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Recurrent Myeloproliferative Neoplasm

MedGen UID:
1712796
•Concept ID:
C5237728
•
Neoplastic Process

Definition

The reemergence of a myeloproliferative neoplasm after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Myeloproliferative Neoplasm

Professional guidelines

PubMed

European LeukemiaNet laboratory recommendations for the diagnosis and management of chronic myeloid leukemia.
Cross NCP, Ernst T, Branford S, Cayuela JM, Deininger M, Fabarius A, Kim DDH, Machova Polakova K, Radich JP, Hehlmann R, Hochhaus A, Apperley JF, Soverini S
Leukemia 2023 Nov;37(11):2150-2167. Epub 2023 Oct 4 doi: 10.1038/s41375-023-02048-y. PMID: 37794101Free PMC Article
Current treatment of myeloproliferative neoplasias: three scenarios.
Xicoy B, Zamora L
Med Clin (Barc) 2020 Feb 28;154(4):131-133. Epub 2019 Jul 24 doi: 10.1016/j.medcli.2019.05.009. PMID: 31351663
Management of chronic myeloid leukemia in blast crisis.
Saußele S, Silver RT
Ann Hematol 2015 Apr;94 Suppl 2:S159-65. Epub 2015 Mar 27 doi: 10.1007/s00277-015-2324-0. PMID: 25814082

Recent clinical studies

Etiology

2024 update on allogeneic hematopoietic stem cell transplant for myelofibrosis: A review of current data and applications on risk stratification and management.
Ali H, Bacigalupo A
Am J Hematol 2024 May;99(5):938-945. Epub 2024 Mar 7 doi: 10.1002/ajh.27274. PMID: 38450790
Outcomes and characteristics of nonmelanoma skin cancers in patients with myeloproliferative neoplasms on ruxolitinib.
Rampotas A, Carter-Brzezinski L, Somervaille TCP, Forryan J, Panitsas F, Harrison C, Witherall R, Innes AJ, Wallis L, Butt NM, Psaila B, Mead AJ, Carter M, Godfrey AL, Laing H, Garg M, Francis S, Ewing J, Teh CH, Cowen HB, Dyer P, McConville C, Wadelin F, Sahra A, McGregor A, Kulakov E, McLornan DP, Lambert J
Blood 2024 Jan 11;143(2):178-182. doi: 10.1182/blood.2023022345. PMID: 37963262
CD36 Drives Metastasis and Relapse in Acute Myeloid Leukemia.
Farge T, Nakhle J, Lagarde D, Cognet G, Polley N, Castellano R, Nicolau ML, Bosc C, Sabatier M, Sahal A, Saland E, Jeanson Y, Guiraud N, Boet E, Bergoglio C, Gotanègre M, Mouchel PL, Stuani L, Larrue C, Sallese M, De Mas V, Moro C, Dray C, Collette Y, Raymond-Letron I, Ader I, Récher C, Sarry JE, Cabon F, Vergez F, Carrière A
Cancer Res 2023 Sep 1;83(17):2824-2838. doi: 10.1158/0008-5472.CAN-22-3682. PMID: 37327406Free PMC Article
Genetics of Myeloproliferative Neoplasms.
Szybinski J, Meyer SC
Hematol Oncol Clin North Am 2021 Apr;35(2):217-236. Epub 2021 Jan 29 doi: 10.1016/j.hoc.2020.12.002. PMID: 33641865
Cerebral vein thrombosis.
Martinelli I
Thromb Res 2013 Jan;131 Suppl 1:S51-4. doi: 10.1016/S0049-3848(13)70022-7. PMID: 23452743

