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Locally Advanced Colon Carcinoma

MedGen UID:
1759831
•Concept ID:
C5418872
•
Neoplastic Process

Definition

Colon carcinoma that has spread to nearby tissues or lymph nodes. [from NCI]

Professional guidelines

PubMed

Trends in management and outcomes of colon cancer in the United States over 15 years: Analysis of the National Cancer Database.
Horesh N, Emile SH, Garoufalia Z, Gefen R, Zhou P, Wexner SD
Int J Cancer 2024 Jul 1;155(1):139-148. Epub 2024 Mar 7 doi: 10.1002/ijc.34910. PMID: 38454540
Management of the adenocarcinoma of the upper rectum: a reappraisal.
Pechlivanides G, Gourtsoyianni S, Gouvas N, Sougklakos J, Xynos E
Updates Surg 2021 Apr;73(2):513-526. Epub 2020 Oct 27 doi: 10.1007/s13304-020-00903-6. PMID: 33108641
Rectal cancer: An evidence-based update for primary care providers.
Gaertner WB, Kwaan MR, Madoff RD, Melton GB
World J Gastroenterol 2015 Jul 7;21(25):7659-71. doi: 10.3748/wjg.v21.i25.7659. PMID: 26167068Free PMC Article

Recent clinical studies

Etiology

Dysfunctional TLR1 reduces the therapeutic efficacy of chemotherapy by attenuating HMGB1-mediated antitumor immunity in locally advanced colorectal cancer.
Huang KC, Ke TW, Chen JY, Hong WZ, Chiang SF, Lai CY, Chen TW, Yang PC, Chen LC, Liang JA, Chen WT, Chao KSC
Sci Rep 2023 Nov 9;13(1):19440. doi: 10.1038/s41598-023-46254-1. PMID: 37945630Free PMC Article
Colo-pancreaticoduodenectomy for locally advanced colon carcinoma-feasibility in patients presenting with acute abdomen.
Chen JB, Luo SC, Chen CC, Wu CC, Yen Y, Chang CH, Chen YA, P'eng FK
World J Emerg Surg 2021 Feb 27;16(1):7. doi: 10.1186/s13017-021-00351-6. PMID: 33639983Free PMC Article
Adoptive transfer of natural killer cells in combination with chemotherapy improves outcomes of patients with locally advanced colon carcinoma.
Li L, Li W, Wang C, Yan X, Wang Y, Niu C, Zhang X, Li M, Tian H, Yao C, Jin H, Han F, Xu D, Han W, Li D, Cui J
Cytotherapy 2018 Jan;20(1):134-148. Epub 2017 Oct 19 doi: 10.1016/j.jcyt.2017.09.009. PMID: 29056549
Adjuvant systemic therapy protocol for Dukes' B2 and C resectable colon carcinoma.
Gennatas C, Mouratidou D, Androulakis G, Georgoulias V, Tsavaris N, Philippakis M, Michailakis E, Kalofonos C, Mpesmpeas S, Katsos J, Tsitoura M, Retalis G, Mallas E, Voros D, Andreadis C, Hatzistylianos G, Pisiotis C, Kamilarios D, Kakoliris S, Komporozos V, Kannas D, Legakis N, Mpatakis T, Ntamtsios J, Papaevangelou E, Peros G, Photopoulos A, Pouli A, Prigouris S, Samanidis L, Sakellariou V, Smyrniotis V, Polymeneas G, Vasiliou J, Athanasiou A, Papadimitriou J
Tumori 2002 Jan-Feb;88(1):32-6. PMID: 12004847
5-fluorouracil modulation in the chemotherapy of colorectal cancer.
Codacci-Pisanelli G, Franchi F
Ital J Gastroenterol 1994 Sep;26(7):369-76. PMID: 7529067

Diagnosis

Cytoreductive Surgery and Intraperitoneal Hyperthermic Chemotherapy (HIPEC) by Minimally Invasive Approach, an Initial Experience.
Arjona-Sanchez A, Rufian-Peña S, Sanchez-Hidalgo JM, Casado-Adam A, Cosano-Alvarez A, Briceño-Delgado J
World J Surg 2018 Oct;42(10):3120-3124. doi: 10.1007/s00268-018-4634-6. PMID: 29691625

