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Refractory Malignant Pharyngeal Neoplasm

MedGen UID:
1654336
•Concept ID:
C4725808
•
Neoplastic Process

Definition

Malignant pharyngeal neoplasm that is resistant to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRefractory Malignant Pharyngeal Neoplasm

Professional guidelines

PubMed

Hyperbaric oxygen therapy for the treatment of radiation-induced xerostomia: a systematic review.
Fox NF, Xiao C, Sood AJ, Lovelace TL, Nguyen SA, Sharma A, Day TA
Oral Surg Oral Med Oral Pathol Oral Radiol 2015 Jul;120(1):22-8. Epub 2015 Mar 25 doi: 10.1016/j.oooo.2015.03.007. PMID: 26093680
Late dysphagia after radiotherapy-based treatment of head and neck cancer.
Hutcheson KA, Lewin JS, Barringer DA, Lisec A, Gunn GB, Moore MW, Holsinger FC
Cancer 2012 Dec 1;118(23):5793-9. Epub 2012 May 17 doi: 10.1002/cncr.27631. PMID: 23640737Free PMC Article
Treatment of head and neck cancers: issues for clinical pharmacists.
Scarpace SL, Brodzik FA, Mehdi S, Belgam R
Pharmacotherapy 2009 May;29(5):578-92. doi: 10.1592/phco.29.5.578. PMID: 19397465

Recent clinical studies

Etiology

A state-of-the-art systematic review of cancer in hidradenitis suppurativa.
Abu Rached N, Rüth J, Gambichler T, Ocker L, Bechara FG
Ann Med 2024 Dec;56(1):2382372. Epub 2024 Jul 24 doi: 10.1080/07853890.2024.2382372. PMID: 39046819Free PMC Article
The efficacy and safety of apatinib plus capecitabine in platinum-refractory metastatic and/or recurrent nasopharyngeal carcinoma: a prospective, phase II trial.
Tang LQ, Li XY, Li ZM, Liu ZG, Lin MZ, Zhou H, Yu QW, Zhou J, Zhao C, Chen ZB, Wang XC, Peng JY, Chen QY, Fang WF, Yang YP, Zhang B, Xia LP, Hu PL, Hu WH, Li YJ, Mai HQ, Cai XY
BMC Med 2023 Mar 16;21(1):94. doi: 10.1186/s12916-023-02790-1. PMID: 36927541Free PMC Article
Efficacy, Safety, and Correlative Biomarkers of Toripalimab in Previously Treated Recurrent or Metastatic Nasopharyngeal Carcinoma: A Phase II Clinical Trial (POLARIS-02).
Wang FH, Wei XL, Feng J, Li Q, Xu N, Hu XC, Liao W, Jiang Y, Lin XY, Zhang QY, Yuan XL, Huang HX, Chen Y, Dai GH, Shi JH, Shen L, Yang SJ, Shu YQ, Liu YP, Wang W, Wu H, Feng H, Yao S, Xu RH
J Clin Oncol 2021 Mar 1;39(7):704-712. Epub 2021 Jan 25 doi: 10.1200/JCO.20.02712. PMID: 33492986Free PMC Article
Future of Radiotherapy in Nasopharyngeal Carcinoma.
Sun XS, Li XY, Chen QY, Tang LQ, Mai HQ
Br J Radiol 2019 Oct;92(1102):20190209. Epub 2019 Jul 9 doi: 10.1259/bjr.20190209. PMID: 31265322Free PMC Article
Cellular-based immunotherapy in Epstein-Barr virus induced nasopharyngeal cancer.
Lee AZE, Tan LSY, Lim CM
Oral Oncol 2018 Sep;84:61-70. Epub 2018 Jul 20 doi: 10.1016/j.oraloncology.2018.07.011. PMID: 30115477

Diagnosis

Anti-SRP-positive necrotising myopathy concurrent with breast malignancy.
Dandasena T, Ingle V, Singhai A, Saigal S
BMJ Case Rep 2023 Dec 11;16(12) doi: 10.1136/bcr-2023-254702. PMID: 38081733Free PMC Article
Multiple TMA-aided CRISPR/Cas13a platform for highly sensitive detection of IL-15 to predict immunotherapeutic response in nasopharyngeal carcinoma.
Wu YX, Xing S, Wang Y, Tian BY, Wu M, Wang XP, Huang Q, He X, Chen SL, Li XH, Zeng MS, Liu WL
J Immunother Cancer 2023 Aug;11(8) doi: 10.1136/jitc-2022-006552. PMID: 37536937Free PMC Article
Radiosensitizer EXO-miR-197-3p Inhibits Nasopharyngeal Carcinoma Progression and Radioresistance by Regulating the AKT/mTOR Axis and HSPA5-mediated Autophagy.
Jiang J, Tang Q, Gong J, Jiang W, Chen Y, Zhou Q, Aldeen A, Wang S, Li C, Lv W, Du T, Wang X, Long X, Feng X
Int J Biol Sci 2022;18(5):1878-1895. Epub 2022 Feb 21 doi: 10.7150/ijbs.69934. PMID: 35342334Free PMC Article
Conformal radiotherapy for locally advanced juvenile nasopharyngeal angio-fibroma.
Mallick S, Benson R, Bhasker S, Mohanti BK
J Cancer Res Ther 2015 Jan-Mar;11(1):73-7. doi: 10.4103/0973-1482.150349. PMID: 25879340
How I treat Burkitt lymphoma in adults.
Jacobson C, LaCasce A
Blood 2014 Nov 6;124(19):2913-20. Epub 2014 Sep 25 doi: 10.1182/blood-2014-06-538504. PMID: 25258344

