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Plasmacytoma

MedGen UID:
18506
•Concept ID:
C0032131
•
Neoplastic Process
Synonyms: Plasma Cell Tumor; Plasma Cell Tumors; Plasmacytomas; Plasmocytoma; Plasmocytomas; Tumor, Plasma Cell; Tumors, Plasma Cell
SNOMED CT: Plasmacytoma (415112005); Plasmacytoma - disorder (415112005); Solitary myeloma (1187107005); Plasmacytoma (1187107005); Solitary plasmacytoma (1187107005); Plasma cell tumor (1187107005)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
HPO: HP:0011857
Monarch Initiative: MONDO:0005615
Orphanet: ORPHA86855

Definition

A discrete mass of neoplastic monoclonal plasma cells either in the bone marrow or in an extramedullary location. [from HPO]

Professional guidelines

PubMed

Multiple myeloma: 2022 update on diagnosis, risk stratification, and management.
Rajkumar SV
Am J Hematol 2022 Aug;97(8):1086-1107. Epub 2022 May 23 doi: 10.1002/ajh.26590. PMID: 35560063Free PMC Article
POEMS Syndrome: 2019 Update on diagnosis, risk-stratification, and management.
Dispenzieri A
Am J Hematol 2019 Jul;94(7):812-827. Epub 2019 May 23 doi: 10.1002/ajh.25495. PMID: 31012139
Diagnosis, treatment, and response assessment in solitary plasmacytoma: updated recommendations from a European Expert Panel.
Caers J, Paiva B, Zamagni E, Leleu X, Bladé J, Kristinsson SY, Touzeau C, Abildgaard N, Terpos E, Heusschen R, Ocio E, Delforge M, Sezer O, Beksac M, Ludwig H, Merlini G, Moreau P, Zweegman S, Engelhardt M, Rosiñol L
J Hematol Oncol 2018 Jan 16;11(1):10. doi: 10.1186/s13045-017-0549-1. PMID: 29338789Free PMC Article

Recent clinical studies

Etiology

Plasma cell neoplasms and related entities-evolution in diagnosis and classification.
Fend F, Dogan A, Cook JR
Virchows Arch 2023 Jan;482(1):163-177. Epub 2022 Nov 21 doi: 10.1007/s00428-022-03431-3. PMID: 36414803Free PMC Article
Expert review on soft-tissue plasmacytomas in multiple myeloma: definition, disease assessment and treatment considerations.
Rosiñol L, Beksac M, Zamagni E, Van de Donk NWCJ, Anderson KC, Badros A, Caers J, Cavo M, Dimopoulos MA, Dispenzieri A, Einsele H, Engelhardt M, Fernández de Larrea C, Gahrton G, Gay F, Hájek R, Hungria V, Jurczyszyn A, Kröger N, Kyle RA, Leal da Costa F, Leleu X, Lentzsch S, Mateos MV, Merlini G, Mohty M, Moreau P, Rasche L, Reece D, Sezer O, Sonneveld P, Usmani SZ, Vanderkerken K, Vesole DH, Waage A, Zweegman S, Richardson PG, Bladé J
Br J Haematol 2021 Aug;194(3):496-507. Epub 2021 Mar 16 doi: 10.1111/bjh.17338. PMID: 33724461
Solitary Plasmacytoma: a Review of Diagnosis and Management.
Pham A, Mahindra A
Curr Hematol Malig Rep 2019 Apr;14(2):63-69. doi: 10.1007/s11899-019-00499-8. PMID: 30788667
Radiation Therapy for Solitary Plasmacytoma and Multiple Myeloma: Guidelines From the International Lymphoma Radiation Oncology Group.
Tsang RW, Campbell BA, Goda JS, Kelsey CR, Kirova YM, Parikh RR, Ng AK, Ricardi U, Suh CO, Mauch PM, Specht L, Yahalom J
Int J Radiat Oncol Biol Phys 2018 Jul 15;101(4):794-808. Epub 2018 Jun 20 doi: 10.1016/j.ijrobp.2018.05.009. PMID: 29976492
Diagnosis, treatment, and response assessment in solitary plasmacytoma: updated recommendations from a European Expert Panel.
Caers J, Paiva B, Zamagni E, Leleu X, Bladé J, Kristinsson SY, Touzeau C, Abildgaard N, Terpos E, Heusschen R, Ocio E, Delforge M, Sezer O, Beksac M, Ludwig H, Merlini G, Moreau P, Zweegman S, Engelhardt M, Rosiñol L
J Hematol Oncol 2018 Jan 16;11(1):10. doi: 10.1186/s13045-017-0549-1. PMID: 29338789Free PMC Article

