U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Locally Advanced Lip and Oral Cavity Carcinoma

MedGen UID:
1719355
•Concept ID:
C5237271
•
Neoplastic Process

Definition

Lip and oral cavity carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLocally Advanced Lip and Oral Cavity Carcinoma

Professional guidelines

PubMed

Primary tumor site as a predictor of treatment outcome for definitive radiotherapy of advanced-stage oral cavity cancers.
Lin CY, Wang HM, Kang CJ, Lee LY, Huang SF, Fan KH, Chen EY, Chen IH, Liao CT, Chang JT
Int J Radiat Oncol Biol Phys 2010 Nov 15;78(4):1011-9. Epub 2010 Apr 29 doi: 10.1016/j.ijrobp.2009.09.074. PMID: 20434273
Interstitial brachytherapy with Ir-192 low-dose-rate in the treatment of primary and recurrent cancer of the oral cavity and oropharynx. Review of 318 patients treated between 1985 and 1997.
Grabenbauer GG, Rödel C, Brunner T, Schulze-Mosgau S, Strnad V, Müller RG, Iro H, Sauer R
Strahlenther Onkol 2001 Jul;177(7):338-44. doi: 10.1007/pl00002416. PMID: 11505619
Neoadjuvant and adjuvant chemotherapy in the multidisciplinary treatment of oral cancer stage III or IV.
Grau JJ, Estapé J, Blanch JL, Vilalta A, Castro V, Biete A, Daniels M
Eur J Cancer B Oral Oncol 1996 Jul;32B(4):238-41. doi: 10.1016/0964-1955(95)00087-9. PMID: 8776419

Recent clinical studies

Etiology

Histopathological and risk factor analyses of oral potentially malignant disorders and oral cancer in a proactive screening in northeastern Thailand.
Klongnoi B, Sresumatchai V, Clypuing H, Wisutthajaree A, Pankam J, Srimaneekarn N, Shrestha B, Khovidhunkit SP
BMC Oral Health 2022 Dec 16;22(1):613. doi: 10.1186/s12903-022-02646-9. PMID: 36527041Free PMC Article
Retrospective analysis of outcome and toxicity after postoperative radiotherapy in patients with squamous cell carcinoma of the lip.
Lang K, Akbaba S, Held T, El Shafie R, Farnia B, Bougatf N, Bernhardt D, Freudlsperger C, Plinkert PK, Rieken S, Debus J, Adeberg S
Tumori 2022 Apr;108(2):125-133. Epub 2021 Mar 1 doi: 10.1177/0300891621996805. PMID: 33641520Free PMC Article
Recurrent squamous cell carcinoma of the lower lip: salvage surgery outcome.
Copelli C, Manfuso A, Cassano L, Pederneschi N, Tewfik K, Pansini A, Cocchi R
Br J Oral Maxillofac Surg 2021 Oct;59(8):921-927. Epub 2020 Nov 4 doi: 10.1016/j.bjoms.2020.10.019. PMID: 34456078
Safety and Efficacy of Pembrolizumab With Chemoradiotherapy in Locally Advanced Head and Neck Squamous Cell Carcinoma: A Phase IB Study.
Powell SF, Gold KA, Gitau MM, Sumey CJ, Lohr MM, McGraw SC, Nowak RK, Jensen AW, Blanchard MJ, Fischer CD, Bykowski J, Ellison CA, Black LJ, Thompson PA, Callejas-Valera JL, Lee JH, Cohen EEW, Spanos WC
J Clin Oncol 2020 Jul 20;38(21):2427-2437. Epub 2020 Jun 1 doi: 10.1200/JCO.19.03156. PMID: 32479189Free PMC Article
Continuous intra-arterial chemotherapy for downstaging locally advanced oral commissure carcinoma.
Wu CF, Chang KP, Huang CJ, Chen CM, Chen CY, Steve Lin CL
Head Neck 2014 Jul;36(7):1027-33. Epub 2013 Sep 18 doi: 10.1002/hed.23408. PMID: 23784874