Therapy

Camrelizumab combined with apatinib in patients with first-line platinum-resistant or PD-1 inhibitor resistant recurrent/metastatic nasopharyngeal carcinoma: a single-arm, phase 2 trial.
Yuan L, Jia GD, Lv XF, Xie SY, Guo SS, Lin DF, Liu LT, Luo DH, Li YF, Deng SW, Guo L, Zeng MS, Cai XY, Liu SL, Sun XS, Li XY, Li SC, Chen QY, Tang LQ, Mai HQ
Nat Commun 2023 Aug 14;14(1):4893. doi: 10.1038/s41467-023-40402-x. PMID: 37580352Free PMC Article
Camrelizumab Plus Apatinib in Patients With Recurrent or Metastatic Nasopharyngeal Carcinoma: An Open-Label, Single-Arm, Phase II Study.
Ding X, Zhang WJ, You R, Zou X, Wang ZQ, Ouyang YF, Peng L, Liu YP, Duan CY, Yang Q, Lin C, Xie YL, Chen SY, Liu YL, Gu CM, Xie RQ, Huang PY, Hong MH, Hua YJ, Chen MY
J Clin Oncol 2023 May 10;41(14):2571-2582. Epub 2023 Feb 3 doi: 10.1200/JCO.22.01450. PMID: 36735896Free PMC Article
Efficacy, Safety, and Correlative Biomarkers of Toripalimab in Previously Treated Recurrent or Metastatic Nasopharyngeal Carcinoma: A Phase II Clinical Trial (POLARIS-02).
Wang FH, Wei XL, Feng J, Li Q, Xu N, Hu XC, Liao W, Jiang Y, Lin XY, Zhang QY, Yuan XL, Huang HX, Chen Y, Dai GH, Shi JH, Shen L, Yang SJ, Shu YQ, Liu YP, Wang W, Wu H, Feng H, Yao S, Xu RH
J Clin Oncol 2021 Mar 1;39(7):704-712. Epub 2021 Jan 25 doi: 10.1200/JCO.20.02712. PMID: 33492986Free PMC Article
Camrelizumab: First Global Approval.
Markham A, Keam SJ
Drugs 2019 Aug;79(12):1355-1361. doi: 10.1007/s40265-019-01167-0. PMID: 31313098
Nasopharyngeal carcinoma: the next challenges.
Razak AR, Siu LL, Liu FF, Ito E, O'Sullivan B, Chan K
Eur J Cancer 2010 Jul;46(11):1967-78. Epub 2010 May 5 doi: 10.1016/j.ejca.2010.04.004. PMID: 20451372

Prognosis

A state-of-the-art systematic review of cancer in hidradenitis suppurativa.
Abu Rached N, Rüth J, Gambichler T, Ocker L, Bechara FG
Ann Med 2024 Dec;56(1):2382372. Epub 2024 Jul 24 doi: 10.1080/07853890.2024.2382372. PMID: 39046819Free PMC Article
A systematic review of antibody-drug conjugates and bispecific antibodies in head and neck squamous cell carcinoma and nasopharyngeal carcinoma: Charting the course of future therapies.
Jiménez-Labaig P, Rullan A, Hernando-Calvo A, Llop S, Bhide S, O'Leary B, Braña I, Harrington KJ
Cancer Treat Rev 2024 Jul;128:102772. Epub 2024 May 26 doi: 10.1016/j.ctrv.2024.102772. PMID: 38820656
Camrelizumab combined with apatinib in patients with first-line platinum-resistant or PD-1 inhibitor resistant recurrent/metastatic nasopharyngeal carcinoma: a single-arm, phase 2 trial.
Yuan L, Jia GD, Lv XF, Xie SY, Guo SS, Lin DF, Liu LT, Luo DH, Li YF, Deng SW, Guo L, Zeng MS, Cai XY, Liu SL, Sun XS, Li XY, Li SC, Chen QY, Tang LQ, Mai HQ
Nat Commun 2023 Aug 14;14(1):4893. doi: 10.1038/s41467-023-40402-x. PMID: 37580352Free PMC Article
Efficacy, Safety, and Correlative Biomarkers of Toripalimab in Previously Treated Recurrent or Metastatic Nasopharyngeal Carcinoma: A Phase II Clinical Trial (POLARIS-02).
Wang FH, Wei XL, Feng J, Li Q, Xu N, Hu XC, Liao W, Jiang Y, Lin XY, Zhang QY, Yuan XL, Huang HX, Chen Y, Dai GH, Shi JH, Shen L, Yang SJ, Shu YQ, Liu YP, Wang W, Wu H, Feng H, Yao S, Xu RH
J Clin Oncol 2021 Mar 1;39(7):704-712. Epub 2021 Jan 25 doi: 10.1200/JCO.20.02712. PMID: 33492986Free PMC Article
Nasopharyngeal carcinoma: the next challenges.
Razak AR, Siu LL, Liu FF, Ito E, O'Sullivan B, Chan K
Eur J Cancer 2010 Jul;46(11):1967-78. Epub 2010 May 5 doi: 10.1016/j.ejca.2010.04.004. PMID: 20451372

