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Locally Advanced Adenocarcinoma

MedGen UID:
1718547
•Concept ID:
C5239285
•
Neoplastic Process

Definition

Adenocarcinoma that has spread to nearby tissues or lymph nodes. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLocally Advanced Adenocarcinoma

Professional guidelines

PubMed

Primary Surgery Not Inferior to Neoadjuvant Chemoradiotherapy for Esophageal Adenocarcinoma.
Bouckaert A, Moons J, Lerut T, Coosemans W, Depypere L, Van Veer H, Nafteux P
Ann Thorac Surg 2023 Sep;116(3):571-578. Epub 2023 Mar 30 doi: 10.1016/j.athoracsur.2023.02.060. PMID: 37003580
Management of Locally Advanced Adenocarcinoma of the Esophagus and Gastroesophageal Junction: Finally a Consensus.
Kleinberg L, Brock M, Gibson M
Curr Treat Options Oncol 2015 Jul;16(7):35. doi: 10.1007/s11864-015-0352-6. PMID: 26112428Free PMC Article
The role of neoadjuvant and adjuvant treatment for adenocarcinoma of the upper gastrointestinal tract.
Matuschek C, Bölke E, Peiper M, Knoefel WT, Budach W, Erhardt A, Scherer A, Gerber PA, Buhren BA, Gattermann N, Baldus SE, Rusnak E, Shukla V, Orth K
Eur J Med Res 2011 Jun 21;16(6):265-74. doi: 10.1186/2047-783x-16-6-265. PMID: 21810561Free PMC Article

Recent clinical studies

Etiology

Trimodality therapy versus perioperative chemotherapy in the management of locally advanced adenocarcinoma of the oesophagus and oesophagogastric junction (Neo-AEGIS): an open-label, randomised, phase 3 trial.
Reynolds JV, Preston SR, O'Neill B, Lowery MA, Baeksgaard L, Crosby T, Cunningham M, Cuffe S, Griffiths GO, Parker I, Risumlund SL, Roy R, Falk S, Hanna GB, Bartlett FR, Alvarez-Iglesias A, Achiam MP, Nilsson M, Piessen G, Ravi N, O'Toole D, Johnston C, McDermott RS, Turkington RC, Wahed S, Sothi S, Ford H, Wadley MS, Power D; Neo-AEGIS Investigators and Trial Group
Lancet Gastroenterol Hepatol 2023 Nov;8(11):1015-1027. Epub 2023 Sep 18 doi: 10.1016/S2468-1253(23)00243-1. PMID: 37734399Free PMC Article
Prognosis after neoadjuvant chemoradiation or chemotherapy for locally advanced gastro-oesophageal junctional adenocarcinoma.
Vos EL, Carr RA, Hsu M, Nakauchi M, Nobel T, Russo A, Barbetta A, Tan KS, Tang L, Ilson D, Ku GY, Wu AJ, Janjigian YY, Yoon SS, Bains MS, Jones DR, Coit D, Molena D, Strong VE
Br J Surg 2021 Nov 11;108(11):1332-1340. doi: 10.1093/bjs/znab228. PMID: 34476473Free PMC Article
Preoperative chemotherapy versus chemoradiotherapy in locally advanced adenocarcinomas of the oesophagogastric junction (POET): Long-term results of a controlled randomised trial.
Stahl M, Walz MK, Riera-Knorrenschild J, Stuschke M, Sandermann A, Bitzer M, Wilke H, Budach W
Eur J Cancer 2017 Aug;81:183-190. doi: 10.1016/j.ejca.2017.04.027. PMID: 28628843
Locally advanced esophageal adenocarcinoma: response to neoadjuvant chemotherapy and survival predicted by ([18F])FDG-PET/CT.
Kauppi JT, Oksala N, Salo JA, Helin H, Karhumäki L, Kemppainen J, Sihvo EI, Räsänen JV
Acta Oncol 2012 May;51(5):636-44. Epub 2012 Jan 2 doi: 10.3109/0284186X.2011.643822. PMID: 22208782
Combinations of hormones and local therapies in locally advanced prostate carcinoma.
Eulau SM, Corn BW
Oncology (Williston Park) 1996 Aug;10(8):1193-202; discussion 1207-14. PMID: 8869960

