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Refractory Malignant Soft Tissue Neoplasm

MedGen UID:
1652605
•Concept ID:
C4725813
•
Neoplastic Process

Definition

Malignant soft tissue neoplasm that is resistant to treatment. [from NCI]

Professional guidelines

PubMed

Advances in treatment of alveolar soft part sarcoma: an updated review.
Fujiwara T, Kunisada T, Nakata E, Nishida K, Yanai H, Nakamura T, Tanaka K, Ozaki T
Jpn J Clin Oncol 2023 Nov 5;53(11):1009-1018. doi: 10.1093/jjco/hyad102. PMID: 37626447Free PMC Article
Current status of and future prospects for the treatment of unresectable or metastatic gastrointestinal stromal tumours.
Naito Y, Nishida T, Doi T
Gastric Cancer 2023 May;26(3):339-351. Epub 2023 Mar 13 doi: 10.1007/s10120-023-01381-6. PMID: 36913072Free PMC Article
Rehabilitation Medicine Approaches to Pain Management.
Cheville AL, Smith SR, Basford JR
Hematol Oncol Clin North Am 2018 Jun;32(3):469-482. Epub 2018 Mar 17 doi: 10.1016/j.hoc.2018.02.001. PMID: 29729782

Recent clinical studies

Etiology

Current status of and future prospects for the treatment of unresectable or metastatic gastrointestinal stromal tumours.
Naito Y, Nishida T, Doi T
Gastric Cancer 2023 May;26(3):339-351. Epub 2023 Mar 13 doi: 10.1007/s10120-023-01381-6. PMID: 36913072Free PMC Article
Protocol for the 2ND-STEP study, Japan Clinical Oncology Group study JCOG1802: a randomized phase II trial of second-line treatment for advanced soft tissue sarcoma comparing trabectedin, eribulin and pazopanib.
Endo M, Kataoka T, Fujiwara T, Tsukushi S, Takahashi M, Kobayashi E, Yamada Y, Tanaka T, Nezu Y, Hiraga H, Wasa J, Nagano A, Nakano K, Nakayama R, Hamada T, Kawano M, Torigoe T, Sakamoto A, Asanuma K, Morii T, Machida R, Sekino Y, Fukuda H, Oda Y, Ozaki T, Tanaka K
BMC Cancer 2023 Mar 8;23(1):219. doi: 10.1186/s12885-023-10693-w. PMID: 36890471Free PMC Article
Extramedullary disease in multiple myeloma: a systematic literature review.
Bladé J, Beksac M, Caers J, Jurczyszyn A, von Lilienfeld-Toal M, Moreau P, Rasche L, Rosiñol L, Usmani SZ, Zamagni E, Richardson P
Blood Cancer J 2022 Mar 21;12(3):45. doi: 10.1038/s41408-022-00643-3. PMID: 35314675Free PMC Article
Randomized Phase II Trial of Vincristine-Irinotecan With or Without Temozolomide, in Children and Adults With Relapsed or Refractory Rhabdomyosarcoma: A European Paediatric Soft Tissue Sarcoma Study Group and Innovative Therapies for Children With Cancer Trial.
Defachelles AS, Bogart E, Casanova M, Merks JHM, Bisogno G, Calareso G, Gallego Melcon S, Gatz SA, Le Deley MC, McHugh K, Probst A, Rocourt N, van Rijn RR, Wheatley K, Minard-Colin V, Chisholm JC
J Clin Oncol 2021 Sep 20;39(27):2979-2990. Epub 2021 Aug 3 doi: 10.1200/JCO.21.00124. PMID: 34343032
Design and end points of clinical trials for patients with progressive prostate cancer and castrate levels of testosterone: recommendations of the Prostate Cancer Clinical Trials Working Group.
Scher HI, Halabi S, Tannock I, Morris M, Sternberg CN, Carducci MA, Eisenberger MA, Higano C, Bubley GJ, Dreicer R, Petrylak D, Kantoff P, Basch E, Kelly WK, Figg WD, Small EJ, Beer TM, Wilding G, Martin A, Hussain M; Prostate Cancer Clinical Trials Working Group
J Clin Oncol 2008 Mar 1;26(7):1148-59. doi: 10.1200/JCO.2007.12.4487. PMID: 18309951Free PMC Article

