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Recurrent Myeloproliferative Neoplasm

MedGen UID:
1712796
•Concept ID:
C5237728
•
Neoplastic Process

Definition

The reemergence of a myeloproliferative neoplasm after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Myeloproliferative Neoplasm

Professional guidelines

PubMed

European LeukemiaNet laboratory recommendations for the diagnosis and management of chronic myeloid leukemia.
Cross NCP, Ernst T, Branford S, Cayuela JM, Deininger M, Fabarius A, Kim DDH, Machova Polakova K, Radich JP, Hehlmann R, Hochhaus A, Apperley JF, Soverini S
Leukemia 2023 Nov;37(11):2150-2167. Epub 2023 Oct 4 doi: 10.1038/s41375-023-02048-y. PMID: 37794101Free PMC Article
Blast phase myeloproliferative neoplasm: contemporary review and 2024 treatment algorithm.
Tefferi A, Alkhateeb H, Gangat N
Blood Cancer J 2023 Jul 18;13(1):108. doi: 10.1038/s41408-023-00878-8. PMID: 37460550Free PMC Article
Pathogenesis and Management of Thrombotic Disease in Myeloproliferative Neoplasms.
Arachchillage DR, Laffan M
Semin Thromb Hemost 2019 Sep;45(6):604-611. Epub 2019 Aug 5 doi: 10.1055/s-0039-1693477. PMID: 31382304

Recent clinical studies

Etiology

CD36 Drives Metastasis and Relapse in Acute Myeloid Leukemia.
Farge T, Nakhle J, Lagarde D, Cognet G, Polley N, Castellano R, Nicolau ML, Bosc C, Sabatier M, Sahal A, Saland E, Jeanson Y, Guiraud N, Boet E, Bergoglio C, Gotanègre M, Mouchel PL, Stuani L, Larrue C, Sallese M, De Mas V, Moro C, Dray C, Collette Y, Raymond-Letron I, Ader I, Récher C, Sarry JE, Cabon F, Vergez F, Carrière A
Cancer Res 2023 Sep 1;83(17):2824-2838. doi: 10.1158/0008-5472.CAN-22-3682. PMID: 37327406Free PMC Article
The genetic landscape of germline DDX41 variants predisposing to myeloid neoplasms.
Li P, Brown S, Williams M, White T, Xie W, Cui W, Peker D, Lei L, Kunder CA, Wang HY, Murray SS, Vagher J, Kovacsovics T, Patel JL
Blood 2022 Aug 18;140(7):716-755. doi: 10.1182/blood.2021015135. PMID: 35671390Free PMC Article
Molecular pathogenesis of the myeloproliferative neoplasms.
Greenfield G, McMullin MF, Mills K
J Hematol Oncol 2021 Jun 30;14(1):103. doi: 10.1186/s13045-021-01116-z. PMID: 34193229Free PMC Article
Myeloproliferative neoplasms and pregnancy: Overview and practice recommendations.
Gangat N, Tefferi A
Am J Hematol 2021 Mar 1;96(3):354-366. Epub 2020 Dec 28 doi: 10.1002/ajh.26067. PMID: 33296529
Leukemia secondary to myeloproliferative neoplasms.
Dunbar AJ, Rampal RK, Levine R
Blood 2020 Jul 2;136(1):61-70. doi: 10.1182/blood.2019000943. PMID: 32430500Free PMC Article

Diagnosis

Progression in Myeloid Neoplasms: Beyond the Myeloblast.
Faria C, Tzankov A
Pathobiology 2024;91(1):55-75. Epub 2023 May 11 doi: 10.1159/000530940. PMID: 37232015Free PMC Article
Myeloid sarcoma: An overview.
Ramia de Cap M, Chen W
Semin Diagn Pathol 2023 May;40(3):129-139. Epub 2023 Apr 17 doi: 10.1053/j.semdp.2023.04.009. PMID: 37149396
Chronic myeloid leukemia: 2022 update on diagnosis, therapy, and monitoring.
Jabbour E, Kantarjian H
Am J Hematol 2022 Sep;97(9):1236-1256. Epub 2022 Jul 6 doi: 10.1002/ajh.26642. PMID: 35751859
Molecular pathogenesis of the myeloproliferative neoplasms.
Greenfield G, McMullin MF, Mills K
J Hematol Oncol 2021 Jun 30;14(1):103. doi: 10.1186/s13045-021-01116-z. PMID: 34193229Free PMC Article
Leukemia secondary to myeloproliferative neoplasms.
Dunbar AJ, Rampal RK, Levine R
Blood 2020 Jul 2;136(1):61-70. doi: 10.1182/blood.2019000943. PMID: 32430500Free PMC Article

