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Locally Advanced Intrahepatic Cholangiocarcinoma

MedGen UID:
1776433
•Concept ID:
C5420398
•
Neoplastic Process

Definition

Intrahepatic cholangiocarcinoma that has spread from its original site of growth to nearby tissues or lymph nodes. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLocally Advanced Intrahepatic Cholangiocarcinoma

Professional guidelines

PubMed

Selective internal radiation therapy using yttrium-90 microspheres for treatment of localized and locally advanced intrahepatic cholangiocarcinoma.
Yu Q, Ungchusri E, Pillai A, Liao CY, Baker T, Fung J, DiSabato D, Zhang M, Liao C, Van Ha T, Ahmed O
Eur Radiol 2024 Apr;34(4):2374-2383. Epub 2023 Oct 9 doi: 10.1007/s00330-023-10203-3. PMID: 37812295
Management of locally advanced intrahepatic cholangiocarcinoma: a narrative review.
Bressler L, Bath N, Manne A, Miller E, Cloyd JM
Chin Clin Oncol 2023 Apr;12(2):15. Epub 2023 Mar 30 doi: 10.21037/cco-22-115. PMID: 37038054
About the Recently Published Paper on JAMA Oncology "Radioembolization Plus Chemotherapy for First-Line Treatment of Locally Advanced Intrahepatic Cholangiocarcinoma: A Phase 2 Clinical Trial".
Bargellini I, Vivaldi C, Crocetti L, Masi G
Cardiovasc Intervent Radiol 2020 Sep;43(9):1418-1419. Epub 2020 Jul 16 doi: 10.1007/s00270-020-02577-4. PMID: 32676960

Recent clinical studies

Etiology

Comparison of 3 Different Therapeutic Particles in Radioembolization of Locally Advanced Intrahepatic Cholangiocarcinoma.
Wagemans MEHM, Kunnen B, Stella M, van Rooij R, Smits M, Bruijnen R, Lam MGEH, de Jong HWAM, Braat AJAT
J Nucl Med 2024 Feb 1;65(2):272-278. doi: 10.2967/jnumed.123.265597. PMID: 38176716
Selective internal radiation therapy using yttrium-90 microspheres for treatment of localized and locally advanced intrahepatic cholangiocarcinoma.
Yu Q, Ungchusri E, Pillai A, Liao CY, Baker T, Fung J, DiSabato D, Zhang M, Liao C, Van Ha T, Ahmed O
Eur Radiol 2024 Apr;34(4):2374-2383. Epub 2023 Oct 9 doi: 10.1007/s00330-023-10203-3. PMID: 37812295
Impact of induction therapy in locally advanced intrahepatic cholangiocarcinoma.
Dhote A, Tzedakis S, Hobeika C, Marchese U, Coriat R, Nassar A, Beaufrère A, Codjia T, Goumard C, Scatton O, Dohan A, Ronot M, Terris B, Lesurtel M, Dokmak S, Cauchy F, Fuks D
Eur J Surg Oncol 2023 Oct;49(10):106939. Epub 2023 May 20 doi: 10.1016/j.ejso.2023.05.014. PMID: 37268522
Yttrium-90 Radioembolization and Concomitant Systemic Gemcitabine, Cisplatin, and Capecitabine as the First-Line Therapy for Locally Advanced Intrahepatic Cholangiocarcinoma.
Ahmed O, Yu Q, Patel M, Hwang G, Pillai A, Liao CY, Fung J, Baker T
J Vasc Interv Radiol 2023 Apr;34(4):702-709. Epub 2022 Dec 13 doi: 10.1016/j.jvir.2022.12.017. PMID: 36521794
Liver transplantation for locally advanced intrahepatic cholangiocarcinoma treated with neoadjuvant therapy: a prospective case-series.
Lunsford KE, Javle M, Heyne K, Shroff RT, Abdel-Wahab R, Gupta N, Mobley CM, Saharia A, Victor DW, Nguyen DT, Graviss EA, Kaseb AO, McFadden RS, Aloia TA, Conrad C, Li XC, Monsour HP, Gaber AO, Vauthey JN, Ghobrial RM; Methodist–MD Anderson Joint Cholangiocarcinoma Collaborative Committee (MMAJCCC)
Lancet Gastroenterol Hepatol 2018 May;3(5):337-348. Epub 2018 Mar 13 doi: 10.1016/S2468-1253(18)30045-1. PMID: 29548617