Diagnosis

Advances in treatment of alveolar soft part sarcoma: an updated review.
Fujiwara T, Kunisada T, Nakata E, Nishida K, Yanai H, Nakamura T, Tanaka K, Ozaki T
Jpn J Clin Oncol 2023 Nov 5;53(11):1009-1018. doi: 10.1093/jjco/hyad102. PMID: 37626447Free PMC Article
Protocol for the 2ND-STEP study, Japan Clinical Oncology Group study JCOG1802: a randomized phase II trial of second-line treatment for advanced soft tissue sarcoma comparing trabectedin, eribulin and pazopanib.
Endo M, Kataoka T, Fujiwara T, Tsukushi S, Takahashi M, Kobayashi E, Yamada Y, Tanaka T, Nezu Y, Hiraga H, Wasa J, Nagano A, Nakano K, Nakayama R, Hamada T, Kawano M, Torigoe T, Sakamoto A, Asanuma K, Morii T, Machida R, Sekino Y, Fukuda H, Oda Y, Ozaki T, Tanaka K
BMC Cancer 2023 Mar 8;23(1):219. doi: 10.1186/s12885-023-10693-w. PMID: 36890471Free PMC Article
Extramedullary disease in multiple myeloma: a systematic literature review.
Bladé J, Beksac M, Caers J, Jurczyszyn A, von Lilienfeld-Toal M, Moreau P, Rasche L, Rosiñol L, Usmani SZ, Zamagni E, Richardson P
Blood Cancer J 2022 Mar 21;12(3):45. doi: 10.1038/s41408-022-00643-3. PMID: 35314675Free PMC Article
ICE Regimen for Relapsed/Refractory Bone and Soft Tissue Sarcomas in Children.
Aydin B, Akyuz C, Varan A, Yalcin B, Kurucu N, Kutluk T
Rev Recent Clin Trials 2018;13(2):126-131. doi: 10.2174/1574887113666180124114818. PMID: 29366426
Snapping scapula syndrome.
Lazar MA, Kwon YW, Rokito AS
J Bone Joint Surg Am 2009 Sep;91(9):2251-62. doi: 10.2106/JBJS.H.01347. PMID: 19724005

Therapy

Current status of and future prospects for the treatment of unresectable or metastatic gastrointestinal stromal tumours.
Naito Y, Nishida T, Doi T
Gastric Cancer 2023 May;26(3):339-351. Epub 2023 Mar 13 doi: 10.1007/s10120-023-01381-6. PMID: 36913072Free PMC Article
Randomized Phase II Trial of Vincristine-Irinotecan With or Without Temozolomide, in Children and Adults With Relapsed or Refractory Rhabdomyosarcoma: A European Paediatric Soft Tissue Sarcoma Study Group and Innovative Therapies for Children With Cancer Trial.
Defachelles AS, Bogart E, Casanova M, Merks JHM, Bisogno G, Calareso G, Gallego Melcon S, Gatz SA, Le Deley MC, McHugh K, Probst A, Rocourt N, van Rijn RR, Wheatley K, Minard-Colin V, Chisholm JC
J Clin Oncol 2021 Sep 20;39(27):2979-2990. Epub 2021 Aug 3 doi: 10.1200/JCO.21.00124. PMID: 34343032
The management of osteoradionecrosis of the jaws--a review.
Rice N, Polyzois I, Ekanayake K, Omer O, Stassen LF
Surgeon 2015 Apr;13(2):101-9. Epub 2014 Jul 30 doi: 10.1016/j.surge.2014.07.003. PMID: 25084627
Design and end points of clinical trials for patients with progressive prostate cancer and castrate levels of testosterone: recommendations of the Prostate Cancer Clinical Trials Working Group.
Scher HI, Halabi S, Tannock I, Morris M, Sternberg CN, Carducci MA, Eisenberger MA, Higano C, Bubley GJ, Dreicer R, Petrylak D, Kantoff P, Basch E, Kelly WK, Figg WD, Small EJ, Beer TM, Wilding G, Martin A, Hussain M; Prostate Cancer Clinical Trials Working Group
J Clin Oncol 2008 Mar 1;26(7):1148-59. doi: 10.1200/JCO.2007.12.4487. PMID: 18309951Free PMC Article
Docetaxel.
Cortes JE, Pazdur R
J Clin Oncol 1995 Oct;13(10):2643-55. doi: 10.1200/JCO.1995.13.10.2643. PMID: 7595719

