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Locally Advanced Hepatocellular Carcinoma

MedGen UID:
1710030
Concept ID:
C5239576
Neoplastic Process

Definition

Hepatocellular carcinoma that has spread to nearby tissues or lymph nodes. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLocally Advanced Hepatocellular Carcinoma

Professional guidelines

PubMed

Chen J, Zhang D, Yuan Y
Clin Exp Med 2023 Jul;23(3):579-590. Epub 2022 Aug 26 doi: 10.1007/s10238-022-00873-6. PMID: 36018466
Aujay G, Etchegaray C, Blanc JF, Lapuyade B, Papadopoulos P, Pey MA, Bordenave L, Trillaud H, Saut O, Pinaquy JB
Diagn Interv Imaging 2022 Jul-Aug;103(7-8):360-366. Epub 2022 Feb 17 doi: 10.1016/j.diii.2022.01.009. PMID: 35183483
Hartenbach M, Weber S, Albert NL, Hartenbach S, Hirtl A, Zacherl MJ, Paprottka PM, Tiling R, Bartenstein P, Hacker M, Haug AR
J Nucl Med 2015 Nov;56(11):1661-6. Epub 2015 Sep 24 doi: 10.2967/jnumed.115.158758. PMID: 26405170

Recent clinical studies

Etiology

Chiang CL, Chiu KWH, Chan KSK, Lee FAS, Li JCB, Wan CWS, Dai WC, Lam TC, Chen W, Wong NSM, Cheung ALY, Lee VWY, Lau VWH, El Helali A, Man K, Kong FMS, Lo CM, Chan AC
Lancet Gastroenterol Hepatol 2023 Feb;8(2):169-178. Epub 2022 Dec 15 doi: 10.1016/S2468-1253(22)00339-9. PMID: 36529152
Lyu N, Wang X, Li JB, Lai JF, Chen QF, Li SL, Deng HJ, He M, Mu LW, Zhao M
J Clin Oncol 2022 Feb 10;40(5):468-480. Epub 2021 Dec 14 doi: 10.1200/JCO.21.01963. PMID: 34905388
Blaise L, Pereira H, Vilgrain V, Sutter O, Gigante E, Walter A, Ganne-Carrié N, Nahon P, Bouattour M, Dioguardi Burgio M, Grando V, Nkontchou G, Seror O, Nault JC
Clin Res Hepatol Gastroenterol 2021 Nov;45(6):101731. Epub 2021 Jun 15 doi: 10.1016/j.clinre.2021.101731. PMID: 34139320
Garin E, Tselikas L, Guiu B, Chalaye J, Edeline J, de Baere T, Assenat E, Tacher V, Robert C, Terroir-Cassou-Mounat M, Mariano-Goulart D, Amaddeo G, Palard X, Hollebecque A, Kafrouni M, Regnault H, Boudjema K, Grimaldi S, Fourcade M, Kobeiter H, Vibert E, Le Sourd S, Piron L, Sommacale D, Laffont S, Campillo-Gimenez B, Rolland Y; DOSISPHERE-01 Study Group
Lancet Gastroenterol Hepatol 2021 Jan;6(1):17-29. Epub 2020 Nov 7 doi: 10.1016/S2468-1253(20)30290-9. PMID: 33166497
Vilgrain V, Pereira H, Assenat E, Guiu B, Ilonca AD, Pageaux GP, Sibert A, Bouattour M, Lebtahi R, Allaham W, Barraud H, Laurent V, Mathias E, Bronowicki JP, Tasu JP, Perdrisot R, Silvain C, Gerolami R, Mundler O, Seitz JF, Vidal V, Aubé C, Oberti F, Couturier O, Brenot-Rossi I, Raoul JL, Sarran A, Costentin C, Itti E, Luciani A, Adam R, Lewin M, Samuel D, Ronot M, Dinut A, Castera L, Chatellier G; SARAH Trial Group
Lancet Oncol 2017 Dec;18(12):1624-1636. Epub 2017 Oct 26 doi: 10.1016/S1470-2045(17)30683-6. PMID: 29107679