Diagnosis

Prognosis after neoadjuvant chemoradiation or chemotherapy for locally advanced gastro-oesophageal junctional adenocarcinoma.
Vos EL, Carr RA, Hsu M, Nakauchi M, Nobel T, Russo A, Barbetta A, Tan KS, Tang L, Ilson D, Ku GY, Wu AJ, Janjigian YY, Yoon SS, Bains MS, Jones DR, Coit D, Molena D, Strong VE
Br J Surg 2021 Nov 11;108(11):1332-1340. doi: 10.1093/bjs/znab228. PMID: 34476473Free PMC Article
Advanced-stage pancreatic cancer: therapy options.
Werner J, Combs SE, Springfeld C, Hartwig W, Hackert T, Büchler MW
Nat Rev Clin Oncol 2013 Jun;10(6):323-33. Epub 2013 Apr 30 doi: 10.1038/nrclinonc.2013.66. PMID: 23629472
Locally advanced esophageal adenocarcinoma: response to neoadjuvant chemotherapy and survival predicted by ([18F])FDG-PET/CT.
Kauppi JT, Oksala N, Salo JA, Helin H, Karhumäki L, Kemppainen J, Sihvo EI, Räsänen JV
Acta Oncol 2012 May;51(5):636-44. Epub 2012 Jan 2 doi: 10.3109/0284186X.2011.643822. PMID: 22208782
Locally advanced pancreatic cancer: current therapeutic approach.
Cardenes HR, Chiorean EG, Dewitt J, Schmidt M, Loehrer P
Oncologist 2006 Jun;11(6):612-23. doi: 10.1634/theoncologist.11-6-612. PMID: 16794240
Preoperative chemoradiation for resectable and locally advanced adenocarcinoma of the pancreas.
Evans DB
J Gastrointest Surg 2001 Jan-Feb;5(1):2-5. doi: 10.1016/s1091-255x(01)80002-0. PMID: 11370617

Therapy

Trimodality therapy versus perioperative chemotherapy in the management of locally advanced adenocarcinoma of the oesophagus and oesophagogastric junction (Neo-AEGIS): an open-label, randomised, phase 3 trial.
Reynolds JV, Preston SR, O'Neill B, Lowery MA, Baeksgaard L, Crosby T, Cunningham M, Cuffe S, Griffiths GO, Parker I, Risumlund SL, Roy R, Falk S, Hanna GB, Bartlett FR, Alvarez-Iglesias A, Achiam MP, Nilsson M, Piessen G, Ravi N, O'Toole D, Johnston C, McDermott RS, Turkington RC, Wahed S, Sothi S, Ford H, Wadley MS, Power D; Neo-AEGIS Investigators and Trial Group
Lancet Gastroenterol Hepatol 2023 Nov;8(11):1015-1027. Epub 2023 Sep 18 doi: 10.1016/S2468-1253(23)00243-1. PMID: 37734399Free PMC Article
Preoperative chemotherapy versus chemoradiotherapy in locally advanced adenocarcinomas of the oesophagogastric junction (POET): Long-term results of a controlled randomised trial.
Stahl M, Walz MK, Riera-Knorrenschild J, Stuschke M, Sandermann A, Bitzer M, Wilke H, Budach W
Eur J Cancer 2017 Aug;81:183-190. doi: 10.1016/j.ejca.2017.04.027. PMID: 28628843
Management of Locally Advanced Adenocarcinoma of the Esophagus and Gastroesophageal Junction: Finally a Consensus.
Kleinberg L, Brock M, Gibson M
Curr Treat Options Oncol 2015 Jul;16(7):35. doi: 10.1007/s11864-015-0352-6. PMID: 26112428Free PMC Article
Therapy for locally advanced adenocarcinoma of the gastroesophageal junction: optimizing outcome.
Kleinberg L
Semin Radiat Oncol 2013 Jan;23(1):38-50. doi: 10.1016/j.semradonc.2012.10.001. PMID: 23207046
The role of neoadjuvant and adjuvant treatment for adenocarcinoma of the upper gastrointestinal tract.
Matuschek C, Bölke E, Peiper M, Knoefel WT, Budach W, Erhardt A, Scherer A, Gerber PA, Buhren BA, Gattermann N, Baldus SE, Rusnak E, Shukla V, Orth K
Eur J Med Res 2011 Jun 21;16(6):265-74. doi: 10.1186/2047-783x-16-6-265. PMID: 21810561Free PMC Article

