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Locally Advanced Lung Non-Small Cell Carcinoma

MedGen UID:
1691150
•Concept ID:
C5205550
•
Neoplastic Process

Definition

A non-small cell carcinoma of the lung that has spread from its original site of growth to nearby tissues or lymph nodes. [from NCI]

Professional guidelines

PubMed

Treatment adherence in concurrent chemoradiation in patients with locally advanced non-small cell lung carcinoma: results of daily intravenous prehydration.
Uyterlinde W, Chen C, Nijkamp J, Obbink MG, Sonke JJ, Belderbos J, van den Heuvel M
Radiother Oncol 2014 Mar;110(3):488-92. Epub 2014 Jan 17 doi: 10.1016/j.radonc.2013.12.008. PMID: 24444531

Recent clinical studies

Etiology

Non-small cell lung cancer in China.
Chen P, Liu Y, Wen Y, Zhou C
Cancer Commun (Lond) 2022 Oct;42(10):937-970. Epub 2022 Sep 8 doi: 10.1002/cac2.12359. PMID: 36075878Free PMC Article
Locally Advanced, Unresectable Non-Small Cell Lung Cancer.
Puri S, Saltos A, Perez B, Le X, Gray JE
Curr Oncol Rep 2020 Mar 5;22(4):31. doi: 10.1007/s11912-020-0882-3. PMID: 32140986
Deep Learning Predicts Lung Cancer Treatment Response from Serial Medical Imaging.
Xu Y, Hosny A, Zeleznik R, Parmar C, Coroller T, Franco I, Mak RH, Aerts HJWL
Clin Cancer Res 2019 Jun 1;25(11):3266-3275. Epub 2019 Apr 22 doi: 10.1158/1078-0432.CCR-18-2495. PMID: 31010833Free PMC Article
Early and locally advanced non-small-cell lung cancer (NSCLC): ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up.
Postmus PE, Kerr KM, Oudkerk M, Senan S, Waller DA, Vansteenkiste J, Escriu C, Peters S; ESMO Guidelines Committee
Ann Oncol 2017 Jul 1;28(suppl_4):iv1-iv21. doi: 10.1093/annonc/mdx222. PMID: 28881918
Lung cancer.
Maghfoor I, Perry MC
Ann Saudi Med 2005 Jan-Feb;25(1):1-12. doi: 10.5144/0256-4947.2005.1. PMID: 15822487Free PMC Article

Diagnosis

Non-small-cell lung cancer.
Hendriks LEL, Remon J, Faivre-Finn C, Garassino MC, Heymach JV, Kerr KM, Tan DSW, Veronesi G, Reck M
Nat Rev Dis Primers 2024 Sep 26;10(1):71. doi: 10.1038/s41572-024-00551-9. PMID: 39327441
Non-small cell lung cancer in China.
Chen P, Liu Y, Wen Y, Zhou C
Cancer Commun (Lond) 2022 Oct;42(10):937-970. Epub 2022 Sep 8 doi: 10.1002/cac2.12359. PMID: 36075878Free PMC Article
Advances in systemic therapy for non-small cell lung cancer.
Miller M, Hanna N
BMJ 2021 Nov 9;375:n2363. doi: 10.1136/bmj.n2363. PMID: 34753715
Early and locally advanced non-small-cell lung cancer (NSCLC): ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up.
Postmus PE, Kerr KM, Oudkerk M, Senan S, Waller DA, Vansteenkiste J, Escriu C, Peters S; ESMO Guidelines Committee
Ann Oncol 2017 Jul 1;28(suppl_4):iv1-iv21. doi: 10.1093/annonc/mdx222. PMID: 28881918
Non-small cell lung cancer: epidemiology, risk factors, treatment, and survivorship.
Molina JR, Yang P, Cassivi SD, Schild SE, Adjei AA
Mayo Clin Proc 2008 May;83(5):584-94. doi: 10.4065/83.5.584. PMID: 18452692Free PMC Article

Therapy

Non-Small-Cell Lung Cancer in 2022: A Review for General Practitioners in Oncology.
Mithoowani H, Febbraro M
Curr Oncol 2022 Mar 9;29(3):1828-1839. doi: 10.3390/curroncol29030150. PMID: 35323350Free PMC Article
Systemic and Radiation Therapy Approaches for Locally Advanced Non-Small-Cell Lung Cancer.
Higgins KA, Puri S, Gray JE
J Clin Oncol 2022 Feb 20;40(6):576-585. Epub 2022 Jan 5 doi: 10.1200/JCO.21.01707. PMID: 34985931
Advances in systemic therapy for non-small cell lung cancer.
Miller M, Hanna N
BMJ 2021 Nov 9;375:n2363. doi: 10.1136/bmj.n2363. PMID: 34753715
Lazertinib: First Approval.
Dhillon S
Drugs 2021 Jun;81(9):1107-1113. doi: 10.1007/s40265-021-01533-x. PMID: 34028784Free PMC Article
Meta-analysis of concomitant versus sequential radiochemotherapy in locally advanced non-small-cell lung cancer.
Aupérin A, Le Péchoux C, Rolland E, Curran WJ, Furuse K, Fournel P, Belderbos J, Clamon G, Ulutin HC, Paulus R, Yamanaka T, Bozonnat MC, Uitterhoeve A, Wang X, Stewart L, Arriagada R, Burdett S, Pignon JP
J Clin Oncol 2010 May 1;28(13):2181-90. Epub 2010 Mar 29 doi: 10.1200/JCO.2009.26.2543. PMID: 20351327