Therapy

Dysfunctional TLR1 reduces the therapeutic efficacy of chemotherapy by attenuating HMGB1-mediated antitumor immunity in locally advanced colorectal cancer.
Huang KC, Ke TW, Chen JY, Hong WZ, Chiang SF, Lai CY, Chen TW, Yang PC, Chen LC, Liang JA, Chen WT, Chao KSC
Sci Rep 2023 Nov 9;13(1):19440. doi: 10.1038/s41598-023-46254-1. PMID: 37945630Free PMC Article
Evaluating the oncological safety of neoadjuvant chemotherapy in locally advanced colon carcinoma: a systematic review and meta-analysis of randomised clinical trials and propensity-matched studies.
Davey MG, Amir AH, Ryan OK, Donnelly M, Donlon NE, Regan M, Meshkat B, Nugent E, Joyce M, Hogan AM
Int J Colorectal Dis 2023 Jul 11;38(1):193. doi: 10.1007/s00384-023-04482-x. PMID: 37432559Free PMC Article
Adoptive transfer of natural killer cells in combination with chemotherapy improves outcomes of patients with locally advanced colon carcinoma.
Li L, Li W, Wang C, Yan X, Wang Y, Niu C, Zhang X, Li M, Tian H, Yao C, Jin H, Han F, Xu D, Han W, Li D, Cui J
Cytotherapy 2018 Jan;20(1):134-148. Epub 2017 Oct 19 doi: 10.1016/j.jcyt.2017.09.009. PMID: 29056549
Adjuvant systemic therapy protocol for Dukes' B2 and C resectable colon carcinoma.
Gennatas C, Mouratidou D, Androulakis G, Georgoulias V, Tsavaris N, Philippakis M, Michailakis E, Kalofonos C, Mpesmpeas S, Katsos J, Tsitoura M, Retalis G, Mallas E, Voros D, Andreadis C, Hatzistylianos G, Pisiotis C, Kamilarios D, Kakoliris S, Komporozos V, Kannas D, Legakis N, Mpatakis T, Ntamtsios J, Papaevangelou E, Peros G, Photopoulos A, Pouli A, Prigouris S, Samanidis L, Sakellariou V, Smyrniotis V, Polymeneas G, Vasiliou J, Athanasiou A, Papadimitriou J
Tumori 2002 Jan-Feb;88(1):32-6. PMID: 12004847
5-fluorouracil modulation in the chemotherapy of colorectal cancer.
Codacci-Pisanelli G, Franchi F
Ital J Gastroenterol 1994 Sep;26(7):369-76. PMID: 7529067

Prognosis

Dysfunctional TLR1 reduces the therapeutic efficacy of chemotherapy by attenuating HMGB1-mediated antitumor immunity in locally advanced colorectal cancer.
Huang KC, Ke TW, Chen JY, Hong WZ, Chiang SF, Lai CY, Chen TW, Yang PC, Chen LC, Liang JA, Chen WT, Chao KSC
Sci Rep 2023 Nov 9;13(1):19440. doi: 10.1038/s41598-023-46254-1. PMID: 37945630Free PMC Article
Adoptive transfer of natural killer cells in combination with chemotherapy improves outcomes of patients with locally advanced colon carcinoma.
Li L, Li W, Wang C, Yan X, Wang Y, Niu C, Zhang X, Li M, Tian H, Yao C, Jin H, Han F, Xu D, Han W, Li D, Cui J
Cytotherapy 2018 Jan;20(1):134-148. Epub 2017 Oct 19 doi: 10.1016/j.jcyt.2017.09.009. PMID: 29056549
Adjuvant systemic therapy protocol for Dukes' B2 and C resectable colon carcinoma.
Gennatas C, Mouratidou D, Androulakis G, Georgoulias V, Tsavaris N, Philippakis M, Michailakis E, Kalofonos C, Mpesmpeas S, Katsos J, Tsitoura M, Retalis G, Mallas E, Voros D, Andreadis C, Hatzistylianos G, Pisiotis C, Kamilarios D, Kakoliris S, Komporozos V, Kannas D, Legakis N, Mpatakis T, Ntamtsios J, Papaevangelou E, Peros G, Photopoulos A, Pouli A, Prigouris S, Samanidis L, Sakellariou V, Smyrniotis V, Polymeneas G, Vasiliou J, Athanasiou A, Papadimitriou J
Tumori 2002 Jan-Feb;88(1):32-6. PMID: 12004847

Clinical prediction guides

Dysfunctional TLR1 reduces the therapeutic efficacy of chemotherapy by attenuating HMGB1-mediated antitumor immunity in locally advanced colorectal cancer.
Huang KC, Ke TW, Chen JY, Hong WZ, Chiang SF, Lai CY, Chen TW, Yang PC, Chen LC, Liang JA, Chen WT, Chao KSC
Sci Rep 2023 Nov 9;13(1):19440. doi: 10.1038/s41598-023-46254-1. PMID: 37945630Free PMC Article
Evaluating the oncological safety of neoadjuvant chemotherapy in locally advanced colon carcinoma: a systematic review and meta-analysis of randomised clinical trials and propensity-matched studies.
Davey MG, Amir AH, Ryan OK, Donnelly M, Donlon NE, Regan M, Meshkat B, Nugent E, Joyce M, Hogan AM
Int J Colorectal Dis 2023 Jul 11;38(1):193. doi: 10.1007/s00384-023-04482-x. PMID: 37432559Free PMC Article
Cytoreductive Surgery and Intraperitoneal Hyperthermic Chemotherapy (HIPEC) by Minimally Invasive Approach, an Initial Experience.
Arjona-Sanchez A, Rufian-Peña S, Sanchez-Hidalgo JM, Casado-Adam A, Cosano-Alvarez A, Briceño-Delgado J
World J Surg 2018 Oct;42(10):3120-3124. doi: 10.1007/s00268-018-4634-6. PMID: 29691625
5-fluorouracil modulation in the chemotherapy of colorectal cancer.
Codacci-Pisanelli G, Franchi F
Ital J Gastroenterol 1994 Sep;26(7):369-76. PMID: 7529067

Recent systematic reviews

Evaluating the oncological safety of neoadjuvant chemotherapy in locally advanced colon carcinoma: a systematic review and meta-analysis of randomised clinical trials and propensity-matched studies.
Davey MG, Amir AH, Ryan OK, Donnelly M, Donlon NE, Regan M, Meshkat B, Nugent E, Joyce M, Hogan AM
Int J Colorectal Dis 2023 Jul 11;38(1):193. doi: 10.1007/s00384-023-04482-x. PMID: 37432559Free PMC Article

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