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Locally Advanced Lung Non-Small Cell Carcinoma

MedGen UID:
1691150
•Concept ID:
C5205550
•
Neoplastic Process

Definition

A non-small cell carcinoma of the lung that has spread from its original site of growth to nearby tissues or lymph nodes. [from NCI]

Professional guidelines

PubMed

Treatment adherence in concurrent chemoradiation in patients with locally advanced non-small cell lung carcinoma: results of daily intravenous prehydration.
Uyterlinde W, Chen C, Nijkamp J, Obbink MG, Sonke JJ, Belderbos J, van den Heuvel M
Radiother Oncol 2014 Mar;110(3):488-92. Epub 2014 Jan 17 doi: 10.1016/j.radonc.2013.12.008. PMID: 24444531

Recent clinical studies

Etiology

Dynamic circulating tumor DNA during chemoradiotherapy predicts clinical outcomes for locally advanced non-small cell lung cancer patients.
Pan Y, Zhang JT, Gao X, Chen ZY, Yan B, Tan PX, Yang XR, Gao W, Gong Y, Tian Z, Liu SM, Lin H, Sun H, Huang J, Liu SY, Yan HH, Dong S, Xu CR, Chen HJ, Wang Z, Li P, Guan Y, Wang BC, Yang JJ, Tu HY, Yang XN, Zhong WZ, Xia X, Yi X, Zhou Q, Wu YL
Cancer Cell 2023 Oct 9;41(10):1763-1773.e4. doi: 10.1016/j.ccell.2023.09.007. PMID: 37816331
Non-small cell lung cancer in China.
Chen P, Liu Y, Wen Y, Zhou C
Cancer Commun (Lond) 2022 Oct;42(10):937-970. Epub 2022 Sep 8 doi: 10.1002/cac2.12359. PMID: 36075878Free PMC Article
Early assessment of circulating tumor DNA after curative-intent resection predicts tumor recurrence in early-stage and locally advanced non-small-cell lung cancer.
Waldeck S, Mitschke J, Wiesemann S, Rassner M, Andrieux G, Deuter M, Mutter J, Lüchtenborg AM, Kottmann D, Titze L, Zeisel C, Jolic M, Philipp U, Lassmann S, Bronsert P, Greil C, Rawluk J, Becker H, Isbell L, Müller A, Doostkam S, Passlick B, Börries M, Duyster J, Wehrle J, Scherer F, von Bubnoff N
Mol Oncol 2022 Jan;16(2):527-537. Epub 2021 Oct 31 doi: 10.1002/1878-0261.13116. PMID: 34653314Free PMC Article
Early and locally advanced non-small-cell lung cancer (NSCLC): ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up.
Postmus PE, Kerr KM, Oudkerk M, Senan S, Waller DA, Vansteenkiste J, Escriu C, Peters S; ESMO Guidelines Committee
Ann Oncol 2017 Jul 1;28(suppl_4):iv1-iv21. doi: 10.1093/annonc/mdx222. PMID: 28881918
Lung cancer.
Maghfoor I, Perry MC
Ann Saudi Med 2005 Jan-Feb;25(1):1-12. doi: 10.5144/0256-4947.2005.1. PMID: 15822487Free PMC Article

Diagnosis

Non-small cell lung cancer in China.
Chen P, Liu Y, Wen Y, Zhou C
Cancer Commun (Lond) 2022 Oct;42(10):937-970. Epub 2022 Sep 8 doi: 10.1002/cac2.12359. PMID: 36075878Free PMC Article
Advances in systemic therapy for non-small cell lung cancer.
Miller M, Hanna N
BMJ 2021 Nov 9;375:n2363. doi: 10.1136/bmj.n2363. PMID: 34753715
Early and locally advanced non-small-cell lung cancer (NSCLC): ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up.
Postmus PE, Kerr KM, Oudkerk M, Senan S, Waller DA, Vansteenkiste J, Escriu C, Peters S; ESMO Guidelines Committee
Ann Oncol 2017 Jul 1;28(suppl_4):iv1-iv21. doi: 10.1093/annonc/mdx222. PMID: 28881918
Non-small cell lung cancer: epidemiology, risk factors, treatment, and survivorship.
Molina JR, Yang P, Cassivi SD, Schild SE, Adjei AA
Mayo Clin Proc 2008 May;83(5):584-94. doi: 10.4065/83.5.584. PMID: 18452692Free PMC Article
Lung cancer.
Maghfoor I, Perry MC
Ann Saudi Med 2005 Jan-Feb;25(1):1-12. doi: 10.5144/0256-4947.2005.1. PMID: 15822487Free PMC Article