Diagnosis

Case Report of Concomitant Diagnosis of Locally Advanced Intrahepatic Cholangiocarcinoma and Solitary Plasmacytoma of T11 Vertebra: Impact on Diagnostic and Clinical Management.
Touchefeu Y, Barbaud M, Prin-Felix L, Samarut E, Jamet B, Ollivier L, Bouda D
Curr Oncol 2024 Sep 2;31(9):5164-5170. doi: 10.3390/curroncol31090382. PMID: 39330010Free PMC Article
Yttrium-90 Radioembolization and Concomitant Systemic Gemcitabine, Cisplatin, and Capecitabine as the First-Line Therapy for Locally Advanced Intrahepatic Cholangiocarcinoma.
Ahmed O, Yu Q, Patel M, Hwang G, Pillai A, Liao CY, Fung J, Baker T
J Vasc Interv Radiol 2023 Apr;34(4):702-709. Epub 2022 Dec 13 doi: 10.1016/j.jvir.2022.12.017. PMID: 36521794
Liver transplantation for locally advanced intrahepatic cholangiocarcinoma treated with neoadjuvant therapy: a prospective case-series.
Lunsford KE, Javle M, Heyne K, Shroff RT, Abdel-Wahab R, Gupta N, Mobley CM, Saharia A, Victor DW, Nguyen DT, Graviss EA, Kaseb AO, McFadden RS, Aloia TA, Conrad C, Li XC, Monsour HP, Gaber AO, Vauthey JN, Ghobrial RM; Methodist–MD Anderson Joint Cholangiocarcinoma Collaborative Committee (MMAJCCC)
Lancet Gastroenterol Hepatol 2018 May;3(5):337-348. Epub 2018 Mar 13 doi: 10.1016/S2468-1253(18)30045-1. PMID: 29548617

Therapy

Selective internal radiation therapy using yttrium-90 microspheres for treatment of localized and locally advanced intrahepatic cholangiocarcinoma.
Yu Q, Ungchusri E, Pillai A, Liao CY, Baker T, Fung J, DiSabato D, Zhang M, Liao C, Van Ha T, Ahmed O
Eur Radiol 2024 Apr;34(4):2374-2383. Epub 2023 Oct 9 doi: 10.1007/s00330-023-10203-3. PMID: 37812295
Management of locally advanced intrahepatic cholangiocarcinoma: a narrative review.
Bressler L, Bath N, Manne A, Miller E, Cloyd JM
Chin Clin Oncol 2023 Apr;12(2):15. Epub 2023 Mar 30 doi: 10.21037/cco-22-115. PMID: 37038054
Yttrium-90 Radioembolization and Concomitant Systemic Gemcitabine, Cisplatin, and Capecitabine as the First-Line Therapy for Locally Advanced Intrahepatic Cholangiocarcinoma.
Ahmed O, Yu Q, Patel M, Hwang G, Pillai A, Liao CY, Fung J, Baker T
J Vasc Interv Radiol 2023 Apr;34(4):702-709. Epub 2022 Dec 13 doi: 10.1016/j.jvir.2022.12.017. PMID: 36521794
Radioembolization Plus Chemotherapy for First-line Treatment of Locally Advanced Intrahepatic Cholangiocarcinoma: A Phase 2 Clinical Trial.
Edeline J, Touchefeu Y, Guiu B, Farge O, Tougeron D, Baumgaertner I, Ayav A, Campillo-Gimenez B, Beuzit L, Pracht M, Lièvre A, Le Sourd S, Boudjema K, Rolland Y, Boucher E, Garin E
JAMA Oncol 2020 Jan 1;6(1):51-59. doi: 10.1001/jamaoncol.2019.3702. PMID: 31670746Free PMC Article
Liver transplantation for locally advanced intrahepatic cholangiocarcinoma treated with neoadjuvant therapy: a prospective case-series.
Lunsford KE, Javle M, Heyne K, Shroff RT, Abdel-Wahab R, Gupta N, Mobley CM, Saharia A, Victor DW, Nguyen DT, Graviss EA, Kaseb AO, McFadden RS, Aloia TA, Conrad C, Li XC, Monsour HP, Gaber AO, Vauthey JN, Ghobrial RM; Methodist–MD Anderson Joint Cholangiocarcinoma Collaborative Committee (MMAJCCC)
Lancet Gastroenterol Hepatol 2018 May;3(5):337-348. Epub 2018 Mar 13 doi: 10.1016/S2468-1253(18)30045-1. PMID: 29548617

