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Metastatic Malignant Pancreatic Neoplasm

MedGen UID:
1668931
•Concept ID:
C4744416
•
Neoplastic Process

Definition

A malignant neoplasm that arises from the pancreas and has metastasized to another anatomic site. [from NCI]

Professional guidelines

PubMed

Pancreatic Cancer: A Review of Current Treatment and Novel Therapies.
Kolbeinsson HM, Chandana S, Wright GP, Chung M
J Invest Surg 2023 Dec 31;36(1):2129884. Epub 2022 Oct 3 doi: 10.1080/08941939.2022.2129884. PMID: 36191926
Surgical management of pancreatic cancer liver oligometastases.
Macfie R, Berger Y, Sarpel U, Hiotis S, Golas B, Labow D, Cohen N
Crit Rev Oncol Hematol 2022 May;173:103654. Epub 2022 Mar 14 doi: 10.1016/j.critrevonc.2022.103654. PMID: 35301097
Pancreatic Adenocarcinoma, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology.
Tempero MA, Malafa MP, Al-Hawary M, Behrman SW, Benson AB, Cardin DB, Chiorean EG, Chung V, Czito B, Del Chiaro M, Dillhoff M, Donahue TR, Dotan E, Ferrone CR, Fountzilas C, Hardacre J, Hawkins WG, Klute K, Ko AH, Kunstman JW, LoConte N, Lowy AM, Moravek C, Nakakura EK, Narang AK, Obando J, Polanco PM, Reddy S, Reyngold M, Scaife C, Shen J, Vollmer C, Wolff RA, Wolpin BM, Lynn B, George GV
J Natl Compr Canc Netw 2021 Apr 1;19(4):439-457. doi: 10.6004/jnccn.2021.0017. PMID: 33845462

Recent clinical studies

Etiology

Long-term surveillance of branch-duct intraductal papillary mucinous neoplasms without worrisome or high-risk features.
Lattimore CM, Kane WJ, Subbarao S, Venitti C, Cramer CL, Turkheimer LM, Bauer TW, Turrentine FE, Zaydfudim VM
J Surg Oncol 2023 Dec;128(7):1087-1094. Epub 2023 Aug 2 doi: 10.1002/jso.27414. PMID: 37530526Free PMC Article
Systemic Therapy for Metastatic Pancreatic Cancer.
Ettrich TJ, Seufferlein T
Curr Treat Options Oncol 2021 Oct 19;22(11):106. doi: 10.1007/s11864-021-00895-4. PMID: 34665339Free PMC Article
Pancreatoblastoma in children: EXPeRT/PARTNER diagnostic and therapeutic recommendations.
Bien E, Roganovic J, Krawczyk MA, Godzinski J, Orbach D, Cecchetto G, Barthlen W, Defachelles AS, Ferrari A, Weldon CB, Brecht IB, Schneider DT, Bisogno G, Kolenova A, Ben-Ami T, Martinova K, Virgone C, Stachowicz-Stencel T, Kachanov D, Reguerre Y
Pediatr Blood Cancer 2021 Jun;68 Suppl 4:e29112. doi: 10.1002/pbc.29112. PMID: 34174157
Nonfunctional pancreatic neuroendocrine tumors.
Kuo JH, Lee JA, Chabot JA
Surg Clin North Am 2014 Jun;94(3):689-708. Epub 2014 Apr 13 doi: 10.1016/j.suc.2014.02.010. PMID: 24857584
Pancreatic manifestations of von Hippel-Lindau disease.
Safo AO, Pambuccian SE
Arch Pathol Lab Med 2010 Jul;134(7):1080-3. doi: 10.5858/2009-0172-RS.1. PMID: 20586642

Diagnosis

Pancreatic Cancer: A Review.
Park W, Chawla A, O'Reilly EM
JAMA 2021 Sep 7;326(9):851-862. doi: 10.1001/jama.2021.13027. PMID: 34547082Free PMC Article
Diagnosis and Detection of Pancreatic Cancer.
Chu LC, Goggins MG, Fishman EK
Cancer J 2017 Nov/Dec;23(6):333-342. doi: 10.1097/PPO.0000000000000290. PMID: 29189329
Neuroendocrine Tumors.
Basuroy R, Srirajaskanthan R, Ramage JK
Gastroenterol Clin North Am 2016 Sep;45(3):487-507. doi: 10.1016/j.gtc.2016.04.007. PMID: 27546845
Nonfunctional pancreatic neuroendocrine tumors.
Kuo JH, Lee JA, Chabot JA
Surg Clin North Am 2014 Jun;94(3):689-708. Epub 2014 Apr 13 doi: 10.1016/j.suc.2014.02.010. PMID: 24857584
Metastases to the pancreas.
Merkle EM, Boaz T, Kolokythas O, Haaga JR, Lewin JS, Brambs HJ
Br J Radiol 1998 Nov;71(851):1208-14. doi: 10.1259/bjr.71.851.10434919. PMID: 10434919

Therapy

Pancreatic Cancer: A Review.
Park W, Chawla A, O'Reilly EM
JAMA 2021 Sep 7;326(9):851-862. doi: 10.1001/jama.2021.13027. PMID: 34547082Free PMC Article
Radiopharmaceuticals for Neuroendocrine Tumors.
Chin RI, Wu FS, Menda Y, Kim H
Semin Radiat Oncol 2021 Jan;31(1):60-70. doi: 10.1016/j.semradonc.2020.07.007. PMID: 33246637
Pancreatic ductal adenocarcinoma: metastatic disease.
Muñoz Martín AJ, Adeva J, Martínez-Galán J, Reina JJ, Hidalgo M
Clin Transl Oncol 2017 Dec;19(12):1423-1429. Epub 2017 Jun 16 doi: 10.1007/s12094-017-1690-6. PMID: 28623515
Neuroendocrine Tumors.
Basuroy R, Srirajaskanthan R, Ramage JK
Gastroenterol Clin North Am 2016 Sep;45(3):487-507. doi: 10.1016/j.gtc.2016.04.007. PMID: 27546845
Adjuvant therapy in pancreatic cancer.
Jones OP, Melling JD, Ghaneh P
World J Gastroenterol 2014 Oct 28;20(40):14733-46. doi: 10.3748/wjg.v20.i40.14733. PMID: 25356036Free PMC Article

