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Locally Advanced Large Cell Neuroendocrine Carcinoma

MedGen UID:
1698583
•Concept ID:
C5204068
•
Neoplastic Process

Definition

A large cell neuroendocrine carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLocally Advanced Large Cell Neuroendocrine Carcinoma

Professional guidelines

PubMed

Factors associated with treatment receipt and overall survival for patients with locally advanced large cell neuroendocrine carcinoma of the lung: A National Cancer Database analysis.
Limonnik V, Abel S, Finley GG, Long GS, Wegner RE
Lung Cancer 2020 Dec;150:107-113. Epub 2020 Oct 6 doi: 10.1016/j.lungcan.2020.10.001. PMID: 33126090

Recent clinical studies

Etiology

Role of radiotherapy in the management of rare gynaecological cancers.
Morcet-Delattre R, Espenel S, Tas P, Chargari C, Escande A
Cancer Radiother 2023 Dec;27(8):778-788. Epub 2023 Nov 2 doi: 10.1016/j.canrad.2023.08.006. PMID: 37925347
Clinicopathological and genomic features in patients with head and neck neuroendocrine carcinoma.
Ohmoto A, Sato Y, Asaka R, Fukuda N, Wang X, Urasaki T, Hayashi N, Sato Y, Nakano K, Yunokawa M, Ono M, Tomomatsu J, Toshiyasu T, Mitani H, Takeuchi K, Mori S, Takahashi S
Mod Pathol 2021 Nov;34(11):1979-1989. Epub 2021 Jul 10 doi: 10.1038/s41379-021-00869-9. PMID: 34247193Free PMC Article
Results of Surgical Resection of Locally Advanced Pulmonary Neuroendocrine Tumors.
Girelli L, Casiraghi M, Sandri A, Petrella F, Galetta D, Gasparri R, Maisonneuve P, Fazio N, Spaggiari L
Ann Thorac Surg 2021 Aug;112(2):405-414. Epub 2020 Oct 29 doi: 10.1016/j.athoracsur.2020.09.021. PMID: 33130114
Outcomes for Surgery in Large Cell Lung Neuroendocrine Cancer.
Raman V, Jawitz OK, Yang CJ, Voigt SL, Tong BC, D'Amico TA, Harpole DH
J Thorac Oncol 2019 Dec;14(12):2143-2151. Epub 2019 Sep 23 doi: 10.1016/j.jtho.2019.09.005. PMID: 31557535Free PMC Article
Neuroendrocrine tumors of the uterine cervix: A therapeutic challenge for gynecologic oncologists.
Gadducci A, Carinelli S, Aletti G
Gynecol Oncol 2017 Mar;144(3):637-646. Epub 2017 Jan 3 doi: 10.1016/j.ygyno.2016.12.003. PMID: 28057354

Diagnosis

Role of radiotherapy in the management of rare gynaecological cancers.
Morcet-Delattre R, Espenel S, Tas P, Chargari C, Escande A
Cancer Radiother 2023 Dec;27(8):778-788. Epub 2023 Nov 2 doi: 10.1016/j.canrad.2023.08.006. PMID: 37925347
Radiation therapy of cutaneous cancers.
Hennequin C, Rio E, Quéro L, Clavère P
Cancer Radiother 2022 Feb-Apr;26(1-2):397-403. Epub 2021 Dec 23 doi: 10.1016/j.canrad.2021.11.020. PMID: 34955421
Results of Surgical Resection of Locally Advanced Pulmonary Neuroendocrine Tumors.
Girelli L, Casiraghi M, Sandri A, Petrella F, Galetta D, Gasparri R, Maisonneuve P, Fazio N, Spaggiari L
Ann Thorac Surg 2021 Aug;112(2):405-414. Epub 2020 Oct 29 doi: 10.1016/j.athoracsur.2020.09.021. PMID: 33130114
Surgical management of medullary thyroid carcinoma.
Konstantinidis A, Stang M, Roman SA, Sosa JA
Updates Surg 2017 Jun;69(2):151-160. Epub 2017 Apr 13 doi: 10.1007/s13304-017-0443-y. PMID: 28409442
Management of advanced medullary thyroid cancer.
Hadoux J, Pacini F, Tuttle RM, Schlumberger M
Lancet Diabetes Endocrinol 2016 Jan;4(1):64-71. Epub 2015 Oct 23 doi: 10.1016/S2213-8587(15)00337-X. PMID: 26608066

Therapy

Radiation therapy of cutaneous cancers.
Hennequin C, Rio E, Quéro L, Clavère P
Cancer Radiother 2022 Feb-Apr;26(1-2):397-403. Epub 2021 Dec 23 doi: 10.1016/j.canrad.2021.11.020. PMID: 34955421
Neuroendocrine carcinoma of the cervix: a systematic review of the literature.
Tempfer CB, Tischoff I, Dogan A, Hilal Z, Schultheis B, Kern P, Rezniczek GA
BMC Cancer 2018 May 4;18(1):530. doi: 10.1186/s12885-018-4447-x. PMID: 29728073Free PMC Article
Chemotherapy and tyrosine-kinase inhibitors for medullary thyroid cancer.
Hadoux J, Schlumberger M
Best Pract Res Clin Endocrinol Metab 2017 Jun;31(3):335-347. Epub 2017 Apr 28 doi: 10.1016/j.beem.2017.04.009. PMID: 28911729
Surgical management of medullary thyroid carcinoma.
Konstantinidis A, Stang M, Roman SA, Sosa JA
Updates Surg 2017 Jun;69(2):151-160. Epub 2017 Apr 13 doi: 10.1007/s13304-017-0443-y. PMID: 28409442
Management of advanced medullary thyroid cancer.
Hadoux J, Pacini F, Tuttle RM, Schlumberger M
Lancet Diabetes Endocrinol 2016 Jan;4(1):64-71. Epub 2015 Oct 23 doi: 10.1016/S2213-8587(15)00337-X. PMID: 26608066

