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Locally Advanced Cutaneous Melanoma

MedGen UID:
1723072
Concept ID:
C5419072
Neoplastic Process

Definition

Cutaneous melanoma that has spread from its original site of growth to nearby tissues or lymph nodes. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLocally Advanced Cutaneous Melanoma

Professional guidelines

PubMed

Peris K, Fargnoli MC, Kaufmann R, Arenberger P, Bastholt L, Seguin NB, Bataille V, Brochez L, Del Marmol V, Dummer R, Forsea AM, Gaudy-Marqueste C, Harwood CA, Hauschild A, Höller C, Kandolf L, Kellerners-Smeets NWJ, Lallas A, Leiter U, Malvehy J, Marinović B, Mijuskovic Z, Moreno-Ramirez D, Nagore E, Nathan P, Stratigos AJ, Stockfleth E, Tagliaferri L, Trakatelli M, Vieira R, Zalaudek I, Garbe C; EADO”A, EDF”B, ESTRO”C, UEMS”D and EADV”E
Eur J Cancer 2023 Oct;192:113254. Epub 2023 Jul 28 doi: 10.1016/j.ejca.2023.113254. PMID: 37604067
Rashid S, Shaughnessy M, Tsao H
Dermatol Clin 2023 Jan;41(1):49-63. Epub 2022 Oct 28 doi: 10.1016/j.det.2022.07.017. PMID: 36410983
Bagchi S, Yuan R, Engleman EG
Annu Rev Pathol 2021 Jan 24;16:223-249. Epub 2020 Nov 16 doi: 10.1146/annurev-pathol-042020-042741. PMID: 33197221

Recent clinical studies

Etiology

Hyeraci M, Papanikolau ES, Grimaldi M, Ricci F, Pallotta S, Monetta R, Minafò YA, Di Lella G, Galdo G, Abeni D, Fania L, Dellambra E
Biomolecules 2023 Jul 2;13(7) doi: 10.3390/biom13071067. PMID: 37509103Free PMC Article
Carvajal RD, Sacco JJ, Jager MJ, Eschelman DJ, Olofsson Bagge R, Harbour JW, Chieng ND, Patel SP, Joshua AM, Piperno-Neumann S
Nat Rev Clin Oncol 2023 Feb;20(2):99-115. Epub 2023 Jan 4 doi: 10.1038/s41571-022-00714-1. PMID: 36600005
Deli T, Orosz M, Jakab A
Pathol Oncol Res 2020 Jan;26(1):63-78. Epub 2019 Jan 8 doi: 10.1007/s12253-018-00569-x. PMID: 30617760Free PMC Article
Hartman RI, Lin JY
Hematol Oncol Clin North Am 2019 Feb;33(1):25-38. doi: 10.1016/j.hoc.2018.09.005. PMID: 30497675
Pavri SN, Clune J, Ariyan S, Narayan D
Plast Reconstr Surg 2016 Aug;138(2):330e-340e. doi: 10.1097/PRS.0000000000002367. PMID: 27465194