Clinical prediction guides

Camrelizumab combined with apatinib in patients with first-line platinum-resistant or PD-1 inhibitor resistant recurrent/metastatic nasopharyngeal carcinoma: a single-arm, phase 2 trial.
Yuan L, Jia GD, Lv XF, Xie SY, Guo SS, Lin DF, Liu LT, Luo DH, Li YF, Deng SW, Guo L, Zeng MS, Cai XY, Liu SL, Sun XS, Li XY, Li SC, Chen QY, Tang LQ, Mai HQ
Nat Commun 2023 Aug 14;14(1):4893. doi: 10.1038/s41467-023-40402-x. PMID: 37580352Free PMC Article
The efficacy and safety of apatinib plus capecitabine in platinum-refractory metastatic and/or recurrent nasopharyngeal carcinoma: a prospective, phase II trial.
Tang LQ, Li XY, Li ZM, Liu ZG, Lin MZ, Zhou H, Yu QW, Zhou J, Zhao C, Chen ZB, Wang XC, Peng JY, Chen QY, Fang WF, Yang YP, Zhang B, Xia LP, Hu PL, Hu WH, Li YJ, Mai HQ, Cai XY
BMC Med 2023 Mar 16;21(1):94. doi: 10.1186/s12916-023-02790-1. PMID: 36927541Free PMC Article
Efficacy, Safety, and Correlative Biomarkers of Toripalimab in Previously Treated Recurrent or Metastatic Nasopharyngeal Carcinoma: A Phase II Clinical Trial (POLARIS-02).
Wang FH, Wei XL, Feng J, Li Q, Xu N, Hu XC, Liao W, Jiang Y, Lin XY, Zhang QY, Yuan XL, Huang HX, Chen Y, Dai GH, Shi JH, Shen L, Yang SJ, Shu YQ, Liu YP, Wang W, Wu H, Feng H, Yao S, Xu RH
J Clin Oncol 2021 Mar 1;39(7):704-712. Epub 2021 Jan 25 doi: 10.1200/JCO.20.02712. PMID: 33492986Free PMC Article
Cellular-based immunotherapy in Epstein-Barr virus induced nasopharyngeal cancer.
Lee AZE, Tan LSY, Lim CM
Oral Oncol 2018 Sep;84:61-70. Epub 2018 Jul 20 doi: 10.1016/j.oraloncology.2018.07.011. PMID: 30115477
Nasopharyngeal carcinoma: the next challenges.
Razak AR, Siu LL, Liu FF, Ito E, O'Sullivan B, Chan K
Eur J Cancer 2010 Jul;46(11):1967-78. Epub 2010 May 5 doi: 10.1016/j.ejca.2010.04.004. PMID: 20451372

Recent systematic reviews

A state-of-the-art systematic review of cancer in hidradenitis suppurativa.
Abu Rached N, Rüth J, Gambichler T, Ocker L, Bechara FG
Ann Med 2024 Dec;56(1):2382372. Epub 2024 Jul 24 doi: 10.1080/07853890.2024.2382372. PMID: 39046819Free PMC Article
A systematic review of antibody-drug conjugates and bispecific antibodies in head and neck squamous cell carcinoma and nasopharyngeal carcinoma: Charting the course of future therapies.
Jiménez-Labaig P, Rullan A, Hernando-Calvo A, Llop S, Bhide S, O'Leary B, Braña I, Harrington KJ
Cancer Treat Rev 2024 Jul;128:102772. Epub 2024 May 26 doi: 10.1016/j.ctrv.2024.102772. PMID: 38820656
Hyperbaric oxygen therapy for the treatment of radiation-induced xerostomia: a systematic review.
Fox NF, Xiao C, Sood AJ, Lovelace TL, Nguyen SA, Sharma A, Day TA
Oral Surg Oral Med Oral Pathol Oral Radiol 2015 Jul;120(1):22-8. Epub 2015 Mar 25 doi: 10.1016/j.oooo.2015.03.007. PMID: 26093680

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