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Recurrent Chronic Leukemia

MedGen UID:
1663873
•Concept ID:
C4725601
•
Neoplastic Process

Definition

The reemergence of chronic leukemia after a period of remission. [from NCI]

Professional guidelines

PubMed

European LeukemiaNet laboratory recommendations for the diagnosis and management of chronic myeloid leukemia.
Cross NCP, Ernst T, Branford S, Cayuela JM, Deininger M, Fabarius A, Kim DDH, Machova Polakova K, Radich JP, Hehlmann R, Hochhaus A, Apperley JF, Soverini S
Leukemia 2023 Nov;37(11):2150-2167. Epub 2023 Oct 4 doi: 10.1038/s41375-023-02048-y. PMID: 37794101Free PMC Article
Current treatment of myeloproliferative neoplasias: three scenarios.
Xicoy B, Zamora L
Med Clin (Barc) 2020 Feb 28;154(4):131-133. Epub 2019 Jul 24 doi: 10.1016/j.medcli.2019.05.009. PMID: 31351663
NCCN: Non-Hodgkin's lymphoma.
Zelenetz AD, Hoppe RT; NCCN Non-Hodgkin's Lymphoma Practice Guidelines Panel
Cancer Control 2001 Nov-Dec;8(6 Suppl 2):102-13. PMID: 11760551

Recent clinical studies

Etiology

Richter transformation-is there light at the end of this tunnel?
Eyre TA
Hematology Am Soc Hematol Educ Program 2023 Dec 8;2023(1):427-432. doi: 10.1182/hematology.2023000442. PMID: 38066897Free PMC Article
Leukemia relapse via genetic immune escape after allogeneic hematopoietic cell transplantation.
Pagliuca S, Gurnari C, Hercus C, Hergalant S, Hong S, Dhuyser A, D'Aveni M, Aarnink A, Rubio MT, Feugier P, Ferraro F, Carraway HE, Sobecks R, Hamilton BK, Majhail NS, Visconte V, Maciejewski JP
Nat Commun 2023 May 31;14(1):3153. doi: 10.1038/s41467-023-38113-4. PMID: 37258544Free PMC Article
Chronic lymphocytic leukemia treatment algorithm 2018.
Parikh SA
Blood Cancer J 2018 Oct 3;8(10):93. doi: 10.1038/s41408-018-0131-2. PMID: 30283014Free PMC Article
Chronic lymphocytic leukaemia.
Hallek M, Shanafelt TD, Eichhorst B
Lancet 2018 Apr 14;391(10129):1524-1537. Epub 2018 Feb 21 doi: 10.1016/S0140-6736(18)30422-7. PMID: 29477250
Chronic myelogenous leukaemia.
Lee SJ
Br J Haematol 2000 Dec;111(4):993-1009. doi: 10.1046/j.1365-2141.2000.02216.x. PMID: 11167734

Diagnosis

European LeukemiaNet laboratory recommendations for the diagnosis and management of chronic myeloid leukemia.
Cross NCP, Ernst T, Branford S, Cayuela JM, Deininger M, Fabarius A, Kim DDH, Machova Polakova K, Radich JP, Hehlmann R, Hochhaus A, Apperley JF, Soverini S
Leukemia 2023 Nov;37(11):2150-2167. Epub 2023 Oct 4 doi: 10.1038/s41375-023-02048-y. PMID: 37794101Free PMC Article
Chronic myeloid leukemia: 2022 update on diagnosis, therapy, and monitoring.
Jabbour E, Kantarjian H
Am J Hematol 2022 Sep;97(9):1236-1256. Epub 2022 Jul 6 doi: 10.1002/ajh.26642. PMID: 35751859
Declaration of Bcr-Abl1 independence.
Zhao H, Deininger MW
Leukemia 2020 Nov;34(11):2827-2836. Epub 2020 Sep 10 doi: 10.1038/s41375-020-01037-9. PMID: 32908250
Chronic lymphocytic leukemia treatment algorithm 2018.
Parikh SA
Blood Cancer J 2018 Oct 3;8(10):93. doi: 10.1038/s41408-018-0131-2. PMID: 30283014Free PMC Article
Chronic lymphocytic leukaemia.
Hallek M, Shanafelt TD, Eichhorst B
Lancet 2018 Apr 14;391(10129):1524-1537. Epub 2018 Feb 21 doi: 10.1016/S0140-6736(18)30422-7. PMID: 29477250