Diagnosis

Peris K, Fargnoli MC, Kaufmann R, Arenberger P, Bastholt L, Seguin NB, Bataille V, Brochez L, Del Marmol V, Dummer R, Forsea AM, Gaudy-Marqueste C, Harwood CA, Hauschild A, Höller C, Kandolf L, Kellerners-Smeets NWJ, Lallas A, Leiter U, Malvehy J, Marinović B, Mijuskovic Z, Moreno-Ramirez D, Nagore E, Nathan P, Stratigos AJ, Stockfleth E, Tagliaferri L, Trakatelli M, Vieira R, Zalaudek I, Garbe C; EADO”A, EDF”B, ESTRO”C, UEMS”D and EADV”E
Eur J Cancer 2023 Oct;192:113254. Epub 2023 Jul 28 doi: 10.1016/j.ejca.2023.113254. PMID: 37604067
Rashid S, Shaughnessy M, Tsao H
Dermatol Clin 2023 Jan;41(1):49-63. Epub 2022 Oct 28 doi: 10.1016/j.det.2022.07.017. PMID: 36410983
Peris K, Fargnoli MC, Garbe C, Kaufmann R, Bastholt L, Seguin NB, Bataille V, Marmol VD, Dummer R, Harwood CA, Hauschild A, Höller C, Haedersdal M, Malvehy J, Middleton MR, Morton CA, Nagore E, Stratigos AJ, Szeimies RM, Tagliaferri L, Trakatelli M, Zalaudek I, Eggermont A, Grob JJ; European Dermatology Forum (EDF), the European Association of Dermato-Oncology (EADO) and the European Organization for Research and Treatment of Cancer (EORTC)
Eur J Cancer 2019 Sep;118:10-34. Epub 2019 Jul 6 doi: 10.1016/j.ejca.2019.06.003. PMID: 31288208
Hartman RI, Lin JY
Hematol Oncol Clin North Am 2019 Feb;33(1):25-38. doi: 10.1016/j.hoc.2018.09.005. PMID: 30497675
Pavri SN, Clune J, Ariyan S, Narayan D
Plast Reconstr Surg 2016 Aug;138(2):330e-340e. doi: 10.1097/PRS.0000000000002367. PMID: 27465194

Therapy

Villani A, Potestio L, Fabbrocini G, Troncone G, Malapelle U, Scalvenzi M
Int J Mol Sci 2022 Jun 7;23(12) doi: 10.3390/ijms23126388. PMID: 35742834Free PMC Article
Deli T, Orosz M, Jakab A
Pathol Oncol Res 2020 Jan;26(1):63-78. Epub 2019 Jan 8 doi: 10.1007/s12253-018-00569-x. PMID: 30617760Free PMC Article
Tracey EH, Vij A
Dermatol Clin 2019 Jan;37(1):73-82. doi: 10.1016/j.det.2018.08.003. PMID: 30466690
Long GV, Hauschild A, Santinami M, Atkinson V, Mandalà M, Chiarion-Sileni V, Larkin J, Nyakas M, Dutriaux C, Haydon A, Robert C, Mortier L, Schachter J, Schadendorf D, Lesimple T, Plummer R, Ji R, Zhang P, Mookerjee B, Legos J, Kefford R, Dummer R, Kirkwood JM
N Engl J Med 2017 Nov 9;377(19):1813-1823. Epub 2017 Sep 10 doi: 10.1056/NEJMoa1708539. PMID: 28891408
Tracy ET, Aldrink JH
Semin Pediatr Surg 2016 Oct;25(5):290-298. Epub 2016 Sep 20 doi: 10.1053/j.sempedsurg.2016.09.010. PMID: 27955732

Prognosis

Fastner S, Hieken TJ, McWilliams RR, Hyngstrom J
J Surg Oncol 2023 Sep;128(4):635-644. Epub 2023 Jul 3 doi: 10.1002/jso.27381. PMID: 37395165
Carvajal RD, Sacco JJ, Jager MJ, Eschelman DJ, Olofsson Bagge R, Harbour JW, Chieng ND, Patel SP, Joshua AM, Piperno-Neumann S
Nat Rev Clin Oncol 2023 Feb;20(2):99-115. Epub 2023 Jan 4 doi: 10.1038/s41571-022-00714-1. PMID: 36600005
Hartman RI, Lin JY
Hematol Oncol Clin North Am 2019 Feb;33(1):25-38. doi: 10.1016/j.hoc.2018.09.005. PMID: 30497675
Salvini C, Scarfì F, Fabroni C, Taviti F
G Ital Dermatol Venereol 2017 Jun;152(3):274-285. Epub 2017 Jan 24 doi: 10.23736/S0392-0488.17.05558-4. PMID: 28121082
Eggermont AM, Spatz A, Robert C
Lancet 2014 Mar 1;383(9919):816-27. Epub 2013 Sep 19 doi: 10.1016/S0140-6736(13)60802-8. PMID: 24054424

