothorax following left pneumonectomy.
Rus O, Motas C, Motas N, Achim D, Horvat T
Chirurgia (Bucur) 2014 Nov-Dec;109(6):827-31. PMID: 25560508
Advanced-stage pancreatic cancer: therapy options.
Werner J, Combs SE, Springfeld C, Hartwig W, Hackert T, Büchler MW
Nat Rev Clin Oncol 2013 Jun;10(6):323-33. Epub 2013 Apr 30 doi: 10.1038/nrclinonc.2013.66. PMID: 23629472
Hormones and radiation therapy in locally advanced adenocarcinoma of the prostate.
Lawton CA
Semin Radiat Oncol 2003 Apr;13(2):141-51. doi: 10.1053/srao.2003.50013. PMID: 12728443

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