Therapy

Richter transformation-is there light at the end of this tunnel?
Eyre TA
Hematology Am Soc Hematol Educ Program 2023 Dec 8;2023(1):427-432. doi: 10.1182/hematology.2023000442. PMID: 38066897Free PMC Article
Leukemia relapse via genetic immune escape after allogeneic hematopoietic cell transplantation.
Pagliuca S, Gurnari C, Hercus C, Hergalant S, Hong S, Dhuyser A, D'Aveni M, Aarnink A, Rubio MT, Feugier P, Ferraro F, Carraway HE, Sobecks R, Hamilton BK, Majhail NS, Visconte V, Maciejewski JP
Nat Commun 2023 May 31;14(1):3153. doi: 10.1038/s41467-023-38113-4. PMID: 37258544Free PMC Article
Chronic lymphocytic leukaemia.
Hallek M, Shanafelt TD, Eichhorst B
Lancet 2018 Apr 14;391(10129):1524-1537. Epub 2018 Feb 21 doi: 10.1016/S0140-6736(18)30422-7. PMID: 29477250
'Epinephrine-resistant' angioedema.
Ange N, Rabbolini DJ, Pidcock M, Randall KL
BMJ Case Rep 2016 Jan 28;2016 doi: 10.1136/bcr-2015-213880. PMID: 26823364Free PMC Article
Chronic myelogenous leukaemia.
Lee SJ
Br J Haematol 2000 Dec;111(4):993-1009. doi: 10.1046/j.1365-2141.2000.02216.x. PMID: 11167734

Prognosis

Richter transformation-is there light at the end of this tunnel?
Eyre TA
Hematology Am Soc Hematol Educ Program 2023 Dec 8;2023(1):427-432. doi: 10.1182/hematology.2023000442. PMID: 38066897Free PMC Article
European LeukemiaNet laboratory recommendations for the diagnosis and management of chronic myeloid leukemia.
Cross NCP, Ernst T, Branford S, Cayuela JM, Deininger M, Fabarius A, Kim DDH, Machova Polakova K, Radich JP, Hehlmann R, Hochhaus A, Apperley JF, Soverini S
Leukemia 2023 Nov;37(11):2150-2167. Epub 2023 Oct 4 doi: 10.1038/s41375-023-02048-y. PMID: 37794101Free PMC Article
Chronic lymphocytic leukemia treatment algorithm 2018.
Parikh SA
Blood Cancer J 2018 Oct 3;8(10):93. doi: 10.1038/s41408-018-0131-2. PMID: 30283014Free PMC Article
Chronic lymphocytic leukaemia.
Hallek M, Shanafelt TD, Eichhorst B
Lancet 2018 Apr 14;391(10129):1524-1537. Epub 2018 Feb 21 doi: 10.1016/S0140-6736(18)30422-7. PMID: 29477250
'Epinephrine-resistant' angioedema.
Ange N, Rabbolini DJ, Pidcock M, Randall KL
BMJ Case Rep 2016 Jan 28;2016 doi: 10.1136/bcr-2015-213880. PMID: 26823364Free PMC Article