Diagnosis

Cutaneous multiple myeloma.
Forsyth C, Lai S, Jagger J
Br J Haematol 2020 Jul;190(2):134. Epub 2020 Apr 16 doi: 10.1111/bjh.16646. PMID: 32301114
Solitary Plasmacytoma: a Review of Diagnosis and Management.
Pham A, Mahindra A
Curr Hematol Malig Rep 2019 Apr;14(2):63-69. doi: 10.1007/s11899-019-00499-8. PMID: 30788667
Plasmacytoma of the mesentery.
Thambi SM, Nair SG, Benson R
J Postgrad Med 2018 Oct-Dec;64(4):255-257. doi: 10.4103/jpgm.JPGM_296_18. PMID: 30207325Free PMC Article
Diagnosis, treatment, and response assessment in solitary plasmacytoma: updated recommendations from a European Expert Panel.
Caers J, Paiva B, Zamagni E, Leleu X, Bladé J, Kristinsson SY, Touzeau C, Abildgaard N, Terpos E, Heusschen R, Ocio E, Delforge M, Sezer O, Beksac M, Ludwig H, Merlini G, Moreau P, Zweegman S, Engelhardt M, Rosiñol L
J Hematol Oncol 2018 Jan 16;11(1):10. doi: 10.1186/s13045-017-0549-1. PMID: 29338789Free PMC Article
A review for solitary plasmacytoma of bone and extramedullary plasmacytoma.
Kilciksiz S, Karakoyun-Celik O, Agaoglu FY, Haydaroglu A
ScientificWorldJournal 2012;2012:895765. Epub 2012 May 2 doi: 10.1100/2012/895765. PMID: 22654647Free PMC Article

Therapy

A bispecific CAR-T cell therapy targeting BCMA and CD38 in relapsed or refractory multiple myeloma.
Mei H, Li C, Jiang H, Zhao X, Huang Z, Jin D, Guo T, Kou H, Liu L, Tang L, Yin P, Wang Z, Ai L, Ke S, Xia Y, Deng J, Chen L, Cai L, Sun C, Xia L, Hua G, Hu Y
J Hematol Oncol 2021 Oct 9;14(1):161. doi: 10.1186/s13045-021-01170-7. PMID: 34627333Free PMC Article
Expert review on soft-tissue plasmacytomas in multiple myeloma: definition, disease assessment and treatment considerations.
Rosiñol L, Beksac M, Zamagni E, Van de Donk NWCJ, Anderson KC, Badros A, Caers J, Cavo M, Dimopoulos MA, Dispenzieri A, Einsele H, Engelhardt M, Fernández de Larrea C, Gahrton G, Gay F, Hájek R, Hungria V, Jurczyszyn A, Kröger N, Kyle RA, Leal da Costa F, Leleu X, Lentzsch S, Mateos MV, Merlini G, Mohty M, Moreau P, Rasche L, Reece D, Sezer O, Sonneveld P, Usmani SZ, Vanderkerken K, Vesole DH, Waage A, Zweegman S, Richardson PG, Bladé J
Br J Haematol 2021 Aug;194(3):496-507. Epub 2021 Mar 16 doi: 10.1111/bjh.17338. PMID: 33724461
Metformin and blood cancers.
Cunha Júnior AD, Pericole FV, Carvalheira JBC
Clinics (Sao Paulo) 2018 Sep 6;73(suppl 1):e412s. doi: 10.6061/clinics/2018/e412s. PMID: 30208162Free PMC Article
Multiple myeloma.
Singhal S, Mehta J
Clin J Am Soc Nephrol 2006 Nov;1(6):1322-30. Epub 2006 Oct 11 doi: 10.2215/CJN.03060906. PMID: 17699365
Krestin (PSK).
Tsukagoshi S, Hashimoto Y, Fujii G, Kobayashi H, Nomoto K, Orita K
Cancer Treat Rev 1984 Jun;11(2):131-55. doi: 10.1016/0305-7372(84)90005-7. PMID: 6238674