Therapy

Chronic myeloid leukemia: 2022 update on diagnosis, therapy, and monitoring.
Jabbour E, Kantarjian H
Am J Hematol 2022 Sep;97(9):1236-1256. Epub 2022 Jul 6 doi: 10.1002/ajh.26642. PMID: 35751859
Myeloproliferative neoplasms and pregnancy: Overview and practice recommendations.
Gangat N, Tefferi A
Am J Hematol 2021 Mar 1;96(3):354-366. Epub 2020 Dec 28 doi: 10.1002/ajh.26067. PMID: 33296529
Myelodysplastic syndrome/myeloproliferative neoplasm overlap syndromes: a focused review.
Patnaik MM, Lasho T
Hematology Am Soc Hematol Educ Program 2020 Dec 4;2020(1):460-464. doi: 10.1182/hematology.2020000163. PMID: 33275673Free PMC Article
Leukemia secondary to myeloproliferative neoplasms.
Dunbar AJ, Rampal RK, Levine R
Blood 2020 Jul 2;136(1):61-70. doi: 10.1182/blood.2019000943. PMID: 32430500Free PMC Article
Chronic myelogenous leukaemia.
Lee SJ
Br J Haematol 2000 Dec;111(4):993-1009. doi: 10.1046/j.1365-2141.2000.02216.x. PMID: 11167734

Prognosis

European LeukemiaNet laboratory recommendations for the diagnosis and management of chronic myeloid leukemia.
Cross NCP, Ernst T, Branford S, Cayuela JM, Deininger M, Fabarius A, Kim DDH, Machova Polakova K, Radich JP, Hehlmann R, Hochhaus A, Apperley JF, Soverini S
Leukemia 2023 Nov;37(11):2150-2167. Epub 2023 Oct 4 doi: 10.1038/s41375-023-02048-y. PMID: 37794101Free PMC Article
CD36 Drives Metastasis and Relapse in Acute Myeloid Leukemia.
Farge T, Nakhle J, Lagarde D, Cognet G, Polley N, Castellano R, Nicolau ML, Bosc C, Sabatier M, Sahal A, Saland E, Jeanson Y, Guiraud N, Boet E, Bergoglio C, Gotanègre M, Mouchel PL, Stuani L, Larrue C, Sallese M, De Mas V, Moro C, Dray C, Collette Y, Raymond-Letron I, Ader I, Récher C, Sarry JE, Cabon F, Vergez F, Carrière A
Cancer Res 2023 Sep 1;83(17):2824-2838. doi: 10.1158/0008-5472.CAN-22-3682. PMID: 37327406Free PMC Article
Myeloid sarcoma: An overview.
Ramia de Cap M, Chen W
Semin Diagn Pathol 2023 May;40(3):129-139. Epub 2023 Apr 17 doi: 10.1053/j.semdp.2023.04.009. PMID: 37149396
Molecular pathogenesis of the myeloproliferative neoplasms.
Greenfield G, McMullin MF, Mills K
J Hematol Oncol 2021 Jun 30;14(1):103. doi: 10.1186/s13045-021-01116-z. PMID: 34193229Free PMC Article
Myelodysplastic syndrome/myeloproliferative neoplasm overlap syndromes: a focused review.
Patnaik MM, Lasho T
Hematology Am Soc Hematol Educ Program 2020 Dec 4;2020(1):460-464. doi: 10.1182/hematology.2020000163. PMID: 33275673Free PMC Article

