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Locally Advanced Basal Cell Carcinoma

MedGen UID:
1652163
•Concept ID:
C4745056
•
Neoplastic Process

Definition

A basal cell carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLocally Advanced Basal Cell Carcinoma

Professional guidelines

PubMed

Sonidegib in the Treatment of Locally Advanced Basal Cell Carcinoma.
Sanmartín O, Llombart B, Carretero Hernández G, Flórez Menéndez Á, Botella-Estrada R, Herrera Ceballos E, Puig S
Actas Dermosifiliogr (Engl Ed) 2021 Apr;112(4):295-301. Epub 2020 Nov 13 doi: 10.1016/j.ad.2020.11.002. PMID: 33197438
Sonidegib and vismodegib in the treatment of patients with locally advanced basal cell carcinoma: a joint expert opinion.
Dummer R, Ascierto PA, Basset-Seguin N, Dréno B, Garbe C, Gutzmer R, Hauschild A, Krattinger R, Lear JT, Malvehy J, Schadendorf D, Grob JJ
J Eur Acad Dermatol Venereol 2020 Sep;34(9):1944-1956. Epub 2020 Mar 4 doi: 10.1111/jdv.16230. PMID: 31990414
Hedgehog Pathway Inhibition for the Treatment of Basal Cell Carcinoma.
Gutzmer R, Solomon JA
Target Oncol 2019 Jun;14(3):253-267. doi: 10.1007/s11523-019-00648-2. PMID: 31243642

Recent clinical studies

Etiology

Vismodegib in Locally Advanced Basal Cell Carcinoma in Slovenia.
Mesti T, Sever M, Ocvirk J
Dermatology 2023;239(1):158-164. Epub 2022 Jul 27 doi: 10.1159/000525612. PMID: 35896082Free PMC Article
Cemiplimab for locally advanced and metastatic basal cell carcinoma.
Damsin T, Lebas E, Marchal N, Rorive A, Nikkels AF
Expert Rev Anticancer Ther 2022 Mar;22(3):243-248. Epub 2022 Feb 22 doi: 10.1080/14737140.2022.2043748. PMID: 35175882
Cemiplimab in locally advanced basal cell carcinoma after hedgehog inhibitor therapy: an open-label, multi-centre, single-arm, phase 2 trial.
Stratigos AJ, Sekulic A, Peris K, Bechter O, Prey S, Kaatz M, Lewis KD, Basset-Seguin N, Chang ALS, Dalle S, Orland AF, Licitra L, Robert C, Ulrich C, Hauschild A, Migden MR, Dummer R, Li S, Yoo SY, Mohan K, Coates E, Jankovic V, Fiaschi N, Okoye E, Bassukas ID, Loquai C, De Giorgi V, Eroglu Z, Gutzmer R, Ulrich J, Puig S, Seebach F, Thurston G, Weinreich DM, Yancopoulos GD, Lowy I, Bowler T, Fury MG
Lancet Oncol 2021 Jun;22(6):848-857. Epub 2021 May 14 doi: 10.1016/S1470-2045(21)00126-1. PMID: 34000246
Sonidegib and vismodegib in the treatment of patients with locally advanced basal cell carcinoma: a joint expert opinion.
Dummer R, Ascierto PA, Basset-Seguin N, Dréno B, Garbe C, Gutzmer R, Hauschild A, Krattinger R, Lear JT, Malvehy J, Schadendorf D, Grob JJ
J Eur Acad Dermatol Venereol 2020 Sep;34(9):1944-1956. Epub 2020 Mar 4 doi: 10.1111/jdv.16230. PMID: 31990414
Defining and recognising locally advanced basal cell carcinoma.
Amici JM, Battistella M, Beylot-Barry M, Chatellier A, Dalac-Ra S, Dreno B, Falandry C, Froget N, Giacchero D, Grob JJ, Guerreschir P, Leccia MT, Malard O, Mortier L, Routier E, Stefan A, Stefan D, Stoebner PE, Basset-Seguin N
Eur J Dermatol 2015 Nov-Dec;25(6):586-94. doi: 10.1684/ejd.2015.2641. PMID: 26574792

