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Refractory Malignant Pharyngeal Neoplasm

MedGen UID:
1654336
•Concept ID:
C4725808
•
Neoplastic Process

Definition

Malignant pharyngeal neoplasm that is resistant to treatment. [from NCI]

Professional guidelines

PubMed

Hyperbaric oxygen therapy for the treatment of radiation-induced xerostomia: a systematic review.
Fox NF, Xiao C, Sood AJ, Lovelace TL, Nguyen SA, Sharma A, Day TA
Oral Surg Oral Med Oral Pathol Oral Radiol 2015 Jul;120(1):22-8. Epub 2015 Mar 25 doi: 10.1016/j.oooo.2015.03.007. PMID: 26093680
Late dysphagia after radiotherapy-based treatment of head and neck cancer.
Hutcheson KA, Lewin JS, Barringer DA, Lisec A, Gunn GB, Moore MW, Holsinger FC
Cancer 2012 Dec 1;118(23):5793-9. Epub 2012 May 17 doi: 10.1002/cncr.27631. PMID: 23640737Free PMC Article
Treatment of head and neck cancers: issues for clinical pharmacists.
Scarpace SL, Brodzik FA, Mehdi S, Belgam R
Pharmacotherapy 2009 May;29(5):578-92. doi: 10.1592/phco.29.5.578. PMID: 19397465

Recent clinical studies

Etiology

Efficacy, Safety, and Correlative Biomarkers of Toripalimab in Previously Treated Recurrent or Metastatic Nasopharyngeal Carcinoma: A Phase II Clinical Trial (POLARIS-02).
Wang FH, Wei XL, Feng J, Li Q, Xu N, Hu XC, Liao W, Jiang Y, Lin XY, Zhang QY, Yuan XL, Huang HX, Chen Y, Dai GH, Shi JH, Shen L, Yang SJ, Shu YQ, Liu YP, Wang W, Wu H, Feng H, Yao S, Xu RH
J Clin Oncol 2021 Mar 1;39(7):704-712. Epub 2021 Jan 25 doi: 10.1200/JCO.20.02712. PMID: 33492986Free PMC Article
Future of Radiotherapy in Nasopharyngeal Carcinoma.
Sun XS, Li XY, Chen QY, Tang LQ, Mai HQ
Br J Radiol 2019 Oct;92(1102):20190209. Epub 2019 Jul 9 doi: 10.1259/bjr.20190209. PMID: 31265322Free PMC Article
Cellular-based immunotherapy in Epstein-Barr virus induced nasopharyngeal cancer.
Lee AZE, Tan LSY, Lim CM
Oral Oncol 2018 Sep;84:61-70. Epub 2018 Jul 20 doi: 10.1016/j.oraloncology.2018.07.011. PMID: 30115477
Blockage of SSRP1/Ets-1/Pim-3 signalling enhances chemosensitivity of nasopharyngeal carcinoma to docetaxel in vitro.
Ai J, Li W, Zeng R, Xie Z, Liu H, Hou M, Tan G
Biomed Pharmacother 2016 Oct;83:1022-1031. Epub 2016 Aug 12 doi: 10.1016/j.biopha.2016.08.022. PMID: 27525970
Treatment of head and neck cancers: issues for clinical pharmacists.
Scarpace SL, Brodzik FA, Mehdi S, Belgam R
Pharmacotherapy 2009 May;29(5):578-92. doi: 10.1592/phco.29.5.578. PMID: 19397465