Prognosis

Current status of and future prospects for the treatment of unresectable or metastatic gastrointestinal stromal tumours.
Naito Y, Nishida T, Doi T
Gastric Cancer 2023 May;26(3):339-351. Epub 2023 Mar 13 doi: 10.1007/s10120-023-01381-6. PMID: 36913072Free PMC Article
Extramedullary disease in multiple myeloma: a systematic literature review.
Bladé J, Beksac M, Caers J, Jurczyszyn A, von Lilienfeld-Toal M, Moreau P, Rasche L, Rosiñol L, Usmani SZ, Zamagni E, Richardson P
Blood Cancer J 2022 Mar 21;12(3):45. doi: 10.1038/s41408-022-00643-3. PMID: 35314675Free PMC Article
ICE Regimen for Relapsed/Refractory Bone and Soft Tissue Sarcomas in Children.
Aydin B, Akyuz C, Varan A, Yalcin B, Kurucu N, Kutluk T
Rev Recent Clin Trials 2018;13(2):126-131. doi: 10.2174/1574887113666180124114818. PMID: 29366426
Design and end points of clinical trials for patients with progressive prostate cancer and castrate levels of testosterone: recommendations of the Prostate Cancer Clinical Trials Working Group.
Scher HI, Halabi S, Tannock I, Morris M, Sternberg CN, Carducci MA, Eisenberger MA, Higano C, Bubley GJ, Dreicer R, Petrylak D, Kantoff P, Basch E, Kelly WK, Figg WD, Small EJ, Beer TM, Wilding G, Martin A, Hussain M; Prostate Cancer Clinical Trials Working Group
J Clin Oncol 2008 Mar 1;26(7):1148-59. doi: 10.1200/JCO.2007.12.4487. PMID: 18309951Free PMC Article
Docetaxel.
Cortes JE, Pazdur R
J Clin Oncol 1995 Oct;13(10):2643-55. doi: 10.1200/JCO.1995.13.10.2643. PMID: 7595719

Clinical prediction guides

Exploratory study of an anti-PD-L1/TGF-β antibody, TQB2858, in patients with refractory or recurrent osteosarcoma and alveolar soft part sarcoma: a report from Chinese sarcoma study group (TQB2858-Ib-02).
Xie L, Liang X, Xu J, Sun X, Liu K, Sun K, Li Y, Tang X, Li X, Zhan X, Niu X, Guo W
BMC Cancer 2023 Sep 15;23(1):868. doi: 10.1186/s12885-023-11390-4. PMID: 37715133Free PMC Article
Immune and pathologic responses in patients with localized prostate cancer who received daratumumab (anti-CD38) or edicotinib (CSF-1R inhibitor).
Siddiqui BA, Chapin BF, Jindal S, Duan F, Basu S, Yadav SS, Gu AD, Espejo AB, Kinder M, Pettaway CA, Ward JF, Tidwell RSS, Troncoso P, Corn PG, Logothetis CJ, Knoblauch R, Hutnick N, Gottardis M, Drake CG, Sharma P, Subudhi SK
J Immunother Cancer 2023 Mar;11(3) doi: 10.1136/jitc-2022-006262. PMID: 36948506Free PMC Article
Alveolar soft part sarcoma: progress toward improvement in survival? A population-based study.
Fujiwara T, Nakata E, Kunisada T, Ozaki T, Kawai A
BMC Cancer 2022 Aug 15;22(1):891. doi: 10.1186/s12885-022-09968-5. PMID: 35971085Free PMC Article
Design and end points of clinical trials for patients with progressive prostate cancer and castrate levels of testosterone: recommendations of the Prostate Cancer Clinical Trials Working Group.
Scher HI, Halabi S, Tannock I, Morris M, Sternberg CN, Carducci MA, Eisenberger MA, Higano C, Bubley GJ, Dreicer R, Petrylak D, Kantoff P, Basch E, Kelly WK, Figg WD, Small EJ, Beer TM, Wilding G, Martin A, Hussain M; Prostate Cancer Clinical Trials Working Group
J Clin Oncol 2008 Mar 1;26(7):1148-59. doi: 10.1200/JCO.2007.12.4487. PMID: 18309951Free PMC Article
Docetaxel.
Cortes JE, Pazdur R
J Clin Oncol 1995 Oct;13(10):2643-55. doi: 10.1200/JCO.1995.13.10.2643. PMID: 7595719

Recent systematic reviews

A systematic review of early phase studies for children and young people with relapsed and refractory rhabdomyosarcoma: The REFoRMS-SR project.
Evans C, Shepherd L, Bryan G, Fulbright H, Crowther S, Wakeling S, Stewart A, Stewart C, Chisholm J, Gibson F, Phillips B, Morgan JE
Int J Cancer 2024 Apr 1;154(7):1235-1260. Epub 2023 Dec 10 doi: 10.1002/ijc.34808. PMID: 38071594
Extramedullary disease in multiple myeloma: a systematic literature review.
Bladé J, Beksac M, Caers J, Jurczyszyn A, von Lilienfeld-Toal M, Moreau P, Rasche L, Rosiñol L, Usmani SZ, Zamagni E, Richardson P
Blood Cancer J 2022 Mar 21;12(3):45. doi: 10.1038/s41408-022-00643-3. PMID: 35314675Free PMC Article

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