Diagnosis

Histopathological and risk factor analyses of oral potentially malignant disorders and oral cancer in a proactive screening in northeastern Thailand.
Klongnoi B, Sresumatchai V, Clypuing H, Wisutthajaree A, Pankam J, Srimaneekarn N, Shrestha B, Khovidhunkit SP
BMC Oral Health 2022 Dec 16;22(1):613. doi: 10.1186/s12903-022-02646-9. PMID: 36527041Free PMC Article
Retrospective analysis of outcome and toxicity after postoperative radiotherapy in patients with squamous cell carcinoma of the lip.
Lang K, Akbaba S, Held T, El Shafie R, Farnia B, Bougatf N, Bernhardt D, Freudlsperger C, Plinkert PK, Rieken S, Debus J, Adeberg S
Tumori 2022 Apr;108(2):125-133. Epub 2021 Mar 1 doi: 10.1177/0300891621996805. PMID: 33641520Free PMC Article
Degree of Cancer Spread at Presentation and Survival Among Adolescents and Young Adults in New South Wales, Australia.
Li M, Holliday L, Roder D, Tervonen H, Anazodo A, Dallapozza L, Hesketh E, Currow D
J Adolesc Young Adult Oncol 2021 Apr;10(2):156-163. Epub 2020 May 22 doi: 10.1089/jayao.2020.0023. PMID: 32456575
Malignant tumors requiring maxillectomy.
Yücel A, Cinar C, Aydin Y, Senyuva C, Güzel Z, Cetinkale O, Altintaŝ M
J Craniofac Surg 2000 Sep;11(5):418-29. doi: 10.1097/00001665-200011050-00003. PMID: 11314064
Regional epidemiological features of lip, oral cavity, and oropharyngeal cancer.
Erisen L, Basut O, Tezel I, Onart S, Arat M, Hizalan I, Coskun H
J Environ Pathol Toxicol Oncol 1996;15(2-4):225-9. PMID: 9216811

Therapy

Safety and Efficacy of Pembrolizumab With Chemoradiotherapy in Locally Advanced Head and Neck Squamous Cell Carcinoma: A Phase IB Study.
Powell SF, Gold KA, Gitau MM, Sumey CJ, Lohr MM, McGraw SC, Nowak RK, Jensen AW, Blanchard MJ, Fischer CD, Bykowski J, Ellison CA, Black LJ, Thompson PA, Callejas-Valera JL, Lee JH, Cohen EEW, Spanos WC
J Clin Oncol 2020 Jul 20;38(21):2427-2437. Epub 2020 Jun 1 doi: 10.1200/JCO.19.03156. PMID: 32479189Free PMC Article
Continuous intra-arterial chemotherapy for downstaging locally advanced oral commissure carcinoma.
Wu CF, Chang KP, Huang CJ, Chen CM, Chen CY, Steve Lin CL
Head Neck 2014 Jul;36(7):1027-33. Epub 2013 Sep 18 doi: 10.1002/hed.23408. PMID: 23784874
Primary tumor site as a predictor of treatment outcome for definitive radiotherapy of advanced-stage oral cavity cancers.
Lin CY, Wang HM, Kang CJ, Lee LY, Huang SF, Fan KH, Chen EY, Chen IH, Liao CT, Chang JT
Int J Radiat Oncol Biol Phys 2010 Nov 15;78(4):1011-9. Epub 2010 Apr 29 doi: 10.1016/j.ijrobp.2009.09.074. PMID: 20434273
Comparison of approaches for oral cavity cancer resection: lip-split versus visor flap.
Cilento BW, Izzard M, Weymuller EA, Futran N
Otolaryngol Head Neck Surg 2007 Sep;137(3):428-32. doi: 10.1016/j.otohns.2007.05.006. PMID: 17765770
Interstitial brachytherapy with Ir-192 low-dose-rate in the treatment of primary and recurrent cancer of the oral cavity and oropharynx. Review of 318 patients treated between 1985 and 1997.
Grabenbauer GG, Rödel C, Brunner T, Schulze-Mosgau S, Strnad V, Müller RG, Iro H, Sauer R
Strahlenther Onkol 2001 Jul;177(7):338-44. doi: 10.1007/pl00002416. PMID: 11505619