Prognosis

Role of radiotherapy in the management of rare gynaecological cancers.
Morcet-Delattre R, Espenel S, Tas P, Chargari C, Escande A
Cancer Radiother 2023 Dec;27(8):778-788. Epub 2023 Nov 2 doi: 10.1016/j.canrad.2023.08.006. PMID: 37925347
Radiation therapy of cutaneous cancers.
Hennequin C, Rio E, Quéro L, Clavère P
Cancer Radiother 2022 Feb-Apr;26(1-2):397-403. Epub 2021 Dec 23 doi: 10.1016/j.canrad.2021.11.020. PMID: 34955421
Results of Surgical Resection of Locally Advanced Pulmonary Neuroendocrine Tumors.
Girelli L, Casiraghi M, Sandri A, Petrella F, Galetta D, Gasparri R, Maisonneuve P, Fazio N, Spaggiari L
Ann Thorac Surg 2021 Aug;112(2):405-414. Epub 2020 Oct 29 doi: 10.1016/j.athoracsur.2020.09.021. PMID: 33130114
Neuroendocrine carcinoma of the cervix: a systematic review of the literature.
Tempfer CB, Tischoff I, Dogan A, Hilal Z, Schultheis B, Kern P, Rezniczek GA
BMC Cancer 2018 May 4;18(1):530. doi: 10.1186/s12885-018-4447-x. PMID: 29728073Free PMC Article
Primary Biliary Mixed Adenoneuroendocrine Carcinoma (MANEC): A Short Review.
Acosta AM, Wiley EL
Arch Pathol Lab Med 2016 Oct;140(10):1157-62. doi: 10.5858/arpa.2015-0102-RS. PMID: 27684986

Clinical prediction guides

Pembrolizumab and other immune checkpoint inhibitors in locally advanced or metastatic Merkel Cell Carcinoma: safety and efficacy.
Marchand A, Kervarrec T, Bhatia S, Samimi M
Expert Rev Anticancer Ther 2020 Dec;20(12):1093-1106. Epub 2020 Nov 4 doi: 10.1080/14737140.2021.1835477. PMID: 33044876
Outcomes for Surgery in Large Cell Lung Neuroendocrine Cancer.
Raman V, Jawitz OK, Yang CJ, Voigt SL, Tong BC, D'Amico TA, Harpole DH
J Thorac Oncol 2019 Dec;14(12):2143-2151. Epub 2019 Sep 23 doi: 10.1016/j.jtho.2019.09.005. PMID: 31557535Free PMC Article
Small cell carcinoma of the urinary bladder: a clinicopathological and immunohistochemical analysis of 81 cases.
Wang G, Xiao L, Zhang M, Kamat AM, Siefker-Radtke A, Dinney CP, Czerniak B, Guo CC
Hum Pathol 2018 Sep;79:57-65. Epub 2018 May 12 doi: 10.1016/j.humpath.2018.05.005. PMID: 29763719Free PMC Article
Immune Checkpoint Inhibitors in the Treatment of Patients with Neuroendocrine Neoplasia.
Weber MM, Fottner C
Oncol Res Treat 2018;41(5):306-312. Epub 2018 Apr 26 doi: 10.1159/000488996. PMID: 29742518
Small cell neuroendocrine carcinoma of the endometrium: a clinicopathologic study of six cases.
Koo YJ, Kim DY, Kim KR, Kim JH, Kim YM, Kim YT, Nam JH
Taiwan J Obstet Gynecol 2014 Sep;53(3):355-9. doi: 10.1016/j.tjog.2013.05.006. PMID: 25286790

Recent systematic reviews

Small cell and large cell neuroendocrine carcinoma of the larynx: A comparative analysis.
Strojan P, Hernandez-Prera JC, Beitler JJ, Eisbruch A, Saba NF, Mendenhall WM, Nieto CS, Smee R, Rinaldo A, Ferlito A
Cancer Treat Rev 2019 Aug;78:42-51. Epub 2019 Aug 8 doi: 10.1016/j.ctrv.2019.08.002. PMID: 31437725
Neuroendocrine carcinoma of the cervix: a systematic review of the literature.
Tempfer CB, Tischoff I, Dogan A, Hilal Z, Schultheis B, Kern P, Rezniczek GA
BMC Cancer 2018 May 4;18(1):530. doi: 10.1186/s12885-018-4447-x. PMID: 29728073Free PMC Article
Neuroendrocrine tumors of the uterine cervix: A therapeutic challenge for gynecologic oncologists.
Gadducci A, Carinelli S, Aletti G
Gynecol Oncol 2017 Mar;144(3):637-646. Epub 2017 Jan 3 doi: 10.1016/j.ygyno.2016.12.003. PMID: 28057354

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