Diagnosis

European LeukemiaNet laboratory recommendations for the diagnosis and management of chronic myeloid leukemia.
Cross NCP, Ernst T, Branford S, Cayuela JM, Deininger M, Fabarius A, Kim DDH, Machova Polakova K, Radich JP, Hehlmann R, Hochhaus A, Apperley JF, Soverini S
Leukemia 2023 Nov;37(11):2150-2167. Epub 2023 Oct 4 doi: 10.1038/s41375-023-02048-y. PMID: 37794101Free PMC Article
Myeloid sarcoma: An overview.
Ramia de Cap M, Chen W
Semin Diagn Pathol 2023 May;40(3):129-139. Epub 2023 Apr 17 doi: 10.1053/j.semdp.2023.04.009. PMID: 37149396
Chronic myeloid leukemia: 2022 update on diagnosis, therapy, and monitoring.
Jabbour E, Kantarjian H
Am J Hematol 2022 Sep;97(9):1236-1256. Epub 2022 Jul 6 doi: 10.1002/ajh.26642. PMID: 35751859
Declaration of Bcr-Abl1 independence.
Zhao H, Deininger MW
Leukemia 2020 Nov;34(11):2827-2836. Epub 2020 Sep 10 doi: 10.1038/s41375-020-01037-9. PMID: 32908250
Another gastroenteritis?
Biskup E, Necek M, Changjin Q
Praxis (Bern 1994) 2016 May 11;105(10):581-6. doi: 10.1024/1661-8157/a002350. PMID: 27167481

Therapy

2024 update on allogeneic hematopoietic stem cell transplant for myelofibrosis: A review of current data and applications on risk stratification and management.
Ali H, Bacigalupo A
Am J Hematol 2024 May;99(5):938-945. Epub 2024 Mar 7 doi: 10.1002/ajh.27274. PMID: 38450790
Chronic myeloid leukemia: 2022 update on diagnosis, therapy, and monitoring.
Jabbour E, Kantarjian H
Am J Hematol 2022 Sep;97(9):1236-1256. Epub 2022 Jul 6 doi: 10.1002/ajh.26642. PMID: 35751859
Myelodysplastic syndrome/myeloproliferative neoplasm overlap syndromes: a focused review.
Patnaik MM, Lasho T
Hematology Am Soc Hematol Educ Program 2020 Dec 4;2020(1):460-464. doi: 10.1182/hematology.2020000163. PMID: 33275673Free PMC Article
Cerebral vein thrombosis.
Martinelli I
Thromb Res 2013 Jan;131 Suppl 1:S51-4. doi: 10.1016/S0049-3848(13)70022-7. PMID: 23452743
Chronic myelogenous leukaemia.
Lee SJ
Br J Haematol 2000 Dec;111(4):993-1009. doi: 10.1046/j.1365-2141.2000.02216.x. PMID: 11167734

Prognosis

2024 update on allogeneic hematopoietic stem cell transplant for myelofibrosis: A review of current data and applications on risk stratification and management.
Ali H, Bacigalupo A
Am J Hematol 2024 May;99(5):938-945. Epub 2024 Mar 7 doi: 10.1002/ajh.27274. PMID: 38450790
Myeloid sarcoma: An overview.
Ramia de Cap M, Chen W
Semin Diagn Pathol 2023 May;40(3):129-139. Epub 2023 Apr 17 doi: 10.1053/j.semdp.2023.04.009. PMID: 37149396
Genetics of Myeloproliferative Neoplasms.
Szybinski J, Meyer SC
Hematol Oncol Clin North Am 2021 Apr;35(2):217-236. Epub 2021 Jan 29 doi: 10.1016/j.hoc.2020.12.002. PMID: 33641865
Genetics of myeloproliferative neoplasms.
Viny AD, Levine RL
Cancer J 2014 Jan-Feb;20(1):61-5. doi: 10.1097/PPO.0000000000000013. PMID: 24445766Free PMC Article
Cerebral vein thrombosis.
Martinelli I
Thromb Res 2013 Jan;131 Suppl 1:S51-4. doi: 10.1016/S0049-3848(13)70022-7. PMID: 23452743