Prognosis

Retrospective analysis of outcome and toxicity after postoperative radiotherapy in patients with squamous cell carcinoma of the lip.
Lang K, Akbaba S, Held T, El Shafie R, Farnia B, Bougatf N, Bernhardt D, Freudlsperger C, Plinkert PK, Rieken S, Debus J, Adeberg S
Tumori 2022 Apr;108(2):125-133. Epub 2021 Mar 1 doi: 10.1177/0300891621996805. PMID: 33641520Free PMC Article
Recurrent squamous cell carcinoma of the lower lip: salvage surgery outcome.
Copelli C, Manfuso A, Cassano L, Pederneschi N, Tewfik K, Pansini A, Cocchi R
Br J Oral Maxillofac Surg 2021 Oct;59(8):921-927. Epub 2020 Nov 4 doi: 10.1016/j.bjoms.2020.10.019. PMID: 34456078
Twist and E-cadherin deregulation might predict poor prognosis in lower lip squamous cell carcinoma.
de Morais EF, Santos HBP, Cavalcante IL, Rabenhorst SHB, Dos Santos JN, Galvão HC, Freitas RA
Oral Surg Oral Med Oral Pathol Oral Radiol 2019 Apr;127(4):318-329. Epub 2018 Nov 16 doi: 10.1016/j.oooo.2018.11.003. PMID: 30598410
Continuous intra-arterial chemotherapy for downstaging locally advanced oral commissure carcinoma.
Wu CF, Chang KP, Huang CJ, Chen CM, Chen CY, Steve Lin CL
Head Neck 2014 Jul;36(7):1027-33. Epub 2013 Sep 18 doi: 10.1002/hed.23408. PMID: 23784874
Comparison of approaches for oral cavity cancer resection: lip-split versus visor flap.
Cilento BW, Izzard M, Weymuller EA, Futran N
Otolaryngol Head Neck Surg 2007 Sep;137(3):428-32. doi: 10.1016/j.otohns.2007.05.006. PMID: 17765770

Clinical prediction guides

Histopathological and risk factor analyses of oral potentially malignant disorders and oral cancer in a proactive screening in northeastern Thailand.
Klongnoi B, Sresumatchai V, Clypuing H, Wisutthajaree A, Pankam J, Srimaneekarn N, Shrestha B, Khovidhunkit SP
BMC Oral Health 2022 Dec 16;22(1):613. doi: 10.1186/s12903-022-02646-9. PMID: 36527041Free PMC Article
Recurrent squamous cell carcinoma of the lower lip: salvage surgery outcome.
Copelli C, Manfuso A, Cassano L, Pederneschi N, Tewfik K, Pansini A, Cocchi R
Br J Oral Maxillofac Surg 2021 Oct;59(8):921-927. Epub 2020 Nov 4 doi: 10.1016/j.bjoms.2020.10.019. PMID: 34456078
Surgically Treated Advanced Cutaneous Squamous Cell Carcinoma of the Head and Neck: Outcome Predictors and the Role of Adjuvant Radiation Therapy.
Kampel L, Dorman A, Horowitz G, Fliss DM, Gutfeld O, Muhanna N
Ann Otol Rhinol Laryngol 2021 Sep;130(9):1016-1023. Epub 2021 Jan 29 doi: 10.1177/0003489421990182. PMID: 33514267
Twist and E-cadherin deregulation might predict poor prognosis in lower lip squamous cell carcinoma.
de Morais EF, Santos HBP, Cavalcante IL, Rabenhorst SHB, Dos Santos JN, Galvão HC, Freitas RA
Oral Surg Oral Med Oral Pathol Oral Radiol 2019 Apr;127(4):318-329. Epub 2018 Nov 16 doi: 10.1016/j.oooo.2018.11.003. PMID: 30598410
Primary tumor site as a predictor of treatment outcome for definitive radiotherapy of advanced-stage oral cavity cancers.
Lin CY, Wang HM, Kang CJ, Lee LY, Huang SF, Fan KH, Chen EY, Chen IH, Liao CT, Chang JT
Int J Radiat Oncol Biol Phys 2010 Nov 15;78(4):1011-9. Epub 2010 Apr 29 doi: 10.1016/j.ijrobp.2009.09.074. PMID: 20434273

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...