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Metastatic Malignant Pancreatic Neoplasm

MedGen UID:
1668931
•Concept ID:
C4744416
•
Neoplastic Process

Definition

A malignant neoplasm that arises from the pancreas and has metastasized to another anatomic site. [from NCI]

Professional guidelines

PubMed

Pancreatic Cancer: A Review of Current Treatment and Novel Therapies.
Kolbeinsson HM, Chandana S, Wright GP, Chung M
J Invest Surg 2023 Dec 31;36(1):2129884. Epub 2022 Oct 3 doi: 10.1080/08941939.2022.2129884. PMID: 36191926
Pancreatic Adenocarcinoma, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology.
Tempero MA, Malafa MP, Al-Hawary M, Behrman SW, Benson AB, Cardin DB, Chiorean EG, Chung V, Czito B, Del Chiaro M, Dillhoff M, Donahue TR, Dotan E, Ferrone CR, Fountzilas C, Hardacre J, Hawkins WG, Klute K, Ko AH, Kunstman JW, LoConte N, Lowy AM, Moravek C, Nakakura EK, Narang AK, Obando J, Polanco PM, Reddy S, Reyngold M, Scaife C, Shen J, Vollmer C, Wolff RA, Wolpin BM, Lynn B, George GV
J Natl Compr Canc Netw 2021 Apr 1;19(4):439-457. doi: 10.6004/jnccn.2021.0017. PMID: 33845462
Treatment landscape of metastatic pancreatic cancer.
De Dosso S, Siebenhüner AR, Winder T, Meisel A, Fritsch R, Astaras C, Szturz P, Borner M
Cancer Treat Rev 2021 May;96:102180. Epub 2021 Mar 17 doi: 10.1016/j.ctrv.2021.102180. PMID: 33812339

Recent clinical studies

Etiology

Treatment optimization of locally advanced and metastatic pancreatic cancer (Review).
Barros AG, Pulido CF, Machado M, Brito MJ, Couto N, Sousa O, Melo SA, Mansinho H
Int J Oncol 2021 Dec;59(6) Epub 2021 Dec 3 doi: 10.3892/ijo.2021.5290. PMID: 34859257Free PMC Article
Systemic Therapy for Metastatic Pancreatic Cancer.
Ettrich TJ, Seufferlein T
Curr Treat Options Oncol 2021 Oct 19;22(11):106. doi: 10.1007/s11864-021-00895-4. PMID: 34665339Free PMC Article
Localisation of PGK1 determines metabolic phenotype to balance metastasis and proliferation in patients with SMAD4-negative pancreatic cancer.
Liang C, Shi S, Qin Y, Meng Q, Hua J, Hu Q, Ji S, Zhang B, Xu J, Yu XJ
Gut 2020 May;69(5):888-900. Epub 2019 Oct 14 doi: 10.1136/gutjnl-2018-317163. PMID: 31611300
Pancreatic neuroendocrine tumors.
Perri G, Prakash LR, Katz MHG
Curr Opin Gastroenterol 2019 Sep;35(5):468-477. doi: 10.1097/MOG.0000000000000571. PMID: 31306159
Are There Indications for Total Pancreatectomy in 2016?
Andrén-Sandberg Å, Ansorge C, Yadav TD
Dig Surg 2016;33(4):329-34. Epub 2016 May 25 doi: 10.1159/000445018. PMID: 27215746