Clinical prediction guides

Lineage-specific detection of residual disease predicts relapse in patients with chronic myeloid leukemia stopping therapy.
Pagani IS, Shanmuganathan N, Dang P, Saunders VA, Grose R, Kok CH, James J, Tolland M, Braley JA, Altamura HK, Yeung DT, Branford S, Yong ASM, Hughes TP, Ross DM
Blood 2023 Dec 21;142(25):2192-2197. doi: 10.1182/blood.2023021119. PMID: 37616555
GARP-mediated active TGF-β1 induces bone marrow NK cell dysfunction in AML patients with early relapse post-allo-HSCT.
Wang D, Sun Z, Zhu X, Zheng X, Zhou Y, Lu Y, Yan P, Wang H, Liu H, Jin J, Zhu H, Sun R, Wang Y, Fu B, Tian Z, Wei H
Blood 2022 Dec 29;140(26):2788-2804. doi: 10.1182/blood.2022015474. PMID: 35981475Free PMC Article
Chronic lymphocytic leukemia treatment algorithm 2018.
Parikh SA
Blood Cancer J 2018 Oct 3;8(10):93. doi: 10.1038/s41408-018-0131-2. PMID: 30283014Free PMC Article
Quantitative modeling of chronic myeloid leukemia: insights from radiobiology.
Radivoyevitch T, Hlatky L, Landaw J, Sachs RK
Blood 2012 May 10;119(19):4363-71. Epub 2012 Feb 21 doi: 10.1182/blood-2011-09-381855. PMID: 22353999Free PMC Article
In-vivo generation of leukaemia-derived dendritic cells.
Kolb HJ, Rank A, Chen X, Woiciechowsky A, Roskrow M, Schmid C, Tischer J, Ledderose G
Best Pract Res Clin Haematol 2004 Sep;17(3):439-51. doi: 10.1016/j.beha.2004.06.004. PMID: 15498715

Recent systematic reviews

Late relapse after CAR-T cell therapy for adult patients with hematologic malignancies: A definite evidence from systematic review and meta-analysis on individual data.
Zinzi A, Gaio M, Liguori V, Cagnotta C, Paolino D, Paolisso G, Castaldo G, Nicoletti GF, Rossi F, Capuano A, Rafaniello C
Pharmacol Res 2023 Apr;190:106742. Epub 2023 Mar 22 doi: 10.1016/j.phrs.2023.106742. PMID: 36963592
Can GCSF-stimulated donor lymphocyte infusions improve outcomes for relapsed disease following allogeneic hematopoietic cell transplantation? A systematic review and meta-analysis.
Kirkham AM, Bailey AJM, Masurekar A, Shorr R, Bredeson C, Sabloff M, Allan DS
Leuk Lymphoma 2022 Dec;63(14):3276-3287. Epub 2022 Sep 13 doi: 10.1080/10428194.2022.2118530. PMID: 36098248
Efficacy of azacitidine in preventing relapse after hematopoietic stem cell transplantation for advanced myeloid malignancies: a systematic review and meta-analysis.
Pan T, Han S, Zhou M, Qi J, Wang H, Xu X, Li X, Yao Y, Han Y
Expert Rev Hematol 2022 May;15(5):457-464. Epub 2022 May 10 doi: 10.1080/17474086.2022.2073214. PMID: 35535679
Randomized controlled trials in relapsed/refractory chronic lymphocytic leukemia: a systematic review and meta-analysis.
Police RL, Trask PC, Wang J, Olivares R, Khan S, Abbe A, Colosia A, Njue A, Sherrill B, Ruiz-Soto R, Kaye JA, Hamadani M
Clin Lymphoma Myeloma Leuk 2015 Apr;15(4):199-207. Epub 2014 Oct 2 doi: 10.1016/j.clml.2014.09.008. PMID: 25445467
Comparing efficacy of reduced-toxicity allogeneic hematopoietic cell transplantation with conventional chemo-(immuno) therapy in patients with relapsed or refractory CLL: a Markov decision analysis.
Kharfan-Dabaja MA, Pidala J, Kumar A, Terasawa T, Djulbegovic B
Bone Marrow Transplant 2012 Sep;47(9):1164-70. Epub 2012 May 7 doi: 10.1038/bmt.2012.71. PMID: 22562081

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    Practice guidelines

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