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Plasmacytoma

MedGen UID:
18506
Concept ID:
C0032131
Neoplastic Process
Synonyms: Plasma Cell Tumor; Plasma Cell Tumors; Plasmacytomas; Plasmocytoma; Plasmocytomas; Tumor, Plasma Cell; Tumors, Plasma Cell
SNOMED CT: Plasmacytoma (415112005); Plasmacytoma - disorder (415112005); Solitary myeloma (1187107005); Plasmacytoma (1187107005); Solitary plasmacytoma (1187107005); Plasma cell tumor (1187107005)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
HPO: HP:0011857
Monarch Initiative: MONDO:0005615
Orphanet: ORPHA86855

Definition

A discrete mass of neoplastic monoclonal plasma cells either in the bone marrow or in an extramedullary location. [from HPO]

Professional guidelines

PubMed

Rajkumar SV
Am J Hematol 2022 Aug;97(8):1086-1107. Epub 2022 May 23 doi: 10.1002/ajh.26590. PMID: 35560063Free PMC Article
Rajkumar SV
Am J Hematol 2020 May;95(5):548-567. doi: 10.1002/ajh.25791. PMID: 32212178
Dispenzieri A
Am J Hematol 2019 Jul;94(7):812-827. Epub 2019 May 23 doi: 10.1002/ajh.25495. PMID: 31012139

Recent clinical studies

Etiology

Fend F, Dogan A, Cook JR
Virchows Arch 2023 Jan;482(1):163-177. Epub 2022 Nov 21 doi: 10.1007/s00428-022-03431-3. PMID: 36414803Free PMC Article
Rosiñol L, Beksac M, Zamagni E, Van de Donk NWCJ, Anderson KC, Badros A, Caers J, Cavo M, Dimopoulos MA, Dispenzieri A, Einsele H, Engelhardt M, Fernández de Larrea C, Gahrton G, Gay F, Hájek R, Hungria V, Jurczyszyn A, Kröger N, Kyle RA, Leal da Costa F, Leleu X, Lentzsch S, Mateos MV, Merlini G, Mohty M, Moreau P, Rasche L, Reece D, Sezer O, Sonneveld P, Usmani SZ, Vanderkerken K, Vesole DH, Waage A, Zweegman S, Richardson PG, Bladé J
Br J Haematol 2021 Aug;194(3):496-507. Epub 2021 Mar 16 doi: 10.1111/bjh.17338. PMID: 33724461
Pham A, Mahindra A
Curr Hematol Malig Rep 2019 Apr;14(2):63-69. doi: 10.1007/s11899-019-00499-8. PMID: 30788667
Tsang RW, Campbell BA, Goda JS, Kelsey CR, Kirova YM, Parikh RR, Ng AK, Ricardi U, Suh CO, Mauch PM, Specht L, Yahalom J
Int J Radiat Oncol Biol Phys 2018 Jul 15;101(4):794-808. Epub 2018 Jun 20 doi: 10.1016/j.ijrobp.2018.05.009. PMID: 29976492
Caers J, Paiva B, Zamagni E, Leleu X, Bladé J, Kristinsson SY, Touzeau C, Abildgaard N, Terpos E, Heusschen R, Ocio E, Delforge M, Sezer O, Beksac M, Ludwig H, Merlini G, Moreau P, Zweegman S, Engelhardt M, Rosiñol L
J Hematol Oncol 2018 Jan 16;11(1):10. doi: 10.1186/s13045-017-0549-1. PMID: 29338789Free PMC Article