Prognosis

Plasmacytoma of the Head and Neck: Case Series and Review of the Literature.
Lamb MM, Zeatoun A, Stack TJ, Kim S, Albastoni S, Singer B, Klatt-Cromwell C, Senior BA, Kimple AJ, Thorp BD
ORL J Otorhinolaryngol Relat Spec 2023;85(4):231-237. Epub 2023 Jun 26 doi: 10.1159/000530946. PMID: 37364541
Extramedullary plasmacytoma: Tumor occurrence and therapeutic concepts-A follow-up.
Holler A, Cicha I, Eckstein M, Haderlein M, Pöttler M, Rappl A, Iro H, Alexiou C
Cancer Med 2022 Dec;11(24):4743-4755. Epub 2022 May 16 doi: 10.1002/cam4.4816. PMID: 35578404Free PMC Article
Solitary Plasmacytoma: a Review of Diagnosis and Management.
Pham A, Mahindra A
Curr Hematol Malig Rep 2019 Apr;14(2):63-69. doi: 10.1007/s11899-019-00499-8. PMID: 30788667
Solitary plasmacytoma.
Dagan R, Morris CG, Kirwan J, Mendenhall WM
Am J Clin Oncol 2009 Dec;32(6):612-7. doi: 10.1097/COC.0b013e31819cca18. PMID: 19593082
Multiple myeloma.
Singhal S, Mehta J
Clin J Am Soc Nephrol 2006 Nov;1(6):1322-30. Epub 2006 Oct 11 doi: 10.2215/CJN.03060906. PMID: 17699365

Clinical prediction guides

Molecular Diagnostics of Plasma Cell Neoplasms.
Fitzpatrick MJ, Murali MR, Nardi V
Surg Pathol Clin 2023 Jun;16(2):401-410. Epub 2023 Mar 10 doi: 10.1016/j.path.2023.01.005. PMID: 37149365
Whole-Body Imaging of Multiple Myeloma: Diagnostic Criteria.
Ormond Filho AG, Carneiro BC, Pastore D, Silva IP, Yamashita SR, Consolo FD, Hungria VTM, Sandes AF, Rizzatti EG, Nico MAC
Radiographics 2019 Jul-Aug;39(4):1077-1097. doi: 10.1148/rg.2019180096. PMID: 31283452
Role of (18)F-FDG PET/CT in the diagnosis and management of multiple myeloma and other plasma cell disorders: a consensus statement by the International Myeloma Working Group.
Cavo M, Terpos E, Nanni C, Moreau P, Lentzsch S, Zweegman S, Hillengass J, Engelhardt M, Usmani SZ, Vesole DH, San-Miguel J, Kumar SK, Richardson PG, Mikhael JR, da Costa FL, Dimopoulos MA, Zingaretti C, Abildgaard N, Goldschmidt H, Orlowski RZ, Chng WJ, Einsele H, Lonial S, Barlogie B, Anderson KC, Rajkumar SV, Durie BGM, Zamagni E
Lancet Oncol 2017 Apr;18(4):e206-e217. doi: 10.1016/S1470-2045(17)30189-4. PMID: 28368259
Multiple myeloma.
Singhal S, Mehta J
Clin J Am Soc Nephrol 2006 Nov;1(6):1322-30. Epub 2006 Oct 11 doi: 10.2215/CJN.03060906. PMID: 17699365
Understanding and interpreting serum protein electrophoresis.
O'Connell TX, Horita TJ, Kasravi B
Am Fam Physician 2005 Jan 1;71(1):105-12. PMID: 15663032

Recent systematic reviews

Extramedullary disease in multiple myeloma: a systematic literature review.
Bladé J, Beksac M, Caers J, Jurczyszyn A, von Lilienfeld-Toal M, Moreau P, Rasche L, Rosiñol L, Usmani SZ, Zamagni E, Richardson P
Blood Cancer J 2022 Mar 21;12(3):45. doi: 10.1038/s41408-022-00643-3. PMID: 35314675Free PMC Article
Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Odontogenic and Maxillofacial Bone Tumours.
Vered M, Wright JM
Head Neck Pathol 2022 Mar;16(1):63-75. Epub 2022 Mar 21 doi: 10.1007/s12105-021-01404-7. PMID: 35312978Free PMC Article
Sellar plasmacytomas masquerading as pituitary adenomas: A systematic review.
DiDomenico J, Ampie L, Choy W, Lamano JB, Oyon DE, Kesavabhotla K, Bloch O
J Clin Neurosci 2018 Apr;50:20-23. Epub 2018 Feb 1 doi: 10.1016/j.jocn.2018.01.022. PMID: 29396062
Sellar and clival plasmacytomas: case series of 5 patients with systematic review of 65 published cases.
Lee J, Kulubya E, Pressman BD, Mamelak A, Bannykh S, Zada G, Cooper O
Pituitary 2017 Jun;20(3):381-392. doi: 10.1007/s11102-017-0799-5. PMID: 28251542Free PMC Article
Sinonasal extramedullary plasmacytoma: a systematic review of 175 patients.
D'Aguillo C, Soni RS, Gordhan C, Liu JK, Baredes S, Eloy JA
Int Forum Allergy Rhinol 2014 Feb;4(2):156-63. Epub 2013 Dec 13 doi: 10.1002/alr.21254. PMID: 24339430

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