Diagnosis

Chen J, Zhang D, Yuan Y
Clin Exp Med 2023 Jul;23(3):579-590. Epub 2022 Aug 26 doi: 10.1007/s10238-022-00873-6. PMID: 36018466
Marqueen KE, Kim E, Ang C, Mazumdar M, Buckstein M, Ferket BS
JCO Oncol Pract 2021 Feb;17(2):e266-e277. Epub 2021 Jan 8 doi: 10.1200/OP.20.00443. PMID: 33417490Free PMC Article
Goto Y, Hisaka T, Sakai H, Takagi K, Fukutomi S, Akagi Y, Okuda K
Anticancer Res 2020 Aug;40(8):4773-4777. doi: 10.21873/anticanres.14479. PMID: 32727804
Rhee WJ, Hwang SH, Byun HK, Yun M, Han KH, Seong J
Liver Int 2017 Apr;37(4):592-599. Epub 2016 Nov 27 doi: 10.1111/liv.13297. PMID: 27804192
Lee HS, Choi GH, Choi JS, Kim KS, Han KH, Seong J, Ahn SH, Kim DY, Park JY, Kim SU, Kim BK
Ann Surg Oncol 2014 Oct;21(11):3646-53. Epub 2014 Jun 11 doi: 10.1245/s10434-014-3652-3. PMID: 24916746

Therapy

Chiang CL, Chiu KWH, Chan KSK, Lee FAS, Li JCB, Wan CWS, Dai WC, Lam TC, Chen W, Wong NSM, Cheung ALY, Lee VWY, Lau VWH, El Helali A, Man K, Kong FMS, Lo CM, Chan AC
Lancet Gastroenterol Hepatol 2023 Feb;8(2):169-178. Epub 2022 Dec 15 doi: 10.1016/S2468-1253(22)00339-9. PMID: 36529152
Lyu N, Wang X, Li JB, Lai JF, Chen QF, Li SL, Deng HJ, He M, Mu LW, Zhao M
J Clin Oncol 2022 Feb 10;40(5):468-480. Epub 2021 Dec 14 doi: 10.1200/JCO.21.01963. PMID: 34905388
Garin E, Tselikas L, Guiu B, Chalaye J, Edeline J, de Baere T, Assenat E, Tacher V, Robert C, Terroir-Cassou-Mounat M, Mariano-Goulart D, Amaddeo G, Palard X, Hollebecque A, Kafrouni M, Regnault H, Boudjema K, Grimaldi S, Fourcade M, Kobeiter H, Vibert E, Le Sourd S, Piron L, Sommacale D, Laffont S, Campillo-Gimenez B, Rolland Y; DOSISPHERE-01 Study Group
Lancet Gastroenterol Hepatol 2021 Jan;6(1):17-29. Epub 2020 Nov 7 doi: 10.1016/S2468-1253(20)30290-9. PMID: 33166497
Mondaca S, Yarmohammadi H, Kemeny NE
Surg Oncol Clin N Am 2019 Oct;28(4):717-729. Epub 2019 Aug 7 doi: 10.1016/j.soc.2019.06.008. PMID: 31472915Free PMC Article
Vilgrain V, Pereira H, Assenat E, Guiu B, Ilonca AD, Pageaux GP, Sibert A, Bouattour M, Lebtahi R, Allaham W, Barraud H, Laurent V, Mathias E, Bronowicki JP, Tasu JP, Perdrisot R, Silvain C, Gerolami R, Mundler O, Seitz JF, Vidal V, Aubé C, Oberti F, Couturier O, Brenot-Rossi I, Raoul JL, Sarran A, Costentin C, Itti E, Luciani A, Adam R, Lewin M, Samuel D, Ronot M, Dinut A, Castera L, Chatellier G; SARAH Trial Group
Lancet Oncol 2017 Dec;18(12):1624-1636. Epub 2017 Oct 26 doi: 10.1016/S1470-2045(17)30683-6. PMID: 29107679