Diagnosis

Treatments on the horizon for locally advanced basal cell carcinoma.
Idriss MH, Stull CM, Migden MR
Cancer Lett 2024 May 1;589:216821. Epub 2024 Mar 21 doi: 10.1016/j.canlet.2024.216821. PMID: 38521198
Vismodegib in Locally Advanced Basal Cell Carcinoma in Slovenia.
Mesti T, Sever M, Ocvirk J
Dermatology 2023;239(1):158-164. Epub 2022 Jul 27 doi: 10.1159/000525612. PMID: 35896082Free PMC Article
Current Perspectives in the Treatment of Locally Advanced Basal Cell Carcinoma.
Gupta N, Ruiz ES
Drug Des Devel Ther 2022;16:183-190. Epub 2022 Jan 14 doi: 10.2147/DDDT.S325852. PMID: 35058688Free PMC Article
Cemiplimab in locally advanced basal cell carcinoma after hedgehog inhibitor therapy: an open-label, multi-centre, single-arm, phase 2 trial.
Stratigos AJ, Sekulic A, Peris K, Bechter O, Prey S, Kaatz M, Lewis KD, Basset-Seguin N, Chang ALS, Dalle S, Orland AF, Licitra L, Robert C, Ulrich C, Hauschild A, Migden MR, Dummer R, Li S, Yoo SY, Mohan K, Coates E, Jankovic V, Fiaschi N, Okoye E, Bassukas ID, Loquai C, De Giorgi V, Eroglu Z, Gutzmer R, Ulrich J, Puig S, Seebach F, Thurston G, Weinreich DM, Yancopoulos GD, Lowy I, Bowler T, Fury MG
Lancet Oncol 2021 Jun;22(6):848-857. Epub 2021 May 14 doi: 10.1016/S1470-2045(21)00126-1. PMID: 34000246
Hedgehog Pathway Inhibition for the Treatment of Basal Cell Carcinoma.
Gutzmer R, Solomon JA
Target Oncol 2019 Jun;14(3):253-267. doi: 10.1007/s11523-019-00648-2. PMID: 31243642

Therapy

Cemiplimab in locally advanced basal cell carcinoma after hedgehog inhibitor therapy: an open-label, multi-centre, single-arm, phase 2 trial.
Stratigos AJ, Sekulic A, Peris K, Bechter O, Prey S, Kaatz M, Lewis KD, Basset-Seguin N, Chang ALS, Dalle S, Orland AF, Licitra L, Robert C, Ulrich C, Hauschild A, Migden MR, Dummer R, Li S, Yoo SY, Mohan K, Coates E, Jankovic V, Fiaschi N, Okoye E, Bassukas ID, Loquai C, De Giorgi V, Eroglu Z, Gutzmer R, Ulrich J, Puig S, Seebach F, Thurston G, Weinreich DM, Yancopoulos GD, Lowy I, Bowler T, Fury MG
Lancet Oncol 2021 Jun;22(6):848-857. Epub 2021 May 14 doi: 10.1016/S1470-2045(21)00126-1. PMID: 34000246
Sonidegib in the Treatment of Locally Advanced Basal Cell Carcinoma.
Sanmartín O, Llombart B, Carretero Hernández G, Flórez Menéndez Á, Botella-Estrada R, Herrera Ceballos E, Puig S
Actas Dermosifiliogr (Engl Ed) 2021 Apr;112(4):295-301. Epub 2020 Nov 13 doi: 10.1016/j.ad.2020.11.002. PMID: 33197438
Sonidegib and vismodegib in the treatment of patients with locally advanced basal cell carcinoma: a joint expert opinion.
Dummer R, Ascierto PA, Basset-Seguin N, Dréno B, Garbe C, Gutzmer R, Hauschild A, Krattinger R, Lear JT, Malvehy J, Schadendorf D, Grob JJ
J Eur Acad Dermatol Venereol 2020 Sep;34(9):1944-1956. Epub 2020 Mar 4 doi: 10.1111/jdv.16230. PMID: 31990414
Sonidegib: A Review in Locally Advanced Basal Cell Carcinoma.
Burness CB, Scott LJ
Target Oncol 2016 Apr;11(2):239-46. doi: 10.1007/s11523-016-0418-9. PMID: 26867946
Efficacy and safety of vismodegib in advanced basal-cell carcinoma.
Sekulic A, Migden MR, Oro AE, Dirix L, Lewis KD, Hainsworth JD, Solomon JA, Yoo S, Arron ST, Friedlander PA, Marmur E, Rudin CM, Chang AL, Low JA, Mackey HM, Yauch RL, Graham RA, Reddy JC, Hauschild A
N Engl J Med 2012 Jun 7;366(23):2171-9. doi: 10.1056/NEJMoa1113713. PMID: 22670903Free PMC Article