Diagnosis

Pancreatic Cancer: A Review.
Park W, Chawla A, O'Reilly EM
JAMA 2021 Sep 7;326(9):851-862. doi: 10.1001/jama.2021.13027. PMID: 34547082Free PMC Article
Pancreatic neuroendocrine tumors.
Perri G, Prakash LR, Katz MHG
Curr Opin Gastroenterol 2019 Sep;35(5):468-477. doi: 10.1097/MOG.0000000000000571. PMID: 31306159
Diagnosis and Detection of Pancreatic Cancer.
Chu LC, Goggins MG, Fishman EK
Cancer J 2017 Nov/Dec;23(6):333-342. doi: 10.1097/PPO.0000000000000290. PMID: 29189329
Neuroendocrine Tumors.
Basuroy R, Srirajaskanthan R, Ramage JK
Gastroenterol Clin North Am 2016 Sep;45(3):487-507. doi: 10.1016/j.gtc.2016.04.007. PMID: 27546845
Therapy of metastatic pancreatic neuroendocrine tumors (pNETs): recent insights and advances.
Ito T, Igarashi H, Jensen RT
J Gastroenterol 2012 Sep;47(9):941-60. Epub 2012 Aug 11 doi: 10.1007/s00535-012-0642-8. PMID: 22886480Free PMC Article

Therapy

Systemic Therapy for Metastatic Pancreatic Cancer.
Ettrich TJ, Seufferlein T
Curr Treat Options Oncol 2021 Oct 19;22(11):106. doi: 10.1007/s11864-021-00895-4. PMID: 34665339Free PMC Article
Pancreatic Cancer: A Review.
Park W, Chawla A, O'Reilly EM
JAMA 2021 Sep 7;326(9):851-862. doi: 10.1001/jama.2021.13027. PMID: 34547082Free PMC Article
Treatment landscape of metastatic pancreatic cancer.
De Dosso S, Siebenhüner AR, Winder T, Meisel A, Fritsch R, Astaras C, Szturz P, Borner M
Cancer Treat Rev 2021 May;96:102180. Epub 2021 Mar 17 doi: 10.1016/j.ctrv.2021.102180. PMID: 33812339
Multidisciplinary standards of care and recent progress in pancreatic ductal adenocarcinoma.
Grossberg AJ, Chu LC, Deig CR, Fishman EK, Hwang WL, Maitra A, Marks DL, Mehta A, Nabavizadeh N, Simeone DM, Weekes CD, Thomas CR Jr
CA Cancer J Clin 2020 Sep;70(5):375-403. Epub 2020 Jul 19 doi: 10.3322/caac.21626. PMID: 32683683Free PMC Article
Gastroenteropancreatic Neuroendocrine Tumors.
Cives M, Strosberg JR
CA Cancer J Clin 2018 Nov;68(6):471-487. Epub 2018 Oct 8 doi: 10.3322/caac.21493. PMID: 30295930

Prognosis

Understanding the increasing incidence of neuroendocrine tumors.
Pathak S, Starr JS, Halfdanarson T, Sonbol MB
Expert Rev Endocrinol Metab 2023 Sep-Nov;18(5):377-385. Epub 2023 Jul 19 doi: 10.1080/17446651.2023.2237593. PMID: 37466336
Pancreatic Cancer: A Review.
Park W, Chawla A, O'Reilly EM
JAMA 2021 Sep 7;326(9):851-862. doi: 10.1001/jama.2021.13027. PMID: 34547082Free PMC Article
Pancreatic neuroendocrine tumors.
Perri G, Prakash LR, Katz MHG
Curr Opin Gastroenterol 2019 Sep;35(5):468-477. doi: 10.1097/MOG.0000000000000571. PMID: 31306159
Pancreatic cancer and associated exosomes.
Zhao C, Gao F, Weng S, Liu Q
Cancer Biomark 2017 Dec 6;20(4):357-367. doi: 10.3233/CBM-170258. PMID: 29036786
Pancreatic cancer.
Cohen SJ, Pinover WH, Watson JC, Meropol NJ
Curr Treat Options Oncol 2000 Dec;1(5):375-86. doi: 10.1007/s11864-000-0065-2. PMID: 12057145