Clinical prediction guides

Meric-Bernstam F, Makker V, Oaknin A, Oh DY, Banerjee S, González-Martín A, Jung KH, Ługowska I, Manso L, Manzano A, Melichar B, Siena S, Stroyakovskiy D, Fielding A, Ma Y, Puvvada S, Shire N, Lee JY
J Clin Oncol 2024 Jan 1;42(1):47-58. Epub 2023 Oct 23 doi: 10.1200/JCO.23.02005. PMID: 37870536Free PMC Article
Baggi A, Quaglino P, Rubatto M, Depenni R, Guida M, Ascierto PA, Trojaniello C, Queirolo P, Saponara M, Peris K, Spagnolo F, Bianchi L, De Galitiis F, Potenza MC, Proietti I, Marconcini R, Botticelli A, Barbieri V, Licitra L, Alfieri S, Ficorella C, Cortellini A, Fargnoli MC, Troiani T, Tondulli L, Bossi P
Eur J Cancer 2021 Nov;157:250-258. Epub 2021 Sep 15 doi: 10.1016/j.ejca.2021.08.018. PMID: 34536948
Peris K, Fargnoli MC, Garbe C, Kaufmann R, Bastholt L, Seguin NB, Bataille V, Marmol VD, Dummer R, Harwood CA, Hauschild A, Höller C, Haedersdal M, Malvehy J, Middleton MR, Morton CA, Nagore E, Stratigos AJ, Szeimies RM, Tagliaferri L, Trakatelli M, Zalaudek I, Eggermont A, Grob JJ; European Dermatology Forum (EDF), the European Association of Dermato-Oncology (EADO) and the European Organization for Research and Treatment of Cancer (EORTC)
Eur J Cancer 2019 Sep;118:10-34. Epub 2019 Jul 6 doi: 10.1016/j.ejca.2019.06.003. PMID: 31288208
Long GV, Hauschild A, Santinami M, Atkinson V, Mandalà M, Chiarion-Sileni V, Larkin J, Nyakas M, Dutriaux C, Haydon A, Robert C, Mortier L, Schachter J, Schadendorf D, Lesimple T, Plummer R, Ji R, Zhang P, Mookerjee B, Legos J, Kefford R, Dummer R, Kirkwood JM
N Engl J Med 2017 Nov 9;377(19):1813-1823. Epub 2017 Sep 10 doi: 10.1056/NEJMoa1708539. PMID: 28891408
Eggermont AM, Spatz A, Robert C
Lancet 2014 Mar 1;383(9919):816-27. Epub 2013 Sep 19 doi: 10.1016/S0140-6736(13)60802-8. PMID: 24054424

Recent systematic reviews

Ben Shimol J, Guzman-Prado Y, Karlinskaya M, Davidson T
Crit Rev Oncol Hematol 2021 Nov;167:103499. Epub 2021 Oct 20 doi: 10.1016/j.critrevonc.2021.103499. PMID: 34687896
Rosko AJ, Vankoevering KK, McLean SA, Johnson TM, Moyer JS
JAMA Facial Plast Surg 2017 May 1;19(3):232-238. doi: 10.1001/jamafacial.2016.1846. PMID: 28114438
Aguado-Romeo MJ, Benot-López S, Romero-Tabares A
Actas Dermosifiliogr 2017 Mar;108(2):91-97. Epub 2016 Oct 18 doi: 10.1016/j.ad.2016.08.008. PMID: 27769538
Dunn J, Watson M, Aitken JF, Hyde MK
Psychooncology 2017 Nov;26(11):1722-1731. Epub 2016 Nov 7 doi: 10.1002/pon.4290. PMID: 27696578
Lazarev S, Gupta V, Hu K, Harrison LB, Bakst R
Int J Radiat Oncol Biol Phys 2014 Dec 1;90(5):1108-18. doi: 10.1016/j.ijrobp.2014.03.042. PMID: 25539369

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