Therapy

Non-Small-Cell Lung Cancer in 2022: A Review for General Practitioners in Oncology.
Mithoowani H, Febbraro M
Curr Oncol 2022 Mar 9;29(3):1828-1839. doi: 10.3390/curroncol29030150. PMID: 35323350Free PMC Article
Systemic and Radiation Therapy Approaches for Locally Advanced Non-Small-Cell Lung Cancer.
Higgins KA, Puri S, Gray JE
J Clin Oncol 2022 Feb 20;40(6):576-585. Epub 2022 Jan 5 doi: 10.1200/JCO.21.01707. PMID: 34985931
Advances in systemic therapy for non-small cell lung cancer.
Miller M, Hanna N
BMJ 2021 Nov 9;375:n2363. doi: 10.1136/bmj.n2363. PMID: 34753715
Lazertinib: First Approval.
Dhillon S
Drugs 2021 Jun;81(9):1107-1113. doi: 10.1007/s40265-021-01533-x. PMID: 34028784Free PMC Article
Meta-analysis of concomitant versus sequential radiochemotherapy in locally advanced non-small-cell lung cancer.
Aupérin A, Le Péchoux C, Rolland E, Curran WJ, Furuse K, Fournel P, Belderbos J, Clamon G, Ulutin HC, Paulus R, Yamanaka T, Bozonnat MC, Uitterhoeve A, Wang X, Stewart L, Arriagada R, Burdett S, Pignon JP
J Clin Oncol 2010 May 1;28(13):2181-90. Epub 2010 Mar 29 doi: 10.1200/JCO.2009.26.2543. PMID: 20351327

Prognosis

Systemic Therapy for Locally Advanced and Metastatic Non-Small Cell Lung Cancer: A Review.
Arbour KC, Riely GJ
JAMA 2019 Aug 27;322(8):764-774. doi: 10.1001/jama.2019.11058. PMID: 31454018
Early and locally advanced non-small-cell lung cancer (NSCLC): ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up.
Postmus PE, Kerr KM, Oudkerk M, Senan S, Waller DA, Vansteenkiste J, Escriu C, Peters S; ESMO Guidelines Committee
Ann Oncol 2017 Jul 1;28(suppl_4):iv1-iv21. doi: 10.1093/annonc/mdx222. PMID: 28881918
Radical Radiotherapy for Locally Advanced Non-small Cell Lung Cancer: When Should Concurrent Chemoradiotherapy Not Be Used?
De Ruysscher D, van Loon J
Clin Oncol (R Coll Radiol) 2016 Nov;28(11):708-711. Epub 2016 Aug 9 doi: 10.1016/j.clon.2016.07.011. PMID: 27519158
Safety and antitumour activity of durvalumab plus tremelimumab in non-small cell lung cancer: a multicentre, phase 1b study.
Antonia S, Goldberg SB, Balmanoukian A, Chaft JE, Sanborn RE, Gupta A, Narwal R, Steele K, Gu Y, Karakunnel JJ, Rizvi NA
Lancet Oncol 2016 Mar;17(3):299-308. Epub 2016 Feb 6 doi: 10.1016/S1470-2045(15)00544-6. PMID: 26858122Free PMC Article
Chemotherapy in metastatic and locally advanced non-small cell lung cancer.
Spigel DR, Greco FA
Semin Surg Oncol 2003;21(2):98-110. doi: 10.1002/ssu.10027. PMID: 14508860