Clinical prediction guides

GATA2 Deficiency: Predisposition to Myeloid Malignancy and Hematopoietic Cell Transplantation.
Rajput RV, Arnold DE
Curr Hematol Malig Rep 2023 Aug;18(4):89-97. Epub 2023 May 29 doi: 10.1007/s11899-023-00695-7. PMID: 37247092
The leukaemia stem cell: similarities, differences and clinical prospects in CML and AML.
Vetrie D, Helgason GV, Copland M
Nat Rev Cancer 2020 Mar;20(3):158-173. Epub 2020 Jan 6 doi: 10.1038/s41568-019-0230-9. PMID: 31907378
Efficacy of Ruxolitinib in Patients With Chronic Neutrophilic Leukemia and Atypical Chronic Myeloid Leukemia.
Dao KT, Gotlib J, Deininger MMN, Oh ST, Cortes JE, Collins RH Jr, Winton EF, Parker DR, Lee H, Reister A, Schultz, Savage S, Stevens, Brockett C, Subbiah N, Press RD, Raess PW, Cascio M, Dunlap J, Chen Y, Degnin C, Maxson JE, Tognon CE, Macey T, Druker BJ, Tyner JW
J Clin Oncol 2020 Apr 1;38(10):1006-1018. Epub 2019 Dec 27 doi: 10.1200/JCO.19.00895. PMID: 31880950Free PMC Article
The allosteric inhibitor ABL001 enables dual targeting of BCR-ABL1.
Wylie AA, Schoepfer J, Jahnke W, Cowan-Jacob SW, Loo A, Furet P, Marzinzik AL, Pelle X, Donovan J, Zhu W, Buonamici S, Hassan AQ, Lombardo F, Iyer V, Palmer M, Berellini G, Dodd S, Thohan S, Bitter H, Branford S, Ross DM, Hughes TP, Petruzzelli L, Vanasse KG, Warmuth M, Hofmann F, Keen NJ, Sellers WR
Nature 2017 Mar 30;543(7647):733-737. Epub 2017 Mar 22 doi: 10.1038/nature21702. PMID: 28329763
T-cell acute lymphoblastic leukemia.
Raetz EA, Teachey DT
Hematology Am Soc Hematol Educ Program 2016 Dec 2;2016(1):580-588. doi: 10.1182/asheducation-2016.1.580. PMID: 27913532Free PMC Article

Recent systematic reviews

Current evidence on the use of direct oral anticoagulants in patients with myeloproliferative neoplasm: a systematic review.
Baysal M, Bayrak M, Eşkazan AE
Expert Rev Hematol 2023 Feb;16(2):131-140. Epub 2023 Feb 6 doi: 10.1080/17474086.2023.2174515. PMID: 36709432
Coexistent antiphospholipid syndrome and myeloproliferative neoplasm.
Sayar Z, Nallamilli S, Efthymiou M, Lambert J, Cohen H
Lupus 2021 Aug;30(9):1502-1508. Epub 2021 Jul 1 doi: 10.1177/09612033211021154. PMID: 34192956
A systematic review of antithrombotic treatment of venous thromboembolism in patients with myeloproliferative neoplasms.
Hamulyák EN, Daams JG, Leebeek FWG, Biemond BJ, Te Boekhorst PAW, Middeldorp S, Lauw MN
Blood Adv 2021 Jan 12;5(1):113-121. doi: 10.1182/bloodadvances.2020003628. PMID: 33570633Free PMC Article
Leukocytosis and thrombosis in essential thrombocythemia and polycythemia vera: a systematic review and meta-analysis.
Carobbio A, Ferrari A, Masciulli A, Ghirardi A, Barosi G, Barbui T
Blood Adv 2019 Jun 11;3(11):1729-1737. doi: 10.1182/bloodadvances.2019000211. PMID: 31175128Free PMC Article
The association of pretreatment thrombocytosis with prognosis and clinicopathological significance in cervical cancer: a systematic review and meta-analysis.
Cheng J, Zeng Z, Ye Q, Zhang Y, Yan R, Liang C, Wang J, Li M, Yi M
Oncotarget 2017 Apr 11;8(15):24327-24336. doi: 10.18632/oncotarget.15358. PMID: 28212582Free PMC Article

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