Prognosis

Selective internal radiation therapy using yttrium-90 microspheres for treatment of localized and locally advanced intrahepatic cholangiocarcinoma.
Yu Q, Ungchusri E, Pillai A, Liao CY, Baker T, Fung J, DiSabato D, Zhang M, Liao C, Van Ha T, Ahmed O
Eur Radiol 2024 Apr;34(4):2374-2383. Epub 2023 Oct 9 doi: 10.1007/s00330-023-10203-3. PMID: 37812295
ALPPS for Locally Advanced Intrahepatic Cholangiocarcinoma: Did Aggressive Surgery Lead to the Oncological Benefit? An International Multi-center Study.
Li J, Moustafa M, Linecker M, Lurje G, Capobianco I, Baumgart J, Ratti F, Rauchfuss F, Balci D, Fernandes E, Montalti R, Robles-Campos R, Bjornsson B, Topp SA, Fronek J, Liu C, Wahba R, Bruns C, Brunner SM, Schlitt HJ, Heumann A, Stüben BO, Izbicki JR, Bednarsch J, Gringeri E, Fasolo E, Rolinger J, Kristek J, Hernandez-Alejandro R, Schnitzbauer A, Nuessler N, Schön MR, Voskanyan S, Petrou AS, Hahn O, Soejima Y, Vicente E, Castro-Benitez C, Adam R, Tomassini F, Troisi RI, Kantas A, Oldhafer KJ, Ardiles V, de Santibanes E, Malago M, Clavien PA, Vivarelli M, Settmacher U, Aldrighetti L, Neumann U, Petrowsky H, Cillo U, Lang H, Nadalin S
Ann Surg Oncol 2020 May;27(5):1372-1384. Epub 2020 Jan 30 doi: 10.1245/s10434-019-08192-z. PMID: 32002719Free PMC Article
The impact of liver resection on survival for locally advanced intrahepatic cholangiocarcinoma tumors: A propensity score analysis.
Moustafa M, Fasolo E, Bassi D, D'amico FE, Gringeri E, Pawlik TM, Cillo U
Eur J Surg Oncol 2020 Apr;46(4 Pt A):632-637. Epub 2019 Nov 17 doi: 10.1016/j.ejso.2019.11.502. PMID: 31812289
Radioembolization Plus Chemotherapy for First-line Treatment of Locally Advanced Intrahepatic Cholangiocarcinoma: A Phase 2 Clinical Trial.
Edeline J, Touchefeu Y, Guiu B, Farge O, Tougeron D, Baumgaertner I, Ayav A, Campillo-Gimenez B, Beuzit L, Pracht M, Lièvre A, Le Sourd S, Boudjema K, Rolland Y, Boucher E, Garin E
JAMA Oncol 2020 Jan 1;6(1):51-59. doi: 10.1001/jamaoncol.2019.3702. PMID: 31670746Free PMC Article
Liver transplantation for locally advanced intrahepatic cholangiocarcinoma treated with neoadjuvant therapy: a prospective case-series.
Lunsford KE, Javle M, Heyne K, Shroff RT, Abdel-Wahab R, Gupta N, Mobley CM, Saharia A, Victor DW, Nguyen DT, Graviss EA, Kaseb AO, McFadden RS, Aloia TA, Conrad C, Li XC, Monsour HP, Gaber AO, Vauthey JN, Ghobrial RM; Methodist–MD Anderson Joint Cholangiocarcinoma Collaborative Committee (MMAJCCC)
Lancet Gastroenterol Hepatol 2018 May;3(5):337-348. Epub 2018 Mar 13 doi: 10.1016/S2468-1253(18)30045-1. PMID: 29548617

Clinical prediction guides

Selective internal radiation therapy using yttrium-90 microspheres for treatment of localized and locally advanced intrahepatic cholangiocarcinoma.
Yu Q, Ungchusri E, Pillai A, Liao CY, Baker T, Fung J, DiSabato D, Zhang M, Liao C, Van Ha T, Ahmed O
Eur Radiol 2024 Apr;34(4):2374-2383. Epub 2023 Oct 9 doi: 10.1007/s00330-023-10203-3. PMID: 37812295
ALPPS for Locally Advanced Intrahepatic Cholangiocarcinoma: Did Aggressive Surgery Lead to the Oncological Benefit? An International Multi-center Study.
Li J, Moustafa M, Linecker M, Lurje G, Capobianco I, Baumgart J, Ratti F, Rauchfuss F, Balci D, Fernandes E, Montalti R, Robles-Campos R, Bjornsson B, Topp SA, Fronek J, Liu C, Wahba R, Bruns C, Brunner SM, Schlitt HJ, Heumann A, Stüben BO, Izbicki JR, Bednarsch J, Gringeri E, Fasolo E, Rolinger J, Kristek J, Hernandez-Alejandro R, Schnitzbauer A, Nuessler N, Schön MR, Voskanyan S, Petrou AS, Hahn O, Soejima Y, Vicente E, Castro-Benitez C, Adam R, Tomassini F, Troisi RI, Kantas A, Oldhafer KJ, Ardiles V, de Santibanes E, Malago M, Clavien PA, Vivarelli M, Settmacher U, Aldrighetti L, Neumann U, Petrowsky H, Cillo U, Lang H, Nadalin S
Ann Surg Oncol 2020 May;27(5):1372-1384. Epub 2020 Jan 30 doi: 10.1245/s10434-019-08192-z. PMID: 32002719Free PMC Article
The impact of liver resection on survival for locally advanced intrahepatic cholangiocarcinoma tumors: A propensity score analysis.
Moustafa M, Fasolo E, Bassi D, D'amico FE, Gringeri E, Pawlik TM, Cillo U
Eur J Surg Oncol 2020 Apr;46(4 Pt A):632-637. Epub 2019 Nov 17 doi: 10.1016/j.ejso.2019.11.502. PMID: 31812289
A MAA-based dosimetric study in patients with intrahepatic cholangiocarcinoma treated with a combination of chemotherapy and (90)Y-loaded glass microsphere selective internal radiation therapy.
Manceau V, Palard X, Rolland Y, Pracht M, Le Sourd S, Laffont S, Boudjema K, Lievre A, Mesbah H, Haumont LA, Lenoir L, Brun V, Uguen T, Edeline J, Garin E
Eur J Nucl Med Mol Imaging 2018 Sep;45(10):1731-1741. Epub 2018 Mar 20 doi: 10.1007/s00259-018-3990-7. PMID: 29560519

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