Prognosis

Prognosis of Different Types of Non-Small Cell Lung Cancer Progression: Current State and Perspectives.
Schegoleva AA, Khozyainova AA, Fedorov AA, Gerashchenko TS, Rodionov EO, Topolnitsky EB, Shefer NA, Pankova OV, Durova AA, Zavyalova MV, Perelmuter VM, Denisov EV
Cell Physiol Biochem 2021 Mar 10;55(S2):29-48. doi: 10.33594/000000340. PMID: 33687819
Systemic Therapy for Locally Advanced and Metastatic Non-Small Cell Lung Cancer: A Review.
Arbour KC, Riely GJ
JAMA 2019 Aug 27;322(8):764-774. doi: 10.1001/jama.2019.11058. PMID: 31454018
Early and locally advanced non-small-cell lung cancer (NSCLC): ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up.
Postmus PE, Kerr KM, Oudkerk M, Senan S, Waller DA, Vansteenkiste J, Escriu C, Peters S; ESMO Guidelines Committee
Ann Oncol 2017 Jul 1;28(suppl_4):iv1-iv21. doi: 10.1093/annonc/mdx222. PMID: 28881918
Extending survival of stage IV non-small cell lung cancer.
Carnio S, Novello S, Mele T, Levra MG, Scagliotti GV
Semin Oncol 2014 Feb;41(1):69-92. Epub 2013 Dec 21 doi: 10.1053/j.seminoncol.2013.12.013. PMID: 24565582
Locally advanced lung cancer: an optimal setting for vaccines and other immunotherapies.
Iyengar P, Gerber DE
Cancer J 2013 May-Jun;19(3):247-62. doi: 10.1097/PPO.0b013e318292e51a. PMID: 23708072Free PMC Article

Clinical prediction guides

Non-small-cell lung cancer.
Hendriks LEL, Remon J, Faivre-Finn C, Garassino MC, Heymach JV, Kerr KM, Tan DSW, Veronesi G, Reck M
Nat Rev Dis Primers 2024 Sep 26;10(1):71. doi: 10.1038/s41572-024-00551-9. PMID: 39327441
The cutting-edge progress of immune-checkpoint blockade in lung cancer.
Zhou F, Qiao M, Zhou C
Cell Mol Immunol 2021 Feb;18(2):279-293. Epub 2020 Nov 11 doi: 10.1038/s41423-020-00577-5. PMID: 33177696Free PMC Article
Biomarker-driven therapies for previously treated squamous non-small-cell lung cancer (Lung-MAP SWOG S1400): a biomarker-driven master protocol.
Redman MW, Papadimitrakopoulou VA, Minichiello K, Hirsch FR, Mack PC, Schwartz LH, Vokes E, Ramalingam S, Leighl N, Bradley J, Miao J, Moon J, Highleyman L, Miwa C, LeBlanc ML, Malik S, Miller VA, Sigal EV, Adam S, Wholley D, Sigman C, Smolich B, Blanke CD, Kelly K, Gandara DR, Herbst RS
Lancet Oncol 2020 Dec;21(12):1589-1601. Epub 2020 Oct 27 doi: 10.1016/S1470-2045(20)30475-7. PMID: 33125909Free PMC Article
Systemic Therapy for Locally Advanced and Metastatic Non-Small Cell Lung Cancer: A Review.
Arbour KC, Riely GJ
JAMA 2019 Aug 27;322(8):764-774. doi: 10.1001/jama.2019.11058. PMID: 31454018
Deep Learning Predicts Lung Cancer Treatment Response from Serial Medical Imaging.
Xu Y, Hosny A, Zeleznik R, Parmar C, Coroller T, Franco I, Mak RH, Aerts HJWL
Clin Cancer Res 2019 Jun 1;25(11):3266-3275. Epub 2019 Apr 22 doi: 10.1158/1078-0432.CCR-18-2495. PMID: 31010833Free PMC Article

Recent systematic reviews

Pneumonitis Risk After Chemoradiotherapy With and Without Immunotherapy in Patients With Locally Advanced Non-Small Cell Lung Cancer: A Systematic Review and Meta-Analysis.
Han C, Qiu J, Bai L, Liu T, Chen J, Wang H, Dang J
Int J Radiat Oncol Biol Phys 2024 Jul 15;119(4):1179-1207. Epub 2024 Feb 13 doi: 10.1016/j.ijrobp.2024.01.217. PMID: 38360117
The timing of durvalumab administration affects the risk of pneumonitis in patients with locally advanced non-small cell lung cancer: a systematic review and meta-analysis.
Yang Z, Zhong W, Luo Y, Wu C
BMC Cancer 2023 Oct 10;23(1):962. doi: 10.1186/s12885-023-11472-3. PMID: 37817073Free PMC Article
Pneumonitis with combined immune checkpoint inhibitors and chemoradiotherapy in locally advanced non-small-cell lung cancer: a systematic review and meta-analysis.
Yang L, Li B, Xu Y, Zou B, Fan B, Wang C, Wang L
Future Oncol 2023 May;19(16):1151-1160. Epub 2023 Jun 9 doi: 10.2217/fon-2022-1274. PMID: 37293787
Targeted therapy for advanced anaplastic lymphoma kinase (<I>ALK</I>)-rearranged non-small cell lung cancer.
Cameron LB, Hitchen N, Chandran E, Morris T, Manser R, Solomon BJ, Jordan V
Cochrane Database Syst Rev 2022 Jan 7;1(1):CD013453. doi: 10.1002/14651858.CD013453.pub2. PMID: 34994987Free PMC Article
Uncommon EGFR mutations in non-small-cell lung cancer: A systematic literature review of prevalence and clinical outcomes.
John T, Taylor A, Wang H, Eichinger C, Freeman C, Ahn MJ
Cancer Epidemiol 2022 Feb;76:102080. Epub 2021 Dec 15 doi: 10.1016/j.canep.2021.102080. PMID: 34922050

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