Diagnosis

Lamb MM, Zeatoun A, Stack TJ, Kim S, Albastoni S, Singer B, Klatt-Cromwell C, Senior BA, Kimple AJ, Thorp BD
ORL J Otorhinolaryngol Relat Spec 2023;85(4):231-237. Epub 2023 Jun 26 doi: 10.1159/000530946. PMID: 37364541
Pham A, Mahindra A
Curr Hematol Malig Rep 2019 Apr;14(2):63-69. doi: 10.1007/s11899-019-00499-8. PMID: 30788667
Caers J, Paiva B, Zamagni E, Leleu X, Bladé J, Kristinsson SY, Touzeau C, Abildgaard N, Terpos E, Heusschen R, Ocio E, Delforge M, Sezer O, Beksac M, Ludwig H, Merlini G, Moreau P, Zweegman S, Engelhardt M, Rosiñol L
J Hematol Oncol 2018 Jan 16;11(1):10. doi: 10.1186/s13045-017-0549-1. PMID: 29338789Free PMC Article
Lopes da Silva R
J Dig Dis 2012 Jan;13(1):10-8. doi: 10.1111/j.1751-2980.2011.00544.x. PMID: 22188911
Joukhadar R, Chiu K
Pituitary 2012 Jun;15(2):146-9. doi: 10.1007/s11102-011-0352-x. PMID: 21986873

Therapy

Mei H, Li C, Jiang H, Zhao X, Huang Z, Jin D, Guo T, Kou H, Liu L, Tang L, Yin P, Wang Z, Ai L, Ke S, Xia Y, Deng J, Chen L, Cai L, Sun C, Xia L, Hua G, Hu Y
J Hematol Oncol 2021 Oct 9;14(1):161. doi: 10.1186/s13045-021-01170-7. PMID: 34627333Free PMC Article
Rosiñol L, Beksac M, Zamagni E, Van de Donk NWCJ, Anderson KC, Badros A, Caers J, Cavo M, Dimopoulos MA, Dispenzieri A, Einsele H, Engelhardt M, Fernández de Larrea C, Gahrton G, Gay F, Hájek R, Hungria V, Jurczyszyn A, Kröger N, Kyle RA, Leal da Costa F, Leleu X, Lentzsch S, Mateos MV, Merlini G, Mohty M, Moreau P, Rasche L, Reece D, Sezer O, Sonneveld P, Usmani SZ, Vanderkerken K, Vesole DH, Waage A, Zweegman S, Richardson PG, Bladé J
Br J Haematol 2021 Aug;194(3):496-507. Epub 2021 Mar 16 doi: 10.1111/bjh.17338. PMID: 33724461
Cavo M, Gay F, Beksac M, Pantani L, Petrucci MT, Dimopoulos MA, Dozza L, van der Holt B, Zweegman S, Oliva S, van der Velden VHJ, Zamagni E, Palumbo GA, Patriarca F, Montefusco V, Galli M, Maisnar V, Gamberi B, Hansson M, Belotti A, Pour L, Ypma P, Grasso M, Croockewit A, Ballanti S, Offidani M, Vincelli ID, Zambello R, Liberati AM, Andersen NF, Broijl A, Troia R, Pascarella A, Benevolo G, Levin MD, Bos G, Ludwig H, Aquino S, Morelli AM, Wu KL, Boersma R, Hajek R, Durian M, von dem Borne PA, Caravita di Toritto T, Zander T, Driessen C, Specchia G, Waage A, Gimsing P, Mellqvist UH, van Marwijk Kooy M, Minnema M, Mandigers C, Cafro AM, Palmas A, Carvalho S, Spencer A, Boccadoro M, Sonneveld P
Lancet Haematol 2020 Jun;7(6):e456-e468. Epub 2020 Apr 30 doi: 10.1016/S2352-3026(20)30099-5. PMID: 32359506
Cunha Júnior AD, Pericole FV, Carvalheira JBC
Clinics (Sao Paulo) 2018 Sep 6;73(suppl 1):e412s. doi: 10.6061/clinics/2018/e412s. PMID: 30208162Free PMC Article
International Myeloma Working Group
Br J Haematol 2003 Jun;121(5):749-57. PMID: 12780789