Prognosis

Chen J, Zhang D, Yuan Y
Clin Exp Med 2023 Jul;23(3):579-590. Epub 2022 Aug 26 doi: 10.1007/s10238-022-00873-6. PMID: 36018466
Lyu N, Wang X, Li JB, Lai JF, Chen QF, Li SL, Deng HJ, He M, Mu LW, Zhao M
J Clin Oncol 2022 Feb 10;40(5):468-480. Epub 2021 Dec 14 doi: 10.1200/JCO.21.01963. PMID: 34905388
Bent EH, Wehrenberg-Klee E, Koay EJ, Goyal L, Wo JY
J Natl Compr Canc Netw 2021 May;19(5):567-576. Epub 2020 Oct 1 doi: 10.6004/jnccn.2021.7037. PMID: 34030132
Mondaca S, Yarmohammadi H, Kemeny NE
Surg Oncol Clin N Am 2019 Oct;28(4):717-729. Epub 2019 Aug 7 doi: 10.1016/j.soc.2019.06.008. PMID: 31472915Free PMC Article
Vilgrain V, Pereira H, Assenat E, Guiu B, Ilonca AD, Pageaux GP, Sibert A, Bouattour M, Lebtahi R, Allaham W, Barraud H, Laurent V, Mathias E, Bronowicki JP, Tasu JP, Perdrisot R, Silvain C, Gerolami R, Mundler O, Seitz JF, Vidal V, Aubé C, Oberti F, Couturier O, Brenot-Rossi I, Raoul JL, Sarran A, Costentin C, Itti E, Luciani A, Adam R, Lewin M, Samuel D, Ronot M, Dinut A, Castera L, Chatellier G; SARAH Trial Group
Lancet Oncol 2017 Dec;18(12):1624-1636. Epub 2017 Oct 26 doi: 10.1016/S1470-2045(17)30683-6. PMID: 29107679

Clinical prediction guides

Chiang CL, Chiu KWH, Chan KSK, Lee FAS, Li JCB, Wan CWS, Dai WC, Lam TC, Chen W, Wong NSM, Cheung ALY, Lee VWY, Lau VWH, El Helali A, Man K, Kong FMS, Lo CM, Chan AC
Lancet Gastroenterol Hepatol 2023 Feb;8(2):169-178. Epub 2022 Dec 15 doi: 10.1016/S2468-1253(22)00339-9. PMID: 36529152
Chen J, Zhang D, Yuan Y
Clin Exp Med 2023 Jul;23(3):579-590. Epub 2022 Aug 26 doi: 10.1007/s10238-022-00873-6. PMID: 36018466
Lyu N, Wang X, Li JB, Lai JF, Chen QF, Li SL, Deng HJ, He M, Mu LW, Zhao M
J Clin Oncol 2022 Feb 10;40(5):468-480. Epub 2021 Dec 14 doi: 10.1200/JCO.21.01963. PMID: 34905388
Shiba S, Shibuya K, Okamoto M, Okazaki S, Komatsu S, Kubota Y, Nakano T, Ohno T
Radiat Oncol 2020 Aug 14;15(1):195. doi: 10.1186/s13014-020-01634-z. PMID: 32795340Free PMC Article
Vilgrain V, Pereira H, Assenat E, Guiu B, Ilonca AD, Pageaux GP, Sibert A, Bouattour M, Lebtahi R, Allaham W, Barraud H, Laurent V, Mathias E, Bronowicki JP, Tasu JP, Perdrisot R, Silvain C, Gerolami R, Mundler O, Seitz JF, Vidal V, Aubé C, Oberti F, Couturier O, Brenot-Rossi I, Raoul JL, Sarran A, Costentin C, Itti E, Luciani A, Adam R, Lewin M, Samuel D, Ronot M, Dinut A, Castera L, Chatellier G; SARAH Trial Group
Lancet Oncol 2017 Dec;18(12):1624-1636. Epub 2017 Oct 26 doi: 10.1016/S1470-2045(17)30683-6. PMID: 29107679

Recent systematic reviews

Abdel-Rahman O, Elsayed Z
Cochrane Database Syst Rev 2020 Jan 24;1(1):CD011313. doi: 10.1002/14651858.CD011313.pub3. PMID: 31978267Free PMC Article
Zou J, Zhu W, Meng H, Luo P, Zhang J
Expert Rev Gastroenterol Hepatol 2019 Mar;13(3):271-279. Epub 2019 Jan 25 doi: 10.1080/17474124.2019.1570135. PMID: 30791765

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