Prognosis

Understanding the increasing incidence of neuroendocrine tumors.
Pathak S, Starr JS, Halfdanarson T, Sonbol MB
Expert Rev Endocrinol Metab 2023 Sep-Nov;18(5):377-385. Epub 2023 Jul 19 doi: 10.1080/17446651.2023.2237593. PMID: 37466336
Pancreatic Cancer: A Review.
Park W, Chawla A, O'Reilly EM
JAMA 2021 Sep 7;326(9):851-862. doi: 10.1001/jama.2021.13027. PMID: 34547082Free PMC Article
PEGPH20 for metastatic pancreatic ductal adenocarcinoma.
Gourd E
Lancet Oncol 2018 Feb;19(2):e81. Epub 2017 Dec 21 doi: 10.1016/S1470-2045(17)30953-1. PMID: 29276021
Nonfunctional pancreatic neuroendocrine tumors.
Kuo JH, Lee JA, Chabot JA
Surg Clin North Am 2014 Jun;94(3):689-708. Epub 2014 Apr 13 doi: 10.1016/j.suc.2014.02.010. PMID: 24857584
Pancreatic cancer.
Cohen SJ, Pinover WH, Watson JC, Meropol NJ
Curr Treat Options Oncol 2000 Dec;1(5):375-86. doi: 10.1007/s11864-000-0065-2. PMID: 12057145

Clinical prediction guides

Pancreatic Cancer: A Review.
Park W, Chawla A, O'Reilly EM
JAMA 2021 Sep 7;326(9):851-862. doi: 10.1001/jama.2021.13027. PMID: 34547082Free PMC Article
Positron emission tomography/computer tomography in gastrointestinal malignancies: current potential and challenges.
Tind S, Vestergaard S, Farahani ZA, Hess S
Minerva Chir 2017 Oct;72(5):397-415. Epub 2017 May 30 doi: 10.23736/S0026-4733.17.07409-0. PMID: 28565893
Irreversible Electroporation of Hepatic and Pancreatic Malignancies: Radiologic-Pathologic Correlation.
Gonzalez-Beicos A, Venkat S, Songrug T, Poveda J, Garcia-Buitrago M, Poozhikunnath Mohan P, Narayanan G
Tech Vasc Interv Radiol 2015 Sep;18(3):176-82. Epub 2015 Jun 18 doi: 10.1053/j.tvir.2015.06.009. PMID: 26365548
Translational research in pancreatic ductal adenocarcinoma: current evidence and future concepts.
Kruger S, Haas M, Ormanns S, Bächmann S, Siveke JT, Kirchner T, Heinemann V, Boeck S
World J Gastroenterol 2014 Aug 21;20(31):10769-77. doi: 10.3748/wjg.v20.i31.10769. PMID: 25152580Free PMC Article
The role of surgery in the management of isolated metastases to the pancreas.
Reddy S, Wolfgang CL
Lancet Oncol 2009 Mar;10(3):287-93. doi: 10.1016/S1470-2045(09)70065-8. PMID: 19261257

Recent systematic reviews

NALIRIFOX, FOLFIRINOX, and Gemcitabine With Nab-Paclitaxel as First-Line Chemotherapy for Metastatic Pancreatic Cancer: A Systematic Review and Meta-Analysis.
Nichetti F, Rota S, Ambrosini P, Pircher C, Gusmaroli E, Droz Dit Busset M, Pusceddu S, Sposito C, Coppa J, Morano F, Pietrantonio F, Di Bartolomeo M, Mariani L, Mazzaferro V, de Braud F, Niger M
JAMA Netw Open 2024 Jan 2;7(1):e2350756. doi: 10.1001/jamanetworkopen.2023.50756. PMID: 38190183Free PMC Article
Treatment strategies for neuroendocrine liver metastases: a systematic review.
Muttillo EM, Mazzarella G, Picardi B, Rossi S, Cinelli L, Diana M, Baiocchini A, Felli E, Pessaux P, Felli E, Muttillo IA
HPB (Oxford) 2022 Nov;24(11):1832-1843. Epub 2022 Jun 21 doi: 10.1016/j.hpb.2022.06.009. PMID: 35794053
Systematic review of minimally invasive ablation treatment for locally advanced pancreatic cancer.
Ierardi AM, Lucchina N, Petrillo M, Floridi C, Piacentino F, Bacuzzi A, Fonio P, Fontana F, Fugazzola C, Brunese L, Carrafiello G
Radiol Med 2014 Jul;119(7):483-98. Epub 2014 Jul 1 doi: 10.1007/s11547-014-0417-9. PMID: 24981482
Systematic review of novel ablative methods in locally advanced pancreatic cancer.
Keane MG, Bramis K, Pereira SP, Fusai GK
World J Gastroenterol 2014 Mar 7;20(9):2267-78. doi: 10.3748/wjg.v20.i9.2267. PMID: 24605026Free PMC Article
Diagnostic laparoscopy: indications and benefits.
Rau B, Hünerbein M
Langenbecks Arch Surg 2005 Jun;390(3):187-96. Epub 2004 May 20 doi: 10.1007/s00423-004-0483-x. PMID: 15156319

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