Prognosis

Lamb MM, Zeatoun A, Stack TJ, Kim S, Albastoni S, Singer B, Klatt-Cromwell C, Senior BA, Kimple AJ, Thorp BD
ORL J Otorhinolaryngol Relat Spec 2023;85(4):231-237. Epub 2023 Jun 26 doi: 10.1159/000530946. PMID: 37364541
Holler A, Cicha I, Eckstein M, Haderlein M, Pöttler M, Rappl A, Iro H, Alexiou C
Cancer Med 2022 Dec;11(24):4743-4755. Epub 2022 May 16 doi: 10.1002/cam4.4816. PMID: 35578404Free PMC Article
Pham A, Mahindra A
Curr Hematol Malig Rep 2019 Apr;14(2):63-69. doi: 10.1007/s11899-019-00499-8. PMID: 30788667
Lombardo EM, Maito FLDM, Heitz C
Braz J Otorhinolaryngol 2018 Nov-Dec;84(6):790-798. Epub 2018 Jun 11 doi: 10.1016/j.bjorl.2018.05.002. PMID: 29941386Free PMC Article
Dagan R, Morris CG, Kirwan J, Mendenhall WM
Am J Clin Oncol 2009 Dec;32(6):612-7. doi: 10.1097/COC.0b013e31819cca18. PMID: 19593082

Clinical prediction guides

Fitzpatrick MJ, Murali MR, Nardi V
Surg Pathol Clin 2023 Jun;16(2):401-410. Epub 2023 Mar 10 doi: 10.1016/j.path.2023.01.005. PMID: 37149365
Cavo M, Terpos E, Nanni C, Moreau P, Lentzsch S, Zweegman S, Hillengass J, Engelhardt M, Usmani SZ, Vesole DH, San-Miguel J, Kumar SK, Richardson PG, Mikhael JR, da Costa FL, Dimopoulos MA, Zingaretti C, Abildgaard N, Goldschmidt H, Orlowski RZ, Chng WJ, Einsele H, Lonial S, Barlogie B, Anderson KC, Rajkumar SV, Durie BGM, Zamagni E
Lancet Oncol 2017 Apr;18(4):e206-e217. doi: 10.1016/S1470-2045(17)30189-4. PMID: 28368259
Dayton VD, Williams SJ, McKenna RW, Linden MA
Hum Pathol 2017 Apr;62:13-22. Epub 2016 Dec 23 doi: 10.1016/j.humpath.2016.12.014. PMID: 28025076
O'Connell TX, Horita TJ, Kasravi B
Am Fam Physician 2005 Jan 1;71(1):105-12. PMID: 15663032
Greipp PR
Mayo Clin Proc 1994 Sep;69(9):895-902. doi: 10.1016/s0025-6196(12)61797-2. PMID: 8065197

Recent systematic reviews

Bladé J, Beksac M, Caers J, Jurczyszyn A, von Lilienfeld-Toal M, Moreau P, Rasche L, Rosiñol L, Usmani SZ, Zamagni E, Richardson P
Blood Cancer J 2022 Mar 21;12(3):45. doi: 10.1038/s41408-022-00643-3. PMID: 35314675Free PMC Article
Vered M, Wright JM
Head Neck Pathol 2022 Mar;16(1):63-75. Epub 2022 Mar 21 doi: 10.1007/s12105-021-01404-7. PMID: 35312978Free PMC Article
Venkatesulu B, Mallick S, Giridhar P, Upadhyay AD, Rath GK
Eur Arch Otorhinolaryngol 2018 Feb;275(2):595-606. Epub 2017 Dec 9 doi: 10.1007/s00405-017-4817-z. PMID: 29224044
Lee J, Kulubya E, Pressman BD, Mamelak A, Bannykh S, Zada G, Cooper O
Pituitary 2017 Jun;20(3):381-392. doi: 10.1007/s11102-017-0799-5. PMID: 28251542Free PMC Article
D'Aguillo C, Soni RS, Gordhan C, Liu JK, Baredes S, Eloy JA
Int Forum Allergy Rhinol 2014 Feb;4(2):156-63. Epub 2013 Dec 13 doi: 10.1002/alr.21254. PMID: 24339430

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