Prognosis

Prognosis after neoadjuvant chemoradiation or chemotherapy for locally advanced gastro-oesophageal junctional adenocarcinoma.
Vos EL, Carr RA, Hsu M, Nakauchi M, Nobel T, Russo A, Barbetta A, Tan KS, Tang L, Ilson D, Ku GY, Wu AJ, Janjigian YY, Yoon SS, Bains MS, Jones DR, Coit D, Molena D, Strong VE
Br J Surg 2021 Nov 11;108(11):1332-1340. doi: 10.1093/bjs/znab228. PMID: 34476473Free PMC Article
Management of Locally Advanced Adenocarcinoma of the Esophagus and Gastroesophageal Junction: Finally a Consensus.
Kleinberg L, Brock M, Gibson M
Curr Treat Options Oncol 2015 Jul;16(7):35. doi: 10.1007/s11864-015-0352-6. PMID: 26112428Free PMC Article
Advanced-stage pancreatic cancer: therapy options.
Werner J, Combs SE, Springfeld C, Hartwig W, Hackert T, Büchler MW
Nat Rev Clin Oncol 2013 Jun;10(6):323-33. Epub 2013 Apr 30 doi: 10.1038/nrclinonc.2013.66. PMID: 23629472
Locally advanced esophageal adenocarcinoma: response to neoadjuvant chemotherapy and survival predicted by ([18F])FDG-PET/CT.
Kauppi JT, Oksala N, Salo JA, Helin H, Karhumäki L, Kemppainen J, Sihvo EI, Räsänen JV
Acta Oncol 2012 May;51(5):636-44. Epub 2012 Jan 2 doi: 10.3109/0284186X.2011.643822. PMID: 22208782
The role of neoadjuvant and adjuvant treatment for adenocarcinoma of the upper gastrointestinal tract.
Matuschek C, Bölke E, Peiper M, Knoefel WT, Budach W, Erhardt A, Scherer A, Gerber PA, Buhren BA, Gattermann N, Baldus SE, Rusnak E, Shukla V, Orth K
Eur J Med Res 2011 Jun 21;16(6):265-74. doi: 10.1186/2047-783x-16-6-265. PMID: 21810561Free PMC Article

Clinical prediction guides

Locally Advanced Adenocarcinoma of the Esophagus: Is Esophagectomy Associated with Improved Overall Survival?
Kramer SP, Swanson J, Fernando M, Park S, Verm R, Abdelsattar Z, Cohn T, Luchette FA, Baker MS
J Am Coll Surg 2024 Jul 1;239(1):68-75. Epub 2024 Mar 14 doi: 10.1097/XCS.0000000000001073. PMID: 38483131
Neoadjuvant chemoradiation versus adjuvant chemotherapy for locally advanced adenocarcinoma of the rectosigmoid junction.
Salami AC, Obaid T, Nweze NJ, Deleon M, Force L, Gorgun E, Wexner S, Joshi ART
Colorectal Dis 2020 May;22(5):513-520. Epub 2019 Dec 20 doi: 10.1111/codi.14918. PMID: 31782601
Advanced-stage pancreatic cancer: therapy options.
Werner J, Combs SE, Springfeld C, Hartwig W, Hackert T, Büchler MW
Nat Rev Clin Oncol 2013 Jun;10(6):323-33. Epub 2013 Apr 30 doi: 10.1038/nrclinonc.2013.66. PMID: 23629472
Locally advanced esophageal adenocarcinoma: response to neoadjuvant chemotherapy and survival predicted by ([18F])FDG-PET/CT.
Kauppi JT, Oksala N, Salo JA, Helin H, Karhumäki L, Kemppainen J, Sihvo EI, Räsänen JV
Acta Oncol 2012 May;51(5):636-44. Epub 2012 Jan 2 doi: 10.3109/0284186X.2011.643822. PMID: 22208782
Hormones and radiation therapy in locally advanced adenocarcinoma of the prostate.
Lawton CA
Semin Radiat Oncol 2003 Apr;13(2):141-51. doi: 10.1053/srao.2003.50013. PMID: 12728443

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