Prognosis

Treatments on the horizon for locally advanced basal cell carcinoma.
Idriss MH, Stull CM, Migden MR
Cancer Lett 2024 May 1;589:216821. Epub 2024 Mar 21 doi: 10.1016/j.canlet.2024.216821. PMID: 38521198
Safety and efficacy of nivolumab, an anti-PD1 immunotherapy, in patients with advanced basal cell carcinoma, after failure or intolerance to sonic Hedgehog inhibitors: UNICANCER AcSé NIVOLUMAB trial.
Véron M, Chevret S, Grob JJ, Beylot-Barry M, Saiag P, Fléchon A, You B, Maubec E, Jouary T, Toulemonde E, Jamme P, Gambotti L, Lamrani-Ghaouti A, Dupuy A, Lebbe C, Seguin NB, Houede N, Leccia MT, Le Du F, de Pontville M, Gaudy-Marquestre C, Guillot B, Simon C, Marabelle A, Mortier L
Eur J Cancer 2022 Dec;177:103-111. Epub 2022 Oct 11 doi: 10.1016/j.ejca.2022.09.013. PMID: 36335780
Real-world assessment and treatment of locally advanced basal cell carcinoma: Findings from the RegiSONIC disease registry.
Sekulic A, Yoo S, Kudchadkar R, Guillen J, Rogers G, Chang ALS, Guenthner S, Raskin B, Dawson K, Mun Y, Chu L, McKenna E, Lacouture M
PLoS One 2022;17(1):e0262151. Epub 2022 Jan 14 doi: 10.1371/journal.pone.0262151. PMID: 35030185Free PMC Article
Neoadjuvant vismodegib in the management of locally advanced periocular basal cell carcinoma.
Curragh DS, Huilgol SC, Selva D
Eye (Lond) 2021 Oct;35(10):2740-2745. Epub 2020 Nov 24 doi: 10.1038/s41433-020-01291-2. PMID: 33235336Free PMC Article
Gene-Related Response of Basal Cell Carcinoma to Biologic Treatment with Vismodegib.
Sternfeld A, Rosenwasser-Weiss S, Ben-Yehuda G, Shefer HK, Friedman-Gohas M, Yassur I, Tauber G, Bejar J, Olshinka A, Vardizer Y, Ad El D, Goldenberg-Cohen N
Sci Rep 2020 Jan 27;10(1):1244. doi: 10.1038/s41598-020-58117-0. PMID: 31988301Free PMC Article

Clinical prediction guides

Sonidegib in the Treatment of Locally Advanced Basal Cell Carcinoma: a Retrospective Study.
Herms F, Baroudjian B, Delyon J, Laly P, Tetu P, Lebbe C, Basset-Seguin N
Acta Derm Venereol 2022 May 23;102:adv00740. doi: 10.2340/actadv.v102.1995. PMID: 35604234Free PMC Article
Cemiplimab for locally advanced and metastatic basal cell carcinoma.
Damsin T, Lebas E, Marchal N, Rorive A, Nikkels AF
Expert Rev Anticancer Ther 2022 Mar;22(3):243-248. Epub 2022 Feb 22 doi: 10.1080/14737140.2022.2043748. PMID: 35175882
Cemiplimab in locally advanced basal cell carcinoma after hedgehog inhibitor therapy: an open-label, multi-centre, single-arm, phase 2 trial.
Stratigos AJ, Sekulic A, Peris K, Bechter O, Prey S, Kaatz M, Lewis KD, Basset-Seguin N, Chang ALS, Dalle S, Orland AF, Licitra L, Robert C, Ulrich C, Hauschild A, Migden MR, Dummer R, Li S, Yoo SY, Mohan K, Coates E, Jankovic V, Fiaschi N, Okoye E, Bassukas ID, Loquai C, De Giorgi V, Eroglu Z, Gutzmer R, Ulrich J, Puig S, Seebach F, Thurston G, Weinreich DM, Yancopoulos GD, Lowy I, Bowler T, Fury MG
Lancet Oncol 2021 Jun;22(6):848-857. Epub 2021 May 14 doi: 10.1016/S1470-2045(21)00126-1. PMID: 34000246
Gene-Related Response of Basal Cell Carcinoma to Biologic Treatment with Vismodegib.
Sternfeld A, Rosenwasser-Weiss S, Ben-Yehuda G, Shefer HK, Friedman-Gohas M, Yassur I, Tauber G, Bejar J, Olshinka A, Vardizer Y, Ad El D, Goldenberg-Cohen N
Sci Rep 2020 Jan 27;10(1):1244. doi: 10.1038/s41598-020-58117-0. PMID: 31988301Free PMC Article
Defining locally advanced basal cell carcinoma and integrating smoothened inhibitors into clinical practice.
Khoo AB, Ali FR, Lear JT
Curr Opin Oncol 2016 Mar;28(2):180-4. doi: 10.1097/CCO.0000000000000259. PMID: 26780190

Recent systematic reviews

Outcomes of adjunctive therapies post hedgehog inhibitors in the management of locally advanced basal cell carcinoma: A systematic review and pooled analysis.
Patel A, Kim JS, Liss J, Howard L, Jung SH, Kheterpal M
Dermatol Ther 2021 Nov;34(6):e15172. Epub 2021 Oct 28 doi: 10.1111/dth.15172. PMID: 34676633
Hedgehog Pathway Inhibitor Therapy for Locally Advanced and Metastatic Basal Cell Carcinoma: A Systematic Review and Pooled Analysis of Interventional Studies.
Jacobsen AA, Aldahan AS, Hughes OB, Shah VV, Strasswimmer J
JAMA Dermatol 2016 Jul 1;152(7):816-24. doi: 10.1001/jamadermatol.2016.0780. PMID: 27096888

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