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CTRP Clinical Finding

MedGen UID:
1742773
•Concept ID:
C5401372
•
Finding
Synonym: CTRP Disease Finding

Definition

A finding concept that has been requested by CTRP to be used in the disease field for abstraction and search of clinical trials. [from NCI]

Recent clinical studies

Etiology

Serum levels of C1q/TNF-related protein-1 (CTRP-1) are closely associated with coronary artery disease.
Wang H, Wang R, Du D, Li F, Li Y
BMC Cardiovasc Disord 2016 May 11;16:92. doi: 10.1186/s12872-016-0266-7. PMID: 27169633Free PMC Article
Plasma levels of C1q/TNF-related protein 1 and interleukin 6 in patients with acute coronary syndrome or stable angina pectoris.
Tang JN, Shen DL, Liu CL, Wang XF, Zhang L, Xuan XX, Cui LL, Zhang JY
Am J Med Sci 2015 Feb;349(2):130-6. doi: 10.1097/MAJ.0000000000000378. PMID: 25635749
Implications of C1q/TNF-related protein-3 (CTRP-3) and progranulin in patients with acute coronary syndrome and stable angina pectoris.
Choi KM, Hwang SY, Hong HC, Choi HY, Yoo HJ, Youn BS, Baik SH, Seo HS
Cardiovasc Diabetol 2014 Jan 13;13:14. doi: 10.1186/1475-2840-13-14. PMID: 24417980Free PMC Article
Effects of a combined aerobic and resistance exercise program on C1q/TNF-related protein-3 (CTRP-3) and CTRP-5 levels.
Choi HY, Park JW, Lee N, Hwang SY, Cho GJ, Hong HC, Yoo HJ, Hwang TG, Kim SM, Baik SH, Park KS, Youn BS, Choi KM
Diabetes Care 2013 Oct;36(10):3321-7. Epub 2013 Jun 18 doi: 10.2337/dc13-0178. PMID: 23780948Free PMC Article
C1q/TNF-related protein-3 (CTRP-3) and pigment epithelium-derived factor (PEDF) concentrations in patients with type 2 diabetes and metabolic syndrome.
Choi KM, Hwang SY, Hong HC, Yang SJ, Choi HY, Yoo HJ, Lee KW, Nam MS, Park YS, Woo JT, Kim YS, Choi DS, Youn BS, Baik SH
Diabetes 2012 Nov;61(11):2932-6. Epub 2012 Jul 26 doi: 10.2337/db12-0217. PMID: 22837306Free PMC Article

Diagnosis

Low Complement C1q/TNF-related Protein-13 Levels are Associated with Childhood Obesity But not Binge Eating Disorder.
Erbaş İM, Paketçi A, Turan S, Şişman AR, Demir K, Böber E, Abacı A
J Clin Res Pediatr Endocrinol 2022 Jun 7;14(2):179-187. Epub 2022 Jan 11 doi: 10.4274/jcrpe.galenos.2021.2021-11-1. PMID: 35014243Free PMC Article
The C1q/TNF-related proteins (CTRPs) in pathogenesis of obesity-related metabolic disorders: Focus on type 2 diabetes and cardiovascular diseases.
Shanaki M, Shabani P, Goudarzi A, Omidifar A, Bashash D, Emamgholipour S
Life Sci 2020 Sep 1;256:117913. Epub 2020 Jun 8 doi: 10.1016/j.lfs.2020.117913. PMID: 32526287
Serum levels of C1q/TNF-related protein-1 (CTRP-1) are closely associated with coronary artery disease.
Wang H, Wang R, Du D, Li F, Li Y
BMC Cardiovasc Disord 2016 May 11;16:92. doi: 10.1186/s12872-016-0266-7. PMID: 27169633Free PMC Article
Implications of C1q/TNF-related protein-3 (CTRP-3) and progranulin in patients with acute coronary syndrome and stable angina pectoris.
Choi KM, Hwang SY, Hong HC, Choi HY, Yoo HJ, Youn BS, Baik SH, Seo HS
Cardiovasc Diabetol 2014 Jan 13;13:14. doi: 10.1186/1475-2840-13-14. PMID: 24417980Free PMC Article
C1q/TNF-related protein-3 (CTRP-3) and pigment epithelium-derived factor (PEDF) concentrations in patients with type 2 diabetes and metabolic syndrome.
Choi KM, Hwang SY, Hong HC, Yang SJ, Choi HY, Yoo HJ, Lee KW, Nam MS, Park YS, Woo JT, Kim YS, Choi DS, Youn BS, Baik SH
Diabetes 2012 Nov;61(11):2932-6. Epub 2012 Jul 26 doi: 10.2337/db12-0217. PMID: 22837306Free PMC Article