Clinical prediction guides

Early assessment of circulating tumor DNA after curative-intent resection predicts tumor recurrence in early-stage and locally advanced non-small-cell lung cancer.
Waldeck S, Mitschke J, Wiesemann S, Rassner M, Andrieux G, Deuter M, Mutter J, Lüchtenborg AM, Kottmann D, Titze L, Zeisel C, Jolic M, Philipp U, Lassmann S, Bronsert P, Greil C, Rawluk J, Becker H, Isbell L, Müller A, Doostkam S, Passlick B, Börries M, Duyster J, Wehrle J, Scherer F, von Bubnoff N
Mol Oncol 2022 Jan;16(2):527-537. Epub 2021 Oct 31 doi: 10.1002/1878-0261.13116. PMID: 34653314Free PMC Article
Neoadjuvant immunotherapy for non-small cell lung cancer: State of the art.
Kang J, Zhang C, Zhong WZ
Cancer Commun (Lond) 2021 Apr;41(4):287-302. Epub 2021 Mar 10 doi: 10.1002/cac2.12153. PMID: 33689225Free PMC Article
The cutting-edge progress of immune-checkpoint blockade in lung cancer.
Zhou F, Qiao M, Zhou C
Cell Mol Immunol 2021 Feb;18(2):279-293. Epub 2020 Nov 11 doi: 10.1038/s41423-020-00577-5. PMID: 33177696Free PMC Article
Biomarker-driven therapies for previously treated squamous non-small-cell lung cancer (Lung-MAP SWOG S1400): a biomarker-driven master protocol.
Redman MW, Papadimitrakopoulou VA, Minichiello K, Hirsch FR, Mack PC, Schwartz LH, Vokes E, Ramalingam S, Leighl N, Bradley J, Miao J, Moon J, Highleyman L, Miwa C, LeBlanc ML, Malik S, Miller VA, Sigal EV, Adam S, Wholley D, Sigman C, Smolich B, Blanke CD, Kelly K, Gandara DR, Herbst RS
Lancet Oncol 2020 Dec;21(12):1589-1601. Epub 2020 Oct 27 doi: 10.1016/S1470-2045(20)30475-7. PMID: 33125909Free PMC Article
Systemic Therapy for Locally Advanced and Metastatic Non-Small Cell Lung Cancer: A Review.
Arbour KC, Riely GJ
JAMA 2019 Aug 27;322(8):764-774. doi: 10.1001/jama.2019.11058. PMID: 31454018

Recent systematic reviews

Efficacy and safety of EGFR inhibitors and radiotherapy in locally advanced non-small-cell lung cancer: a meta-analysis.
Li X, Wang F, Jia H, Lian Z, Ren K, Yuan Z, Wang P, Zhao L
Future Oncol 2022 Sep;18(27):3055-3065. Epub 2022 Aug 10 doi: 10.2217/fon-2022-0491. PMID: 35947522
Targeted therapy for advanced anaplastic lymphoma kinase (<I>ALK</I>)-rearranged non-small cell lung cancer.
Cameron LB, Hitchen N, Chandran E, Morris T, Manser R, Solomon BJ, Jordan V
Cochrane Database Syst Rev 2022 Jan 7;1(1):CD013453. doi: 10.1002/14651858.CD013453.pub2. PMID: 34994987Free PMC Article
Uncommon EGFR mutations in non-small-cell lung cancer: A systematic literature review of prevalence and clinical outcomes.
John T, Taylor A, Wang H, Eichinger C, Freeman C, Ahn MJ
Cancer Epidemiol 2022 Feb;76:102080. Epub 2021 Dec 15 doi: 10.1016/j.canep.2021.102080. PMID: 34922050
First-line treatment of advanced epidermal growth factor receptor (EGFR) mutation positive non-squamous non-small cell lung cancer.
Greenhalgh J, Boland A, Bates V, Vecchio F, Dundar Y, Chaplin M, Green JA
Cochrane Database Syst Rev 2021 Mar 18;3(3):CD010383. doi: 10.1002/14651858.CD010383.pub3. PMID: 33734432Free PMC Article
Clinical effectiveness and cost-effectiveness of first-line chemotherapy for adult patients with locally advanced or metastatic non-small cell lung cancer: a systematic review and economic evaluation.
Brown T, Pilkington G, Bagust A, Boland A, Oyee J, Tudur-Smith C, Blundell M, Lai M, Martin Saborido C, Greenhalgh J, Dundar Y, Dickson R
Health Technol Assess 2013 Jul;17(31):1-278. doi: 10.3310/hta17310. PMID: 23886301Free PMC Article

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