Clinical prediction guides

2024 update on allogeneic hematopoietic stem cell transplant for myelofibrosis: A review of current data and applications on risk stratification and management.
Ali H, Bacigalupo A
Am J Hematol 2024 May;99(5):938-945. Epub 2024 Mar 7 doi: 10.1002/ajh.27274. PMID: 38450790
New scaffolds for type II JAK2 inhibitors overcome the acquired G993A resistance mutation.
Arwood ML, Liu Y, Harkins SK, Weinstock DM, Yang L, Stevenson KE, Plana OD, Dong J, Cirka H, Jones KL, Virtanen AT, Gupta DG, Ceas A, Lawney B, Yoda A, Leahy C, Hao M, He Z, Choi HG, Wang Y, Silvennoinen O, Hubbard SR, Zhang T, Gray NS, Li LS
Cell Chem Biol 2023 Jun 15;30(6):618-631.e12. Epub 2023 Jun 7 doi: 10.1016/j.chembiol.2023.05.007. PMID: 37290440Free PMC Article
Recurrent germline variant in ATM associated with familial myeloproliferative neoplasms.
Braunstein EM, Imada E, Pasca S, Wang S, Chen H, Alba C, Hupalo DN, Wilkerson M, Dalgard CL, Ghannam J, Liu Y, Marchionni L, Moliterno A, Hourigan CS, Gondek LP
Leukemia 2023 Mar;37(3):627-635. Epub 2022 Dec 21 doi: 10.1038/s41375-022-01797-6. PMID: 36543879
Prospects for achieving treatment-free remission in chronic myeloid leukaemia.
Saglio G, Gale RP
Br J Haematol 2020 Aug;190(3):318-327. Epub 2020 Feb 14 doi: 10.1111/bjh.16506. PMID: 32057102Free PMC Article
Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia.
Druker BJ, Talpaz M, Resta DJ, Peng B, Buchdunger E, Ford JM, Lydon NB, Kantarjian H, Capdeville R, Ohno-Jones S, Sawyers CL
N Engl J Med 2001 Apr 5;344(14):1031-7. doi: 10.1056/NEJM200104053441401. PMID: 11287972

Recent systematic reviews

Second-Generation Tyrosine Kinase Inhibitor Discontinuation in Chronic Myeloid Leukemia Patients with Stable Deep Molecular Response: A Systematic Review and a Meta-Analysis.
Di Q, Deng H, Zhao Y, Li BY, Qin L
Comput Math Methods Med 2021;2021:3110622. Epub 2021 Dec 16 doi: 10.1155/2021/3110622. PMID: 34956393Free PMC Article
State-of-the-art review: allogeneic stem cell transplantation for myelofibrosis in 2019.
McLornan DP, Yakoub-Agha I, Robin M, Chalandon Y, Harrison CN, Kroger N
Haematologica 2019 Apr;104(4):659-668. Epub 2019 Mar 14 doi: 10.3324/haematol.2018.206151. PMID: 30872371Free PMC Article
The prognostic role of pretreatment thrombocytosis in gastric cancer: A systematic review and meta-analysis.
Yang C, Jiang H, Huang S, Hong H, Huang X, Wang X, Liao W, Wang X, Chen X, Jiang L
Medicine (Baltimore) 2018 Aug;97(31):e11763. doi: 10.1097/MD.0000000000011763. PMID: 30075601Free PMC Article
Myeloid neoplasms with t(12;22)(p13;q12)/MN1-EVT6: a systematic review of 12 cases.
Shao H, Cen J, Chen S, Qiu H, Pan J
Ann Hematol 2018 Mar;97(3):417-424. Epub 2017 Dec 22 doi: 10.1007/s00277-017-3208-2. PMID: 29273914
Imatinib discontinuation in chronic myeloid leukaemia patients with undetectable BCR-ABL transcript level: A systematic review and a meta-analysis.
Campiotti L, Suter MB, Guasti L, Piazza R, Gambacorti-Passerini C, Grandi AM, Squizzato A
Eur J Cancer 2017 May;77:48-56. Epub 2017 Mar 30 doi: 10.1016/j.ejca.2017.02.028. PMID: 28365527

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