Diagnosis

Multiple TMA-aided CRISPR/Cas13a platform for highly sensitive detection of IL-15 to predict immunotherapeutic response in nasopharyngeal carcinoma.
Wu YX, Xing S, Wang Y, Tian BY, Wu M, Wang XP, Huang Q, He X, Chen SL, Li XH, Zeng MS, Liu WL
J Immunother Cancer 2023 Aug;11(8) doi: 10.1136/jitc-2022-006552. PMID: 37536937Free PMC Article
EBV-positive mucocutaneous ulcer presenting as a nasopharyngeal tumor in an immune suppressed patient.
Law RH, Rizzi MD
Am J Otolaryngol 2023 Jan-Feb;44(1):103685. Epub 2022 Oct 22 doi: 10.1016/j.amjoto.2022.103685. PMID: 36323155
Radiosensitizer EXO-miR-197-3p Inhibits Nasopharyngeal Carcinoma Progression and Radioresistance by Regulating the AKT/mTOR Axis and HSPA5-mediated Autophagy.
Jiang J, Tang Q, Gong J, Jiang W, Chen Y, Zhou Q, Aldeen A, Wang S, Li C, Lv W, Du T, Wang X, Long X, Feng X
Int J Biol Sci 2022;18(5):1878-1895. Epub 2022 Feb 21 doi: 10.7150/ijbs.69934. PMID: 35342334Free PMC Article
An Unusual Presentation of Nasopharyngeal Carcinoma as Lemierre Syndrome.
Ito T, Majima H, Ozawa T, Maeda M, Iwamoto S, Hirayama M, Azuma E
Am J Case Rep 2019 Feb 28;20:263-267. doi: 10.12659/AJCR.913755. PMID: 30814483Free PMC Article
Controlled sedation for refractory symptoms in dying patients.
Mercadante S, Intravaia G, Villari P, Ferrera P, David F, Casuccio A
J Pain Symptom Manage 2009 May;37(5):771-9. Epub 2008 Nov 28 doi: 10.1016/j.jpainsymman.2008.04.020. PMID: 19041216

Therapy

Camrelizumab Plus Apatinib in Patients With Recurrent or Metastatic Nasopharyngeal Carcinoma: An Open-Label, Single-Arm, Phase II Study.
Ding X, Zhang WJ, You R, Zou X, Wang ZQ, Ouyang YF, Peng L, Liu YP, Duan CY, Yang Q, Lin C, Xie YL, Chen SY, Liu YL, Gu CM, Xie RQ, Huang PY, Hong MH, Hua YJ, Chen MY
J Clin Oncol 2023 May 10;41(14):2571-2582. Epub 2023 Feb 3 doi: 10.1200/JCO.22.01450. PMID: 36735896Free PMC Article
Efficacy, Safety, and Correlative Biomarkers of Toripalimab in Previously Treated Recurrent or Metastatic Nasopharyngeal Carcinoma: A Phase II Clinical Trial (POLARIS-02).
Wang FH, Wei XL, Feng J, Li Q, Xu N, Hu XC, Liao W, Jiang Y, Lin XY, Zhang QY, Yuan XL, Huang HX, Chen Y, Dai GH, Shi JH, Shen L, Yang SJ, Shu YQ, Liu YP, Wang W, Wu H, Feng H, Yao S, Xu RH
J Clin Oncol 2021 Mar 1;39(7):704-712. Epub 2021 Jan 25 doi: 10.1200/JCO.20.02712. PMID: 33492986Free PMC Article
Camrelizumab: First Global Approval.
Markham A, Keam SJ
Drugs 2019 Aug;79(12):1355-1361. doi: 10.1007/s40265-019-01167-0. PMID: 31313098
Nasopharyngeal carcinoma: the next challenges.
Razak AR, Siu LL, Liu FF, Ito E, O'Sullivan B, Chan K
Eur J Cancer 2010 Jul;46(11):1967-78. Epub 2010 May 5 doi: 10.1016/j.ejca.2010.04.004. PMID: 20451372
Treatment of head and neck cancers: issues for clinical pharmacists.
Scarpace SL, Brodzik FA, Mehdi S, Belgam R
Pharmacotherapy 2009 May;29(5):578-92. doi: 10.1592/phco.29.5.578. PMID: 19397465