Clinical prediction guides

Pancreatic Cancer: A Review.
Park W, Chawla A, O'Reilly EM
JAMA 2021 Sep 7;326(9):851-862. doi: 10.1001/jama.2021.13027. PMID: 34547082Free PMC Article
Localisation of PGK1 determines metabolic phenotype to balance metastasis and proliferation in patients with SMAD4-negative pancreatic cancer.
Liang C, Shi S, Qin Y, Meng Q, Hua J, Hu Q, Ji S, Zhang B, Xu J, Yu XJ
Gut 2020 May;69(5):888-900. Epub 2019 Oct 14 doi: 10.1136/gutjnl-2018-317163. PMID: 31611300
Pancreatic neuroendocrine tumors.
Perri G, Prakash LR, Katz MHG
Curr Opin Gastroenterol 2019 Sep;35(5):468-477. doi: 10.1097/MOG.0000000000000571. PMID: 31306159
Comparing the diagnostic accuracy of five common tumour biomarkers and CA19-9 for pancreatic cancer: a protocol for a network meta-analysis of diagnostic test accuracy.
Ge L, Pan B, Song F, Ma J, Zeraatkar D, Zhou J, Tian J
BMJ Open 2017 Dec 26;7(12):e018175. doi: 10.1136/bmjopen-2017-018175. PMID: 29282264Free PMC Article
Pancreatic cancer-improved care achievable.
Buanes TA
World J Gastroenterol 2014 Aug 14;20(30):10405-18. doi: 10.3748/wjg.v20.i30.10405. PMID: 25132756Free PMC Article

Recent systematic reviews

NALIRIFOX, FOLFIRINOX, and Gemcitabine With Nab-Paclitaxel as First-Line Chemotherapy for Metastatic Pancreatic Cancer: A Systematic Review and Meta-Analysis.
Nichetti F, Rota S, Ambrosini P, Pircher C, Gusmaroli E, Droz Dit Busset M, Pusceddu S, Sposito C, Coppa J, Morano F, Pietrantonio F, Di Bartolomeo M, Mariani L, Mazzaferro V, de Braud F, Niger M
JAMA Netw Open 2024 Jan 2;7(1):e2350756. doi: 10.1001/jamanetworkopen.2023.50756. PMID: 38190183Free PMC Article
Comparison of different second line treatments for metastatic pancreatic cancer: a systematic review and network meta-analysis.
Petrelli F, Parisi A, Tomasello G, Mini E, Arru M, Russo A, Garrone O, Khakoo S, Ardito R, Ghidini M
BMC Gastroenterol 2023 Jun 19;23(1):212. doi: 10.1186/s12876-023-02853-w. PMID: 37337148Free PMC Article
Exercise for cancer cachexia in adults.
Grande AJ, Silva V, Sawaris Neto L, Teixeira Basmage JP, Peccin MS, Maddocks M
Cochrane Database Syst Rev 2021 Mar 18;3(3):CD010804. doi: 10.1002/14651858.CD010804.pub3. PMID: 33735441Free PMC Article
The Impact of Preoperative Immune Modulating Nutrition on Outcomes in Patients Undergoing Surgery for Gastrointestinal Cancer: A Systematic Review and Meta-analysis.
Adiamah A, Skořepa P, Weimann A, Lobo DN
Ann Surg 2019 Aug;270(2):247-256. doi: 10.1097/SLA.0000000000003256. PMID: 30817349
FOLFIRINOX for locally advanced pancreatic cancer: a systematic review and patient-level meta-analysis.
Suker M, Beumer BR, Sadot E, Marthey L, Faris JE, Mellon EA, El-Rayes BF, Wang-Gillam A, Lacy J, Hosein PJ, Moorcraft SY, Conroy T, Hohla F, Allen P, Taieb J, Hong TS, Shridhar R, Chau I, van Eijck CH, Koerkamp BG
Lancet Oncol 2016 Jun;17(6):801-810. Epub 2016 May 6 doi: 10.1016/S1470-2045(16)00172-8. PMID: 27160474Free PMC Article

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