Therapy

Betahistine alleviates benign paroxysmal positional vertigo (BPPV) through inducing production of multiple CTRP family members and activating the ERK1/2-AKT/PPARy pathway.
Hui J, Lei Q, Ji Z, Zi D
Biol Res 2022 Apr 4;55(1):16. doi: 10.1186/s40659-022-00385-3. PMID: 35379352Free PMC Article
Plasma CTRP-3 concentrations in Chinese patients with obesity and type II diabetes negatively correlate with insulin resistance.
Qu H, Deng M, Wang H, Wei H, Liu F, Wu J, Deng H
J Clin Lipidol 2015 May-Jun;9(3):289-94. Epub 2015 Mar 28 doi: 10.1016/j.jacl.2015.03.006. PMID: 26073386
Implications of C1q/TNF-related protein-3 (CTRP-3) and progranulin in patients with acute coronary syndrome and stable angina pectoris.
Choi KM, Hwang SY, Hong HC, Choi HY, Yoo HJ, Youn BS, Baik SH, Seo HS
Cardiovasc Diabetol 2014 Jan 13;13:14. doi: 10.1186/1475-2840-13-14. PMID: 24417980Free PMC Article
Effects of a combined aerobic and resistance exercise program on C1q/TNF-related protein-3 (CTRP-3) and CTRP-5 levels.
Choi HY, Park JW, Lee N, Hwang SY, Cho GJ, Hong HC, Yoo HJ, Hwang TG, Kim SM, Baik SH, Park KS, Youn BS, Choi KM
Diabetes Care 2013 Oct;36(10):3321-7. Epub 2013 Jun 18 doi: 10.2337/dc13-0178. PMID: 23780948Free PMC Article
C1q/TNF-related protein-3 (CTRP-3) and pigment epithelium-derived factor (PEDF) concentrations in patients with type 2 diabetes and metabolic syndrome.
Choi KM, Hwang SY, Hong HC, Yang SJ, Choi HY, Yoo HJ, Lee KW, Nam MS, Park YS, Woo JT, Kim YS, Choi DS, Youn BS, Baik SH
Diabetes 2012 Nov;61(11):2932-6. Epub 2012 Jul 26 doi: 10.2337/db12-0217. PMID: 22837306Free PMC Article

Prognosis

4-Hydroxyphenylpyruvate Dioxygenase-Like predicts the prognosis and the immunotherapy response of cancers: a pan-cancer analysis.
Li H, Liu J, Wang S, Xu Y, Tang Q, Ying G
Aging (Albany NY) 2024 Mar 6;16(5):4327-4347. doi: 10.18632/aging.205591. PMID: 38451188Free PMC Article
Progranulin serum levels and gene expression in subcutaneous vs visceral adipose tissue of severely obese patients undergoing bariatric surgery.
Brock J, Schmid A, Karrasch T, Pfefferle P, Schlegel J, Busse I, Hauenschild A, Schmidt B, Koukou M, Arapogianni E, Schultz A, Thomalla M, Akinci S, Kruse J, Padberg W, Schäffler A, Albrecht J
Clin Endocrinol (Oxf) 2019 Sep;91(3):400-410. Epub 2019 Jun 7 doi: 10.1111/cen.14040. PMID: 31102282
Serum levels of C1q/TNF-related protein-1 (CTRP-1) are closely associated with coronary artery disease.
Wang H, Wang R, Du D, Li F, Li Y
BMC Cardiovasc Disord 2016 May 11;16:92. doi: 10.1186/s12872-016-0266-7. PMID: 27169633Free PMC Article
Plasma levels of C1q/TNF-related protein 1 and interleukin 6 in patients with acute coronary syndrome or stable angina pectoris.
Tang JN, Shen DL, Liu CL, Wang XF, Zhang L, Xuan XX, Cui LL, Zhang JY
Am J Med Sci 2015 Feb;349(2):130-6. doi: 10.1097/MAJ.0000000000000378. PMID: 25635749
Effects of a combined aerobic and resistance exercise program on C1q/TNF-related protein-3 (CTRP-3) and CTRP-5 levels.
Choi HY, Park JW, Lee N, Hwang SY, Cho GJ, Hong HC, Yoo HJ, Hwang TG, Kim SM, Baik SH, Park KS, Youn BS, Choi KM
Diabetes Care 2013 Oct;36(10):3321-7. Epub 2013 Jun 18 doi: 10.2337/dc13-0178. PMID: 23780948Free PMC Article

Clinical prediction guides

Betahistine alleviates benign paroxysmal positional vertigo (BPPV) through inducing production of multiple CTRP family members and activating the ERK1/2-AKT/PPARy pathway.
Hui J, Lei Q, Ji Z, Zi D
Biol Res 2022 Apr 4;55(1):16. doi: 10.1186/s40659-022-00385-3. PMID: 35379352Free PMC Article
Downregulation of CTRP-3 by Weight Loss In Vivo and by Bile Acids and Incretins in Adipocytes In Vitro.
Schmid A, Gehl J, Thomalla M, Hochberg A, Kreiß A, Patz M, Karrasch T, Schäffler A
Int J Mol Sci 2020 Oct 31;21(21) doi: 10.3390/ijms21218168. PMID: 33142914Free PMC Article
C1q/TNF-related protein 2 (CTRP2) deletion promotes adipose tissue lipolysis and hepatic triglyceride secretion.
Lei X, Wong GW
J Biol Chem 2019 Oct 25;294(43):15638-15649. Epub 2019 Aug 22 doi: 10.1074/jbc.RA119.009230. PMID: 31439668Free PMC Article
Plasma levels of C1q/TNF-related protein 1 and interleukin 6 in patients with acute coronary syndrome or stable angina pectoris.
Tang JN, Shen DL, Liu CL, Wang XF, Zhang L, Xuan XX, Cui LL, Zhang JY
Am J Med Sci 2015 Feb;349(2):130-6. doi: 10.1097/MAJ.0000000000000378. PMID: 25635749
Effects of a combined aerobic and resistance exercise program on C1q/TNF-related protein-3 (CTRP-3) and CTRP-5 levels.
Choi HY, Park JW, Lee N, Hwang SY, Cho GJ, Hong HC, Yoo HJ, Hwang TG, Kim SM, Baik SH, Park KS, Youn BS, Choi KM
Diabetes Care 2013 Oct;36(10):3321-7. Epub 2013 Jun 18 doi: 10.2337/dc13-0178. PMID: 23780948Free PMC Article

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