Prognosis

Radiosensitizer EXO-miR-197-3p Inhibits Nasopharyngeal Carcinoma Progression and Radioresistance by Regulating the AKT/mTOR Axis and HSPA5-mediated Autophagy.
Jiang J, Tang Q, Gong J, Jiang W, Chen Y, Zhou Q, Aldeen A, Wang S, Li C, Lv W, Du T, Wang X, Long X, Feng X
Int J Biol Sci 2022;18(5):1878-1895. Epub 2022 Feb 21 doi: 10.7150/ijbs.69934. PMID: 35342334Free PMC Article
LACTB2 renders radioresistance by activating PINK1/Parkin-dependent mitophagy in nasopharyngeal carcinoma.
Chen Q, Zheng W, Zhu L, Liu H, Song Y, Hu S, Bai Y, Pan Y, Zhang J, Guan J, Shao C
Cancer Lett 2021 Oct 10;518:127-139. Epub 2021 Jul 13 doi: 10.1016/j.canlet.2021.07.019. PMID: 34271102
Efficacy, Safety, and Correlative Biomarkers of Toripalimab in Previously Treated Recurrent or Metastatic Nasopharyngeal Carcinoma: A Phase II Clinical Trial (POLARIS-02).
Wang FH, Wei XL, Feng J, Li Q, Xu N, Hu XC, Liao W, Jiang Y, Lin XY, Zhang QY, Yuan XL, Huang HX, Chen Y, Dai GH, Shi JH, Shen L, Yang SJ, Shu YQ, Liu YP, Wang W, Wu H, Feng H, Yao S, Xu RH
J Clin Oncol 2021 Mar 1;39(7):704-712. Epub 2021 Jan 25 doi: 10.1200/JCO.20.02712. PMID: 33492986Free PMC Article
Future of Radiotherapy in Nasopharyngeal Carcinoma.
Sun XS, Li XY, Chen QY, Tang LQ, Mai HQ
Br J Radiol 2019 Oct;92(1102):20190209. Epub 2019 Jul 9 doi: 10.1259/bjr.20190209. PMID: 31265322Free PMC Article
Nasopharyngeal carcinoma: the next challenges.
Razak AR, Siu LL, Liu FF, Ito E, O'Sullivan B, Chan K
Eur J Cancer 2010 Jul;46(11):1967-78. Epub 2010 May 5 doi: 10.1016/j.ejca.2010.04.004. PMID: 20451372

Clinical prediction guides

Efficacy, Safety, and Correlative Biomarkers of Toripalimab in Previously Treated Recurrent or Metastatic Nasopharyngeal Carcinoma: A Phase II Clinical Trial (POLARIS-02).
Wang FH, Wei XL, Feng J, Li Q, Xu N, Hu XC, Liao W, Jiang Y, Lin XY, Zhang QY, Yuan XL, Huang HX, Chen Y, Dai GH, Shi JH, Shen L, Yang SJ, Shu YQ, Liu YP, Wang W, Wu H, Feng H, Yao S, Xu RH
J Clin Oncol 2021 Mar 1;39(7):704-712. Epub 2021 Jan 25 doi: 10.1200/JCO.20.02712. PMID: 33492986Free PMC Article
Future of Radiotherapy in Nasopharyngeal Carcinoma.
Sun XS, Li XY, Chen QY, Tang LQ, Mai HQ
Br J Radiol 2019 Oct;92(1102):20190209. Epub 2019 Jul 9 doi: 10.1259/bjr.20190209. PMID: 31265322Free PMC Article
Cellular-based immunotherapy in Epstein-Barr virus induced nasopharyngeal cancer.
Lee AZE, Tan LSY, Lim CM
Oral Oncol 2018 Sep;84:61-70. Epub 2018 Jul 20 doi: 10.1016/j.oraloncology.2018.07.011. PMID: 30115477
Nasopharyngeal carcinoma: the next challenges.
Razak AR, Siu LL, Liu FF, Ito E, O'Sullivan B, Chan K
Eur J Cancer 2010 Jul;46(11):1967-78. Epub 2010 May 5 doi: 10.1016/j.ejca.2010.04.004. PMID: 20451372
Development of cyclin-dependent kinase modulators as novel therapeutic approaches for hematological malignancies.
Senderowicz AM
Leukemia 2001 Jan;15(1):1-9. doi: 10.1038/sj.leu.2401994. PMID: 11243375

Recent systematic reviews

Hyperbaric oxygen therapy for the treatment of radiation-induced xerostomia: a systematic review.
Fox NF, Xiao C, Sood AJ, Lovelace TL, Nguyen SA, Sharma A, Day TA
Oral Surg Oral Med Oral Pathol Oral Radiol 2015 Jul;120(1):22-8. Epub 2015 Mar 25 doi: 10.1016/j.oooo.2015.03.007. PMID: 26093680

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